Eukaryotic initiation factor 4E family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E type 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HEN3_LEIBR

TriTrypDb:

LbrM.26.0270 , LBRM2903_260007500

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEN3

PDB structure(s): 7kcj_A , 7kcj_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0003743	translation initiation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CKS1_1	12	17	PF01111	0.587
DOC_MAPK_MEF2A_6	142	149	PF00069	0.488
DOC_PP2B_PxIxI_1	171	177	PF00149	0.421
DOC_PP4_FxxP_1	26	29	PF00568	0.545
DOC_SPAK_OSR1_1	90	94	PF12202	0.545
DOC_WW_Pin1_4	11	16	PF00397	0.507
DOC_WW_Pin1_4	123	128	PF00397	0.482
DOC_WW_Pin1_4	151	156	PF00397	0.560
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_deltaCOP1_diTrp_1	21	26	PF00928	0.510
LIG_FHA_1	104	110	PF00498	0.469
LIG_FHA_1	38	44	PF00498	0.545
LIG_FHA_2	46	52	PF00498	0.467
LIG_LIR_Gen_1	50	61	PF02991	0.468
LIG_LIR_Gen_1	79	89	PF02991	0.436
LIG_LIR_Nem_3	21	27	PF02991	0.477
LIG_LIR_Nem_3	50	56	PF02991	0.427
LIG_LIR_Nem_3	79	85	PF02991	0.457
LIG_Pex14_1	23	27	PF04695	0.468
LIG_SH2_CRK	53	57	PF00017	0.510
LIG_SH2_NCK_1	53	57	PF00017	0.510
LIG_SH2_SRC	27	30	PF00017	0.510
LIG_SH2_STAT5	107	110	PF00017	0.546
LIG_SH2_STAT5	163	166	PF00017	0.360
LIG_SH2_STAT5	27	30	PF00017	0.427
LIG_SH2_STAT5	45	48	PF00017	0.468
LIG_SH3_2	15	20	PF14604	0.513
LIG_SH3_3	9	15	PF00018	0.564
LIG_TRAF2_1	48	51	PF00917	0.441
LIG_UBA3_1	25	32	PF00899	0.371
MOD_CK1_1	166	172	PF00069	0.390
MOD_CK1_1	4	10	PF00069	0.589
MOD_CK2_1	44	50	PF00069	0.461
MOD_GlcNHglycan	176	179	PF01048	0.362
MOD_GSK3_1	163	170	PF00069	0.325
MOD_GSK3_1	51	58	PF00069	0.486
MOD_GSK3_1	7	14	PF00069	0.657
MOD_NEK2_1	1	6	PF00069	0.533
MOD_NEK2_1	164	169	PF00069	0.505
MOD_NEK2_1	71	76	PF00069	0.550
MOD_NEK2_1	89	94	PF00069	0.473
MOD_NEK2_2	141	146	PF00069	0.545
MOD_PIKK_1	96	102	PF00454	0.525
MOD_PKA_2	89	95	PF00069	0.468
MOD_Plk_1	2	8	PF00069	0.558
MOD_Plk_4	103	109	PF00069	0.469
MOD_Plk_4	135	141	PF00069	0.475
MOD_ProDKin_1	11	17	PF00069	0.497
MOD_ProDKin_1	123	129	PF00069	0.482
MOD_ProDKin_1	151	157	PF00069	0.560
MOD_SUMO_rev_2	35	43	PF00179	0.516
TRG_ENDOCYTIC_2	53	56	PF00928	0.510
TRG_NES_CRM1_1	103	115	PF08389	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E4	Leptomonas seymouri	73%	100%
A0A0N1ILF7	Leptomonas seymouri	33%	96%
A0A0S4IN32	Bodo saltans	37%	99%
A0A0S4IZ31	Bodo saltans	36%	100%
A0A1X0NSI0	Trypanosomatidae	44%	98%
A0A1X0P9L6	Trypanosomatidae	33%	87%
A0A3S7WZL5	Leishmania donovani	93%	100%
A0A3S7XAF1	Leishmania donovani	32%	85%
A0A422P286	Trypanosoma rangeli	34%	91%
A4HNR9	Leishmania braziliensis	31%	85%
A4I1W1	Leishmania infantum	92%	100%
A4ICS5	Leishmania infantum	32%	85%
C9ZS59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
D0A2M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
E9ASH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	85%
E9AY06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q217	Leishmania major	32%	100%
Q4Q9G7	Leishmania major	92%	100%
V5BZH5	Trypanosoma cruzi	46%	98%