Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HEN2_LEIBR

TriTrypDb:

LbrM.26.0260 , LBRM2903_260007400

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.597
CLV_NRD_NRD_1	196	198	PF00675	0.446
CLV_NRD_NRD_1	337	339	PF00675	0.532
CLV_NRD_NRD_1	366	368	PF00675	0.593
CLV_NRD_NRD_1	57	59	PF00675	0.542
CLV_NRD_NRD_1	68	70	PF00675	0.481
CLV_NRD_NRD_1	79	81	PF00675	0.439
CLV_PCSK_KEX2_1	196	198	PF00082	0.493
CLV_PCSK_KEX2_1	337	339	PF00082	0.746
CLV_PCSK_KEX2_1	366	368	PF00082	0.593
CLV_PCSK_KEX2_1	57	59	PF00082	0.542
CLV_PCSK_KEX2_1	68	70	PF00082	0.477
CLV_PCSK_KEX2_1	78	80	PF00082	0.484
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.415
CLV_PCSK_PC7_1	333	339	PF00082	0.530
CLV_PCSK_SKI1_1	199	203	PF00082	0.729
DEG_APCC_DBOX_1	85	93	PF00400	0.535
DEG_Nend_UBRbox_1	1	4	PF02207	0.568
DOC_CYCLIN_RxL_1	196	205	PF00134	0.689
DOC_CYCLIN_RxL_1	86	98	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.783
DOC_MAPK_gen_1	2	11	PF00069	0.479
DOC_MAPK_gen_1	65	75	PF00069	0.576
DOC_MAPK_MEF2A_6	68	75	PF00069	0.368
DOC_PP1_RVXF_1	292	299	PF00149	0.440
DOC_PP1_RVXF_1	88	95	PF00149	0.575
DOC_PP2B_LxvP_1	118	121	PF13499	0.529
DOC_PP2B_LxvP_1	165	168	PF13499	0.499
DOC_PP4_FxxP_1	259	262	PF00568	0.545
DOC_PP4_FxxP_1	94	97	PF00568	0.667
DOC_USP7_MATH_1	112	116	PF00917	0.666
DOC_USP7_MATH_1	236	240	PF00917	0.371
DOC_USP7_MATH_1	262	266	PF00917	0.428
DOC_USP7_MATH_1	314	318	PF00917	0.724
DOC_USP7_MATH_1	47	51	PF00917	0.625
DOC_USP7_UBL2_3	74	78	PF12436	0.423
DOC_WW_Pin1_4	177	182	PF00397	0.668
DOC_WW_Pin1_4	200	205	PF00397	0.702
DOC_WW_Pin1_4	258	263	PF00397	0.546
DOC_WW_Pin1_4	328	333	PF00397	0.662
DOC_WW_Pin1_4	338	343	PF00397	0.619
DOC_WW_Pin1_4	93	98	PF00397	0.584
LIG_14-3-3_CanoR_1	210	217	PF00244	0.497
LIG_14-3-3_CanoR_1	345	349	PF00244	0.687
LIG_14-3-3_CanoR_1	8	16	PF00244	0.392
LIG_14-3-3_CanoR_1	86	90	PF00244	0.526
LIG_Actin_WH2_1	345	363	PF00022	0.654
LIG_Actin_WH2_2	278	296	PF00022	0.436
LIG_Clathr_ClatBox_1	248	252	PF01394	0.587
LIG_FHA_1	160	166	PF00498	0.587
LIG_FHA_1	28	34	PF00498	0.674
LIG_FHA_1	301	307	PF00498	0.478
LIG_FHA_1	4	10	PF00498	0.599
LIG_FHA_1	61	67	PF00498	0.597
LIG_FHA_1	86	92	PF00498	0.386
LIG_FHA_2	203	209	PF00498	0.673
LIG_FHA_2	351	357	PF00498	0.685
LIG_LIR_Gen_1	132	141	PF02991	0.445
LIG_LIR_Gen_1	185	194	PF02991	0.710
LIG_LIR_Gen_1	353	360	PF02991	0.681
LIG_LIR_Nem_3	13	19	PF02991	0.530
LIG_LIR_Nem_3	132	136	PF02991	0.460
LIG_LIR_Nem_3	185	191	PF02991	0.717
LIG_LIR_Nem_3	286	292	PF02991	0.530
LIG_LIR_Nem_3	321	325	PF02991	0.779
LIG_LIR_Nem_3	353	357	PF02991	0.679
LIG_NRBOX	149	155	PF00104	0.391
LIG_PCNA_yPIPBox_3	137	151	PF02747	0.409
LIG_RPA_C_Fungi	63	75	PF08784	0.568
LIG_SH2_CRK	289	293	PF00017	0.528
LIG_SH2_STAP1	188	192	PF00017	0.717
LIG_SH2_STAP1	23	27	PF00017	0.519
LIG_SH2_STAP1	354	358	PF00017	0.676
LIG_SH2_STAT3	23	26	PF00017	0.520
LIG_SH2_STAT5	284	287	PF00017	0.555
LIG_SH3_3	248	254	PF00018	0.350
LIG_SH3_3	266	272	PF00018	0.536
LIG_SH3_3	285	291	PF00018	0.616
LIG_SH3_3	320	326	PF00018	0.708
LIG_SH3_3	94	100	PF00018	0.615
LIG_Sin3_3	226	233	PF02671	0.345
LIG_SUMO_SIM_par_1	264	271	PF11976	0.538
LIG_SUMO_SIM_par_1	325	331	PF11976	0.520
LIG_TRAF2_1	18	21	PF00917	0.581
LIG_TRAF2_1	353	356	PF00917	0.689
LIG_TRAF2_1	82	85	PF00917	0.640
LIG_TYR_ITIM	352	357	PF00017	0.639
MOD_CDK_SPK_2	328	333	PF00069	0.521
MOD_CDK_SPxxK_3	338	345	PF00069	0.740
MOD_CK1_1	182	188	PF00069	0.605
MOD_CK1_1	261	267	PF00069	0.561
MOD_CK1_1	283	289	PF00069	0.598
MOD_CK1_1	3	9	PF00069	0.570
MOD_CK1_1	341	347	PF00069	0.739
MOD_CK1_1	350	356	PF00069	0.556
MOD_CK2_1	202	208	PF00069	0.598
MOD_CK2_1	350	356	PF00069	0.693
MOD_CK2_1	48	54	PF00069	0.521
MOD_DYRK1A_RPxSP_1	95	99	PF00069	0.453
MOD_GlcNHglycan	174	177	PF01048	0.668
MOD_GlcNHglycan	182	185	PF01048	0.697
MOD_GlcNHglycan	316	319	PF01048	0.714
MOD_GlcNHglycan	50	53	PF01048	0.611
MOD_GSK3_1	172	179	PF00069	0.715
MOD_GSK3_1	258	265	PF00069	0.396
MOD_GSK3_1	314	321	PF00069	0.683
MOD_GSK3_1	340	347	PF00069	0.742
MOD_NEK2_1	113	118	PF00069	0.703
MOD_NEK2_1	159	164	PF00069	0.581
MOD_NEK2_1	280	285	PF00069	0.498
MOD_NEK2_1	360	365	PF00069	0.516
MOD_NEK2_2	60	65	PF00069	0.455
MOD_OFUCOSY	34	40	PF10250	0.598
MOD_PIKK_1	33	39	PF00454	0.492
MOD_PIKK_1	347	353	PF00454	0.697
MOD_PKA_2	209	215	PF00069	0.482
MOD_PKA_2	27	33	PF00069	0.414
MOD_PKA_2	344	350	PF00069	0.683
MOD_PKA_2	85	91	PF00069	0.540
MOD_Plk_1	12	18	PF00069	0.539
MOD_Plk_4	149	155	PF00069	0.563
MOD_Plk_4	236	242	PF00069	0.546
MOD_Plk_4	262	268	PF00069	0.560
MOD_Plk_4	280	286	PF00069	0.589
MOD_Plk_4	344	350	PF00069	0.721
MOD_ProDKin_1	177	183	PF00069	0.658
MOD_ProDKin_1	200	206	PF00069	0.706
MOD_ProDKin_1	258	264	PF00069	0.545
MOD_ProDKin_1	328	334	PF00069	0.661
MOD_ProDKin_1	338	344	PF00069	0.613
MOD_ProDKin_1	93	99	PF00069	0.592
MOD_SUMO_rev_2	355	363	PF00179	0.676
TRG_DiLeu_BaEn_1	146	151	PF01217	0.532
TRG_DiLeu_BaEn_1	276	281	PF01217	0.383
TRG_DiLeu_BaEn_4	355	361	PF01217	0.674
TRG_DiLeu_BaEn_4	84	90	PF01217	0.628
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.526
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.644
TRG_ENDOCYTIC_2	188	191	PF00928	0.718
TRG_ENDOCYTIC_2	289	292	PF00928	0.532
TRG_ENDOCYTIC_2	354	357	PF00928	0.678
TRG_ER_diArg_1	365	367	PF00400	0.600
TRG_ER_diArg_1	56	58	PF00400	0.551
TRG_ER_diArg_1	68	70	PF00400	0.449
TRG_ER_diArg_1	79	81	PF00400	0.429
TRG_NLS_Bipartite_1	68	82	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P503	Leptomonas seymouri	38%	94%
A0A3Q8IDK6	Leishmania donovani	71%	100%
A4I1W0	Leishmania infantum	71%	100%
E9AY05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q9G8	Leishmania major	71%	100%