LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein pelota homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein pelota homolog
Gene product:
eukaryotic peptide chain release factor subunit 1, putative
Species:
Leishmania braziliensis
UniProt:
A4HEM6_LEIBR
TriTrypDb:
LbrM.26.0200 , LBRM2903_260007100
Length:
406

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HEM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEM6

Function

Biological processes
Term Name Level Count
GO:0000956 nuclear-transcribed mRNA catabolic process 7 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006401 RNA catabolic process 5 12
GO:0006402 mRNA catabolic process 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009057 macromolecule catabolic process 4 12
GO:0009892 negative regulation of metabolic process 4 12
GO:0009987 cellular process 1 12
GO:0010468 regulation of gene expression 5 12
GO:0010605 negative regulation of macromolecule metabolic process 5 12
GO:0010629 negative regulation of gene expression 6 12
GO:0016070 RNA metabolic process 5 12
GO:0016071 mRNA metabolic process 6 12
GO:0019222 regulation of metabolic process 3 12
GO:0019439 aromatic compound catabolic process 4 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034655 nucleobase-containing compound catabolic process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044265 obsolete cellular macromolecule catabolic process 4 12
GO:0044270 cellular nitrogen compound catabolic process 4 12
GO:0046483 heterocycle metabolic process 3 12
GO:0046700 heterocycle catabolic process 4 12
GO:0048519 negative regulation of biological process 3 12
GO:0050789 regulation of biological process 2 12
GO:0060255 regulation of macromolecule metabolic process 4 12
GO:0065007 biological regulation 1 12
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay 8 12
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay 8 12
GO:0071025 RNA surveillance 6 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901361 organic cyclic compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0016072 rRNA metabolic process 7 1
GO:0016075 rRNA catabolic process 7 1
GO:0022411 cellular component disassembly 4 1
GO:0032790 ribosome disassembly 6 1
GO:0034660 ncRNA metabolic process 6 1
GO:0034661 ncRNA catabolic process 6 1
GO:0070651 nonfunctional rRNA decay 8 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903008 organelle disassembly 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004518 nuclease activity 4 12
GO:0004519 endonuclease activity 5 12
GO:0005488 binding 1 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 14 20 PF00089 0.180
CLV_NRD_NRD_1 329 331 PF00675 0.266
CLV_NRD_NRD_1 44 46 PF00675 0.255
CLV_PCSK_KEX2_1 329 331 PF00082 0.266
CLV_PCSK_KEX2_1 44 46 PF00082 0.255
CLV_PCSK_SKI1_1 184 188 PF00082 0.246
CLV_PCSK_SKI1_1 203 207 PF00082 0.255
CLV_PCSK_SKI1_1 222 226 PF00082 0.333
CLV_PCSK_SKI1_1 242 246 PF00082 0.264
CLV_PCSK_SKI1_1 257 261 PF00082 0.266
CLV_PCSK_SKI1_1 329 333 PF00082 0.341
CLV_PCSK_SKI1_1 353 357 PF00082 0.337
CLV_PCSK_SKI1_1 70 74 PF00082 0.278
DEG_APCC_DBOX_1 329 337 PF00400 0.480
DEG_APCC_KENBOX_2 86 90 PF00400 0.516
DEG_COP1_1 376 386 PF00400 0.584
DEG_Nend_UBRbox_1 1 4 PF02207 0.455
DEG_SPOP_SBC_1 248 252 PF00917 0.518
DOC_CKS1_1 151 156 PF01111 0.383
DOC_CKS1_1 296 301 PF01111 0.455
DOC_CYCLIN_RxL_1 237 249 PF00134 0.467
DOC_MAPK_gen_1 160 167 PF00069 0.455
DOC_MAPK_gen_1 329 335 PF00069 0.466
DOC_MAPK_MEF2A_6 160 167 PF00069 0.455
DOC_MAPK_MEF2A_6 61 69 PF00069 0.460
DOC_PP1_RVXF_1 68 75 PF00149 0.516
DOC_PP4_FxxP_1 372 375 PF00568 0.533
DOC_USP7_MATH_1 10 14 PF00917 0.546
DOC_USP7_UBL2_3 172 176 PF12436 0.541
DOC_USP7_UBL2_3 42 46 PF12436 0.480
DOC_WW_Pin1_4 150 155 PF00397 0.383
DOC_WW_Pin1_4 206 211 PF00397 0.451
DOC_WW_Pin1_4 295 300 PF00397 0.455
DOC_WW_Pin1_4 322 327 PF00397 0.398
DOC_WW_Pin1_4 72 77 PF00397 0.466
LIG_14-3-3_CanoR_1 17 27 PF00244 0.560
LIG_14-3-3_CanoR_1 330 336 PF00244 0.481
LIG_14-3-3_CanoR_1 340 350 PF00244 0.474
LIG_14-3-3_CanoR_1 371 375 PF00244 0.560
LIG_14-3-3_CterR_2 403 406 PF00244 0.569
LIG_Actin_WH2_2 241 259 PF00022 0.471
LIG_Actin_WH2_2 356 373 PF00022 0.560
LIG_deltaCOP1_diTrp_1 24 32 PF00928 0.541
LIG_FHA_1 135 141 PF00498 0.304
LIG_FHA_1 200 206 PF00498 0.560
LIG_FHA_1 270 276 PF00498 0.516
LIG_FHA_1 344 350 PF00498 0.528
LIG_FHA_1 399 405 PF00498 0.565
LIG_FHA_1 97 103 PF00498 0.466
LIG_FHA_2 111 117 PF00498 0.541
LIG_FHA_2 20 26 PF00498 0.455
LIG_FHA_2 73 79 PF00498 0.528
LIG_FHA_2 83 89 PF00498 0.496
LIG_IRF3_LxIS_1 311 317 PF10401 0.496
LIG_LIR_Gen_1 115 125 PF02991 0.455
LIG_LIR_Gen_1 153 163 PF02991 0.517
LIG_LIR_Gen_1 215 224 PF02991 0.518
LIG_LIR_Gen_1 241 248 PF02991 0.544
LIG_LIR_Nem_3 115 120 PF02991 0.455
LIG_LIR_Nem_3 153 159 PF02991 0.517
LIG_LIR_Nem_3 215 221 PF02991 0.473
LIG_LIR_Nem_3 24 30 PF02991 0.455
LIG_LIR_Nem_3 241 246 PF02991 0.494
LIG_PDZ_Class_2 401 406 PF00595 0.554
LIG_REV1ctd_RIR_1 183 191 PF16727 0.466
LIG_SH2_CRK 218 222 PF00017 0.380
LIG_SH2_CRK 30 34 PF00017 0.455
LIG_SH2_SRC 218 221 PF00017 0.504
LIG_SH2_STAP1 304 308 PF00017 0.560
LIG_SH2_STAT3 297 300 PF00017 0.455
LIG_SH2_STAT5 220 223 PF00017 0.516
LIG_SH2_STAT5 297 300 PF00017 0.452
LIG_SH3_3 293 299 PF00018 0.455
LIG_SUMO_SIM_anti_2 202 209 PF11976 0.560
LIG_SUMO_SIM_par_1 148 153 PF11976 0.466
LIG_SUMO_SIM_par_1 202 209 PF11976 0.458
LIG_TRAF2_1 106 109 PF00917 0.541
LIG_UBA3_1 62 70 PF00899 0.560
MOD_CDK_SPxxK_3 322 329 PF00069 0.394
MOD_CK1_1 19 25 PF00069 0.516
MOD_CK1_1 249 255 PF00069 0.568
MOD_CK1_1 342 348 PF00069 0.471
MOD_CK2_1 110 116 PF00069 0.541
MOD_CK2_1 18 24 PF00069 0.394
MOD_CK2_1 322 328 PF00069 0.394
MOD_CK2_1 370 376 PF00069 0.570
MOD_CK2_1 72 78 PF00069 0.466
MOD_CK2_1 82 88 PF00069 0.466
MOD_DYRK1A_RPxSP_1 322 326 PF00069 0.394
MOD_GlcNHglycan 253 256 PF01048 0.316
MOD_GlcNHglycan 341 344 PF01048 0.341
MOD_GlcNHglycan 6 9 PF01048 0.180
MOD_GSK3_1 112 119 PF00069 0.536
MOD_GSK3_1 16 23 PF00069 0.433
MOD_GSK3_1 247 254 PF00069 0.511
MOD_GSK3_1 320 327 PF00069 0.505
MOD_GSK3_1 339 346 PF00069 0.350
MOD_GSK3_1 349 356 PF00069 0.423
MOD_GSK3_1 358 365 PF00069 0.355
MOD_GSK3_1 398 405 PF00069 0.520
MOD_GSK3_1 87 94 PF00069 0.417
MOD_N-GLC_1 398 403 PF02516 0.464
MOD_N-GLC_2 127 129 PF02516 0.180
MOD_NEK2_1 199 204 PF00069 0.560
MOD_NEK2_1 238 243 PF00069 0.502
MOD_NEK2_1 269 274 PF00069 0.448
MOD_NEK2_1 284 289 PF00069 0.474
MOD_NEK2_1 331 336 PF00069 0.460
MOD_NEK2_1 370 375 PF00069 0.567
MOD_NEK2_1 38 43 PF00069 0.541
MOD_NEK2_1 4 9 PF00069 0.476
MOD_NEK2_1 91 96 PF00069 0.560
MOD_PIKK_1 222 228 PF00454 0.541
MOD_PIKK_1 358 364 PF00454 0.480
MOD_PK_1 178 184 PF00069 0.455
MOD_PKA_2 16 22 PF00069 0.560
MOD_PKA_2 339 345 PF00069 0.546
MOD_PKA_2 370 376 PF00069 0.560
MOD_Plk_1 163 169 PF00069 0.473
MOD_Plk_1 178 184 PF00069 0.403
MOD_Plk_1 87 93 PF00069 0.493
MOD_Plk_2-3 116 122 PF00069 0.541
MOD_Plk_4 152 158 PF00069 0.387
MOD_Plk_4 331 337 PF00069 0.461
MOD_Plk_4 87 93 PF00069 0.482
MOD_ProDKin_1 150 156 PF00069 0.383
MOD_ProDKin_1 206 212 PF00069 0.451
MOD_ProDKin_1 295 301 PF00069 0.455
MOD_ProDKin_1 322 328 PF00069 0.398
MOD_ProDKin_1 72 78 PF00069 0.466
MOD_SUMO_rev_2 168 177 PF00179 0.541
MOD_SUMO_rev_2 66 72 PF00179 0.560
TRG_DiLeu_BaEn_1 200 205 PF01217 0.516
TRG_DiLeu_BaEn_2 327 333 PF01217 0.541
TRG_DiLeu_BaEn_2 390 396 PF01217 0.551
TRG_ENDOCYTIC_2 218 221 PF00928 0.380
TRG_ENDOCYTIC_2 30 33 PF00928 0.455
TRG_ENDOCYTIC_2 304 307 PF00928 0.559
TRG_ER_diArg_1 329 331 PF00400 0.472
TRG_NES_CRM1_1 24 37 PF08389 0.466
TRG_NES_CRM1_1 59 71 PF08389 0.476
TRG_NLS_MonoExtC_3 168 174 PF00514 0.466

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBN0 Leptomonas seymouri 80% 100%
A0A0S4ING8 Bodo saltans 52% 97%
A0A1X0NU89 Trypanosomatidae 60% 100%
A0A3Q8IDP0 Leishmania donovani 90% 100%
A0A3R7NPE6 Trypanosoma rangeli 60% 100%
A0B6U3 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 28% 100%
A2BL82 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 25% 100%
A2SQV7 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 22% 100%
A3CU20 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 25% 100%
A3DMX7 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 24% 100%
A4G0A4 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 25% 100%
A4I1V7 Leishmania infantum 90% 100%
A5UKW7 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 27% 100%
A6UR75 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 24% 100%
A6UUY1 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 25% 100%
A6VI74 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 25% 100%
A7I7Y6 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 23% 100%
A9A8K6 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 24% 100%
B0R5R9 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 25% 100%
B1L659 Korarchaeum cryptofilum (strain OPF8) 24% 100%
B6YUV3 Thermococcus onnurineus (strain NA1) 28% 100%
B8D691 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 22% 100%
B8GIR5 Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) 24% 100%
B9LQI7 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) 24% 100%
C3MJN7 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 24% 100%
C3MYZ5 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 24% 100%
C3N044 Sulfolobus islandicus (strain M.16.27) 24% 100%
C3N8Q8 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 24% 100%
C3NMR0 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 24% 100%
C4KJ83 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 24% 100%
C5A5T8 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 28% 100%
C9ZS64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9AY02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
O27679 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 26% 100%
O29421 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 23% 100%
O59148 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 26% 100%
P33309 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P48612 Drosophila melanogaster 37% 100%
P50444 Caenorhabditis elegans 35% 100%
P96026 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 23% 100%
Q0W6H4 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 26% 100%
Q12W71 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 27% 100%
Q18J81 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 22% 100%
Q2FQH4 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 26% 100%
Q2NFD9 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 22% 100%
Q3INN9 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 23% 100%
Q46C69 Methanosarcina barkeri (strain Fusaro / DSM 804) 26% 100%
Q4JCI0 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 21% 100%
Q4Q9H1 Leishmania major 90% 100%
Q57638 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 25% 100%
Q58DV0 Bos taurus 38% 100%
Q5JIB9 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 27% 100%
Q5RCE3 Pongo abelii 38% 100%
Q5U567 Xenopus laevis 36% 100%
Q5V3G6 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 24% 100%
Q5XIP1 Rattus norvegicus 39% 100%
Q5ZK01 Gallus gallus 39% 100%
Q6M133 Methanococcus maripaludis (strain S2 / LL) 25% 100%
Q7ZWC4 Danio rerio 37% 100%
Q80X73 Mus musculus 39% 100%
Q8PVZ0 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 27% 100%
Q8TSZ1 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 26% 100%
Q8TZ98 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 26% 100%
Q8U150 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 27% 100%
Q96YU9 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 23% 100%
Q97BJ3 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 23% 100%
Q9BRX2 Homo sapiens 38% 100%
Q9HJ74 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 25% 100%
Q9HPR5 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 25% 100%
Q9M2H7 Arabidopsis thaliana 31% 100%
Q9USL5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
Q9V0V3 Pyrococcus abyssi (strain GE5 / Orsay) 27% 100%
Q9YAZ5 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 23% 100%
Q9ZT87 Arabidopsis thaliana 34% 100%
V5B9H7 Trypanosoma cruzi 59% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS