DUF2062 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEM4_LEIBR

TriTrypDb:

LbrM.26.0180 , LBRM2903_260006900

Length:

160

Annotations

LeishMANIAdb annotations

A conserved eukaryotic protein family also seen in higher plants. Its function is, however very unclear.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HEM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.384
CLV_PCSK_KEX2_1	2	4	PF00082	0.384
CLV_PCSK_SKI1_1	123	127	PF00082	0.494
CLV_PCSK_SKI1_1	2	6	PF00082	0.520
CLV_PCSK_SKI1_1	21	25	PF00082	0.173
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DOC_CKS1_1	135	140	PF01111	0.195
DOC_CKS1_1	74	79	PF01111	0.261
DOC_MAPK_gen_1	13	20	PF00069	0.636
DOC_PP1_RVXF_1	19	26	PF00149	0.385
DOC_PP2B_LxvP_1	16	19	PF13499	0.507
DOC_PP4_FxxP_1	41	44	PF00568	0.261
DOC_PP4_FxxP_1	74	77	PF00568	0.300
DOC_WW_Pin1_4	134	139	PF00397	0.195
DOC_WW_Pin1_4	73	78	PF00397	0.261
LIG_14-3-3_CanoR_1	21	26	PF00244	0.389
LIG_14-3-3_CanoR_1	59	67	PF00244	0.525
LIG_FHA_1	135	141	PF00498	0.195
LIG_FHA_1	38	44	PF00498	0.258
LIG_FHA_1	45	51	PF00498	0.320
LIG_FHA_1	60	66	PF00498	0.557
LIG_FHA_1	68	74	PF00498	0.318
LIG_FHA_1	7	13	PF00498	0.487
LIG_FHA_2	22	28	PF00498	0.346
LIG_FHA_2	59	65	PF00498	0.602
LIG_FHA_2	92	98	PF00498	0.439
LIG_LIR_Apic_2	40	44	PF02991	0.195
LIG_LIR_Gen_1	24	32	PF02991	0.334
LIG_LIR_Gen_1	85	93	PF02991	0.283
LIG_LIR_Nem_3	129	135	PF02991	0.424
LIG_LIR_Nem_3	24	28	PF02991	0.334
LIG_LIR_Nem_3	85	89	PF02991	0.287
LIG_SH2_CRK	127	131	PF00017	0.401
LIG_SH2_NCK_1	127	131	PF00017	0.300
LIG_SH2_STAP1	114	118	PF00017	0.402
LIG_SH2_STAT5	57	60	PF00017	0.453
LIG_SH3_3	132	138	PF00018	0.352
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.195
LIG_SUMO_SIM_anti_2	47	54	PF11976	0.265
LIG_SUMO_SIM_par_1	27	33	PF11976	0.359
LIG_TRAF2_1	105	108	PF00917	0.252
LIG_TRFH_1	80	84	PF08558	0.284
LIG_TYR_ITIM	125	130	PF00017	0.352
LIG_WRC_WIRS_1	114	119	PF05994	0.337
LIG_WRC_WIRS_1	83	88	PF05994	0.238
MOD_CK1_1	48	54	PF00069	0.283
MOD_CK2_1	21	27	PF00069	0.494
MOD_CK2_1	58	64	PF00069	0.510
MOD_CK2_1	89	95	PF00069	0.379
MOD_GSK3_1	113	120	PF00069	0.330
MOD_GSK3_1	152	159	PF00069	0.505
MOD_GSK3_1	44	51	PF00069	0.272
MOD_NEK2_1	106	111	PF00069	0.382
MOD_NEK2_1	117	122	PF00069	0.298
MOD_NEK2_1	126	131	PF00069	0.296
MOD_NEK2_1	133	138	PF00069	0.299
MOD_NEK2_1	37	42	PF00069	0.270
MOD_NEK2_1	45	50	PF00069	0.275
MOD_NEK2_1	5	10	PF00069	0.492
MOD_NEK2_1	67	72	PF00069	0.367
MOD_NEK2_1	89	94	PF00069	0.276
MOD_PIKK_1	152	158	PF00454	0.513
MOD_PIKK_1	6	12	PF00454	0.562
MOD_PKA_2	152	158	PF00069	0.554
MOD_PKA_2	58	64	PF00069	0.523
MOD_Plk_1	96	102	PF00069	0.263
MOD_Plk_4	113	119	PF00069	0.354
MOD_Plk_4	45	51	PF00069	0.297
MOD_ProDKin_1	134	140	PF00069	0.195
MOD_ProDKin_1	73	79	PF00069	0.261
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.517
TRG_ENDOCYTIC_2	114	117	PF00928	0.375
TRG_ENDOCYTIC_2	127	130	PF00928	0.336
TRG_ER_diArg_1	1	3	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS7	Leptomonas seymouri	59%	92%
A0A1X0NSJ4	Trypanosomatidae	28%	100%
A0A3R7KTL0	Trypanosoma rangeli	34%	100%
A0A3S7WZK4	Leishmania donovani	73%	99%
A4I1V5	Leishmania infantum	73%	99%
E9AY00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q9H3	Leishmania major	73%	100%