Putative 60S ribosomal protein L7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7, putative

Species:

Leishmania braziliensis

UniProt:

A4HEM3_LEIBR

TriTrypDb:

LbrM.26.0170 , LBRM2903_260006800

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	17
GO:0022625	cytosolic large ribosomal subunit	5	17
GO:0032991	protein-containing complex	1	17
GO:0044391	ribosomal subunit	3	17
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEM3

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	17
GO:0000470	maturation of LSU-rRNA	9	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006364	rRNA processing	8	17
GO:0006396	RNA processing	6	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016070	RNA metabolic process	5	17
GO:0016072	rRNA metabolic process	7	17
GO:0034470	ncRNA processing	7	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034660	ncRNA metabolic process	6	17
GO:0043170	macromolecule metabolic process	3	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0046483	heterocycle metabolic process	3	17
GO:0071704	organic substance metabolic process	2	17
GO:0090304	nucleic acid metabolic process	4	17
GO:1901360	organic cyclic compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.356
CLV_NRD_NRD_1	232	234	PF00675	0.602
CLV_NRD_NRD_1	63	65	PF00675	0.372
CLV_NRD_NRD_1	80	82	PF00675	0.212
CLV_PCSK_FUR_1	229	233	PF00082	0.603
CLV_PCSK_FUR_1	61	65	PF00082	0.250
CLV_PCSK_KEX2_1	164	166	PF00082	0.550
CLV_PCSK_KEX2_1	231	233	PF00082	0.606
CLV_PCSK_KEX2_1	28	30	PF00082	0.345
CLV_PCSK_KEX2_1	63	65	PF00082	0.414
CLV_PCSK_KEX2_1	80	82	PF00082	0.326
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.550
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.606
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.345
CLV_PCSK_SKI1_1	114	118	PF00082	0.345
CLV_PCSK_SKI1_1	123	127	PF00082	0.345
CLV_PCSK_SKI1_1	210	214	PF00082	0.515
CLV_PCSK_SKI1_1	29	33	PF00082	0.345
CLV_PCSK_SKI1_1	48	52	PF00082	0.345
CLV_PCSK_SKI1_1	75	79	PF00082	0.414
DEG_APCC_DBOX_1	113	121	PF00400	0.356
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DOC_ANK_TNKS_1	232	239	PF00023	0.606
DOC_MAPK_gen_1	112	122	PF00069	0.345
DOC_MAPK_gen_1	164	170	PF00069	0.525
DOC_PP2B_LxvP_1	221	224	PF13499	0.606
DOC_USP7_UBL2_3	108	112	PF12436	0.356
DOC_USP7_UBL2_3	51	55	PF12436	0.388
LIG_14-3-3_CanoR_1	174	183	PF00244	0.616
LIG_14-3-3_CanoR_1	210	219	PF00244	0.673
LIG_14-3-3_CanoR_1	81	91	PF00244	0.393
LIG_Actin_WH2_2	126	144	PF00022	0.345
LIG_FHA_1	126	132	PF00498	0.345
LIG_FHA_1	211	217	PF00498	0.444
LIG_LIR_Gen_1	128	137	PF02991	0.345
LIG_LIR_Nem_3	145	150	PF02991	0.428
LIG_LYPXL_yS_3	152	155	PF13949	0.563
LIG_PCNA_yPIPBox_3	108	120	PF02747	0.347
LIG_PCNA_yPIPBox_3	132	141	PF02747	0.356
LIG_Pex14_2	126	130	PF04695	0.345
LIG_PTB_Apo_2	124	131	PF02174	0.345
LIG_PTB_Apo_2	197	204	PF02174	0.526
LIG_PTB_Phospho_1	197	203	PF10480	0.524
LIG_SH2_CRK	150	154	PF00017	0.567
LIG_SH2_NCK_1	187	191	PF00017	0.683
LIG_SH2_PTP2	13	16	PF00017	0.492
LIG_SH2_SRC	90	93	PF00017	0.370
LIG_SH2_STAP1	65	69	PF00017	0.345
LIG_SH2_STAT5	13	16	PF00017	0.492
LIG_SH2_STAT5	147	150	PF00017	0.584
LIG_SH2_STAT5	167	170	PF00017	0.337
LIG_SH2_STAT5	203	206	PF00017	0.565
LIG_SH2_STAT5	90	93	PF00017	0.356
LIG_SH3_3	15	21	PF00018	0.639
LIG_TRFH_1	219	223	PF08558	0.599
MOD_CK1_1	154	160	PF00069	0.540
MOD_Cter_Amidation	61	64	PF01082	0.396
MOD_GlcNHglycan	24	27	PF01048	0.333
MOD_GlcNHglycan	8	11	PF01048	0.713
MOD_GSK3_1	2	9	PF00069	0.508
MOD_LATS_1	208	214	PF00433	0.529
MOD_PKA_1	63	69	PF00069	0.484
MOD_PKA_2	243	249	PF00069	0.589
MOD_PKA_2	63	69	PF00069	0.271
MOD_PKB_1	61	69	PF00069	0.484
MOD_Plk_4	12	18	PF00069	0.658
MOD_Plk_4	125	131	PF00069	0.345
MOD_Plk_4	243	249	PF00069	0.589
MOD_SUMO_rev_2	68	77	PF00179	0.347
TRG_ENDOCYTIC_2	13	16	PF00928	0.492
TRG_ENDOCYTIC_2	152	155	PF00928	0.563
TRG_ENDOCYTIC_2	167	170	PF00928	0.506
TRG_ER_diArg_1	120	123	PF00400	0.345
TRG_ER_diArg_1	61	64	PF00400	0.490
TRG_ER_diArg_1	79	81	PF00400	0.194
TRG_NLS_MonoExtN_4	229	235	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU7	Leptomonas seymouri	95%	100%
A0A0S4IU62	Bodo saltans	83%	100%
A0A0S4JDH9	Bodo saltans	24%	73%
A0A1D8PDL6	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	100%
A0A1X0NSK2	Trypanosomatidae	88%	100%
A0A3Q8INU3	Leishmania donovani	94%	100%
A0A3R7M5J8	Trypanosoma rangeli	76%	100%
A0A3S7WZH9	Leishmania donovani	93%	100%
A0A422NVF3	Trypanosoma rangeli	85%	100%
A0BD73	Paramecium tetraurelia	43%	100%
A0CEY2	Paramecium tetraurelia	43%	100%
A1RU38	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	30%	100%
A2BME0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	27%	100%
A3MU87	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	31%	100%
A4HEM2	Leishmania braziliensis	100%	100%
A4I1V4	Leishmania infantum	93%	94%
A4WHQ9	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	31%	100%
A5GFQ0	Sus scrofa	28%	100%
A8MDN0	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	28%	100%
B1Y8Q5	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	27%	100%
C9ZS66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
C9ZS67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
E9AHB0	Leishmania infantum	94%	100%
E9AXZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AXZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	88%
O01802	Caenorhabditis elegans	46%	100%
O60143	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P05426	Rattus norvegicus	48%	98%
P05737	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P0DJ13	Tetrahymena thermophila	38%	100%
P11874	Dictyostelium discoideum	45%	100%
P14148	Mus musculus	49%	95%
P17937	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P18124	Homo sapiens	49%	100%
P25457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P32100	Drosophila melanogaster	48%	100%
P40693	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	80%
P60039	Arabidopsis thaliana	44%	100%
P60040	Arabidopsis thaliana	45%	100%
Q12213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
Q4Q9H4	Leishmania major	94%	100%
Q4R506	Macaca fascicularis	48%	100%
Q58DT1	Bos taurus	49%	100%
Q5R9R4	Pongo abelii	49%	100%
Q5RAH8	Pongo abelii	30%	100%
Q5ZJ56	Gallus gallus	50%	100%
Q6BTA4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6C603	Yarrowia lipolytica (strain CLIB 122 / E 150)	45%	100%
Q6DKI1	Homo sapiens	31%	100%
Q6FSN6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	42%	100%
Q755A7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q75ET5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	87%
Q7SBD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q8SS93	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8ZXN8	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	31%	100%
Q9D8M4	Mus musculus	30%	100%
Q9LHP1	Arabidopsis thaliana	45%	100%
Q9SAI5	Arabidopsis thaliana	31%	100%
V5DR72	Trypanosoma cruzi	85%	100%