Nuclear lim interactor-interacting factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear lim interactor-interacting factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEM1_LEIBR

TriTrypDb:

LbrM.26.0150 , LBRM2903_260006500

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEM1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0016787	hydrolase activity	2	19
GO:0016788	hydrolase activity, acting on ester bonds	3	19
GO:0016791	phosphatase activity	5	19
GO:0042578	phosphoric ester hydrolase activity	4	19
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.432
CLV_NRD_NRD_1	225	227	PF00675	0.408
CLV_NRD_NRD_1	69	71	PF00675	0.572
CLV_NRD_NRD_1	81	83	PF00675	0.348
CLV_PCSK_KEX2_1	168	170	PF00082	0.411
CLV_PCSK_KEX2_1	225	227	PF00082	0.408
CLV_PCSK_KEX2_1	69	71	PF00082	0.607
CLV_PCSK_PC7_1	164	170	PF00082	0.432
CLV_PCSK_SKI1_1	99	103	PF00082	0.471
DOC_CYCLIN_yCln2_LP_2	101	104	PF00134	0.487
DOC_MAPK_DCC_7	99	107	PF00069	0.534
DOC_MAPK_gen_1	168	175	PF00069	0.290
DOC_MAPK_gen_1	219	229	PF00069	0.287
DOC_MAPK_MEF2A_6	112	119	PF00069	0.273
DOC_MAPK_MEF2A_6	255	263	PF00069	0.290
DOC_MAPK_MEF2A_6	99	107	PF00069	0.451
DOC_MAPK_NFAT4_5	112	120	PF00069	0.318
DOC_PP2B_LxvP_1	101	104	PF13499	0.393
DOC_PP2B_LxvP_1	140	143	PF13499	0.327
DOC_SPAK_OSR1_1	169	173	PF12202	0.363
DOC_USP7_MATH_1	106	110	PF00917	0.504
DOC_WW_Pin1_4	230	235	PF00397	0.295
DOC_WW_Pin1_4	29	34	PF00397	0.691
DOC_WW_Pin1_4	81	86	PF00397	0.445
LIG_14-3-3_CanoR_1	147	152	PF00244	0.164
LIG_14-3-3_CanoR_1	70	80	PF00244	0.497
LIG_Actin_WH2_2	210	227	PF00022	0.408
LIG_APCC_ABBA_1	199	204	PF00400	0.317
LIG_APCC_ABBA_1	262	267	PF00400	0.429
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BRCT_BRCA1_1	166	170	PF00533	0.408
LIG_EVH1_1	102	106	PF00568	0.388
LIG_EVH1_2	103	107	PF00568	0.419
LIG_FHA_1	112	118	PF00498	0.289
LIG_FHA_1	148	154	PF00498	0.267
LIG_FHA_1	59	65	PF00498	0.645
LIG_FHA_1	73	79	PF00498	0.500
LIG_FHA_2	205	211	PF00498	0.408
LIG_FHA_2	6	12	PF00498	0.543
LIG_FHA_2	74	80	PF00498	0.552
LIG_LIR_Gen_1	133	143	PF02991	0.425
LIG_LIR_Gen_1	160	170	PF02991	0.303
LIG_LIR_Gen_1	258	266	PF02991	0.368
LIG_LIR_Gen_1	274	284	PF02991	0.306
LIG_LIR_Nem_3	133	139	PF02991	0.379
LIG_LIR_Nem_3	152	158	PF02991	0.125
LIG_LIR_Nem_3	160	165	PF02991	0.259
LIG_LIR_Nem_3	167	173	PF02991	0.234
LIG_LIR_Nem_3	258	263	PF02991	0.368
LIG_LIR_Nem_3	274	279	PF02991	0.310
LIG_MAD2	226	234	PF02301	0.290
LIG_MYND_1	100	104	PF01753	0.430
LIG_PCNA_TLS_4	156	163	PF02747	0.408
LIG_PDZ_Class_3	285	290	PF00595	0.461
LIG_REV1ctd_RIR_1	13	21	PF16727	0.537
LIG_SH2_CRK	136	140	PF00017	0.342
LIG_SH2_STAP1	136	140	PF00017	0.363
LIG_SH2_STAP1	149	153	PF00017	0.363
LIG_SH2_STAT3	237	240	PF00017	0.305
LIG_SH2_STAT5	149	152	PF00017	0.310
LIG_SH2_STAT5	158	161	PF00017	0.298
LIG_SH2_STAT5	182	185	PF00017	0.317
LIG_SH2_STAT5	213	216	PF00017	0.305
LIG_SH3_3	53	59	PF00018	0.586
LIG_SH3_3	97	103	PF00018	0.411
LIG_SH3_4	6	13	PF00018	0.613
LIG_SUMO_SIM_anti_2	73	82	PF11976	0.566
LIG_SUMO_SIM_par_1	113	118	PF11976	0.303
LIG_SUMO_SIM_par_1	226	231	PF11976	0.333
LIG_TRAF2_1	8	11	PF00917	0.621
LIG_TRFH_1	260	264	PF08558	0.408
LIG_TYR_ITIM	134	139	PF00017	0.408
LIG_WRPW_2	155	158	PF00400	0.330
LIG_WW_2	103	106	PF00397	0.405
MOD_CK1_1	25	31	PF00069	0.665
MOD_CK1_1	274	280	PF00069	0.327
MOD_CK1_1	34	40	PF00069	0.658
MOD_CK1_1	71	77	PF00069	0.576
MOD_CK2_1	204	210	PF00069	0.441
MOD_CK2_1	5	11	PF00069	0.573
MOD_GlcNHglycan	2	5	PF01048	0.695
MOD_GlcNHglycan	24	27	PF01048	0.680
MOD_GlcNHglycan	70	73	PF01048	0.441
MOD_GSK3_1	119	126	PF00069	0.319
MOD_GSK3_1	25	32	PF00069	0.560
MOD_GSK3_1	267	274	PF00069	0.250
MOD_GSK3_1	34	41	PF00069	0.566
MOD_GSK3_1	68	75	PF00069	0.502
MOD_N-GLC_1	38	43	PF02516	0.619
MOD_N-GLC_1	86	91	PF02516	0.364
MOD_NEK2_1	123	128	PF00069	0.327
MOD_NEK2_1	175	180	PF00069	0.313
MOD_NEK2_1	265	270	PF00069	0.393
MOD_NEK2_1	271	276	PF00069	0.422
MOD_NEK2_2	149	154	PF00069	0.367
MOD_PIKK_1	31	37	PF00454	0.691
MOD_PIKK_1	45	51	PF00454	0.424
MOD_PIKK_1	6	12	PF00454	0.615
MOD_PKA_2	68	74	PF00069	0.670
MOD_Plk_1	119	125	PF00069	0.305
MOD_Plk_1	209	215	PF00069	0.315
MOD_Plk_2-3	204	210	PF00069	0.408
MOD_Plk_4	111	117	PF00069	0.326
MOD_Plk_4	119	125	PF00069	0.309
MOD_Plk_4	246	252	PF00069	0.334
MOD_Plk_4	271	277	PF00069	0.322
MOD_ProDKin_1	230	236	PF00069	0.295
MOD_ProDKin_1	29	35	PF00069	0.692
MOD_ProDKin_1	81	87	PF00069	0.436
TRG_AP2beta_CARGO_1	160	169	PF09066	0.408
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.476
TRG_ENDOCYTIC_2	136	139	PF00928	0.349
TRG_ENDOCYTIC_2	276	279	PF00928	0.341
TRG_ER_diArg_1	168	170	PF00400	0.435
TRG_ER_diArg_1	224	226	PF00400	0.408
TRG_NES_CRM1_1	44	58	PF08389	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	27%	100%
A0A0N1HTD7	Leptomonas seymouri	72%	100%
A0A0N1PG96	Leptomonas seymouri	53%	82%
A0A0S4IJH3	Bodo saltans	42%	100%
A0A0S4IMS1	Bodo saltans	45%	86%
A0A0S4JIG1	Bodo saltans	43%	79%
A0A1X0NYI7	Trypanosomatidae	51%	72%
A0A3Q8IDG4	Leishmania donovani	50%	79%
A0A3S7WY63	Leishmania donovani	28%	100%
A0A3S7WZH2	Leishmania donovani	88%	100%
A0A3S7X8P8	Leishmania donovani	29%	100%
A0A422P4K3	Trypanosoma rangeli	47%	71%
A4HEA5	Leishmania braziliensis	50%	79%
A4HM58	Leishmania braziliensis	29%	100%
A4I1Q1	Leishmania infantum	50%	79%
A4I1V3	Leishmania infantum	88%	100%
A4IAS0	Leishmania infantum	29%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	69%
E9AEA2	Leishmania major	28%	100%
E9AEJ6	Leishmania major	29%	100%
E9AH40	Leishmania infantum	28%	100%
E9AWL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	79%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O14595	Homo sapiens	36%	100%
Q20432	Caenorhabditis elegans	39%	100%
Q4Q077	Leishmania major	27%	100%
Q4Q9H6	Leishmania major	89%	100%
Q4Q9N6	Leishmania major	50%	80%
Q4QAV2	Leishmania major	28%	100%
Q61C05	Caenorhabditis briggsae	40%	100%
Q9W0S3	Drosophila melanogaster	30%	71%
V5B4L5	Trypanosoma cruzi	28%	85%