Mini-chromosome maintenance complex-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mini-chromosome maintenance complex-binding protein

Species:

Leishmania braziliensis

UniProt:

A4HEM0_LEIBR

TriTrypDb:

LbrM.26.0140 , LBRM2903_260006400

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HEM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEM0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.324
CLV_C14_Caspase3-7	495	499	PF00656	0.324
CLV_C14_Caspase3-7	88	92	PF00656	0.676
CLV_C14_Caspase3-7	96	100	PF00656	0.238
CLV_NRD_NRD_1	132	134	PF00675	0.277
CLV_NRD_NRD_1	156	158	PF00675	0.445
CLV_NRD_NRD_1	279	281	PF00675	0.344
CLV_PCSK_KEX2_1	134	136	PF00082	0.277
CLV_PCSK_KEX2_1	278	280	PF00082	0.337
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.277
CLV_PCSK_SKI1_1	315	319	PF00082	0.288
CLV_PCSK_SKI1_1	519	523	PF00082	0.431
DEG_APCC_DBOX_1	493	501	PF00400	0.313
DOC_CKS1_1	581	586	PF01111	0.370
DOC_CYCLIN_RxL_1	258	268	PF00134	0.324
DOC_CYCLIN_RxL_1	516	525	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.310
DOC_MAPK_MEF2A_6	279	288	PF00069	0.409
DOC_MAPK_MEF2A_6	372	379	PF00069	0.167
DOC_PP2B_LxvP_1	439	442	PF13499	0.350
DOC_PP2B_LxvP_1	586	589	PF13499	0.437
DOC_PP4_FxxP_1	188	191	PF00568	0.400
DOC_PP4_MxPP_1	44	47	PF00568	0.269
DOC_USP7_MATH_1	120	124	PF00917	0.276
DOC_USP7_MATH_1	146	150	PF00917	0.316
DOC_USP7_MATH_1	173	177	PF00917	0.437
DOC_USP7_MATH_1	271	275	PF00917	0.413
DOC_USP7_MATH_1	473	477	PF00917	0.291
DOC_WW_Pin1_4	31	36	PF00397	0.494
DOC_WW_Pin1_4	340	345	PF00397	0.300
DOC_WW_Pin1_4	377	382	PF00397	0.296
DOC_WW_Pin1_4	580	585	PF00397	0.414
LIG_14-3-3_CanoR_1	161	165	PF00244	0.354
LIG_14-3-3_CanoR_1	326	334	PF00244	0.279
LIG_BIR_II_1	1	5	PF00653	0.311
LIG_deltaCOP1_diTrp_1	414	422	PF00928	0.324
LIG_EH_1	215	219	PF12763	0.324
LIG_eIF4E_1	389	395	PF01652	0.167
LIG_EVH1_1	188	192	PF00568	0.187
LIG_FHA_1	16	22	PF00498	0.315
LIG_FHA_1	202	208	PF00498	0.272
LIG_FHA_1	365	371	PF00498	0.324
LIG_FHA_1	436	442	PF00498	0.278
LIG_FHA_1	540	546	PF00498	0.167
LIG_FHA_1	581	587	PF00498	0.664
LIG_FHA_2	1	7	PF00498	0.508
LIG_FHA_2	114	120	PF00498	0.399
LIG_FHA_2	149	155	PF00498	0.403
LIG_FHA_2	18	24	PF00498	0.404
LIG_FHA_2	305	311	PF00498	0.400
LIG_FHA_2	38	44	PF00498	0.550
LIG_FHA_2	561	567	PF00498	0.237
LIG_IRF3_LxIS_1	337	342	PF10401	0.324
LIG_LIR_Apic_2	102	107	PF02991	0.265
LIG_LIR_Gen_1	182	192	PF02991	0.295
LIG_LIR_Gen_1	243	253	PF02991	0.322
LIG_LIR_Gen_1	313	323	PF02991	0.273
LIG_LIR_Gen_1	419	430	PF02991	0.290
LIG_LIR_Gen_1	433	443	PF02991	0.298
LIG_LIR_Nem_3	182	188	PF02991	0.295
LIG_LIR_Nem_3	225	229	PF02991	0.248
LIG_LIR_Nem_3	243	248	PF02991	0.298
LIG_LIR_Nem_3	268	272	PF02991	0.296
LIG_LIR_Nem_3	313	319	PF02991	0.256
LIG_LIR_Nem_3	419	425	PF02991	0.397
LIG_LIR_Nem_3	433	439	PF02991	0.230
LIG_PTB_Apo_2	537	544	PF02174	0.248
LIG_SH2_CRK	269	273	PF00017	0.405
LIG_SH2_NCK_1	269	273	PF00017	0.413
LIG_SH2_PTP2	104	107	PF00017	0.277
LIG_SH2_SRC	104	107	PF00017	0.257
LIG_SH2_SRC	269	272	PF00017	0.167
LIG_SH2_SRC	389	392	PF00017	0.167
LIG_SH2_SRC	496	499	PF00017	0.400
LIG_SH2_STAP1	27	31	PF00017	0.401
LIG_SH2_STAT3	227	230	PF00017	0.400
LIG_SH2_STAT3	434	437	PF00017	0.277
LIG_SH2_STAT5	104	107	PF00017	0.257
LIG_SH2_STAT5	115	118	PF00017	0.269
LIG_SH2_STAT5	301	304	PF00017	0.304
LIG_SH2_STAT5	31	34	PF00017	0.497
LIG_SH2_STAT5	316	319	PF00017	0.190
LIG_SH2_STAT5	389	392	PF00017	0.324
LIG_SH2_STAT5	496	499	PF00017	0.295
LIG_SH2_STAT6	228	232	PF00017	0.264
LIG_SH3_3	186	192	PF00018	0.213
LIG_SH3_3	202	208	PF00018	0.316
LIG_SH3_3	367	373	PF00018	0.167
LIG_SUMO_SIM_anti_2	481	486	PF11976	0.167
LIG_SUMO_SIM_par_1	336	343	PF11976	0.400
LIG_SUMO_SIM_par_1	440	446	PF11976	0.280
LIG_TRAF2_1	116	119	PF00917	0.167
LIG_TRAF2_1	208	211	PF00917	0.342
LIG_TRAF2_1	412	415	PF00917	0.167
LIG_TYR_ITIM	267	272	PF00017	0.324
LIG_UBA3_1	421	427	PF00899	0.321
MOD_CDK_SPK_2	377	382	PF00069	0.296
MOD_CK1_1	15	21	PF00069	0.499
MOD_CK1_1	167	173	PF00069	0.435
MOD_CK1_1	177	183	PF00069	0.454
MOD_CK1_1	541	547	PF00069	0.279
MOD_CK1_1	83	89	PF00069	0.417
MOD_CK2_1	113	119	PF00069	0.387
MOD_CK2_1	146	152	PF00069	0.327
MOD_CK2_1	17	23	PF00069	0.530
MOD_CK2_1	287	293	PF00069	0.300
MOD_CK2_1	82	88	PF00069	0.409
MOD_CK2_1	90	96	PF00069	0.191
MOD_GlcNHglycan	164	167	PF01048	0.378
MOD_GlcNHglycan	176	179	PF01048	0.320
MOD_GlcNHglycan	248	251	PF01048	0.400
MOD_GlcNHglycan	328	331	PF01048	0.335
MOD_GlcNHglycan	350	354	PF01048	0.328
MOD_GlcNHglycan	477	480	PF01048	0.167
MOD_GlcNHglycan	490	493	PF01048	0.404
MOD_GlcNHglycan	523	527	PF01048	0.316
MOD_GlcNHglycan	82	85	PF01048	0.456
MOD_GSK3_1	13	20	PF00069	0.476
MOD_GSK3_1	160	167	PF00069	0.369
MOD_GSK3_1	173	180	PF00069	0.278
MOD_GSK3_1	511	518	PF00069	0.330
MOD_GSK3_1	82	89	PF00069	0.489
MOD_N-GLC_1	251	256	PF02516	0.324
MOD_N-GLC_1	539	544	PF02516	0.248
MOD_NEK2_1	14	19	PF00069	0.558
MOD_NEK2_1	265	270	PF00069	0.465
MOD_NEK2_1	286	291	PF00069	0.282
MOD_NEK2_1	302	307	PF00069	0.291
MOD_NEK2_1	339	344	PF00069	0.400
MOD_NEK2_1	450	455	PF00069	0.216
MOD_NEK2_1	465	470	PF00069	0.367
MOD_NEK2_1	50	55	PF00069	0.450
MOD_NEK2_1	503	508	PF00069	0.436
MOD_NEK2_1	522	527	PF00069	0.301
MOD_NEK2_1	538	543	PF00069	0.281
MOD_NEK2_1	74	79	PF00069	0.456
MOD_NEK2_1	82	87	PF00069	0.521
MOD_NEK2_2	496	501	PF00069	0.167
MOD_PIKK_1	45	51	PF00454	0.463
MOD_PKA_1	133	139	PF00069	0.239
MOD_PKA_2	160	166	PF00069	0.291
MOD_PKA_2	515	521	PF00069	0.395
MOD_PKB_1	138	146	PF00069	0.167
MOD_PKB_1	324	332	PF00069	0.167
MOD_Plk_1	140	146	PF00069	0.397
MOD_Plk_1	443	449	PF00069	0.296
MOD_Plk_1	503	509	PF00069	0.325
MOD_Plk_1	539	545	PF00069	0.248
MOD_Plk_2-3	504	510	PF00069	0.167
MOD_Plk_4	201	207	PF00069	0.253
MOD_Plk_4	443	449	PF00069	0.198
MOD_Plk_4	504	510	PF00069	0.367
MOD_Plk_4	99	105	PF00069	0.284
MOD_ProDKin_1	31	37	PF00069	0.490
MOD_ProDKin_1	340	346	PF00069	0.300
MOD_ProDKin_1	377	383	PF00069	0.296
MOD_ProDKin_1	580	586	PF00069	0.427
TRG_DiLeu_BaEn_1	504	509	PF01217	0.167
TRG_DiLeu_BaEn_1	6	11	PF01217	0.303
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.400
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.400
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.400
TRG_ENDOCYTIC_2	229	232	PF00928	0.264
TRG_ENDOCYTIC_2	269	272	PF00928	0.405
TRG_ENDOCYTIC_2	316	319	PF00928	0.248
TRG_ENDOCYTIC_2	418	421	PF00928	0.398
TRG_ENDOCYTIC_2	436	439	PF00928	0.371
TRG_ER_diArg_1	132	135	PF00400	0.281
TRG_ER_diArg_1	277	280	PF00400	0.353
TRG_ER_diArg_1	324	327	PF00400	0.241
TRG_ER_FFAT_1	91	102	PF00635	0.167
TRG_ER_FFAT_2	77	86	PF00635	0.303
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX8	Leptomonas seymouri	51%	95%
A0A0S4IND2	Bodo saltans	30%	100%
A0A0S4ISE5	Bodo saltans	30%	100%
A0A1X0NSJ6	Trypanosomatidae	33%	98%
A0A3Q8ICQ6	Leishmania donovani	74%	100%
A0A422NVG0	Trypanosoma rangeli	36%	100%
A4I1V2	Leishmania infantum	75%	100%
A5PJM5	Bos taurus	22%	93%
B5DG51	Salmo salar	24%	95%
C9ZS69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AXZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q28DV7	Xenopus tropicalis	24%	95%
Q4Q9H7	Leishmania major	75%	100%
Q501D5	Arabidopsis thaliana	24%	100%
Q5ZJV4	Gallus gallus	23%	94%
Q9BTE3	Homo sapiens	23%	93%
Q9VM60	Drosophila melanogaster	24%	99%
V5BZF8	Trypanosoma cruzi	37%	100%