Adenine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenine phosphoribosyltransferase

Species:

Leishmania braziliensis

UniProt:

A4HEL9_LEIBR

TriTrypDb:

LbrM.26.0130 , LBRM2903_260006300

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HEL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL9

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003999	adenine phosphoribosyltransferase activity	6	8
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	1
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016763	pentosyltransferase activity	4	8
GO:0106130	purine phosphoribosyltransferase activity	5	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.296
CLV_PCSK_SKI1_1	141	145	PF00082	0.296
CLV_PCSK_SKI1_1	196	200	PF00082	0.712
CLV_PCSK_SKI1_1	59	63	PF00082	0.312
CLV_PCSK_SKI1_1	82	86	PF00082	0.296
DOC_CDC14_PxL_1	175	183	PF14671	0.764
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.473
DOC_MAPK_gen_1	194	203	PF00069	0.678
DOC_MAPK_MEF2A_6	4	12	PF00069	0.406

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K2	Leptomonas seymouri	28%	100%
A0A0N1PAP7	Leptomonas seymouri	72%	100%
A0A0S4IJH4	Bodo saltans	50%	99%
A0A1X0NSL0	Trypanosomatidae	59%	100%
A0A1X0NT10	Trypanosomatidae	38%	100%
A0A3Q8IFK1	Leishmania donovani	78%	100%
A0A3R7NXU7	Trypanosoma rangeli	66%	100%
A0A3S5IQF5	Trypanosoma rangeli	36%	100%
A0A422NVD4	Trypanosoma rangeli	35%	100%
A0KAK7	Burkholderia cenocepacia (strain HI2424)	34%	100%

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