Adenine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenine phosphoribosyltransferase

Species:

Leishmania braziliensis

UniProt:

A4HEL8_LEIBR

TriTrypDb:

LbrM.26.0120 , LBRM2903_260006200

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0016757	glycosyltransferase activity	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.363
CLV_NRD_NRD_1	27	29	PF00675	0.163
CLV_PCSK_FUR_1	109	113	PF00082	0.329
CLV_PCSK_KEX2_1	111	113	PF00082	0.332
CLV_PCSK_KEX2_1	27	29	PF00082	0.178
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.332
CLV_PCSK_SKI1_1	111	115	PF00082	0.524
CLV_PCSK_SKI1_1	193	197	PF00082	0.666
DEG_APCC_DBOX_1	145	153	PF00400	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.178
DEG_ODPH_VHL_1	152	165	PF01847	0.383
DOC_CDC14_PxL_1	150	158	PF14671	0.381
DOC_CDC14_PxL_1	205	213	PF14671	0.417
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.349
DOC_MAPK_gen_1	111	121	PF00069	0.357
DOC_MAPK_MEF2A_6	43	51	PF00069	0.458
DOC_MAPK_RevD_3	13	28	PF00069	0.363
DOC_PP2B_LxvP_1	11	14	PF13499	0.376
DOC_PP2B_LxvP_1	19	22	PF13499	0.346
DOC_PP4_FxxP_1	185	188	PF00568	0.401
DOC_PP4_FxxP_1	196	199	PF00568	0.384
DOC_USP7_MATH_1	207	211	PF00917	0.415
DOC_WW_Pin1_4	144	149	PF00397	0.384
DOC_WW_Pin1_4	195	200	PF00397	0.401
LIG_14-3-3_CanoR_1	123	132	PF00244	0.305
LIG_ActinCP_TwfCPI_2	185	193	PF01115	0.404
LIG_BRCT_BRCA1_1	146	150	PF00533	0.393
LIG_BRCT_BRCA1_1	181	185	PF00533	0.654
LIG_BRCT_BRCA1_1	209	213	PF00533	0.414
LIG_CtBP_PxDLS_1	189	193	PF00389	0.407
LIG_DCNL_PONY_1	1	4	PF03556	0.178
LIG_FHA_1	126	132	PF00498	0.456
LIG_FHA_1	90	96	PF00498	0.363
LIG_FHA_2	36	42	PF00498	0.363
LIG_LIR_Apic_2	182	188	PF02991	0.407
LIG_LIR_Gen_1	191	199	PF02991	0.465
LIG_LIR_Nem_3	167	171	PF02991	0.642
LIG_LIR_Nem_3	191	197	PF02991	0.480
LIG_LIR_Nem_3	210	216	PF02991	0.374
LIG_PCNA_yPIPBox_3	109	122	PF02747	0.353
LIG_PDZ_Class_2	211	216	PF00595	0.416
LIG_Pex14_2	164	168	PF04695	0.380
LIG_Pex14_2	174	178	PF04695	0.410
LIG_SH2_CRK	194	198	PF00017	0.478
LIG_SH2_STAT5	106	109	PF00017	0.288
LIG_SH2_STAT5	204	207	PF00017	0.423
LIG_SH3_2	22	27	PF14604	0.363
LIG_SH3_3	166	172	PF00018	0.389
LIG_SH3_3	19	25	PF00018	0.499
LIG_SH3_3	42	48	PF00018	0.406
LIG_SUMO_SIM_anti_2	60	67	PF11976	0.370
LIG_SUMO_SIM_par_1	60	67	PF11976	0.360
LIG_SUMO_SIM_par_1	91	97	PF11976	0.363
LIG_TRFH_1	150	154	PF08558	0.379
LIG_TYR_ITIM	192	197	PF00017	0.482
LIG_UBA3_1	149	157	PF00899	0.382
MOD_CK1_1	198	204	PF00069	0.408
MOD_CK1_1	32	38	PF00069	0.363
MOD_CK1_1	54	60	PF00069	0.370
MOD_CK1_1	71	77	PF00069	0.336
MOD_GlcNHglycan	56	59	PF01048	0.276
MOD_GlcNHglycan	76	79	PF01048	0.131
MOD_GlcNHglycan	97	101	PF01048	0.189
MOD_GSK3_1	144	151	PF00069	0.388
MOD_GSK3_1	35	42	PF00069	0.416
MOD_GSK3_1	67	74	PF00069	0.443
MOD_GSK3_1	85	92	PF00069	0.563
MOD_NEK2_1	142	147	PF00069	0.434
MOD_NEK2_1	164	169	PF00069	0.379
MOD_NEK2_1	68	73	PF00069	0.494
MOD_NEK2_1	98	103	PF00069	0.441
MOD_PK_1	52	58	PF00069	0.360
MOD_PKA_2	142	148	PF00069	0.440
MOD_PKA_2	51	57	PF00069	0.487
MOD_PKB_1	123	131	PF00069	0.305
MOD_Plk_1	32	38	PF00069	0.363
MOD_Plk_4	117	123	PF00069	0.264
MOD_Plk_4	209	215	PF00069	0.413
MOD_Plk_4	32	38	PF00069	0.371
MOD_Plk_4	85	91	PF00069	0.373
MOD_ProDKin_1	144	150	PF00069	0.386
MOD_ProDKin_1	195	201	PF00069	0.399
MOD_SUMO_rev_2	39	45	PF00179	0.406
TRG_ENDOCYTIC_2	194	197	PF00928	0.483
TRG_ER_diArg_1	122	125	PF00400	0.339
TRG_ER_diArg_1	26	28	PF00400	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K2	Leptomonas seymouri	55%	98%
A0A1X0NT10	Trypanosomatidae	36%	96%
V5B9I1	Trypanosoma cruzi	33%	96%