Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEL7_LEIBR

TriTrypDb:

LbrM.26.0110 , LBRM2903_260006100

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Previous1Next

Expansion

Sequence features

A4HEL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	4
GO:0004252	serine-type endopeptidase activity	5	4
GO:0008233	peptidase activity	3	5
GO:0008236	serine-type peptidase activity	4	4
GO:0016787	hydrolase activity	2	5
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	5

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.308
CLV_NRD_NRD_1	214	216	PF00675	0.646
CLV_NRD_NRD_1	233	235	PF00675	0.655
CLV_PCSK_FUR_1	212	216	PF00082	0.468
CLV_PCSK_KEX2_1	155	157	PF00082	0.247
CLV_PCSK_KEX2_1	183	185	PF00082	0.262
CLV_PCSK_KEX2_1	214	216	PF00082	0.469
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.261
CLV_PCSK_PC7_1	179	185	PF00082	0.354
CLV_PCSK_SKI1_1	221	225	PF00082	0.656

Previous1 2 3 4 5…11Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	75%	99%
A0A0S4INS6	Bodo saltans	43%	100%
A0A1X0NU17	Trypanosomatidae	57%	100%
A0A3Q8IDK2	Leishmania donovani	87%	100%
A0A422N342	Trypanosoma rangeli	58%	100%
A4I1V0	Leishmania infantum	87%	100%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AXZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9H9	Leishmania major	86%	100%
Q4Q9I2	Leishmania major	86%	100%

Previous1 2Next