Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEL7_LEIBR

TriTrypDb:

LbrM.26.0110 , LBRM2903_260006100

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HEL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	4
GO:0004252	serine-type endopeptidase activity	5	4
GO:0008233	peptidase activity	3	5
GO:0008236	serine-type peptidase activity	4	4
GO:0016787	hydrolase activity	2	5
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.308
CLV_NRD_NRD_1	214	216	PF00675	0.646
CLV_NRD_NRD_1	233	235	PF00675	0.655
CLV_PCSK_FUR_1	212	216	PF00082	0.468
CLV_PCSK_KEX2_1	155	157	PF00082	0.247
CLV_PCSK_KEX2_1	183	185	PF00082	0.262
CLV_PCSK_KEX2_1	214	216	PF00082	0.469
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.261
CLV_PCSK_PC7_1	179	185	PF00082	0.354
CLV_PCSK_SKI1_1	221	225	PF00082	0.656
CLV_PCSK_SKI1_1	47	51	PF00082	0.494
CLV_PCSK_SKI1_1	85	89	PF00082	0.540
DOC_MAPK_gen_1	183	191	PF00069	0.447
DOC_MAPK_MEF2A_6	94	101	PF00069	0.288
DOC_MAPK_NFAT4_5	94	102	PF00069	0.172
DOC_USP7_MATH_1	115	119	PF00917	0.557
DOC_USP7_MATH_1	135	139	PF00917	0.400
DOC_WW_Pin1_4	174	179	PF00397	0.540
LIG_14-3-3_CanoR_1	119	126	PF00244	0.372
LIG_14-3-3_CanoR_1	53	59	PF00244	0.324
LIG_Actin_WH2_2	139	157	PF00022	0.540
LIG_BRCT_BRCA1_1	207	211	PF00533	0.375
LIG_eIF4E_1	100	106	PF01652	0.365
LIG_eIF4E_1	139	145	PF01652	0.540
LIG_eIF4E_1	175	181	PF01652	0.540
LIG_FHA_1	139	145	PF00498	0.479
LIG_FHA_1	19	25	PF00498	0.350
LIG_FHA_1	6	12	PF00498	0.489
LIG_FHA_1	86	92	PF00498	0.292
LIG_FHA_2	169	175	PF00498	0.503
LIG_FHA_2	211	217	PF00498	0.332
LIG_GBD_Chelix_1	97	105	PF00786	0.180
LIG_LIR_Apic_2	173	178	PF02991	0.447
LIG_LIR_Apic_2	57	61	PF02991	0.307
LIG_LIR_Gen_1	107	117	PF02991	0.289
LIG_LIR_Gen_1	138	146	PF02991	0.527
LIG_LIR_Gen_1	203	211	PF02991	0.365
LIG_LIR_Gen_1	222	232	PF02991	0.292
LIG_LIR_Gen_1	3	12	PF02991	0.555
LIG_LIR_Nem_3	107	112	PF02991	0.289
LIG_LIR_Nem_3	138	142	PF02991	0.531
LIG_LIR_Nem_3	148	153	PF02991	0.551
LIG_LIR_Nem_3	171	175	PF02991	0.508
LIG_LIR_Nem_3	203	209	PF02991	0.393
LIG_LIR_Nem_3	21	26	PF02991	0.206
LIG_LIR_Nem_3	222	227	PF02991	0.362
LIG_LIR_Nem_3	3	7	PF02991	0.625
LIG_Pex14_2	109	113	PF04695	0.286
LIG_PTB_Apo_2	190	197	PF02174	0.447
LIG_SH2_CRK	139	143	PF00017	0.540
LIG_SH2_CRK	206	210	PF00017	0.365
LIG_SH2_NCK_1	4	8	PF00017	0.517
LIG_SH2_PTP2	175	178	PF00017	0.456
LIG_SH2_SRC	4	7	PF00017	0.525
LIG_SH2_STAP1	136	140	PF00017	0.501
LIG_SH2_STAP1	172	176	PF00017	0.464
LIG_SH2_STAP1	206	210	PF00017	0.365
LIG_SH2_STAT5	100	103	PF00017	0.402
LIG_SH2_STAT5	111	114	PF00017	0.271
LIG_SH2_STAT5	150	153	PF00017	0.455
LIG_SH2_STAT5	166	169	PF00017	0.460
LIG_SH2_STAT5	175	178	PF00017	0.461
LIG_SH2_STAT5	66	69	PF00017	0.298
LIG_SH3_3	80	86	PF00018	0.338
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.479
LIG_SUMO_SIM_par_1	34	41	PF11976	0.349
LIG_TYR_ITIM	204	209	PF00017	0.416
LIG_WRC_WIRS_1	106	111	PF05994	0.271
MOD_CDK_SPK_2	174	179	PF00069	0.416
MOD_CK1_1	129	135	PF00069	0.180
MOD_CK1_1	138	144	PF00069	0.166
MOD_CK1_1	54	60	PF00069	0.375
MOD_CK2_1	168	174	PF00069	0.365
MOD_GlcNHglycan	127	131	PF01048	0.322
MOD_GSK3_1	115	122	PF00069	0.298
MOD_GSK3_1	14	21	PF00069	0.330
MOD_GSK3_1	200	207	PF00069	0.352
MOD_N-GLC_1	54	59	PF02516	0.526
MOD_N-GLC_1	68	73	PF02516	0.469
MOD_NEK2_1	105	110	PF00069	0.286
MOD_NEK2_1	126	131	PF00069	0.285
MOD_NEK2_1	146	151	PF00069	0.173
MOD_NEK2_1	204	209	PF00069	0.309
MOD_NEK2_1	210	215	PF00069	0.306
MOD_NEK2_1	219	224	PF00069	0.424
MOD_NEK2_1	37	42	PF00069	0.379
MOD_NEK2_1	51	56	PF00069	0.355
MOD_NEK2_1	65	70	PF00069	0.288
MOD_PIKK_1	121	127	PF00454	0.331
MOD_PKA_2	146	152	PF00069	0.204
MOD_PKA_2	38	44	PF00069	0.520
MOD_Plk_1	18	24	PF00069	0.393
MOD_Plk_1	54	60	PF00069	0.266
MOD_Plk_4	140	146	PF00069	0.295
MOD_Plk_4	18	24	PF00069	0.273
MOD_Plk_4	205	211	PF00069	0.271
MOD_Plk_4	7	13	PF00069	0.298
MOD_ProDKin_1	174	180	PF00069	0.416
TRG_ENDOCYTIC_2	139	142	PF00928	0.440
TRG_ENDOCYTIC_2	206	209	PF00928	0.365
TRG_ENDOCYTIC_2	4	7	PF00928	0.395
TRG_ER_diArg_1	183	185	PF00400	0.416
TRG_ER_diArg_1	211	214	PF00400	0.305
TRG_NES_CRM1_1	6	19	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	75%	99%
A0A0S4INS6	Bodo saltans	43%	100%
A0A1X0NU17	Trypanosomatidae	57%	100%
A0A3Q8IDK2	Leishmania donovani	87%	100%
A0A422N342	Trypanosoma rangeli	58%	100%
A4I1V0	Leishmania infantum	87%	100%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AXZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9H9	Leishmania major	86%	100%
Q4Q9I2	Leishmania major	86%	100%
V5B9I6	Trypanosoma cruzi	57%	100%