Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEL6_LEIBR

TriTrypDb:

LbrM.26.0100 , LBRM2903_260006000

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.547
CLV_NRD_NRD_1	283	285	PF00675	0.472
CLV_NRD_NRD_1	342	344	PF00675	0.662
CLV_NRD_NRD_1	62	64	PF00675	0.425
CLV_PCSK_FUR_1	246	250	PF00082	0.560
CLV_PCSK_KEX2_1	248	250	PF00082	0.592
CLV_PCSK_KEX2_1	342	344	PF00082	0.679
CLV_PCSK_KEX2_1	62	64	PF00082	0.371
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.592
CLV_PCSK_PC7_1	244	250	PF00082	0.581
CLV_PCSK_SKI1_1	249	253	PF00082	0.505
CLV_PCSK_SKI1_1	284	288	PF00082	0.538
CLV_PCSK_SKI1_1	84	88	PF00082	0.468
DEG_APCC_DBOX_1	283	291	PF00400	0.452
DOC_MAPK_gen_1	284	290	PF00069	0.452
DOC_MAPK_gen_1	79	88	PF00069	0.486
DOC_MAPK_MEF2A_6	82	90	PF00069	0.462
DOC_PP2B_LxvP_1	90	93	PF13499	0.435
DOC_SPAK_OSR1_1	71	75	PF12202	0.388
DOC_USP7_MATH_1	108	112	PF00917	0.481
DOC_WW_Pin1_4	218	223	PF00397	0.580
DOC_WW_Pin1_4	266	271	PF00397	0.557
DOC_WW_Pin1_4	341	346	PF00397	0.569
DOC_WW_Pin1_4	349	354	PF00397	0.738
LIG_14-3-3_CanoR_1	186	195	PF00244	0.473
LIG_14-3-3_CanoR_1	215	222	PF00244	0.449
LIG_14-3-3_CanoR_1	294	300	PF00244	0.442
LIG_14-3-3_CanoR_1	312	319	PF00244	0.228
LIG_14-3-3_CanoR_1	77	86	PF00244	0.357
LIG_Actin_WH2_2	298	314	PF00022	0.494
LIG_APCC_ABBA_1	316	321	PF00400	0.274
LIG_BRCT_BRCA1_1	110	114	PF00533	0.452
LIG_FHA_1	121	127	PF00498	0.412
LIG_FHA_1	47	53	PF00498	0.483
LIG_FHA_2	150	156	PF00498	0.443
LIG_FHA_2	333	339	PF00498	0.544
LIG_LIR_Apic_2	127	133	PF02991	0.512
LIG_LIR_Apic_2	96	102	PF02991	0.411
LIG_LIR_Gen_1	189	199	PF02991	0.365
LIG_LIR_Gen_1	301	311	PF02991	0.483
LIG_LIR_LC3C_4	123	126	PF02991	0.378
LIG_LIR_Nem_3	189	194	PF02991	0.363
LIG_LIR_Nem_3	293	299	PF02991	0.371
LIG_LIR_Nem_3	301	307	PF02991	0.512
LIG_LIR_Nem_3	61	67	PF02991	0.392
LIG_NRBOX	336	342	PF00104	0.558
LIG_PTB_Apo_2	153	160	PF02174	0.491
LIG_RPA_C_Fungi	239	251	PF08784	0.538
LIG_SH2_NCK_1	237	241	PF00017	0.517
LIG_SH2_SRC	304	307	PF00017	0.559
LIG_SH2_STAP1	178	182	PF00017	0.467
LIG_SH2_STAP1	48	52	PF00017	0.505
LIG_SH2_STAT5	191	194	PF00017	0.455
LIG_SH2_STAT5	304	307	PF00017	0.441
LIG_SH2_STAT5	48	51	PF00017	0.510
LIG_SH2_STAT5	99	102	PF00017	0.383
LIG_SH3_2	11	16	PF14604	0.425
LIG_SH3_3	133	139	PF00018	0.519
LIG_SH3_3	347	353	PF00018	0.741
LIG_SH3_3	47	53	PF00018	0.478
LIG_SH3_3	8	14	PF00018	0.445
LIG_Sin3_3	22	29	PF02671	0.476
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.496
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.452
LIG_SUMO_SIM_anti_2	332	341	PF11976	0.561
LIG_SUMO_SIM_par_1	122	127	PF11976	0.480
LIG_TRAF2_1	251	254	PF00917	0.531
LIG_TYR_ITIM	302	307	PF00017	0.461
LIG_WRC_WIRS_1	191	196	PF05994	0.223
LIG_WW_3	13	17	PF00397	0.637
MOD_CDC14_SPxK_1	269	272	PF00782	0.438
MOD_CDK_SPxK_1	266	272	PF00069	0.420
MOD_CDK_SPxxK_3	341	348	PF00069	0.425
MOD_CK1_1	120	126	PF00069	0.472
MOD_CK1_1	218	224	PF00069	0.578
MOD_CK1_1	295	301	PF00069	0.443
MOD_CK1_1	332	338	PF00069	0.509
MOD_CK2_1	149	155	PF00069	0.488
MOD_Cter_Amidation	1	4	PF01082	0.701
MOD_GlcNHglycan	110	113	PF01048	0.383
MOD_GlcNHglycan	119	122	PF01048	0.369
MOD_GlcNHglycan	79	82	PF01048	0.503
MOD_GSK3_1	186	193	PF00069	0.314
MOD_GSK3_1	276	283	PF00069	0.425
MOD_GSK3_1	329	336	PF00069	0.431
MOD_N-GLC_1	186	191	PF02516	0.403
MOD_N-GLC_1	280	285	PF02516	0.596
MOD_NEK2_1	159	164	PF00069	0.412
MOD_NEK2_1	280	285	PF00069	0.552
MOD_NEK2_1	311	316	PF00069	0.563
MOD_NEK2_2	292	297	PF00069	0.544
MOD_NEK2_2	93	98	PF00069	0.519
MOD_PKA_1	3	9	PF00069	0.700
MOD_PKA_2	311	317	PF00069	0.542
MOD_PKB_1	184	192	PF00069	0.499
MOD_Plk_1	264	270	PF00069	0.642
MOD_Plk_1	292	298	PF00069	0.521
MOD_Plk_1	333	339	PF00069	0.588
MOD_Plk_4	120	126	PF00069	0.487
MOD_Plk_4	190	196	PF00069	0.372
MOD_ProDKin_1	218	224	PF00069	0.578
MOD_ProDKin_1	266	272	PF00069	0.563
MOD_ProDKin_1	341	347	PF00069	0.577
MOD_ProDKin_1	349	355	PF00069	0.739
MOD_SUMO_rev_2	267	276	PF00179	0.709
TRG_ENDOCYTIC_2	191	194	PF00928	0.452
TRG_ENDOCYTIC_2	304	307	PF00928	0.463
TRG_ENDOCYTIC_2	64	67	PF00928	0.429
TRG_ER_diArg_1	341	343	PF00400	0.609
TRG_ER_diArg_1	62	64	PF00400	0.385
TRG_ER_diArg_1	76	79	PF00400	0.399
TRG_NLS_MonoExtN_4	246	252	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL9	Leptomonas seymouri	58%	89%
A0A0S4IRP2	Bodo saltans	28%	100%
A0A1X0NU99	Trypanosomatidae	39%	100%
A0A3Q8ICK6	Leishmania donovani	89%	100%
A0A422N352	Trypanosoma rangeli	40%	100%
A4I1U9	Leishmania infantum	89%	100%
C9ZS73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZS78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHA8	Leishmania infantum	89%	100%
E9AXZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9I0	Leishmania major	89%	100%
V5DR77	Trypanosoma cruzi	40%	100%