Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEL4_LEIBR

TriTrypDb:

LbrM.26.0080 , LBRM2903_260005700

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.626
CLV_NRD_NRD_1	242	244	PF00675	0.780
CLV_NRD_NRD_1	31	33	PF00675	0.579
CLV_NRD_NRD_1	43	45	PF00675	0.652
CLV_NRD_NRD_1	61	63	PF00675	0.560
CLV_NRD_NRD_1	81	83	PF00675	0.650
CLV_PCSK_FUR_1	78	82	PF00082	0.569
CLV_PCSK_KEX2_1	113	115	PF00082	0.635
CLV_PCSK_KEX2_1	242	244	PF00082	0.780
CLV_PCSK_KEX2_1	42	44	PF00082	0.690
CLV_PCSK_KEX2_1	80	82	PF00082	0.691
CLV_PCSK_SKI1_1	114	118	PF00082	0.704
CLV_PCSK_SKI1_1	176	180	PF00082	0.476
CLV_PCSK_SKI1_1	283	287	PF00082	0.793
CLV_PCSK_SKI1_1	63	67	PF00082	0.398
DEG_APCC_DBOX_1	113	121	PF00400	0.697
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.494
DOC_MAPK_gen_1	118	126	PF00069	0.415
DOC_MAPK_gen_1	78	86	PF00069	0.467
DOC_PP1_RVXF_1	25	31	PF00149	0.393
DOC_PP1_RVXF_1	80	87	PF00149	0.431
DOC_USP7_MATH_1	157	161	PF00917	0.770
DOC_USP7_MATH_1	17	21	PF00917	0.698
DOC_USP7_MATH_1	234	238	PF00917	0.626
DOC_USP7_MATH_1	270	274	PF00917	0.533
DOC_USP7_MATH_1	48	52	PF00917	0.441
DOC_WW_Pin1_4	161	166	PF00397	0.649
DOC_WW_Pin1_4	219	224	PF00397	0.632
DOC_WW_Pin1_4	273	278	PF00397	0.764
DOC_WW_Pin1_4	290	295	PF00397	0.815
LIG_14-3-3_CanoR_1	113	117	PF00244	0.693
LIG_14-3-3_CanoR_1	132	137	PF00244	0.423
LIG_14-3-3_CanoR_1	138	147	PF00244	0.554
LIG_14-3-3_CanoR_1	176	181	PF00244	0.474
LIG_14-3-3_CanoR_1	187	193	PF00244	0.438
LIG_14-3-3_CanoR_1	81	87	PF00244	0.663
LIG_BIR_III_2	296	300	PF00653	0.570
LIG_FHA_2	177	183	PF00498	0.471
LIG_Integrin_RGD_1	243	245	PF01839	0.690
LIG_LIR_Gen_1	150	161	PF02991	0.595
LIG_LIR_Gen_1	20	28	PF02991	0.403
LIG_LIR_Nem_3	150	156	PF02991	0.595
LIG_LIR_Nem_3	196	202	PF02991	0.696
LIG_LIR_Nem_3	20	24	PF02991	0.476
LIG_LIR_Nem_3	85	89	PF02991	0.538
LIG_SH2_CRK	89	93	PF00017	0.668
LIG_SH2_STAP1	89	93	PF00017	0.566
LIG_SH2_STAT5	275	278	PF00017	0.527
LIG_SH2_STAT5	279	282	PF00017	0.513
LIG_SH3_3	113	119	PF00018	0.702
LIG_SH3_3	159	165	PF00018	0.604
LIG_SH3_3	199	205	PF00018	0.761
LIG_SH3_3	221	227	PF00018	0.627
LIG_SH3_3	42	48	PF00018	0.499
LIG_TRAF2_1	100	103	PF00917	0.750
LIG_TRAF2_1	20	23	PF00917	0.415
LIG_TYR_ITIM	197	202	PF00017	0.542
LIG_UBA3_1	24	33	PF00899	0.397
LIG_WRC_WIRS_1	83	88	PF05994	0.429
MOD_CK1_1	273	279	PF00069	0.682
MOD_CK1_1	281	287	PF00069	0.750
MOD_CK2_1	136	142	PF00069	0.462
MOD_CK2_1	17	23	PF00069	0.686
MOD_CK2_1	234	240	PF00069	0.613
MOD_CK2_1	48	54	PF00069	0.581
MOD_CK2_1	97	103	PF00069	0.637
MOD_GlcNHglycan	138	141	PF01048	0.585
MOD_GlcNHglycan	266	269	PF01048	0.646
MOD_GlcNHglycan	280	283	PF01048	0.605
MOD_GlcNHglycan	39	42	PF01048	0.563
MOD_GlcNHglycan	9	12	PF01048	0.630
MOD_GSK3_1	132	139	PF00069	0.542
MOD_GSK3_1	157	164	PF00069	0.587
MOD_GSK3_1	259	266	PF00069	0.695
MOD_GSK3_1	273	280	PF00069	0.662
MOD_GSK3_1	286	293	PF00069	0.650
MOD_GSK3_1	93	100	PF00069	0.584
MOD_N-GLC_1	169	174	PF02516	0.746
MOD_N-GLC_1	270	275	PF02516	0.785
MOD_NEK2_1	136	141	PF00069	0.507
MOD_NEK2_1	37	42	PF00069	0.588
MOD_PKA_2	112	118	PF00069	0.454
MOD_PKA_2	131	137	PF00069	0.355
MOD_PKB_1	130	138	PF00069	0.493
MOD_PKB_1	80	88	PF00069	0.642
MOD_Plk_1	169	175	PF00069	0.644
MOD_Plk_1	270	276	PF00069	0.611
MOD_Plk_1	97	103	PF00069	0.565
MOD_Plk_4	132	138	PF00069	0.592
MOD_Plk_4	170	176	PF00069	0.582
MOD_Plk_4	245	251	PF00069	0.549
MOD_Plk_4	256	262	PF00069	0.737
MOD_ProDKin_1	161	167	PF00069	0.648
MOD_ProDKin_1	219	225	PF00069	0.631
MOD_ProDKin_1	273	279	PF00069	0.765
MOD_ProDKin_1	290	296	PF00069	0.817
TRG_ENDOCYTIC_2	199	202	PF00928	0.664
TRG_ENDOCYTIC_2	21	24	PF00928	0.410
TRG_ENDOCYTIC_2	89	92	PF00928	0.671
TRG_ER_diArg_1	130	133	PF00400	0.461
TRG_ER_diArg_1	241	243	PF00400	0.771
TRG_ER_diArg_1	42	44	PF00400	0.658
TRG_ER_diArg_1	78	81	PF00400	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M0	Leptomonas seymouri	39%	87%
A0A3Q8IDN0	Leishmania donovani	63%	100%
A4I1U5	Leishmania infantum	63%	100%
E9AXY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q9I5	Leishmania major	64%	100%