TPX2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEL3_LEIBR

TriTrypDb:

LbrM.26.0070 , LBRM2903_260005600

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	121	123	PF00082	0.495
CLV_PCSK_KEX2_1	249	251	PF00082	0.615
CLV_PCSK_KEX2_1	71	73	PF00082	0.662
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.495
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.615
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.662
CLV_PCSK_PC7_1	117	123	PF00082	0.488
CLV_PCSK_SKI1_1	72	76	PF00082	0.524
CLV_PCSK_SKI1_1	8	12	PF00082	0.572
CLV_Separin_Metazoa	134	138	PF03568	0.550
DEG_Nend_UBRbox_3	1	3	PF02207	0.435
DOC_CKS1_1	190	195	PF01111	0.524
DOC_CKS1_1	199	204	PF01111	0.529
DOC_MAPK_gen_1	248	259	PF00069	0.480
DOC_MAPK_gen_1	82	91	PF00069	0.663
DOC_MAPK_MEF2A_6	82	91	PF00069	0.516
DOC_USP7_MATH_1	224	228	PF00917	0.702
DOC_USP7_MATH_1	233	237	PF00917	0.725
DOC_USP7_UBL2_3	248	252	PF12436	0.608
DOC_USP7_UBL2_3	67	71	PF12436	0.767
DOC_USP7_UBL2_3	8	12	PF12436	0.572
DOC_WW_Pin1_4	189	194	PF00397	0.707
DOC_WW_Pin1_4	198	203	PF00397	0.701
DOC_WW_Pin1_4	240	245	PF00397	0.765
LIG_14-3-3_CanoR_1	114	123	PF00244	0.754
LIG_BRCT_BRCA1_1	39	43	PF00533	0.538
LIG_FHA_1	161	167	PF00498	0.652
LIG_FHA_1	95	101	PF00498	0.607
LIG_FHA_2	162	168	PF00498	0.676
LIG_LIR_Nem_3	85	89	PF02991	0.667
LIG_Pex14_2	6	10	PF04695	0.558
LIG_PTAP_UEV_1	176	181	PF05743	0.556
LIG_SH3_2	244	249	PF14604	0.765
LIG_SH3_3	151	157	PF00018	0.646
LIG_SH3_3	174	180	PF00018	0.705
LIG_SH3_3	187	193	PF00018	0.744
LIG_SH3_3	218	224	PF00018	0.830
LIG_SH3_3	241	247	PF00018	0.749
LIG_SUMO_SIM_par_1	163	170	PF11976	0.739
LIG_TRAF2_1	50	53	PF00917	0.539
LIG_WRC_WIRS_1	7	12	PF05994	0.569
MOD_CK1_1	145	151	PF00069	0.497
MOD_CK1_1	175	181	PF00069	0.674
MOD_CK1_1	207	213	PF00069	0.748
MOD_CK1_1	236	242	PF00069	0.707
MOD_CK2_1	161	167	PF00069	0.676
MOD_CK2_1	248	254	PF00069	0.612
MOD_GlcNHglycan	149	152	PF01048	0.681
MOD_GlcNHglycan	174	177	PF01048	0.665
MOD_GlcNHglycan	235	238	PF01048	0.560
MOD_GlcNHglycan	44	47	PF01048	0.720
MOD_GSK3_1	200	207	PF00069	0.766
MOD_GSK3_1	208	215	PF00069	0.662
MOD_GSK3_1	236	243	PF00069	0.704
MOD_N-GLC_1	1	6	PF02516	0.517
MOD_N-GLC_1	94	99	PF02516	0.560
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	142	147	PF00069	0.660
MOD_NEK2_1	172	177	PF00069	0.582
MOD_NEK2_1	255	260	PF00069	0.436
MOD_PIKK_1	1	7	PF00454	0.569
MOD_PIKK_1	116	122	PF00454	0.501
MOD_PKA_1	248	254	PF00069	0.612
MOD_PKA_2	116	122	PF00069	0.501
MOD_PKA_2	29	35	PF00069	0.705
MOD_Plk_1	1	7	PF00069	0.569
MOD_Plk_2-3	37	43	PF00069	0.543
MOD_Plk_4	161	167	PF00069	0.596
MOD_Plk_4	181	187	PF00069	0.776
MOD_Plk_4	204	210	PF00069	0.549
MOD_ProDKin_1	189	195	PF00069	0.709
MOD_ProDKin_1	198	204	PF00069	0.703
MOD_ProDKin_1	240	246	PF00069	0.761
TRG_DiLeu_BaEn_1	167	172	PF01217	0.754
TRG_ER_diArg_1	136	139	PF00400	0.647
TRG_ER_FFAT_2	37	49	PF00635	0.546
TRG_NLS_MonoCore_2	120	125	PF00514	0.465
TRG_NLS_MonoExtC_3	120	126	PF00514	0.494
TRG_NLS_MonoExtC_3	247	252	PF00514	0.627
TRG_NLS_MonoExtN_4	247	253	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS9	Leptomonas seymouri	41%	99%
A0A3S5H7F4	Leishmania donovani	62%	100%
A4I1U4	Leishmania infantum	62%	100%
E9AXY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q9I6	Leishmania major	59%	100%