Methylmalonyl-coa epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylmalonyl-coa epimerase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEL0_LEIBR

TriTrypDb:

LbrM.26.0040 , LBRM2903_260005300

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEL0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035383	thioester metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046491	L-methylmalonyl-CoA metabolic process	5	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004493	methylmalonyl-CoA epimerase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016854	racemase and epimerase activity	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.596
CLV_PCSK_KEX2_1	3	5	PF00082	0.596
CLV_PCSK_KEX2_1	39	41	PF00082	0.298
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.216
CLV_PCSK_SKI1_1	39	43	PF00082	0.278
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.432
DOC_MAPK_gen_1	3	11	PF00069	0.503
DOC_MAPK_gen_1	39	46	PF00069	0.368
DOC_MAPK_MEF2A_6	137	146	PF00069	0.437
DOC_MAPK_MEF2A_6	17	25	PF00069	0.344
DOC_PP2B_LxvP_1	9	12	PF13499	0.431
DOC_PP4_FxxP_1	133	136	PF00568	0.539
DOC_WW_Pin1_4	76	81	PF00397	0.344
LIG_14-3-3_CanoR_1	4	10	PF00244	0.541
LIG_APCC_ABBA_1	58	63	PF00400	0.455
LIG_Clathr_ClatBox_1	143	147	PF01394	0.486
LIG_FHA_1	57	63	PF00498	0.344
LIG_FHA_2	107	113	PF00498	0.389
LIG_LIR_Gen_1	59	69	PF02991	0.346
LIG_LIR_Nem_3	36	41	PF02991	0.469
LIG_PCNA_yPIPBox_3	78	89	PF02747	0.357
LIG_SH2_CRK	38	42	PF00017	0.344
LIG_SH3_3	43	49	PF00018	0.352
LIG_SH3_3	59	65	PF00018	0.308
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.344
LIG_SUMO_SIM_par_1	142	148	PF11976	0.489
LIG_UBA3_1	143	150	PF00899	0.435
MOD_CK1_1	5	11	PF00069	0.428
MOD_CK2_1	106	112	PF00069	0.314
MOD_CK2_1	27	33	PF00069	0.469
MOD_CK2_1	64	70	PF00069	0.344
MOD_GlcNHglycan	102	106	PF01048	0.216
MOD_N-GLC_1	76	81	PF02516	0.278
MOD_NEK2_1	2	7	PF00069	0.497
MOD_NEK2_2	106	111	PF00069	0.314
MOD_NEK2_2	56	61	PF00069	0.344
MOD_PKA_2	2	8	PF00069	0.575
MOD_ProDKin_1	76	82	PF00069	0.344
MOD_SUMO_rev_2	145	151	PF00179	0.628
TRG_ENDOCYTIC_2	38	41	PF00928	0.344
TRG_ER_diArg_1	2	4	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K5	Leptomonas seymouri	79%	99%
A0A0S4INE6	Bodo saltans	62%	100%
A0A3S7WZI1	Leishmania donovani	82%	100%
A4I1U1	Leishmania infantum	81%	100%
E9AXY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O58010	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	32%	100%
P54540	Bacillus subtilis (strain 168)	32%	100%
Q2KIZ3	Bos taurus	58%	86%
Q3IZP4	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	57%	100%
Q4Q9I9	Leishmania major	82%	100%
Q553V2	Dictyostelium discoideum	58%	91%
Q96PE7	Homo sapiens	60%	86%
Q9D1I5	Mus musculus	57%	85%