Ribosome production factor 2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

brix domain containing-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEK9_LEIBR

TriTrypDb:

LbrM.26.0030 , LBRM2903_260005200

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HEK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEK9

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	12
GO:0000470	maturation of LSU-rRNA	9	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043933	protein-containing complex organization	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.263
CLV_NRD_NRD_1	260	262	PF00675	0.248
CLV_NRD_NRD_1	316	318	PF00675	0.480
CLV_NRD_NRD_1	322	324	PF00675	0.514
CLV_NRD_NRD_1	345	347	PF00675	0.632
CLV_NRD_NRD_1	9	11	PF00675	0.472
CLV_PCSK_KEX2_1	100	102	PF00082	0.242
CLV_PCSK_KEX2_1	18	20	PF00082	0.476
CLV_PCSK_KEX2_1	260	262	PF00082	0.258
CLV_PCSK_KEX2_1	316	318	PF00082	0.480
CLV_PCSK_KEX2_1	322	324	PF00082	0.514
CLV_PCSK_KEX2_1	33	35	PF00082	0.337
CLV_PCSK_KEX2_1	344	346	PF00082	0.629
CLV_PCSK_KEX2_1	8	10	PF00082	0.476
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.247
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.407
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.476
CLV_PCSK_SKI1_1	10	14	PF00082	0.491
CLV_PCSK_SKI1_1	145	149	PF00082	0.247
CLV_PCSK_SKI1_1	165	169	PF00082	0.116
CLV_PCSK_SKI1_1	18	22	PF00082	0.351
CLV_PCSK_SKI1_1	187	191	PF00082	0.308
CLV_PCSK_SKI1_1	241	245	PF00082	0.333
CLV_PCSK_SKI1_1	316	320	PF00082	0.486
CLV_PCSK_SKI1_1	33	37	PF00082	0.325
CLV_PCSK_SKI1_1	64	68	PF00082	0.251
DEG_APCC_DBOX_1	277	285	PF00400	0.575
DEG_APCC_DBOX_1	76	84	PF00400	0.447
DEG_SPOP_SBC_1	12	16	PF00917	0.329
DOC_CKS1_1	264	269	PF01111	0.406
DOC_CYCLIN_RxL_1	162	170	PF00134	0.472
DOC_CYCLIN_RxL_1	31	42	PF00134	0.445
DOC_MAPK_gen_1	99	107	PF00069	0.442
DOC_PP1_RVXF_1	185	192	PF00149	0.458
DOC_PP1_RVXF_1	258	265	PF00149	0.542
DOC_PP1_RVXF_1	31	38	PF00149	0.391
DOC_PP4_FxxP_1	264	267	PF00568	0.390
DOC_USP7_MATH_1	12	16	PF00917	0.478
DOC_USP7_UBL2_3	59	63	PF12436	0.449
DOC_USP7_UBL2_3	64	68	PF12436	0.444
DOC_WW_Pin1_4	263	268	PF00397	0.384
LIG_14-3-3_CanoR_1	163	168	PF00244	0.387
LIG_14-3-3_CanoR_1	260	265	PF00244	0.506
LIG_14-3-3_CanoR_1	285	291	PF00244	0.465
LIG_Actin_WH2_2	269	287	PF00022	0.529
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_EH1_1	112	120	PF00400	0.447
LIG_EH1_1	48	56	PF00400	0.368
LIG_FHA_1	132	138	PF00498	0.533
LIG_FHA_1	42	48	PF00498	0.374
LIG_FHA_2	1	7	PF00498	0.534
LIG_FHA_2	264	270	PF00498	0.405
LIG_LIR_Apic_2	263	267	PF02991	0.401
LIG_LIR_Gen_1	158	169	PF02991	0.447
LIG_LIR_Nem_3	158	164	PF02991	0.447
LIG_LIR_Nem_3	81	85	PF02991	0.458
LIG_NRBOX	163	169	PF00104	0.472
LIG_PDZ_Class_1	357	362	PF00595	0.629
LIG_REV1ctd_RIR_1	188	198	PF16727	0.533
LIG_SH2_GRB2like	210	213	PF00017	0.533
LIG_SH2_STAT5	171	174	PF00017	0.553
LIG_SH2_STAT5	210	213	PF00017	0.533
LIG_SH2_STAT5	61	64	PF00017	0.520
LIG_SH3_3	26	32	PF00018	0.447
LIG_SH3_3	350	356	PF00018	0.497
LIG_SH3_4	59	66	PF00018	0.458
LIG_TRAF2_1	266	269	PF00917	0.499
LIG_UBA3_1	54	59	PF00899	0.508
MOD_CK1_1	14	20	PF00069	0.464
MOD_CK1_1	192	198	PF00069	0.447
MOD_CK1_1	263	269	PF00069	0.413
MOD_CK1_1	336	342	PF00069	0.620
MOD_CK1_1	41	47	PF00069	0.468
MOD_CK2_1	263	269	PF00069	0.398
MOD_GlcNHglycan	140	143	PF01048	0.302
MOD_GlcNHglycan	233	236	PF01048	0.334
MOD_GSK3_1	150	157	PF00069	0.508
MOD_GSK3_1	204	211	PF00069	0.422
MOD_GSK3_1	280	287	PF00069	0.471
MOD_GSK3_1	41	48	PF00069	0.417
MOD_GSK3_1	8	15	PF00069	0.548
MOD_N-GLC_1	103	108	PF02516	0.317
MOD_N-GLC_1	175	180	PF02516	0.265
MOD_N-GLC_2	87	89	PF02516	0.247
MOD_NEK2_1	129	134	PF00069	0.497
MOD_NEK2_1	189	194	PF00069	0.458
MOD_NEK2_1	284	289	PF00069	0.429
MOD_NEK2_1	38	43	PF00069	0.383
MOD_NEK2_1	55	60	PF00069	0.422
MOD_NEK2_1	94	99	PF00069	0.533
MOD_PIKK_1	129	135	PF00454	0.533
MOD_PIKK_1	192	198	PF00454	0.422
MOD_PKA_1	231	237	PF00069	0.533
MOD_PKA_1	260	266	PF00069	0.525
MOD_PKA_1	8	14	PF00069	0.569
MOD_PKA_2	260	266	PF00069	0.509
MOD_PKA_2	277	283	PF00069	0.400
MOD_PKA_2	284	290	PF00069	0.465
MOD_PKA_2	8	14	PF00069	0.569
MOD_Plk_1	103	109	PF00069	0.447
MOD_Plk_1	175	181	PF00069	0.481
MOD_Plk_1	87	93	PF00069	0.447
MOD_Plk_4	163	169	PF00069	0.456
MOD_Plk_4	175	181	PF00069	0.411
MOD_Plk_4	87	93	PF00069	0.441
MOD_ProDKin_1	263	269	PF00069	0.388
MOD_SUMO_rev_2	263	273	PF00179	0.426
TRG_ER_diArg_1	259	261	PF00400	0.458
TRG_ER_diArg_1	315	317	PF00400	0.486
TRG_ER_diArg_1	343	346	PF00400	0.627
TRG_NES_CRM1_1	294	309	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z8	Leptomonas seymouri	81%	100%
A0A0S4IUC1	Bodo saltans	56%	100%
A0A1X0NSB0	Trypanosomatidae	72%	93%
A0A3S7WZF9	Leishmania donovani	83%	100%
A0A422N200	Trypanosoma rangeli	67%	100%
A4I1U0	Leishmania infantum	84%	100%
C9ZRP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	98%
E8NHL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P36160	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q2YDN6	Bos taurus	33%	100%
Q4Q9J0	Leishmania major	81%	100%
Q54DJ0	Dictyostelium discoideum	30%	100%
Q9AWM9	Oryza sativa subsp. japonica	30%	100%
Q9H7B2	Homo sapiens	33%	100%
Q9JJ80	Mus musculus	33%	100%
Q9LUG5	Arabidopsis thaliana	29%	100%
Q9N3F0	Caenorhabditis elegans	31%	100%
Q9UUG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9VEB3	Drosophila melanogaster	33%	100%
V5BAA9	Trypanosoma cruzi	74%	100%