TATE DNA Transposon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

TATE DNA Transposon

Gene product:

TATE DNA Transposon

Species:

Leishmania braziliensis

UniProt:

A4HEK5_LEIBR

TriTrypDb:

LbrM.25.2620 , LBRM2903_110018000 , LBRM2903_300038700

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEK5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006310	DNA recombination	5	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0015074	DNA integration	5	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.618
CLV_C14_Caspase3-7	598	602	PF00656	0.606
CLV_NRD_NRD_1	215	217	PF00675	0.527
CLV_NRD_NRD_1	282	284	PF00675	0.477
CLV_NRD_NRD_1	327	329	PF00675	0.629
CLV_NRD_NRD_1	332	334	PF00675	0.609
CLV_NRD_NRD_1	493	495	PF00675	0.617
CLV_NRD_NRD_1	521	523	PF00675	0.603
CLV_NRD_NRD_1	843	845	PF00675	0.798
CLV_NRD_NRD_1	91	93	PF00675	0.558
CLV_PCSK_KEX2_1	163	165	PF00082	0.516
CLV_PCSK_KEX2_1	332	334	PF00082	0.669
CLV_PCSK_KEX2_1	396	398	PF00082	0.675
CLV_PCSK_KEX2_1	412	414	PF00082	0.390
CLV_PCSK_KEX2_1	417	419	PF00082	0.547
CLV_PCSK_KEX2_1	492	494	PF00082	0.625
CLV_PCSK_KEX2_1	521	523	PF00082	0.603
CLV_PCSK_KEX2_1	842	844	PF00082	0.790
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.487
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.675
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.390
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.547
CLV_PCSK_PC7_1	328	334	PF00082	0.654
CLV_PCSK_PC7_1	413	419	PF00082	0.645
CLV_PCSK_SKI1_1	132	136	PF00082	0.532
CLV_PCSK_SKI1_1	140	144	PF00082	0.477
CLV_PCSK_SKI1_1	171	175	PF00082	0.464
CLV_PCSK_SKI1_1	195	199	PF00082	0.490
CLV_PCSK_SKI1_1	219	223	PF00082	0.582
CLV_PCSK_SKI1_1	284	288	PF00082	0.471
CLV_PCSK_SKI1_1	308	312	PF00082	0.498
CLV_PCSK_SKI1_1	384	388	PF00082	0.661
CLV_PCSK_SKI1_1	417	421	PF00082	0.631
CLV_PCSK_SKI1_1	439	443	PF00082	0.662
CLV_PCSK_SKI1_1	494	498	PF00082	0.623
CLV_PCSK_SKI1_1	529	533	PF00082	0.580
CLV_PCSK_SKI1_1	552	556	PF00082	0.584
CLV_PCSK_SKI1_1	60	64	PF00082	0.523
CLV_PCSK_SKI1_1	683	687	PF00082	0.633
CLV_PCSK_SKI1_1	716	720	PF00082	0.660
CLV_PCSK_SKI1_1	892	896	PF00082	0.665
CLV_PCSK_SKI1_1	95	99	PF00082	0.517
DEG_APCC_DBOX_1	636	644	PF00400	0.644
DEG_Nend_UBRbox_1	1	4	PF02207	0.485
DOC_CKS1_1	590	595	PF01111	0.607
DOC_CYCLIN_yClb3_PxF_3	147	155	PF00134	0.571
DOC_MAPK_gen_1	526	536	PF00069	0.583
DOC_MAPK_gen_1	722	732	PF00069	0.657
DOC_MAPK_MEF2A_6	171	178	PF00069	0.460
DOC_MAPK_MEF2A_6	529	536	PF00069	0.579
DOC_MAPK_MEF2A_6	677	686	PF00069	0.614
DOC_MAPK_NFAT4_5	171	179	PF00069	0.459
DOC_PP1_RVXF_1	727	733	PF00149	0.661
DOC_PP2B_LxvP_1	407	410	PF13499	0.668
DOC_PP4_FxxP_1	426	429	PF00568	0.608
DOC_PP4_FxxP_1	484	487	PF00568	0.659
DOC_PP4_FxxP_1	851	854	PF00568	0.802
DOC_USP7_MATH_1	151	155	PF00917	0.544
DOC_USP7_MATH_1	201	205	PF00917	0.534
DOC_USP7_MATH_1	228	232	PF00917	0.523
DOC_USP7_MATH_1	3	7	PF00917	0.642
DOC_USP7_UBL2_3	677	681	PF12436	0.613
DOC_WW_Pin1_4	253	258	PF00397	0.453
DOC_WW_Pin1_4	396	401	PF00397	0.656
DOC_WW_Pin1_4	589	594	PF00397	0.603
DOC_WW_Pin1_4	631	636	PF00397	0.628
LIG_14-3-3_CanoR_1	332	341	PF00244	0.619
LIG_14-3-3_CanoR_1	413	420	PF00244	0.637
LIG_14-3-3_CanoR_1	493	499	PF00244	0.616
LIG_14-3-3_CanoR_1	565	570	PF00244	0.596
LIG_14-3-3_CanoR_1	574	578	PF00244	0.441
LIG_14-3-3_CanoR_1	64	69	PF00244	0.520
LIG_14-3-3_CanoR_1	673	677	PF00244	0.604
LIG_14-3-3_CanoR_1	694	700	PF00244	0.600
LIG_14-3-3_CanoR_1	729	733	PF00244	0.673
LIG_14-3-3_CanoR_1	771	780	PF00244	0.733
LIG_14-3-3_CanoR_1	864	871	PF00244	0.741
LIG_Actin_WH2_2	420	438	PF00022	0.627
LIG_Actin_WH2_2	669	685	PF00022	0.604
LIG_BIR_III_2	148	152	PF00653	0.585
LIG_BIR_III_2	541	545	PF00653	0.582
LIG_BIR_III_2	739	743	PF00653	0.663
LIG_BRCT_BRCA1_1	700	704	PF00533	0.595
LIG_deltaCOP1_diTrp_1	127	135	PF00928	0.533
LIG_deltaCOP1_diTrp_1	806	814	PF00928	0.724
LIG_eIF4E_1	919	925	PF01652	0.741
LIG_FHA_1	210	216	PF00498	0.521
LIG_FHA_1	232	238	PF00498	0.540
LIG_FHA_1	495	501	PF00498	0.609
LIG_FHA_1	582	588	PF00498	0.563
LIG_FHA_1	595	601	PF00498	0.373
LIG_FHA_1	654	660	PF00498	0.609
LIG_FHA_1	813	819	PF00498	0.780
LIG_FHA_2	238	244	PF00498	0.518
LIG_FHA_2	397	403	PF00498	0.651
LIG_FHA_2	445	451	PF00498	0.628
LIG_FHA_2	483	489	PF00498	0.647
LIG_FHA_2	584	590	PF00498	0.574
LIG_FHA_2	596	602	PF00498	0.390
LIG_FHA_2	772	778	PF00498	0.746
LIG_GBD_Chelix_1	237	245	PF00786	0.492
LIG_Integrin_isoDGR_2	666	668	PF01839	0.658
LIG_LIR_Gen_1	205	215	PF02991	0.464
LIG_LIR_Gen_1	375	385	PF02991	0.663
LIG_LIR_Gen_1	537	547	PF02991	0.595
LIG_LIR_Gen_1	584	593	PF02991	0.591
LIG_LIR_Gen_1	777	788	PF02991	0.689
LIG_LIR_Nem_3	133	138	PF02991	0.524
LIG_LIR_Nem_3	205	211	PF02991	0.481
LIG_LIR_Nem_3	375	380	PF02991	0.654
LIG_LIR_Nem_3	430	435	PF02991	0.634
LIG_LIR_Nem_3	535	539	PF02991	0.591
LIG_LIR_Nem_3	560	566	PF02991	0.616
LIG_LIR_Nem_3	584	588	PF02991	0.574
LIG_LIR_Nem_3	701	707	PF02991	0.601
LIG_LIR_Nem_3	731	735	PF02991	0.680
LIG_LIR_Nem_3	777	783	PF02991	0.694
LIG_LIR_Nem_3	791	796	PF02991	0.451
LIG_PCNA_PIPBox_1	309	318	PF02747	0.498
LIG_PCNA_yPIPBox_3	308	316	PF02747	0.496
LIG_PCNA_yPIPBox_3	872	882	PF02747	0.694
LIG_Pex14_1	131	135	PF04695	0.518
LIG_SH2_CRK	432	436	PF00017	0.643
LIG_SH2_CRK	540	544	PF00017	0.586
LIG_SH2_CRK	724	728	PF00017	0.647
LIG_SH2_CRK	780	784	PF00017	0.671
LIG_SH2_NCK_1	540	544	PF00017	0.586
LIG_SH2_NCK_1	780	784	PF00017	0.671
LIG_SH2_PTP2	208	211	PF00017	0.458
LIG_SH2_SRC	743	746	PF00017	0.673
LIG_SH2_STAP1	116	120	PF00017	0.361
LIG_SH2_STAP1	515	519	PF00017	0.668
LIG_SH2_STAP1	527	531	PF00017	0.378
LIG_SH2_STAP1	780	784	PF00017	0.671
LIG_SH2_STAP1	865	869	PF00017	0.742
LIG_SH2_STAT3	116	119	PF00017	0.511
LIG_SH2_STAT3	318	321	PF00017	0.561
LIG_SH2_STAT3	530	533	PF00017	0.572
LIG_SH2_STAT5	208	211	PF00017	0.504
LIG_SH2_STAT5	315	318	PF00017	0.456
LIG_SH2_STAT5	663	666	PF00017	0.605
LIG_SH2_STAT5	743	746	PF00017	0.673
LIG_SH3_3	144	150	PF00018	0.604
LIG_SH3_3	469	475	PF00018	0.693
LIG_SH3_3	757	763	PF00018	0.635
LIG_SUMO_SIM_anti_2	698	704	PF11976	0.597
LIG_SUMO_SIM_par_1	586	592	PF11976	0.587
LIG_SUMO_SIM_par_1	614	621	PF11976	0.592
LIG_TRAF2_1	20	23	PF00917	0.517
LIG_TRAF2_1	240	243	PF00917	0.515
LIG_TRAF2_1	250	253	PF00917	0.438
LIG_TRAF2_1	363	366	PF00917	0.663
LIG_TRAF2_1	644	647	PF00917	0.614
LIG_TRAF2_1	751	754	PF00917	0.637
LIG_UBA3_1	300	308	PF00899	0.522
LIG_ULM_U2AF65_1	92	97	PF00076	0.532
LIG_WRC_WIRS_1	374	379	PF05994	0.322
MOD_CDC14_SPxK_1	634	637	PF00782	0.644
MOD_CDK_SPxK_1	631	637	PF00069	0.627
MOD_CK1_1	204	210	PF00069	0.499
MOD_CK1_1	231	237	PF00069	0.491
MOD_CK1_1	352	358	PF00069	0.749
MOD_CK1_1	6	12	PF00069	0.635
MOD_CK1_1	653	659	PF00069	0.616
MOD_CK1_1	67	73	PF00069	0.541
MOD_CK1_1	675	681	PF00069	0.609
MOD_CK1_1	695	701	PF00069	0.247
MOD_CK2_1	17	23	PF00069	0.658
MOD_CK2_1	237	243	PF00069	0.506
MOD_CK2_1	444	450	PF00069	0.630
MOD_CK2_1	482	488	PF00069	0.641
MOD_CK2_1	641	647	PF00069	0.617
MOD_CK2_1	748	754	PF00069	0.645
MOD_CK2_1	771	777	PF00069	0.746
MOD_Cter_Amidation	246	249	PF01082	0.362
MOD_Cter_Amidation	490	493	PF01082	0.629
MOD_Cter_Amidation	519	522	PF01082	0.618
MOD_GlcNHglycan	132	135	PF01048	0.531
MOD_GlcNHglycan	303	306	PF01048	0.528
MOD_GlcNHglycan	334	337	PF01048	0.627
MOD_GlcNHglycan	652	655	PF01048	0.617
MOD_GlcNHglycan	846	849	PF01048	0.825
MOD_GlcNHglycan	865	868	PF01048	0.415
MOD_GSK3_1	130	137	PF00069	0.528
MOD_GSK3_1	349	356	PF00069	0.751
MOD_GSK3_1	408	415	PF00069	0.665
MOD_GSK3_1	60	67	PF00069	0.523
MOD_GSK3_1	744	751	PF00069	0.656
MOD_GSK3_1	772	779	PF00069	0.741
MOD_GSK3_1	802	809	PF00069	0.719
MOD_LATS_1	306	312	PF00433	0.532
MOD_LATS_1	58	64	PF00433	0.515
MOD_NEK2_1	115	120	PF00069	0.525
MOD_NEK2_1	142	147	PF00069	0.595
MOD_NEK2_1	237	242	PF00069	0.503
MOD_NEK2_1	301	306	PF00069	0.517
MOD_NEK2_1	435	440	PF00069	0.647
MOD_NEK2_1	45	50	PF00069	0.454
MOD_NEK2_1	686	691	PF00069	0.660
MOD_NEK2_1	707	712	PF00069	0.623
MOD_NEK2_1	84	89	PF00069	0.491
MOD_NEK2_2	3	8	PF00069	0.643
MOD_NEK2_2	728	733	PF00069	0.672
MOD_PIKK_1	115	121	PF00454	0.535
MOD_PIKK_1	17	23	PF00454	0.549
MOD_PIKK_1	349	355	PF00454	0.751
MOD_PIKK_1	40	46	PF00454	0.550
MOD_PIKK_1	707	713	PF00454	0.634
MOD_PKA_1	248	254	PF00069	0.536
MOD_PKA_1	332	338	PF00069	0.634
MOD_PKA_1	412	418	PF00069	0.654
MOD_PKA_2	159	165	PF00069	0.482
MOD_PKA_2	332	338	PF00069	0.634
MOD_PKA_2	412	418	PF00069	0.654
MOD_PKA_2	435	441	PF00069	0.643
MOD_PKA_2	573	579	PF00069	0.580
MOD_PKA_2	672	678	PF00069	0.600
MOD_PKA_2	728	734	PF00069	0.674
MOD_PKA_2	812	818	PF00069	0.769
MOD_PKA_2	863	869	PF00069	0.747
MOD_PKB_1	492	500	PF00069	0.616
MOD_PKB_1	842	850	PF00069	0.813
MOD_Plk_1	187	193	PF00069	0.463
MOD_Plk_1	195	201	PF00069	0.430
MOD_Plk_1	661	667	PF00069	0.597
MOD_Plk_1	744	750	PF00069	0.663
MOD_Plk_1	776	782	PF00069	0.706
MOD_Plk_1	786	792	PF00069	0.544
MOD_Plk_2-3	641	647	PF00069	0.653
MOD_Plk_2-3	776	782	PF00069	0.706
MOD_Plk_4	195	201	PF00069	0.512
MOD_Plk_4	204	210	PF00069	0.455
MOD_Plk_4	228	234	PF00069	0.509
MOD_Plk_4	308	314	PF00069	0.613
MOD_Plk_4	373	379	PF00069	0.327
MOD_Plk_4	402	408	PF00069	0.661
MOD_Plk_4	427	433	PF00069	0.622
MOD_Plk_4	595	601	PF00069	0.601
MOD_Plk_4	653	659	PF00069	0.616
MOD_Plk_4	695	701	PF00069	0.597
MOD_ProDKin_1	253	259	PF00069	0.451
MOD_ProDKin_1	396	402	PF00069	0.655
MOD_ProDKin_1	589	595	PF00069	0.602
MOD_ProDKin_1	631	637	PF00069	0.627
TRG_DiLeu_BaEn_1	261	266	PF01217	0.499
TRG_DiLeu_BaEn_1	383	388	PF01217	0.664
TRG_DiLeu_BaEn_4	646	652	PF01217	0.585
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.619
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.617
TRG_ENDOCYTIC_2	208	211	PF00928	0.458
TRG_ENDOCYTIC_2	432	435	PF00928	0.636
TRG_ENDOCYTIC_2	540	543	PF00928	0.578
TRG_ENDOCYTIC_2	563	566	PF00928	0.595
TRG_ENDOCYTIC_2	724	727	PF00928	0.642
TRG_ENDOCYTIC_2	780	783	PF00928	0.677
TRG_ER_diArg_1	164	167	PF00400	0.545
TRG_ER_diArg_1	492	494	PF00400	0.625
TRG_ER_diArg_1	521	524	PF00400	0.613
TRG_ER_diArg_1	555	558	PF00400	0.607
TRG_ER_diArg_1	564	567	PF00400	0.448
TRG_ER_diArg_1	810	813	PF00400	0.739
TRG_ER_diArg_1	841	844	PF00400	0.793
TRG_NES_CRM1_1	476	488	PF08389	0.633
TRG_NLS_MonoExtN_4	160	167	PF00514	0.490
TRG_NLS_MonoExtN_4	90	96	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	820	825	PF00026	0.747
TRG_Pf-PMV_PEXEL_1	879	883	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9A6	Leishmania braziliensis	99%	100%
A4HEK4	Leishmania braziliensis	96%	100%
A4HIQ6	Leishmania braziliensis	97%	66%
A4HIW1	Leishmania braziliensis	99%	100%
A4HIW3	Leishmania braziliensis	85%	69%
A4HJX9	Leishmania braziliensis	96%	100%
A4HM37	Leishmania braziliensis	99%	100%