SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUA domain/NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

A4HEK2_LEIBR

TriTrypDb:

LbrM.25.2590 , LBRM2903_250011600

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEK2

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0032259	methylation	2	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0008168	methyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.458
CLV_C14_Caspase3-7	758	762	PF00656	0.500
CLV_NRD_NRD_1	131	133	PF00675	0.547
CLV_NRD_NRD_1	30	32	PF00675	0.538
CLV_NRD_NRD_1	305	307	PF00675	0.764
CLV_NRD_NRD_1	311	313	PF00675	0.568
CLV_NRD_NRD_1	522	524	PF00675	0.556
CLV_NRD_NRD_1	631	633	PF00675	0.537
CLV_NRD_NRD_1	687	689	PF00675	0.295
CLV_PCSK_FUR_1	132	136	PF00082	0.530
CLV_PCSK_KEX2_1	131	133	PF00082	0.547
CLV_PCSK_KEX2_1	134	136	PF00082	0.514
CLV_PCSK_KEX2_1	30	32	PF00082	0.538
CLV_PCSK_KEX2_1	311	313	PF00082	0.441
CLV_PCSK_KEX2_1	357	359	PF00082	0.343
CLV_PCSK_KEX2_1	44	46	PF00082	0.473
CLV_PCSK_KEX2_1	522	524	PF00082	0.556
CLV_PCSK_KEX2_1	631	633	PF00082	0.545
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.522
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.343
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.514
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.545
CLV_PCSK_SKI1_1	375	379	PF00082	0.370
CLV_PCSK_SKI1_1	459	463	PF00082	0.472
CLV_PCSK_SKI1_1	617	621	PF00082	0.495
CLV_PCSK_SKI1_1	632	636	PF00082	0.510
CLV_PCSK_SKI1_1	688	692	PF00082	0.295
DEG_APCC_DBOX_1	310	318	PF00400	0.370
DEG_APCC_DBOX_1	454	462	PF00400	0.472
DEG_Nend_UBRbox_2	1	3	PF02207	0.490
DEG_SCF_FBW7_1	64	70	PF00400	0.512
DEG_SPOP_SBC_1	113	117	PF00917	0.651
DEG_SPOP_SBC_1	242	246	PF00917	0.473
DEG_SPOP_SBC_1	638	642	PF00917	0.431
DEG_SPOP_SBC_1	796	800	PF00917	0.485
DOC_CKS1_1	64	69	PF01111	0.511
DOC_CYCLIN_RxL_1	455	465	PF00134	0.454
DOC_CYCLIN_RxL_1	682	693	PF00134	0.500
DOC_CYCLIN_yClb1_LxF_4	722	728	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.474
DOC_MAPK_gen_1	311	318	PF00069	0.359
DOC_MAPK_gen_1	43	50	PF00069	0.507
DOC_MAPK_gen_1	489	499	PF00069	0.528
DOC_MAPK_gen_1	594	603	PF00069	0.506
DOC_MAPK_MEF2A_6	311	318	PF00069	0.523
DOC_MAPK_MEF2A_6	552	559	PF00069	0.382
DOC_MAPK_MEF2A_6	729	736	PF00069	0.456
DOC_MAPK_MEF2A_6	777	785	PF00069	0.420
DOC_MAPK_NFAT4_5	552	560	PF00069	0.382
DOC_MAPK_RevD_3	507	523	PF00069	0.301
DOC_MIT_MIM_1	226	236	PF04212	0.428
DOC_PP2B_LxvP_1	238	241	PF13499	0.631
DOC_PP2B_LxvP_1	332	335	PF13499	0.535
DOC_PP2B_LxvP_1	657	660	PF13499	0.461
DOC_PP4_FxxP_1	257	260	PF00568	0.550
DOC_PP4_FxxP_1	87	90	PF00568	0.482
DOC_SPAK_OSR1_1	45	49	PF12202	0.507
DOC_USP7_MATH_1	184	188	PF00917	0.604
DOC_USP7_MATH_1	412	416	PF00917	0.584
DOC_USP7_MATH_1	637	641	PF00917	0.650
DOC_USP7_MATH_1	752	756	PF00917	0.628
DOC_WW_Pin1_4	115	120	PF00397	0.504
DOC_WW_Pin1_4	139	144	PF00397	0.477
DOC_WW_Pin1_4	160	165	PF00397	0.549
DOC_WW_Pin1_4	244	249	PF00397	0.571
DOC_WW_Pin1_4	279	284	PF00397	0.602
DOC_WW_Pin1_4	445	450	PF00397	0.449
DOC_WW_Pin1_4	474	479	PF00397	0.769
DOC_WW_Pin1_4	514	519	PF00397	0.498
DOC_WW_Pin1_4	533	538	PF00397	0.651
DOC_WW_Pin1_4	573	578	PF00397	0.573
DOC_WW_Pin1_4	60	65	PF00397	0.501
DOC_WW_Pin1_4	698	703	PF00397	0.535
DOC_WW_Pin1_4	797	802	PF00397	0.527
DOC_WW_Pin1_4	99	104	PF00397	0.619
LIG_14-3-3_CanoR_1	112	121	PF00244	0.539
LIG_14-3-3_CanoR_1	37	46	PF00244	0.521
LIG_14-3-3_CanoR_1	375	382	PF00244	0.451
LIG_14-3-3_CanoR_1	414	418	PF00244	0.563
LIG_14-3-3_CanoR_1	455	459	PF00244	0.457
LIG_14-3-3_CanoR_1	68	72	PF00244	0.521
LIG_14-3-3_CanoR_1	738	747	PF00244	0.495
LIG_Actin_WH2_2	204	221	PF00022	0.332
LIG_Actin_WH2_2	506	524	PF00022	0.515
LIG_BRCT_BRCA1_1	340	344	PF00533	0.515
LIG_BRCT_BRCA1_1	395	399	PF00533	0.458
LIG_BRCT_BRCA1_1	535	539	PF00533	0.406
LIG_BRCT_BRCA1_1	769	773	PF00533	0.427
LIG_CSL_BTD_1	283	286	PF09270	0.500
LIG_CtBP_PxDLS_1	518	522	PF00389	0.331
LIG_EVH1_1	87	91	PF00568	0.480
LIG_FHA_1	139	145	PF00498	0.463
LIG_FHA_1	165	171	PF00498	0.534
LIG_FHA_1	186	192	PF00498	0.502
LIG_FHA_1	213	219	PF00498	0.428
LIG_FHA_1	228	234	PF00498	0.506
LIG_FHA_1	287	293	PF00498	0.699
LIG_FHA_1	376	382	PF00498	0.558
LIG_FHA_1	414	420	PF00498	0.475
LIG_FHA_1	475	481	PF00498	0.672
LIG_FHA_1	551	557	PF00498	0.370
LIG_FHA_1	614	620	PF00498	0.515
LIG_FHA_1	712	718	PF00498	0.485
LIG_FHA_1	801	807	PF00498	0.469
LIG_FHA_2	361	367	PF00498	0.601
LIG_FHA_2	395	401	PF00498	0.456
LIG_FHA_2	539	545	PF00498	0.361
LIG_FHA_2	713	719	PF00498	0.472
LIG_FHA_2	820	826	PF00498	0.465
LIG_LIR_Apic_2	206	212	PF02991	0.424
LIG_LIR_Apic_2	255	260	PF02991	0.526
LIG_LIR_Apic_2	85	90	PF02991	0.490
LIG_LIR_Gen_1	536	547	PF02991	0.321
LIG_LIR_Gen_1	583	591	PF02991	0.363
LIG_LIR_Gen_1	649	660	PF02991	0.361
LIG_LIR_Gen_1	7	18	PF02991	0.476
LIG_LIR_Gen_1	770	781	PF02991	0.346
LIG_LIR_Nem_3	152	157	PF02991	0.517
LIG_LIR_Nem_3	173	178	PF02991	0.462
LIG_LIR_Nem_3	282	287	PF02991	0.652
LIG_LIR_Nem_3	429	433	PF02991	0.536
LIG_LIR_Nem_3	536	542	PF02991	0.351
LIG_LIR_Nem_3	583	588	PF02991	0.476
LIG_LIR_Nem_3	649	655	PF02991	0.325
LIG_LIR_Nem_3	7	13	PF02991	0.479
LIG_LIR_Nem_3	730	734	PF02991	0.591
LIG_LIR_Nem_3	770	776	PF02991	0.373
LIG_LYPXL_yS_3	731	734	PF13949	0.495
LIG_MYND_1	478	482	PF01753	0.568
LIG_MYND_1	668	672	PF01753	0.470
LIG_NRBOX	457	463	PF00104	0.481
LIG_NRBOX	555	561	PF00104	0.433
LIG_NRBOX	599	605	PF00104	0.408
LIG_PCNA_PIPBox_1	601	610	PF02747	0.504
LIG_PCNA_yPIPBox_3	592	604	PF02747	0.449
LIG_PDZ_Class_1	837	842	PF00595	0.597
LIG_Pex14_1	10	14	PF04695	0.481
LIG_Pex14_2	46	50	PF04695	0.502
LIG_Pex14_2	830	834	PF04695	0.326
LIG_SH2_CRK	161	165	PF00017	0.544
LIG_SH2_CRK	209	213	PF00017	0.439
LIG_SH2_CRK	96	100	PF00017	0.513
LIG_SH2_NCK_1	161	165	PF00017	0.544
LIG_SH2_NCK_1	209	213	PF00017	0.495
LIG_SH2_SRC	159	162	PF00017	0.547
LIG_SH2_SRC	333	336	PF00017	0.535
LIG_SH2_STAP1	154	158	PF00017	0.445
LIG_SH2_STAP1	503	507	PF00017	0.400
LIG_SH2_STAT3	157	160	PF00017	0.549
LIG_SH2_STAT3	756	759	PF00017	0.681
LIG_SH2_STAT5	157	160	PF00017	0.556
LIG_SH2_STAT5	270	273	PF00017	0.391
LIG_SH2_STAT5	355	358	PF00017	0.497
LIG_SH2_STAT5	376	379	PF00017	0.552
LIG_SH2_STAT5	614	617	PF00017	0.552
LIG_SH2_STAT5	836	839	PF00017	0.483
LIG_SH3_1	61	67	PF00018	0.503
LIG_SH3_1	699	705	PF00018	0.535
LIG_SH3_2	15	20	PF14604	0.477
LIG_SH3_2	26	31	PF14604	0.482
LIG_SH3_3	12	18	PF00018	0.474
LIG_SH3_3	171	177	PF00018	0.476
LIG_SH3_3	23	29	PF00018	0.469
LIG_SH3_3	280	286	PF00018	0.477
LIG_SH3_3	59	65	PF00018	0.499
LIG_SH3_3	699	705	PF00018	0.535
LIG_SH3_3	85	91	PF00018	0.488
LIG_SUMO_SIM_anti_2	803	810	PF11976	0.490
LIG_SUMO_SIM_par_1	145	150	PF11976	0.303
LIG_SUMO_SIM_par_1	313	319	PF11976	0.351
LIG_TRAF2_1	564	567	PF00917	0.562
LIG_TRAF2_1	595	598	PF00917	0.507
LIG_TRAF2_1	716	719	PF00917	0.495
LIG_TRFH_1	14	18	PF08558	0.472
LIG_UBA3_1	461	466	PF00899	0.663
MOD_CDK_SPK_2	63	68	PF00069	0.507
MOD_CK1_1	162	168	PF00069	0.521
MOD_CK1_1	182	188	PF00069	0.410
MOD_CK1_1	290	296	PF00069	0.708
MOD_CK1_1	302	308	PF00069	0.738
MOD_CK1_1	454	460	PF00069	0.529
MOD_CK1_1	517	523	PF00069	0.329
MOD_CK1_1	676	682	PF00069	0.407
MOD_CK1_1	701	707	PF00069	0.370
MOD_CK1_1	711	717	PF00069	0.262
MOD_CK1_1	755	761	PF00069	0.539
MOD_CK1_1	8	14	PF00069	0.480
MOD_CK1_1	800	806	PF00069	0.394
MOD_CK1_1	83	89	PF00069	0.496
MOD_CK2_1	114	120	PF00069	0.638
MOD_CK2_1	162	168	PF00069	0.519
MOD_CK2_1	297	303	PF00069	0.817
MOD_CK2_1	360	366	PF00069	0.586
MOD_CK2_1	712	718	PF00069	0.318
MOD_Cter_Amidation	132	135	PF01082	0.536
MOD_GlcNHglycan	181	184	PF01048	0.727
MOD_GlcNHglycan	191	194	PF01048	0.578
MOD_GlcNHglycan	238	241	PF01048	0.566
MOD_GlcNHglycan	422	425	PF01048	0.492
MOD_GlcNHglycan	436	439	PF01048	0.367
MOD_GlcNHglycan	473	477	PF01048	0.610
MOD_GlcNHglycan	641	644	PF01048	0.663
MOD_GlcNHglycan	675	678	PF01048	0.333
MOD_GlcNHglycan	682	685	PF01048	0.308
MOD_GlcNHglycan	7	10	PF01048	0.481
MOD_GlcNHglycan	749	753	PF01048	0.504
MOD_GSK3_1	159	166	PF00069	0.500
MOD_GSK3_1	185	192	PF00069	0.583
MOD_GSK3_1	258	265	PF00069	0.552
MOD_GSK3_1	286	293	PF00069	0.644
MOD_GSK3_1	297	304	PF00069	0.753
MOD_GSK3_1	4	11	PF00069	0.478
MOD_GSK3_1	434	441	PF00069	0.595
MOD_GSK3_1	468	475	PF00069	0.676
MOD_GSK3_1	551	558	PF00069	0.399
MOD_GSK3_1	56	63	PF00069	0.496
MOD_GSK3_1	644	651	PF00069	0.572
MOD_GSK3_1	67	74	PF00069	0.485
MOD_GSK3_1	676	683	PF00069	0.384
MOD_GSK3_1	708	715	PF00069	0.351
MOD_GSK3_1	748	755	PF00069	0.493
MOD_GSK3_1	796	803	PF00069	0.482
MOD_GSK3_1	95	102	PF00069	0.512
MOD_LATS_1	110	116	PF00433	0.543
MOD_N-GLC_1	501	506	PF02516	0.376
MOD_NEK2_1	170	175	PF00069	0.526
MOD_NEK2_1	434	439	PF00069	0.593
MOD_NEK2_1	555	560	PF00069	0.398
MOD_NEK2_1	571	576	PF00069	0.498
MOD_NEK2_1	690	695	PF00069	0.347
MOD_NEK2_1	708	713	PF00069	0.217
MOD_NEK2_1	71	76	PF00069	0.507
MOD_NEK2_1	727	732	PF00069	0.480
MOD_NEK2_1	95	100	PF00069	0.514
MOD_NEK2_2	768	773	PF00069	0.438
MOD_OFUCOSY	765	772	PF10250	0.462
MOD_PIKK_1	755	761	PF00454	0.473
MOD_PK_1	199	205	PF00069	0.657
MOD_PK_1	262	268	PF00069	0.350
MOD_PKA_1	632	638	PF00069	0.538
MOD_PKA_2	327	333	PF00069	0.351
MOD_PKA_2	413	419	PF00069	0.519
MOD_PKA_2	454	460	PF00069	0.498
MOD_PKA_2	67	73	PF00069	0.519
MOD_Plk_1	199	205	PF00069	0.657
MOD_Plk_1	501	507	PF00069	0.373
MOD_Plk_1	566	572	PF00069	0.597
MOD_Plk_1	748	754	PF00069	0.479
MOD_Plk_2-3	820	826	PF00069	0.551
MOD_Plk_4	413	419	PF00069	0.463
MOD_Plk_4	502	508	PF00069	0.367
MOD_Plk_4	538	544	PF00069	0.495
MOD_Plk_4	551	557	PF00069	0.290
MOD_Plk_4	599	605	PF00069	0.505
MOD_Plk_4	625	631	PF00069	0.306
MOD_ProDKin_1	115	121	PF00069	0.503
MOD_ProDKin_1	139	145	PF00069	0.463
MOD_ProDKin_1	160	166	PF00069	0.542
MOD_ProDKin_1	244	250	PF00069	0.563
MOD_ProDKin_1	279	285	PF00069	0.600
MOD_ProDKin_1	445	451	PF00069	0.450
MOD_ProDKin_1	474	480	PF00069	0.769
MOD_ProDKin_1	514	520	PF00069	0.495
MOD_ProDKin_1	533	539	PF00069	0.638
MOD_ProDKin_1	573	579	PF00069	0.568
MOD_ProDKin_1	60	66	PF00069	0.502
MOD_ProDKin_1	698	704	PF00069	0.407
MOD_ProDKin_1	797	803	PF00069	0.521
MOD_ProDKin_1	99	105	PF00069	0.619
MOD_SUMO_rev_2	40	46	PF00179	0.514
MOD_SUMO_rev_2	423	433	PF00179	0.511
TRG_DiLeu_BaEn_2	494	500	PF01217	0.377
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.488
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.496
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.526
TRG_ENDOCYTIC_2	503	506	PF00928	0.404
TRG_ENDOCYTIC_2	731	734	PF00928	0.362
TRG_ENDOCYTIC_2	96	99	PF00928	0.517
TRG_ER_diArg_1	29	31	PF00400	0.519
TRG_ER_diArg_1	311	313	PF00400	0.448
TRG_ER_diArg_1	521	523	PF00400	0.544
TRG_ER_diArg_1	592	595	PF00400	0.475
TRG_NLS_MonoExtC_3	630	636	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA86	Leptomonas seymouri	48%	100%
A0A0S4JUU1	Bodo saltans	30%	100%
A0A1X0NZU0	Trypanosomatidae	36%	100%
A0A3Q8IGM4	Leishmania donovani	78%	100%
A4I1J6	Leishmania infantum	79%	100%
Q4Q9U1	Leishmania major	78%	99%