Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEK1_LEIBR

TriTrypDb:

LbrM.25.2580 , LBRM2903_250011700

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.675
CLV_C14_Caspase3-7	415	419	PF00656	0.627
CLV_C14_Caspase3-7	502	506	PF00656	0.520
CLV_NRD_NRD_1	229	231	PF00675	0.419
CLV_NRD_NRD_1	424	426	PF00675	0.633
CLV_NRD_NRD_1	427	429	PF00675	0.626
CLV_NRD_NRD_1	46	48	PF00675	0.500
CLV_PCSK_KEX2_1	228	230	PF00082	0.418
CLV_PCSK_KEX2_1	46	48	PF00082	0.500
CLV_PCSK_PC7_1	225	231	PF00082	0.543
CLV_PCSK_SKI1_1	100	104	PF00082	0.404
CLV_PCSK_SKI1_1	47	51	PF00082	0.501
CLV_Separin_Fungi	81	87	PF03568	0.337
DEG_APCC_DBOX_1	123	131	PF00400	0.663
DEG_COP1_1	132	141	PF00400	0.403
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DEG_SCF_FBW7_1	342	349	PF00400	0.678
DEG_SCF_FBW7_1	357	363	PF00400	0.567
DEG_SCF_FBW7_2	384	389	PF00400	0.557
DEG_SPOP_SBC_1	316	320	PF00917	0.708
DEG_SPOP_SBC_1	399	403	PF00917	0.781
DEG_SPOP_SBC_1	496	500	PF00917	0.619
DOC_CDC14_PxL_1	71	79	PF14671	0.383
DOC_CKS1_1	357	362	PF01111	0.723
DOC_MAPK_gen_1	425	435	PF00069	0.615
DOC_MAPK_MEF2A_6	9	18	PF00069	0.468
DOC_PP1_SILK_1	440	445	PF00149	0.499
DOC_PP2B_LxvP_1	72	75	PF13499	0.420
DOC_PP2B_PxIxI_1	387	393	PF00149	0.635
DOC_PP4_MxPP_1	344	347	PF00568	0.702
DOC_USP7_MATH_1	123	127	PF00917	0.512
DOC_USP7_MATH_1	206	210	PF00917	0.555
DOC_USP7_MATH_1	360	364	PF00917	0.688
DOC_USP7_MATH_1	398	402	PF00917	0.678
DOC_USP7_MATH_1	4	8	PF00917	0.408
DOC_USP7_MATH_1	462	466	PF00917	0.709
DOC_USP7_MATH_1	78	82	PF00917	0.374
DOC_WW_Pin1_4	280	285	PF00397	0.678
DOC_WW_Pin1_4	299	304	PF00397	0.562
DOC_WW_Pin1_4	342	347	PF00397	0.657
DOC_WW_Pin1_4	356	361	PF00397	0.681
DOC_WW_Pin1_4	382	387	PF00397	0.782
LIG_14-3-3_CanoR_1	106	113	PF00244	0.484
LIG_14-3-3_CanoR_1	325	331	PF00244	0.629
LIG_14-3-3_CanoR_1	362	366	PF00244	0.596
LIG_14-3-3_CanoR_1	428	434	PF00244	0.532
LIG_14-3-3_CanoR_1	46	55	PF00244	0.494
LIG_BH_BH3_1	80	96	PF00452	0.459
LIG_BIR_III_2	518	522	PF00653	0.593
LIG_CtBP_PxDLS_1	394	398	PF00389	0.519
LIG_EH1_1	81	89	PF00400	0.415
LIG_FHA_1	244	250	PF00498	0.527
LIG_FHA_1	430	436	PF00498	0.645
LIG_FHA_1	438	444	PF00498	0.538
LIG_FHA_1	472	478	PF00498	0.717
LIG_FHA_2	142	148	PF00498	0.482
LIG_FHA_2	197	203	PF00498	0.522
LIG_FHA_2	404	410	PF00498	0.740
LIG_FHA_2	447	453	PF00498	0.672
LIG_FHA_2	486	492	PF00498	0.567
LIG_FHA_2	92	98	PF00498	0.478
LIG_LIR_Nem_3	505	510	PF02991	0.521
LIG_MAD2	47	55	PF02301	0.519
LIG_SH2_STAT3	182	185	PF00017	0.448
LIG_SH2_STAT5	179	182	PF00017	0.451
LIG_SH2_STAT5	194	197	PF00017	0.552
LIG_SH2_STAT5	524	527	PF00017	0.476
LIG_SH2_STAT5	65	68	PF00017	0.353
LIG_SH2_STAT5	70	73	PF00017	0.395
LIG_SH3_3	297	303	PF00018	0.608
LIG_SH3_3	378	384	PF00018	0.705
LIG_SH3_3	388	394	PF00018	0.579
LIG_SH3_3	72	78	PF00018	0.333
LIG_SUMO_SIM_anti_2	262	270	PF11976	0.531
LIG_SUMO_SIM_par_1	262	270	PF11976	0.682
LIG_SUMO_SIM_par_1	431	441	PF11976	0.584
LIG_UBA3_1	442	450	PF00899	0.517
MOD_CDK_SPxK_1	356	362	PF00069	0.560
MOD_CK1_1	243	249	PF00069	0.597
MOD_CK1_1	278	284	PF00069	0.670
MOD_CK1_1	379	385	PF00069	0.560
MOD_CK1_1	403	409	PF00069	0.713
MOD_CK1_1	438	444	PF00069	0.612
MOD_CK1_1	469	475	PF00069	0.677
MOD_CK1_1	495	501	PF00069	0.624
MOD_CK1_1	7	13	PF00069	0.444
MOD_CK2_1	123	129	PF00069	0.586
MOD_CK2_1	141	147	PF00069	0.439
MOD_CK2_1	168	174	PF00069	0.395
MOD_CK2_1	217	223	PF00069	0.505
MOD_CK2_1	330	336	PF00069	0.589
MOD_CK2_1	403	409	PF00069	0.644
MOD_CK2_1	7	13	PF00069	0.494
MOD_CK2_1	91	97	PF00069	0.469
MOD_GlcNHglycan	144	147	PF01048	0.381
MOD_GlcNHglycan	219	222	PF01048	0.565
MOD_GlcNHglycan	277	280	PF01048	0.701
MOD_GlcNHglycan	363	366	PF01048	0.721
MOD_GlcNHglycan	406	409	PF01048	0.569
MOD_GlcNHglycan	460	463	PF01048	0.686
MOD_GlcNHglycan	464	467	PF01048	0.727
MOD_GlcNHglycan	494	497	PF01048	0.613
MOD_GlcNHglycan	501	504	PF01048	0.516
MOD_GSK3_1	196	203	PF00069	0.658
MOD_GSK3_1	206	213	PF00069	0.456
MOD_GSK3_1	239	246	PF00069	0.502
MOD_GSK3_1	274	281	PF00069	0.637
MOD_GSK3_1	3	10	PF00069	0.547
MOD_GSK3_1	326	333	PF00069	0.566
MOD_GSK3_1	342	349	PF00069	0.660
MOD_GSK3_1	356	363	PF00069	0.605
MOD_GSK3_1	375	382	PF00069	0.664
MOD_GSK3_1	399	406	PF00069	0.806
MOD_GSK3_1	434	441	PF00069	0.550
MOD_GSK3_1	458	465	PF00069	0.648
MOD_GSK3_1	466	473	PF00069	0.621
MOD_GSK3_1	485	492	PF00069	0.725
MOD_GSK3_1	495	502	PF00069	0.616
MOD_N-GLC_1	330	335	PF02516	0.668
MOD_N-GLC_1	496	501	PF02516	0.574
MOD_NEK2_1	141	146	PF00069	0.402
MOD_NEK2_1	168	173	PF00069	0.438
MOD_NEK2_1	217	222	PF00069	0.441
MOD_NEK2_1	470	475	PF00069	0.560
MOD_NEK2_1	91	96	PF00069	0.404
MOD_NEK2_2	210	215	PF00069	0.355
MOD_NEK2_2	4	9	PF00069	0.413
MOD_PIKK_1	200	206	PF00454	0.459
MOD_PIKK_1	76	82	PF00454	0.347
MOD_PKA_2	105	111	PF00069	0.543
MOD_PKA_2	123	129	PF00069	0.467
MOD_PKA_2	361	367	PF00069	0.595
MOD_PKA_2	485	491	PF00069	0.567
MOD_Plk_1	133	139	PF00069	0.404
MOD_Plk_1	243	249	PF00069	0.482
MOD_Plk_1	330	336	PF00069	0.770
MOD_Plk_1	438	444	PF00069	0.576
MOD_Plk_1	496	502	PF00069	0.567
MOD_Plk_2-3	134	140	PF00069	0.391
MOD_Plk_4	243	249	PF00069	0.482
MOD_Plk_4	400	406	PF00069	0.670
MOD_Plk_4	429	435	PF00069	0.686
MOD_Plk_4	438	444	PF00069	0.582
MOD_Plk_4	7	13	PF00069	0.443
MOD_Plk_4	91	97	PF00069	0.449
MOD_ProDKin_1	280	286	PF00069	0.674
MOD_ProDKin_1	299	305	PF00069	0.563
MOD_ProDKin_1	342	348	PF00069	0.660
MOD_ProDKin_1	356	362	PF00069	0.684
MOD_ProDKin_1	382	388	PF00069	0.782
MOD_SUMO_for_1	102	105	PF00179	0.505
MOD_SUMO_for_1	260	263	PF00179	0.520
TRG_DiLeu_BaEn_1	235	240	PF01217	0.556
TRG_DiLeu_BaEn_1	455	460	PF01217	0.642
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.373
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.391
TRG_ER_diArg_1	228	230	PF00400	0.387
TRG_ER_diArg_1	45	47	PF00400	0.493
TRG_NES_CRM1_1	13	27	PF08389	0.374
TRG_NLS_MonoExtC_3	424	429	PF00514	0.705
TRG_NLS_MonoExtN_4	422	429	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY1	Leptomonas seymouri	39%	100%
A0A3Q8ICE6	Leishmania donovani	76%	99%
A4I1J7	Leishmania infantum	76%	99%
E9AXN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q9U0	Leishmania major	75%	100%