Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEK0_LEIBR

TriTrypDb:

LbrM.25.2570 , LBRM2903_250011800

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEK0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.546
CLV_C14_Caspase3-7	364	368	PF00656	0.655
CLV_C14_Caspase3-7	92	96	PF00656	0.579
CLV_NRD_NRD_1	106	108	PF00675	0.618
CLV_NRD_NRD_1	227	229	PF00675	0.607
CLV_NRD_NRD_1	504	506	PF00675	0.411
CLV_NRD_NRD_1	676	678	PF00675	0.290
CLV_NRD_NRD_1	712	714	PF00675	0.261
CLV_NRD_NRD_1	862	864	PF00675	0.614
CLV_NRD_NRD_1	910	912	PF00675	0.821
CLV_PCSK_FUR_1	103	107	PF00082	0.588
CLV_PCSK_KEX2_1	105	107	PF00082	0.631
CLV_PCSK_KEX2_1	504	506	PF00082	0.411
CLV_PCSK_KEX2_1	6	8	PF00082	0.750
CLV_PCSK_KEX2_1	676	678	PF00082	0.290
CLV_PCSK_KEX2_1	712	714	PF00082	0.411
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.750
CLV_PCSK_SKI1_1	228	232	PF00082	0.604
CLV_PCSK_SKI1_1	407	411	PF00082	0.703
CLV_PCSK_SKI1_1	530	534	PF00082	0.411
CLV_PCSK_SKI1_1	577	581	PF00082	0.411
CLV_PCSK_SKI1_1	582	586	PF00082	0.411
CLV_PCSK_SKI1_1	749	753	PF00082	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.836
DOC_CYCLIN_RxL_1	527	537	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	230	233	PF00134	0.752
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.536
DOC_MAPK_gen_1	582	591	PF00069	0.411
DOC_MAPK_gen_1	6	14	PF00069	0.591
DOC_MAPK_gen_1	676	684	PF00069	0.290
DOC_MAPK_gen_1	762	770	PF00069	0.573
DOC_MAPK_gen_1	911	917	PF00069	0.839
DOC_MAPK_JIP1_4	585	591	PF00069	0.411
DOC_MAPK_MEF2A_6	762	770	PF00069	0.573
DOC_MAPK_RevD_3	662	677	PF00069	0.290
DOC_MAPK_RevD_3	896	912	PF00069	0.579
DOC_PP2B_LxvP_1	12	15	PF13499	0.593
DOC_PP2B_LxvP_1	230	233	PF13499	0.779
DOC_PP2B_LxvP_1	296	299	PF13499	0.728
DOC_PP2B_LxvP_1	311	314	PF13499	0.668
DOC_PP2B_LxvP_1	778	781	PF13499	0.625
DOC_PP2B_LxvP_1	865	868	PF13499	0.852
DOC_PP4_FxxP_1	525	528	PF00568	0.411
DOC_USP7_MATH_1	115	119	PF00917	0.683
DOC_USP7_MATH_1	246	250	PF00917	0.717
DOC_USP7_MATH_1	26	30	PF00917	0.580
DOC_USP7_MATH_1	302	306	PF00917	0.767
DOC_USP7_MATH_1	687	691	PF00917	0.513
DOC_USP7_MATH_1	71	75	PF00917	0.667
DOC_USP7_MATH_1	714	718	PF00917	0.323
DOC_USP7_MATH_1	781	785	PF00917	0.736
DOC_USP7_MATH_1	826	830	PF00917	0.617
DOC_USP7_MATH_2	759	765	PF00917	0.573
DOC_WW_Pin1_4	137	142	PF00397	0.588
DOC_WW_Pin1_4	169	174	PF00397	0.797
DOC_WW_Pin1_4	339	344	PF00397	0.743
DOC_WW_Pin1_4	383	388	PF00397	0.552
DOC_WW_Pin1_4	427	432	PF00397	0.627
DOC_WW_Pin1_4	434	439	PF00397	0.521
DOC_WW_Pin1_4	636	641	PF00397	0.383
DOC_WW_Pin1_4	719	724	PF00397	0.411
DOC_WW_Pin1_4	788	793	PF00397	0.719
DOC_WW_Pin1_4	805	810	PF00397	0.562
DOC_WW_Pin1_4	856	861	PF00397	0.749
DOC_WW_Pin1_4	888	893	PF00397	0.813
LIG_14-3-3_CanoR_1	105	113	PF00244	0.584
LIG_14-3-3_CanoR_1	223	232	PF00244	0.789
LIG_14-3-3_CanoR_1	350	356	PF00244	0.626
LIG_14-3-3_CanoR_1	713	723	PF00244	0.323
LIG_14-3-3_CanoR_1	749	754	PF00244	0.744
LIG_14-3-3_CanoR_1	765	771	PF00244	0.571
LIG_14-3-3_CanoR_1	869	875	PF00244	0.835
LIG_14-3-3_CanoR_1	890	896	PF00244	0.789
LIG_14-3-3_CanoR_1	903	910	PF00244	0.644
LIG_Actin_WH2_2	464	481	PF00022	0.411
LIG_APCC_ABBAyCdc20_2	577	583	PF00400	0.411
LIG_BRCT_BRCA1_1	304	308	PF00533	0.800
LIG_Clathr_ClatBox_1	328	332	PF01394	0.553
LIG_CtBP_PxDLS_1	179	183	PF00389	0.798
LIG_eIF4E_1	628	634	PF01652	0.411
LIG_EVH1_2	312	316	PF00568	0.790
LIG_FHA_1	115	121	PF00498	0.566
LIG_FHA_1	19	25	PF00498	0.818
LIG_FHA_1	262	268	PF00498	0.738
LIG_FHA_1	52	58	PF00498	0.702
LIG_FHA_1	555	561	PF00498	0.411
LIG_FHA_1	569	575	PF00498	0.411
LIG_FHA_1	606	612	PF00498	0.357
LIG_FHA_1	621	627	PF00498	0.411
LIG_FHA_1	841	847	PF00498	0.637
LIG_FHA_1	871	877	PF00498	0.620
LIG_FHA_1	917	923	PF00498	0.692
LIG_FHA_2	129	135	PF00498	0.545
LIG_FHA_2	406	412	PF00498	0.818
LIG_FHA_2	544	550	PF00498	0.511
LIG_FHA_2	670	676	PF00498	0.323
LIG_HP1_1	921	925	PF01393	0.571
LIG_Integrin_RGD_1	143	145	PF01839	0.588
LIG_KLC1_Yacidic_2	545	549	PF13176	0.455
LIG_LIR_Apic_2	383	387	PF02991	0.778
LIG_LIR_Apic_2	524	528	PF02991	0.411
LIG_LIR_Apic_2	625	631	PF02991	0.411
LIG_LIR_Gen_1	172	182	PF02991	0.549
LIG_LIR_Gen_1	194	202	PF02991	0.570
LIG_LIR_Nem_3	172	177	PF02991	0.797
LIG_LIR_Nem_3	194	198	PF02991	0.545
LIG_LIR_Nem_3	209	213	PF02991	0.679
LIG_LIR_Nem_3	305	311	PF02991	0.718
LIG_LIR_Nem_3	426	432	PF02991	0.609
LIG_LIR_Nem_3	457	461	PF02991	0.404
LIG_MLH1_MIPbox_1	304	308	PF16413	0.800
LIG_NRBOX	697	703	PF00104	0.261
LIG_PAM2_1	553	565	PF00658	0.411
LIG_SH2_CRK	168	172	PF00017	0.776
LIG_SH2_CRK	174	178	PF00017	0.739
LIG_SH2_CRK	382	386	PF00017	0.529
LIG_SH2_CRK	429	433	PF00017	0.529
LIG_SH2_CRK	458	462	PF00017	0.411
LIG_SH2_GRB2like	647	650	PF00017	0.411
LIG_SH2_NCK_1	429	433	PF00017	0.529
LIG_SH2_NCK_1	538	542	PF00017	0.513
LIG_SH2_PTP2	384	387	PF00017	0.779
LIG_SH2_SRC	647	650	PF00017	0.513
LIG_SH2_STAP1	10	14	PF00017	0.599
LIG_SH2_STAP1	174	178	PF00017	0.556
LIG_SH2_STAP1	253	257	PF00017	0.671
LIG_SH2_STAT5	253	256	PF00017	0.829
LIG_SH2_STAT5	292	295	PF00017	0.795
LIG_SH2_STAT5	307	310	PF00017	0.574
LIG_SH2_STAT5	384	387	PF00017	0.779
LIG_SH2_STAT5	446	449	PF00017	0.353
LIG_SH2_STAT5	462	465	PF00017	0.353
LIG_SH2_STAT5	489	492	PF00017	0.411
LIG_SH2_STAT5	547	550	PF00017	0.411
LIG_SH2_STAT5	562	565	PF00017	0.411
LIG_SH2_STAT5	647	650	PF00017	0.411
LIG_SH2_STAT5	666	669	PF00017	0.411
LIG_SH3_1	864	870	PF00018	0.853
LIG_SH3_3	17	23	PF00018	0.721
LIG_SH3_3	374	380	PF00018	0.530
LIG_SH3_3	425	431	PF00018	0.638
LIG_SH3_3	760	766	PF00018	0.745
LIG_SH3_3	767	773	PF00018	0.761
LIG_SH3_3	864	870	PF00018	0.833
LIG_SUMO_SIM_anti_2	829	836	PF11976	0.822
LIG_SUMO_SIM_anti_2	919	927	PF11976	0.571
LIG_SUMO_SIM_par_1	178	183	PF11976	0.697
LIG_SUMO_SIM_par_1	326	333	PF11976	0.703
LIG_SUMO_SIM_par_1	919	927	PF11976	0.824
LIG_TRAF2_1	234	237	PF00917	0.728
LIG_TRAF2_1	344	347	PF00917	0.585
LIG_TRAF2_1	361	364	PF00917	0.507
LIG_TRAF2_1	743	746	PF00917	0.467
LIG_TRAF2_2	234	239	PF00917	0.701
LIG_TYR_ITIM	427	432	PF00017	0.532
LIG_TYR_ITIM	560	565	PF00017	0.411
LIG_UBA3_1	728	734	PF00899	0.654
LIG_WW_3	597	601	PF00397	0.411
LIG_WW_3	771	775	PF00397	0.669
LIG_WW_3	866	870	PF00397	0.849
LIG_WW_3	908	912	PF00397	0.572
MOD_CDC14_SPxK_1	140	143	PF00782	0.574
MOD_CDC14_SPxK_1	808	811	PF00782	0.588
MOD_CDK_SPK_2	856	861	PF00069	0.838
MOD_CDK_SPK_2	888	893	PF00069	0.592
MOD_CDK_SPxK_1	137	143	PF00069	0.572
MOD_CDK_SPxK_1	805	811	PF00069	0.588
MOD_CDK_SPxxK_3	169	176	PF00069	0.800
MOD_CDK_SPxxK_3	856	863	PF00069	0.606
MOD_CK1_1	161	167	PF00069	0.714
MOD_CK1_1	169	175	PF00069	0.763
MOD_CK1_1	247	253	PF00069	0.625
MOD_CK1_1	273	279	PF00069	0.717
MOD_CK1_1	283	289	PF00069	0.759
MOD_CK1_1	315	321	PF00069	0.548
MOD_CK1_1	368	374	PF00069	0.708
MOD_CK1_1	383	389	PF00069	0.703
MOD_CK1_1	421	427	PF00069	0.672
MOD_CK1_1	47	53	PF00069	0.641
MOD_CK1_1	540	546	PF00069	0.411
MOD_CK1_1	61	67	PF00069	0.516
MOD_CK1_1	620	626	PF00069	0.411
MOD_CK1_1	791	797	PF00069	0.745
MOD_CK1_1	805	811	PF00069	0.720
MOD_CK1_1	852	858	PF00069	0.661
MOD_CK1_1	891	897	PF00069	0.754
MOD_CK1_1	904	910	PF00069	0.696
MOD_CK2_1	341	347	PF00069	0.583
MOD_CK2_1	358	364	PF00069	0.507
MOD_CK2_1	405	411	PF00069	0.795
MOD_CK2_1	512	518	PF00069	0.411
MOD_CK2_1	543	549	PF00069	0.511
MOD_CK2_1	669	675	PF00069	0.299
MOD_CK2_1	740	746	PF00069	0.468
MOD_CK2_1	827	833	PF00069	0.596
MOD_GlcNHglycan	117	120	PF01048	0.586
MOD_GlcNHglycan	160	163	PF01048	0.722
MOD_GlcNHglycan	168	171	PF01048	0.771
MOD_GlcNHglycan	24	27	PF01048	0.609
MOD_GlcNHglycan	246	249	PF01048	0.658
MOD_GlcNHglycan	275	278	PF01048	0.641
MOD_GlcNHglycan	288	291	PF01048	0.777
MOD_GlcNHglycan	3	6	PF01048	0.562
MOD_GlcNHglycan	343	346	PF01048	0.608
MOD_GlcNHglycan	36	39	PF01048	0.807
MOD_GlcNHglycan	360	363	PF01048	0.719
MOD_GlcNHglycan	367	371	PF01048	0.680
MOD_GlcNHglycan	539	542	PF01048	0.411
MOD_GlcNHglycan	59	63	PF01048	0.713
MOD_GlcNHglycan	618	622	PF01048	0.411
MOD_GlcNHglycan	689	692	PF01048	0.485
MOD_GlcNHglycan	69	72	PF01048	0.804
MOD_GlcNHglycan	754	757	PF01048	0.695
MOD_GlcNHglycan	774	777	PF01048	0.506
MOD_GlcNHglycan	793	796	PF01048	0.567
MOD_GlcNHglycan	835	838	PF01048	0.824
MOD_GlcNHglycan	852	855	PF01048	0.570
MOD_GlcNHglycan	856	859	PF01048	0.566
MOD_GlcNHglycan	931	934	PF01048	0.584
MOD_GSK3_1	115	122	PF00069	0.671
MOD_GSK3_1	18	25	PF00069	0.661
MOD_GSK3_1	213	220	PF00069	0.699
MOD_GSK3_1	247	254	PF00069	0.636
MOD_GSK3_1	26	33	PF00069	0.714
MOD_GSK3_1	279	286	PF00069	0.783
MOD_GSK3_1	34	41	PF00069	0.740
MOD_GSK3_1	388	395	PF00069	0.732
MOD_GSK3_1	423	430	PF00069	0.697
MOD_GSK3_1	47	54	PF00069	0.594
MOD_GSK3_1	485	492	PF00069	0.513
MOD_GSK3_1	564	571	PF00069	0.485
MOD_GSK3_1	58	65	PF00069	0.699
MOD_GSK3_1	601	608	PF00069	0.411
MOD_GSK3_1	613	620	PF00069	0.411
MOD_GSK3_1	652	659	PF00069	0.411
MOD_GSK3_1	67	74	PF00069	0.693
MOD_GSK3_1	849	856	PF00069	0.812
MOD_N-GLC_1	155	160	PF02516	0.580
MOD_N-GLC_1	261	266	PF02516	0.547
MOD_N-GLC_1	283	288	PF02516	0.775
MOD_N-GLC_1	323	328	PF02516	0.548
MOD_N-GLC_1	39	44	PF02516	0.574
MOD_N-GLC_1	62	67	PF02516	0.626
MOD_N-GLC_1	805	810	PF02516	0.764
MOD_N-GLC_1	899	904	PF02516	0.727
MOD_N-GLC_2	270	272	PF02516	0.545
MOD_NEK2_1	563	568	PF00069	0.411
MOD_NEK2_1	633	638	PF00069	0.513
MOD_NEK2_1	669	674	PF00069	0.323
MOD_NEK2_1	67	72	PF00069	0.728
MOD_NEK2_1	724	729	PF00069	0.615
MOD_NEK2_1	827	832	PF00069	0.730
MOD_NEK2_1	835	840	PF00069	0.730
MOD_NEK2_1	899	904	PF00069	0.741
MOD_NEK2_2	26	31	PF00069	0.583
MOD_PIKK_1	106	112	PF00454	0.658
MOD_PIKK_1	232	238	PF00454	0.737
MOD_PIKK_1	392	398	PF00454	0.714
MOD_PIKK_1	735	741	PF00454	0.632
MOD_PIKK_1	891	897	PF00454	0.643
MOD_PKA_1	106	112	PF00069	0.584
MOD_PKA_2	106	112	PF00069	0.584
MOD_PKA_2	222	228	PF00069	0.784
MOD_PKA_2	30	36	PF00069	0.810
MOD_PKA_2	334	340	PF00069	0.578
MOD_PKA_2	365	371	PF00069	0.647
MOD_PKA_2	454	460	PF00069	0.411
MOD_PKA_2	714	720	PF00069	0.323
MOD_PKA_2	761	767	PF00069	0.572
MOD_PKA_2	797	803	PF00069	0.624
MOD_PKA_2	902	908	PF00069	0.769
MOD_PKA_2	929	935	PF00069	0.583
MOD_Plk_1	323	329	PF00069	0.548
MOD_Plk_1	38	44	PF00069	0.574
MOD_Plk_1	613	619	PF00069	0.290
MOD_Plk_1	62	68	PF00069	0.560
MOD_Plk_1	735	741	PF00069	0.611
MOD_Plk_1	841	847	PF00069	0.579
MOD_Plk_2-3	782	788	PF00069	0.838
MOD_Plk_4	206	212	PF00069	0.747
MOD_Plk_4	312	318	PF00069	0.795
MOD_Plk_4	324	330	PF00069	0.602
MOD_Plk_4	334	340	PF00069	0.531
MOD_Plk_4	368	374	PF00069	0.803
MOD_Plk_4	380	386	PF00069	0.582
MOD_Plk_4	423	429	PF00069	0.563
MOD_Plk_4	485	491	PF00069	0.429
MOD_Plk_4	512	518	PF00069	0.411
MOD_Plk_4	543	549	PF00069	0.455
MOD_Plk_4	62	68	PF00069	0.628
MOD_Plk_4	72	78	PF00069	0.643
MOD_Plk_4	724	730	PF00069	0.521
MOD_Plk_4	870	876	PF00069	0.827
MOD_Plk_4	894	900	PF00069	0.609
MOD_ProDKin_1	137	143	PF00069	0.591
MOD_ProDKin_1	169	175	PF00069	0.798
MOD_ProDKin_1	339	345	PF00069	0.742
MOD_ProDKin_1	383	389	PF00069	0.549
MOD_ProDKin_1	427	433	PF00069	0.625
MOD_ProDKin_1	434	440	PF00069	0.510
MOD_ProDKin_1	636	642	PF00069	0.383
MOD_ProDKin_1	719	725	PF00069	0.411
MOD_ProDKin_1	788	794	PF00069	0.719
MOD_ProDKin_1	805	811	PF00069	0.566
MOD_ProDKin_1	856	862	PF00069	0.750
MOD_ProDKin_1	888	894	PF00069	0.813
TRG_DiLeu_BaEn_1	423	428	PF01217	0.531
TRG_DiLeu_BaEn_1	697	702	PF01217	0.411
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.690
TRG_ENDOCYTIC_2	10	13	PF00928	0.851
TRG_ENDOCYTIC_2	174	177	PF00928	0.709
TRG_ENDOCYTIC_2	195	198	PF00928	0.755
TRG_ENDOCYTIC_2	382	385	PF00928	0.784
TRG_ENDOCYTIC_2	429	432	PF00928	0.738
TRG_ENDOCYTIC_2	458	461	PF00928	0.384
TRG_ENDOCYTIC_2	562	565	PF00928	0.411
TRG_ENDOCYTIC_2	666	669	PF00928	0.513
TRG_ER_diArg_1	102	105	PF00400	0.580
TRG_ER_diArg_1	106	108	PF00400	0.573
TRG_ER_diArg_1	503	505	PF00400	0.411
TRG_ER_diArg_1	712	715	PF00400	0.261
TRG_NES_CRM1_1	697	709	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	582	587	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I119	Leptomonas seymouri	48%	99%
A0A3Q8IFC6	Leishmania donovani	74%	100%
A4I1J8	Leishmania infantum	74%	100%
E9AXN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q9T9	Leishmania major	74%	100%