Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEJ9_LEIBR

TriTrypDb:

LbrM.25.2560 , LBRM2903_250011900

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.550
CLV_C14_Caspase3-7	29	33	PF00656	0.543
CLV_C14_Caspase3-7	80	84	PF00656	0.628
CLV_NRD_NRD_1	307	309	PF00675	0.664
CLV_PCSK_FUR_1	305	309	PF00082	0.589
CLV_PCSK_KEX2_1	307	309	PF00082	0.628
CLV_PCSK_SKI1_1	188	192	PF00082	0.592
CLV_PCSK_SKI1_1	290	294	PF00082	0.395
CLV_PCSK_SKI1_1	336	340	PF00082	0.590
DEG_Kelch_Keap1_1	527	532	PF01344	0.571
DEG_ODPH_VHL_1	39	50	PF01847	0.343
DEG_SCF_FBW7_1	390	395	PF00400	0.481
DEG_SPOP_SBC_1	24	28	PF00917	0.516
DOC_ANK_TNKS_1	379	386	PF00023	0.485
DOC_CKS1_1	448	453	PF01111	0.476
DOC_CYCLIN_RxL_1	287	294	PF00134	0.395
DOC_CYCLIN_RxL_1	330	344	PF00134	0.589
DOC_MAPK_gen_1	186	195	PF00069	0.485
DOC_MAPK_gen_1	416	422	PF00069	0.591
DOC_MAPK_MEF2A_6	173	182	PF00069	0.447
DOC_MAPK_MEF2A_6	396	404	PF00069	0.562
DOC_PP1_RVXF_1	334	341	PF00149	0.603
DOC_PP1_RVXF_1	560	567	PF00149	0.580
DOC_PP2B_LxvP_1	162	165	PF13499	0.437
DOC_PP4_FxxP_1	135	138	PF00568	0.626
DOC_USP7_MATH_1	23	27	PF00917	0.762
DOC_USP7_MATH_1	266	270	PF00917	0.554
DOC_USP7_MATH_1	280	284	PF00917	0.423
DOC_USP7_MATH_1	366	370	PF00917	0.633
DOC_USP7_MATH_1	444	448	PF00917	0.596
DOC_USP7_MATH_1	526	530	PF00917	0.800
DOC_USP7_MATH_1	82	86	PF00917	0.594
DOC_USP7_MATH_1	88	92	PF00917	0.600
DOC_USP7_MATH_1	95	99	PF00917	0.554
DOC_USP7_UBL2_3	520	524	PF12436	0.540
DOC_WW_Pin1_4	338	343	PF00397	0.451
DOC_WW_Pin1_4	388	393	PF00397	0.712
DOC_WW_Pin1_4	395	400	PF00397	0.624
DOC_WW_Pin1_4	437	442	PF00397	0.681
DOC_WW_Pin1_4	447	452	PF00397	0.737
LIG_14-3-3_CanoR_1	188	196	PF00244	0.591
LIG_14-3-3_CanoR_1	209	215	PF00244	0.644
LIG_14-3-3_CanoR_1	290	300	PF00244	0.470
LIG_14-3-3_CanoR_1	317	326	PF00244	0.709
LIG_14-3-3_CanoR_1	427	432	PF00244	0.626
LIG_14-3-3_CanoR_1	569	577	PF00244	0.682
LIG_APCC_ABBA_1	178	183	PF00400	0.330
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BIR_III_2	19	23	PF00653	0.473
LIG_BRCT_BRCA1_1	562	566	PF00533	0.437
LIG_EH_1	6	10	PF12763	0.453
LIG_eIF4E_1	333	339	PF01652	0.595
LIG_FHA_1	389	395	PF00498	0.617
LIG_FHA_1	408	414	PF00498	0.506
LIG_FHA_1	456	462	PF00498	0.552
LIG_FHA_1	580	586	PF00498	0.679
LIG_FHA_2	115	121	PF00498	0.646
LIG_FHA_2	27	33	PF00498	0.586
LIG_GBD_Chelix_1	471	479	PF00786	0.620
LIG_LIR_Apic_2	133	138	PF02991	0.614
LIG_LIR_Gen_1	13	23	PF02991	0.592
LIG_LIR_Gen_1	357	368	PF02991	0.631
LIG_LIR_Gen_1	44	55	PF02991	0.527
LIG_LIR_Gen_1	565	574	PF02991	0.642
LIG_LIR_Nem_3	13	18	PF02991	0.477
LIG_LIR_Nem_3	251	256	PF02991	0.485
LIG_LIR_Nem_3	357	363	PF02991	0.644
LIG_LIR_Nem_3	395	400	PF02991	0.511
LIG_LIR_Nem_3	44	50	PF02991	0.485
LIG_LIR_Nem_3	66	72	PF02991	0.482
LIG_NRBOX	287	293	PF00104	0.428
LIG_Pex14_2	404	408	PF04695	0.428
LIG_Rb_pABgroove_1	12	20	PF01858	0.613
LIG_REV1ctd_RIR_1	564	573	PF16727	0.645
LIG_SH2_CRK	360	364	PF00017	0.513
LIG_SH2_CRK	476	480	PF00017	0.676
LIG_SH2_PTP2	47	50	PF00017	0.351
LIG_SH2_STAP1	189	193	PF00017	0.550
LIG_SH2_STAP1	360	364	PF00017	0.513
LIG_SH2_STAP1	504	508	PF00017	0.630
LIG_SH2_STAT3	109	112	PF00017	0.398
LIG_SH2_STAT5	246	249	PF00017	0.370
LIG_SH2_STAT5	462	465	PF00017	0.490
LIG_SH2_STAT5	47	50	PF00017	0.429
LIG_SH2_STAT5	490	493	PF00017	0.699
LIG_SH3_3	161	167	PF00018	0.578
LIG_SH3_3	2	8	PF00018	0.568
LIG_SH3_3	235	241	PF00018	0.589
LIG_SH3_3	360	366	PF00018	0.481
LIG_SH3_3	438	444	PF00018	0.753
LIG_SH3_3	503	509	PF00018	0.702
LIG_SH3_3	590	596	PF00018	0.507
LIG_TRAF2_1	221	224	PF00917	0.538
LIG_TYR_ITIM	45	50	PF00017	0.571
LIG_TYR_ITIM	474	479	PF00017	0.641
LIG_UBA3_1	331	336	PF00899	0.588
MOD_CK1_1	199	205	PF00069	0.673
MOD_CK1_1	234	240	PF00069	0.486
MOD_CK1_1	26	32	PF00069	0.587
MOD_CK1_1	269	275	PF00069	0.515
MOD_CK1_1	341	347	PF00069	0.666
MOD_CK1_1	388	394	PF00069	0.630
MOD_CK1_1	395	401	PF00069	0.562
MOD_CK1_1	440	446	PF00069	0.610
MOD_CK1_1	447	453	PF00069	0.620
MOD_CK1_1	558	564	PF00069	0.609
MOD_CK1_1	98	104	PF00069	0.419
MOD_CK2_1	351	357	PF00069	0.657
MOD_CK2_1	516	522	PF00069	0.739
MOD_CK2_1	526	532	PF00069	0.818
MOD_CK2_1	58	64	PF00069	0.557
MOD_CK2_1	583	589	PF00069	0.666
MOD_GlcNHglycan	159	162	PF01048	0.582
MOD_GlcNHglycan	268	271	PF01048	0.672
MOD_GlcNHglycan	282	285	PF01048	0.473
MOD_GlcNHglycan	311	314	PF01048	0.660
MOD_GlcNHglycan	319	322	PF01048	0.687
MOD_GlcNHglycan	353	356	PF01048	0.548
MOD_GlcNHglycan	527	532	PF01048	0.652
MOD_GSK3_1	184	191	PF00069	0.589
MOD_GSK3_1	24	31	PF00069	0.714
MOD_GSK3_1	274	281	PF00069	0.537
MOD_GSK3_1	282	289	PF00069	0.505
MOD_GSK3_1	388	395	PF00069	0.641
MOD_GSK3_1	422	429	PF00069	0.636
MOD_GSK3_1	440	447	PF00069	0.572
MOD_GSK3_1	579	586	PF00069	0.642
MOD_GSK3_1	82	89	PF00069	0.534
MOD_N-GLC_1	199	204	PF02516	0.410
MOD_N-GLC_1	322	327	PF02516	0.716
MOD_N-GLC_1	366	371	PF02516	0.612
MOD_NEK2_1	196	201	PF00069	0.615
MOD_NEK2_1	231	236	PF00069	0.464
MOD_NEK2_1	286	291	PF00069	0.502
MOD_NEK2_1	422	427	PF00069	0.628
MOD_NEK2_1	454	459	PF00069	0.634
MOD_NEK2_1	58	63	PF00069	0.584
MOD_PIKK_1	325	331	PF00454	0.612
MOD_PIKK_1	430	436	PF00454	0.718
MOD_PIKK_1	88	94	PF00454	0.630
MOD_PKA_2	208	214	PF00069	0.647
MOD_PKA_2	309	315	PF00069	0.634
MOD_PKA_2	426	432	PF00069	0.699
MOD_PKA_2	568	574	PF00069	0.686
MOD_PKA_2	583	589	PF00069	0.594
MOD_PKB_1	186	194	PF00069	0.598
MOD_Plk_1	199	205	PF00069	0.531
MOD_Plk_1	322	328	PF00069	0.566
MOD_Plk_1	356	362	PF00069	0.633
MOD_Plk_1	366	372	PF00069	0.578
MOD_Plk_1	82	88	PF00069	0.601
MOD_Plk_2-3	114	120	PF00069	0.652
MOD_Plk_2-3	208	214	PF00069	0.596
MOD_Plk_2-3	32	38	PF00069	0.530
MOD_Plk_2-3	560	566	PF00069	0.695
MOD_Plk_4	269	275	PF00069	0.602
MOD_Plk_4	282	288	PF00069	0.439
MOD_ProDKin_1	338	344	PF00069	0.449
MOD_ProDKin_1	388	394	PF00069	0.712
MOD_ProDKin_1	395	401	PF00069	0.617
MOD_ProDKin_1	437	443	PF00069	0.684
MOD_ProDKin_1	447	453	PF00069	0.719
MOD_SUMO_rev_2	519	526	PF00179	0.654
MOD_SUMO_rev_2	586	593	PF00179	0.714
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.429
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.599
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.622
TRG_ENDOCYTIC_2	360	363	PF00928	0.638
TRG_ENDOCYTIC_2	47	50	PF00928	0.396
TRG_ENDOCYTIC_2	476	479	PF00928	0.671
TRG_ER_diArg_1	186	189	PF00400	0.582
TRG_ER_diArg_1	306	308	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM0	Leptomonas seymouri	47%	100%
A0A1X0NY83	Trypanosomatidae	27%	100%
A0A3S7WZ73	Leishmania donovani	77%	100%
A0A422NL47	Trypanosoma rangeli	30%	100%
A4I1J9	Leishmania infantum	77%	100%
C9ZK33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	96%
Q4Q9T8	Leishmania major	74%	99%