Isopentenyl-diphosphate delta-isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HEJ8_LEIBR

TriTrypDb:

LbrM.25.2550 , LBRM2903_250012000

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.335
CLV_NRD_NRD_1	215	217	PF00675	0.335
CLV_NRD_NRD_1	220	222	PF00675	0.335
CLV_NRD_NRD_1	373	375	PF00675	0.335
CLV_NRD_NRD_1	534	536	PF00675	0.470
CLV_PCSK_KEX2_1	142	144	PF00082	0.335
CLV_PCSK_KEX2_1	215	217	PF00082	0.335
CLV_PCSK_KEX2_1	220	222	PF00082	0.335
CLV_PCSK_KEX2_1	287	289	PF00082	0.227
CLV_PCSK_KEX2_1	373	375	PF00082	0.335
CLV_PCSK_KEX2_1	534	536	PF00082	0.476
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.227
CLV_PCSK_PC7_1	216	222	PF00082	0.363
CLV_PCSK_PC7_1	369	375	PF00082	0.335
CLV_PCSK_SKI1_1	152	156	PF00082	0.480
CLV_PCSK_SKI1_1	266	270	PF00082	0.227
CLV_PCSK_SKI1_1	535	539	PF00082	0.267
CLV_PCSK_SKI1_1	565	569	PF00082	0.593
CLV_PCSK_SKI1_1	63	67	PF00082	0.327
DEG_Nend_UBRbox_3	1	3	PF02207	0.553
DEG_SPOP_SBC_1	673	677	PF00917	0.322
DOC_CKS1_1	105	110	PF01111	0.227
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.409
DOC_MAPK_gen_1	220	227	PF00069	0.363
DOC_MAPK_MEF2A_6	36	44	PF00069	0.430
DOC_MAPK_RevD_3	206	221	PF00069	0.363
DOC_PP4_FxxP_1	297	300	PF00568	0.335
DOC_PP4_FxxP_1	307	310	PF00568	0.335
DOC_PP4_FxxP_1	436	439	PF00568	0.227
DOC_PP4_FxxP_1	529	532	PF00568	0.468
DOC_USP7_MATH_1	191	195	PF00917	0.480
DOC_USP7_MATH_1	282	286	PF00917	0.322
DOC_USP7_MATH_1	400	404	PF00917	0.342
DOC_USP7_MATH_1	46	50	PF00917	0.436
DOC_USP7_MATH_1	533	537	PF00917	0.464
DOC_USP7_MATH_1	673	677	PF00917	0.322
DOC_USP7_MATH_1	81	85	PF00917	0.438
DOC_WW_Pin1_4	104	109	PF00397	0.303
DOC_WW_Pin1_4	118	123	PF00397	0.425
DOC_WW_Pin1_4	132	137	PF00397	0.249
DOC_WW_Pin1_4	296	301	PF00397	0.334
DOC_WW_Pin1_4	379	384	PF00397	0.335
DOC_WW_Pin1_4	74	79	PF00397	0.399
LIG_14-3-3_CanoR_1	162	168	PF00244	0.390
LIG_14-3-3_CanoR_1	180	184	PF00244	0.216
LIG_14-3-3_CanoR_1	304	308	PF00244	0.427
LIG_14-3-3_CanoR_1	534	538	PF00244	0.533
LIG_14-3-3_CanoR_1	68	73	PF00244	0.475
LIG_14-3-3_CanoR_1	699	704	PF00244	0.467
LIG_14-3-3_CanoR_1	89	94	PF00244	0.296
LIG_Actin_RPEL_3	259	278	PF02755	0.227
LIG_Actin_WH2_2	651	669	PF00022	0.463
LIG_AP2alpha_2	93	95	PF02296	0.335
LIG_APCC_ABBA_1	231	236	PF00400	0.466
LIG_APCC_ABBAyCdc20_2	535	541	PF00400	0.536
LIG_BIR_III_4	401	405	PF00653	0.335
LIG_BRCT_BRCA1_1	26	30	PF00533	0.827
LIG_BRCT_BRCA1_1	83	87	PF00533	0.415
LIG_BRCT_BRCA1_1	91	95	PF00533	0.335
LIG_EH1_1	456	464	PF00400	0.374
LIG_EH1_1	465	473	PF00400	0.335
LIG_FHA_1	180	186	PF00498	0.249
LIG_FHA_1	267	273	PF00498	0.227
LIG_FHA_1	304	310	PF00498	0.378
LIG_FHA_1	355	361	PF00498	0.408
LIG_FHA_1	393	399	PF00498	0.399
LIG_FHA_1	419	425	PF00498	0.480
LIG_FHA_1	451	457	PF00498	0.335
LIG_FHA_1	67	73	PF00498	0.378
LIG_FHA_2	585	591	PF00498	0.557
LIG_FHA_2	649	655	PF00498	0.543
LIG_LIR_Apic_2	296	300	PF02991	0.341
LIG_LIR_Apic_2	306	310	PF02991	0.331
LIG_LIR_Apic_2	526	532	PF02991	0.477
LIG_LIR_Gen_1	110	120	PF02991	0.227
LIG_LIR_Gen_1	198	208	PF02991	0.459
LIG_LIR_Gen_1	357	366	PF02991	0.408
LIG_LIR_Gen_1	57	65	PF02991	0.400
LIG_LIR_Gen_1	653	660	PF02991	0.291
LIG_LIR_Gen_1	84	95	PF02991	0.363
LIG_LIR_Nem_3	107	112	PF02991	0.227
LIG_LIR_Nem_3	198	204	PF02991	0.459
LIG_LIR_Nem_3	357	361	PF02991	0.408
LIG_LIR_Nem_3	541	546	PF02991	0.430
LIG_LIR_Nem_3	57	62	PF02991	0.395
LIG_LIR_Nem_3	653	658	PF02991	0.400
LIG_LIR_Nem_3	84	90	PF02991	0.361
LIG_PCNA_yPIPBox_3	447	456	PF02747	0.432
LIG_Pex14_1	201	205	PF04695	0.480
LIG_PTB_Apo_2	384	391	PF02174	0.335
LIG_PTB_Phospho_1	384	390	PF10480	0.480
LIG_Rb_pABgroove_1	603	611	PF01858	0.379
LIG_SH2_CRK	112	116	PF00017	0.227
LIG_SH2_CRK	59	63	PF00017	0.436
LIG_SH2_GRB2like	609	612	PF00017	0.299
LIG_SH2_NCK_1	348	352	PF00017	0.355
LIG_SH2_SRC	609	612	PF00017	0.299
LIG_SH2_SRC	679	682	PF00017	0.443
LIG_SH2_STAP1	539	543	PF00017	0.545
LIG_SH2_STAT5	205	208	PF00017	0.480
LIG_SH2_STAT5	480	483	PF00017	0.335
LIG_SH2_STAT5	679	682	PF00017	0.403
LIG_SH3_3	102	108	PF00018	0.319
LIG_SH3_3	117	123	PF00018	0.390
LIG_SH3_3	205	211	PF00018	0.335
LIG_SH3_3	357	363	PF00018	0.355
LIG_SH3_3	37	43	PF00018	0.651
LIG_SH3_3	624	630	PF00018	0.479
LIG_SH3_3	91	97	PF00018	0.319
LIG_Sin3_3	111	118	PF02671	0.266
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.335
LIG_SUMO_SIM_anti_2	485	491	PF11976	0.335
LIG_TRAF2_1	3	6	PF00917	0.656
LIG_TRFH_1	529	533	PF08558	0.531
LIG_WRC_WIRS_1	294	299	PF05994	0.227
LIG_WRC_WIRS_1	47	52	PF05994	0.447
LIG_WW_2	40	43	PF00397	0.645
LIG_WW_3	531	535	PF00397	0.559
MOD_CK1_1	15	21	PF00069	0.850
MOD_CK1_1	161	167	PF00069	0.427
MOD_CK1_1	299	305	PF00069	0.347
MOD_CK1_1	312	318	PF00069	0.305
MOD_CK1_1	403	409	PF00069	0.351
MOD_CK1_1	524	530	PF00069	0.470
MOD_CK1_1	57	63	PF00069	0.490
MOD_CK1_1	648	654	PF00069	0.495
MOD_CK2_1	20	26	PF00069	0.721
MOD_CK2_1	584	590	PF00069	0.404
MOD_Cter_Amidation	213	216	PF01082	0.335
MOD_Cter_Amidation	218	221	PF01082	0.335
MOD_GlcNHglycan	109	112	PF01048	0.391
MOD_GlcNHglycan	116	119	PF01048	0.483
MOD_GlcNHglycan	164	167	PF01048	0.353
MOD_GlcNHglycan	17	20	PF01048	0.808
MOD_GlcNHglycan	26	29	PF01048	0.761
MOD_GlcNHglycan	289	292	PF01048	0.403
MOD_GlcNHglycan	311	314	PF01048	0.335
MOD_GlcNHglycan	316	319	PF01048	0.335
MOD_GlcNHglycan	401	405	PF01048	0.331
MOD_GlcNHglycan	426	432	PF01048	0.461
MOD_GlcNHglycan	476	479	PF01048	0.342
MOD_GlcNHglycan	512	515	PF01048	0.664
MOD_GlcNHglycan	523	526	PF01048	0.550
MOD_GlcNHglycan	562	565	PF01048	0.648
MOD_GlcNHglycan	569	572	PF01048	0.404
MOD_GlcNHglycan	612	615	PF01048	0.537
MOD_GlcNHglycan	647	650	PF01048	0.553
MOD_GSK3_1	114	121	PF00069	0.406
MOD_GSK3_1	128	135	PF00069	0.377
MOD_GSK3_1	158	165	PF00069	0.396
MOD_GSK3_1	167	174	PF00069	0.450
MOD_GSK3_1	191	198	PF00069	0.480
MOD_GSK3_1	20	27	PF00069	0.726
MOD_GSK3_1	295	302	PF00069	0.350
MOD_GSK3_1	379	386	PF00069	0.422
MOD_GSK3_1	392	399	PF00069	0.252
MOD_GSK3_1	400	407	PF00069	0.331
MOD_GSK3_1	517	524	PF00069	0.552
MOD_GSK3_1	66	73	PF00069	0.340
MOD_GSK3_1	699	706	PF00069	0.493
MOD_N-GLC_1	392	397	PF02516	0.480
MOD_N-GLC_1	57	62	PF02516	0.420
MOD_N-GLC_1	584	589	PF02516	0.556
MOD_N-GLC_1	610	615	PF02516	0.314
MOD_NEK2_1	158	163	PF00069	0.391
MOD_NEK2_1	303	308	PF00069	0.335
MOD_NEK2_1	418	423	PF00069	0.447
MOD_NEK2_1	517	522	PF00069	0.615
MOD_NEK2_1	703	708	PF00069	0.524
MOD_NEK2_2	167	172	PF00069	0.363
MOD_NEK2_2	81	86	PF00069	0.480
MOD_PIKK_1	171	177	PF00454	0.335
MOD_PIKK_1	258	264	PF00454	0.349
MOD_PIKK_1	404	410	PF00454	0.335
MOD_PIKK_1	445	451	PF00454	0.484
MOD_PIKK_1	547	553	PF00454	0.689
MOD_PIKK_1	57	63	PF00454	0.480
MOD_PIKK_1	70	76	PF00454	0.265
MOD_PIKK_1	96	102	PF00454	0.335
MOD_PKA_1	287	293	PF00069	0.227
MOD_PKA_2	15	21	PF00069	0.698
MOD_PKA_2	161	167	PF00069	0.329
MOD_PKA_2	179	185	PF00069	0.237
MOD_PKA_2	24	30	PF00069	0.756
MOD_PKA_2	287	293	PF00069	0.385
MOD_PKA_2	303	309	PF00069	0.301
MOD_PKA_2	533	539	PF00069	0.535
MOD_PKB_1	264	272	PF00069	0.227
MOD_Plk_1	392	398	PF00069	0.447
MOD_Plk_1	57	63	PF00069	0.420
MOD_Plk_1	584	590	PF00069	0.423
MOD_Plk_2-3	20	26	PF00069	0.580
MOD_Plk_4	323	329	PF00069	0.346
MOD_Plk_4	335	341	PF00069	0.312
MOD_Plk_4	46	52	PF00069	0.419
MOD_Plk_4	584	590	PF00069	0.412
MOD_Plk_4	629	635	PF00069	0.523
MOD_ProDKin_1	104	110	PF00069	0.303
MOD_ProDKin_1	118	124	PF00069	0.425
MOD_ProDKin_1	132	138	PF00069	0.249
MOD_ProDKin_1	296	302	PF00069	0.334
MOD_ProDKin_1	379	385	PF00069	0.335
MOD_ProDKin_1	74	80	PF00069	0.399
TRG_ENDOCYTIC_2	112	115	PF00928	0.227
TRG_ENDOCYTIC_2	205	208	PF00928	0.447
TRG_ENDOCYTIC_2	348	351	PF00928	0.355
TRG_ENDOCYTIC_2	480	483	PF00928	0.402
TRG_ENDOCYTIC_2	59	62	PF00928	0.369
TRG_ER_diArg_1	142	144	PF00400	0.336
TRG_ER_diArg_1	215	217	PF00400	0.335
TRG_ER_diArg_1	220	222	PF00400	0.335
TRG_ER_diArg_1	533	535	PF00400	0.490
TRG_NES_CRM1_1	597	610	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT36	Leptomonas seymouri	63%	96%
A0A1X0NYA6	Trypanosomatidae	52%	100%
A0A3R7MPK5	Trypanosoma rangeli	51%	100%
A0A3S7WZ63	Leishmania donovani	84%	95%
A4I1K0	Leishmania infantum	84%	95%
C9ZK34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AXN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%
Q4Q9T7	Leishmania major	85%	100%
V5BHU4	Trypanosoma cruzi	50%	100%