Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEJ6_LEIBR

TriTrypDb:

LbrM.25.2530 , LBRM2903_000008400

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.575
CLV_NRD_NRD_1	392	394	PF00675	0.500
CLV_NRD_NRD_1	402	404	PF00675	0.479
CLV_NRD_NRD_1	450	452	PF00675	0.500
CLV_NRD_NRD_1	512	514	PF00675	0.676
CLV_NRD_NRD_1	832	834	PF00675	0.322
CLV_NRD_NRD_1	94	96	PF00675	0.590
CLV_PCSK_FUR_1	392	396	PF00082	0.584
CLV_PCSK_KEX2_1	11	13	PF00082	0.711
CLV_PCSK_KEX2_1	191	193	PF00082	0.579
CLV_PCSK_KEX2_1	392	394	PF00082	0.609
CLV_PCSK_KEX2_1	449	451	PF00082	0.546
CLV_PCSK_KEX2_1	512	514	PF00082	0.579
CLV_PCSK_KEX2_1	530	532	PF00082	0.588
CLV_PCSK_KEX2_1	832	834	PF00082	0.322
CLV_PCSK_KEX2_1	841	843	PF00082	0.360
CLV_PCSK_KEX2_1	94	96	PF00082	0.582
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.664
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.583
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.588
CLV_PCSK_PC1ET2_1	841	843	PF00082	0.360
CLV_PCSK_SKI1_1	192	196	PF00082	0.543
CLV_PCSK_SKI1_1	246	250	PF00082	0.448
CLV_PCSK_SKI1_1	270	274	PF00082	0.419
CLV_PCSK_SKI1_1	385	389	PF00082	0.483
CLV_PCSK_SKI1_1	463	467	PF00082	0.333
CLV_PCSK_SKI1_1	741	745	PF00082	0.300
CLV_PCSK_SKI1_1	832	836	PF00082	0.300
CLV_PCSK_SKI1_1	841	845	PF00082	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_SPOP_SBC_1	143	147	PF00917	0.651
DEG_SPOP_SBC_1	208	212	PF00917	0.647
DEG_SPOP_SBC_1	48	52	PF00917	0.542
DEG_SPOP_SBC_1	598	602	PF00917	0.518
DOC_CDC14_PxL_1	821	829	PF14671	0.360
DOC_CKS1_1	76	81	PF01111	0.690
DOC_CYCLIN_yClb5_NLxxxL_5	1	10	PF00134	0.608
DOC_MAPK_gen_1	546	555	PF00069	0.682
DOC_MAPK_MEF2A_6	674	682	PF00069	0.366
DOC_PP2B_LxvP_1	457	460	PF13499	0.441
DOC_PP2B_LxvP_1	706	709	PF13499	0.360
DOC_PP2B_PxIxI_1	320	326	PF00149	0.585
DOC_PP4_FxxP_1	349	352	PF00568	0.358
DOC_SPAK_OSR1_1	348	352	PF12202	0.361
DOC_USP7_MATH_1	144	148	PF00917	0.682
DOC_USP7_MATH_1	150	154	PF00917	0.649
DOC_USP7_MATH_1	209	213	PF00917	0.710
DOC_USP7_MATH_1	402	406	PF00917	0.595
DOC_USP7_MATH_1	44	48	PF00917	0.563
DOC_USP7_MATH_1	598	602	PF00917	0.697
DOC_USP7_MATH_1	786	790	PF00917	0.237
DOC_WW_Pin1_4	131	136	PF00397	0.692
DOC_WW_Pin1_4	192	197	PF00397	0.525
DOC_WW_Pin1_4	21	26	PF00397	0.756
DOC_WW_Pin1_4	253	258	PF00397	0.607
DOC_WW_Pin1_4	301	306	PF00397	0.480
DOC_WW_Pin1_4	317	322	PF00397	0.681
DOC_WW_Pin1_4	5	10	PF00397	0.650
DOC_WW_Pin1_4	553	558	PF00397	0.705
DOC_WW_Pin1_4	581	586	PF00397	0.550
DOC_WW_Pin1_4	594	599	PF00397	0.656
DOC_WW_Pin1_4	60	65	PF00397	0.669
DOC_WW_Pin1_4	609	614	PF00397	0.644
DOC_WW_Pin1_4	672	677	PF00397	0.344
DOC_WW_Pin1_4	75	80	PF00397	0.772
LIG_14-3-3_CanoR_1	123	133	PF00244	0.817
LIG_14-3-3_CanoR_1	140	144	PF00244	0.703
LIG_14-3-3_CanoR_1	395	402	PF00244	0.559
LIG_14-3-3_CanoR_1	566	570	PF00244	0.625
LIG_14-3-3_CanoR_1	590	599	PF00244	0.530
LIG_14-3-3_CanoR_1	72	80	PF00244	0.549
LIG_14-3-3_CanoR_1	752	758	PF00244	0.376
LIG_14-3-3_CanoR_1	842	849	PF00244	0.302
LIG_APCC_ABBA_1	273	278	PF00400	0.417
LIG_APCC_ABBAyCdc20_2	178	184	PF00400	0.524
LIG_APCC_ABBAyCdc20_2	479	485	PF00400	0.360
LIG_BIR_III_2	193	197	PF00653	0.514
LIG_BIR_III_2	610	614	PF00653	0.509
LIG_BRCT_BRCA1_1	110	114	PF00533	0.566
LIG_deltaCOP1_diTrp_1	284	290	PF00928	0.430
LIG_EVH1_1	437	441	PF00568	0.617
LIG_FHA_1	101	107	PF00498	0.613
LIG_FHA_1	333	339	PF00498	0.531
LIG_FHA_1	48	54	PF00498	0.693
LIG_FHA_1	5	11	PF00498	0.590
LIG_FHA_1	55	61	PF00498	0.649
LIG_FHA_1	63	69	PF00498	0.523
LIG_FHA_2	302	308	PF00498	0.491
LIG_FHA_2	427	433	PF00498	0.524
LIG_FHA_2	646	652	PF00498	0.360
LIG_FHA_2	684	690	PF00498	0.360
LIG_FHA_2	790	796	PF00498	0.425
LIG_FHA_2	814	820	PF00498	0.333
LIG_FHA_2	842	848	PF00498	0.300
LIG_LIR_Apic_2	670	676	PF02991	0.360
LIG_LIR_Apic_2	73	79	PF02991	0.574
LIG_LIR_Gen_1	195	203	PF02991	0.493
LIG_LIR_Gen_1	243	252	PF02991	0.413
LIG_LIR_Gen_1	284	293	PF02991	0.363
LIG_LIR_Gen_1	320	330	PF02991	0.541
LIG_LIR_Gen_1	471	476	PF02991	0.316
LIG_LIR_Nem_3	176	182	PF02991	0.705
LIG_LIR_Nem_3	195	200	PF02991	0.397
LIG_LIR_Nem_3	224	230	PF02991	0.400
LIG_LIR_Nem_3	243	247	PF02991	0.397
LIG_LIR_Nem_3	284	290	PF02991	0.370
LIG_LIR_Nem_3	320	325	PF02991	0.550
LIG_LIR_Nem_3	471	475	PF02991	0.360
LIG_LIR_Nem_3	504	510	PF02991	0.342
LIG_LIR_Nem_3	664	668	PF02991	0.350
LIG_LIR_Nem_3	750	754	PF02991	0.367
LIG_MAD2	246	254	PF02301	0.464
LIG_Pex14_2	645	649	PF04695	0.360
LIG_Pex14_2	751	755	PF04695	0.300
LIG_Pex14_2	764	768	PF04695	0.300
LIG_REV1ctd_RIR_1	851	857	PF16727	0.376
LIG_SH2_CRK	454	458	PF00017	0.370
LIG_SH2_CRK	467	471	PF00017	0.300
LIG_SH2_CRK	665	669	PF00017	0.326
LIG_SH2_NCK_1	665	669	PF00017	0.367
LIG_SH2_PTP2	322	325	PF00017	0.562
LIG_SH2_PTP2	624	627	PF00017	0.473
LIG_SH2_PTP2	76	79	PF00017	0.549
LIG_SH2_SRC	282	285	PF00017	0.440
LIG_SH2_SRC	59	62	PF00017	0.698
LIG_SH2_STAP1	186	190	PF00017	0.370
LIG_SH2_STAP1	230	234	PF00017	0.415
LIG_SH2_STAP1	235	239	PF00017	0.397
LIG_SH2_STAP1	507	511	PF00017	0.499
LIG_SH2_STAT3	810	813	PF00017	0.219
LIG_SH2_STAT5	120	123	PF00017	0.546
LIG_SH2_STAT5	222	225	PF00017	0.479
LIG_SH2_STAT5	233	236	PF00017	0.357
LIG_SH2_STAT5	282	285	PF00017	0.440
LIG_SH2_STAT5	322	325	PF00017	0.622
LIG_SH2_STAT5	342	345	PF00017	0.341
LIG_SH2_STAT5	355	358	PF00017	0.582
LIG_SH2_STAT5	510	513	PF00017	0.528
LIG_SH2_STAT5	59	62	PF00017	0.794
LIG_SH2_STAT5	624	627	PF00017	0.488
LIG_SH2_STAT5	754	757	PF00017	0.322
LIG_SH2_STAT5	76	79	PF00017	0.567
LIG_SH2_STAT5	810	813	PF00017	0.340
LIG_SH3_1	132	138	PF00018	0.567
LIG_SH3_2	135	140	PF14604	0.549
LIG_SH3_3	130	136	PF00018	0.683
LIG_SH3_3	214	220	PF00018	0.633
LIG_SH3_3	251	257	PF00018	0.580
LIG_SH3_3	295	301	PF00018	0.482
LIG_SH3_3	353	359	PF00018	0.455
LIG_SH3_3	365	371	PF00018	0.392
LIG_SH3_3	430	436	PF00018	0.705
LIG_SH3_3	554	560	PF00018	0.579
LIG_SH3_3	622	628	PF00018	0.497
LIG_SUMO_SIM_par_1	199	206	PF11976	0.532
LIG_SUMO_SIM_par_1	494	502	PF11976	0.360
LIG_SUMO_SIM_par_1	826	831	PF11976	0.360
LIG_TRAF2_1	304	307	PF00917	0.724
LIG_TRAF2_1	799	802	PF00917	0.347
LIG_TRAF2_2	613	618	PF00917	0.635
LIG_TRFH_1	755	759	PF08558	0.376
LIG_TYR_ITIM	452	457	PF00017	0.385
LIG_TYR_ITIM	465	470	PF00017	0.300
LIG_TYR_ITIM	663	668	PF00017	0.300
LIG_WRC_WIRS_1	469	474	PF05994	0.360
LIG_WRC_WIRS_1	646	651	PF05994	0.360
LIG_WRC_WIRS_1	723	728	PF05994	0.349
LIG_WRC_WIRS_1	748	753	PF05994	0.360
LIG_WW_2	438	441	PF00397	0.531
MOD_CDC14_SPxK_1	8	11	PF00782	0.652
MOD_CDK_SPxK_1	5	11	PF00069	0.652
MOD_CDK_SPxxK_3	192	199	PF00069	0.511
MOD_CDK_SPxxK_3	5	12	PF00069	0.655
MOD_CDK_SPxxK_3	609	616	PF00069	0.663
MOD_CK1_1	108	114	PF00069	0.715
MOD_CK1_1	118	124	PF00069	0.686
MOD_CK1_1	127	133	PF00069	0.626
MOD_CK1_1	145	151	PF00069	0.615
MOD_CK1_1	152	158	PF00069	0.584
MOD_CK1_1	324	330	PF00069	0.593
MOD_CK1_1	405	411	PF00069	0.647
MOD_CK1_1	47	53	PF00069	0.672
MOD_CK1_1	556	562	PF00069	0.618
MOD_CK1_1	564	570	PF00069	0.733
MOD_CK1_1	62	68	PF00069	0.589
MOD_CK1_1	789	795	PF00069	0.337
MOD_CK2_1	301	307	PF00069	0.482
MOD_CK2_1	39	45	PF00069	0.773
MOD_CK2_1	538	544	PF00069	0.703
MOD_CK2_1	581	587	PF00069	0.688
MOD_CK2_1	813	819	PF00069	0.230
MOD_CK2_1	841	847	PF00069	0.300
MOD_GlcNHglycan	110	113	PF01048	0.689
MOD_GlcNHglycan	148	151	PF01048	0.694
MOD_GlcNHglycan	217	220	PF01048	0.619
MOD_GlcNHglycan	263	266	PF01048	0.590
MOD_GlcNHglycan	407	410	PF01048	0.574
MOD_GlcNHglycan	42	45	PF01048	0.691
MOD_GlcNHglycan	429	432	PF01048	0.572
MOD_GlcNHglycan	46	49	PF01048	0.643
MOD_GlcNHglycan	592	595	PF01048	0.779
MOD_GlcNHglycan	686	689	PF01048	0.301
MOD_GlcNHglycan	788	791	PF01048	0.374
MOD_GSK3_1	108	115	PF00069	0.747
MOD_GSK3_1	121	128	PF00069	0.635
MOD_GSK3_1	139	146	PF00069	0.681
MOD_GSK3_1	148	155	PF00069	0.626
MOD_GSK3_1	203	210	PF00069	0.695
MOD_GSK3_1	248	255	PF00069	0.362
MOD_GSK3_1	288	295	PF00069	0.415
MOD_GSK3_1	317	324	PF00069	0.556
MOD_GSK3_1	381	388	PF00069	0.427
MOD_GSK3_1	40	47	PF00069	0.631
MOD_GSK3_1	493	500	PF00069	0.346
MOD_GSK3_1	525	532	PF00069	0.766
MOD_GSK3_1	551	558	PF00069	0.676
MOD_GSK3_1	560	567	PF00069	0.627
MOD_GSK3_1	586	593	PF00069	0.616
MOD_GSK3_1	594	601	PF00069	0.734
MOD_GSK3_1	668	675	PF00069	0.307
MOD_GSK3_1	67	74	PF00069	0.655
MOD_GSK3_1	735	742	PF00069	0.419
MOD_GSK3_1	809	816	PF00069	0.436
MOD_N-GLC_1	4	9	PF02516	0.558
MOD_N-GLC_1	564	569	PF02516	0.800
MOD_N-GLC_1	684	689	PF02516	0.376
MOD_N-GLC_1	709	714	PF02516	0.360
MOD_NEK2_1	106	111	PF00069	0.689
MOD_NEK2_1	114	119	PF00069	0.662
MOD_NEK2_1	139	144	PF00069	0.577
MOD_NEK2_1	229	234	PF00069	0.431
MOD_NEK2_1	331	336	PF00069	0.511
MOD_NEK2_1	492	497	PF00069	0.391
MOD_NEK2_1	538	543	PF00069	0.640
MOD_NEK2_1	54	59	PF00069	0.700
MOD_NEK2_1	569	574	PF00069	0.535
MOD_NEK2_1	586	591	PF00069	0.707
MOD_NEK2_1	645	650	PF00069	0.376
MOD_NEK2_1	800	805	PF00069	0.481
MOD_NEK2_1	828	833	PF00069	0.389
MOD_NEK2_2	321	326	PF00069	0.583
MOD_PIKK_1	112	118	PF00454	0.799
MOD_PIKK_1	209	215	PF00454	0.499
MOD_PIKK_1	258	264	PF00454	0.585
MOD_PIKK_1	78	84	PF00454	0.705
MOD_PIKK_1	809	815	PF00454	0.219
MOD_PKA_1	403	409	PF00069	0.520
MOD_PKA_1	529	535	PF00069	0.637
MOD_PKA_1	841	847	PF00069	0.300
MOD_PKA_2	124	130	PF00069	0.738
MOD_PKA_2	139	145	PF00069	0.530
MOD_PKA_2	213	219	PF00069	0.689
MOD_PKA_2	388	394	PF00069	0.558
MOD_PKA_2	402	408	PF00069	0.655
MOD_PKA_2	565	571	PF00069	0.555
MOD_PKA_2	71	77	PF00069	0.579
MOD_PKA_2	841	847	PF00069	0.300
MOD_PKB_1	12	20	PF00069	0.667
MOD_PKB_1	123	131	PF00069	0.667
MOD_PKB_1	393	401	PF00069	0.489
MOD_Plk_1	100	106	PF00069	0.631
MOD_Plk_1	235	241	PF00069	0.454
MOD_Plk_1	288	294	PF00069	0.380
MOD_Plk_1	564	570	PF00069	0.746
MOD_Plk_1	617	623	PF00069	0.559
MOD_Plk_1	650	656	PF00069	0.360
MOD_Plk_1	709	715	PF00069	0.360
MOD_Plk_1	800	806	PF00069	0.360
MOD_Plk_4	229	235	PF00069	0.430
MOD_Plk_4	369	375	PF00069	0.418
MOD_Plk_4	468	474	PF00069	0.360
MOD_Plk_4	49	55	PF00069	0.681
MOD_Plk_4	650	656	PF00069	0.300
MOD_Plk_4	770	776	PF00069	0.387
MOD_ProDKin_1	131	137	PF00069	0.691
MOD_ProDKin_1	192	198	PF00069	0.513
MOD_ProDKin_1	21	27	PF00069	0.756
MOD_ProDKin_1	253	259	PF00069	0.606
MOD_ProDKin_1	301	307	PF00069	0.482
MOD_ProDKin_1	317	323	PF00069	0.668
MOD_ProDKin_1	5	11	PF00069	0.652
MOD_ProDKin_1	553	559	PF00069	0.704
MOD_ProDKin_1	581	587	PF00069	0.552
MOD_ProDKin_1	594	600	PF00069	0.654
MOD_ProDKin_1	60	66	PF00069	0.670
MOD_ProDKin_1	609	615	PF00069	0.640
MOD_ProDKin_1	672	678	PF00069	0.344
MOD_ProDKin_1	75	81	PF00069	0.770
MOD_SUMO_for_1	486	489	PF00179	0.300
MOD_SUMO_rev_2	532	538	PF00179	0.654
MOD_SUMO_rev_2	763	769	PF00179	0.379
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.422
TRG_ENDOCYTIC_2	179	182	PF00928	0.456
TRG_ENDOCYTIC_2	322	325	PF00928	0.626
TRG_ENDOCYTIC_2	454	457	PF00928	0.368
TRG_ENDOCYTIC_2	467	470	PF00928	0.300
TRG_ENDOCYTIC_2	624	627	PF00928	0.473
TRG_ENDOCYTIC_2	658	661	PF00928	0.328
TRG_ENDOCYTIC_2	665	668	PF00928	0.317
TRG_ENDOCYTIC_2	754	757	PF00928	0.369
TRG_ENDOCYTIC_2	837	840	PF00928	0.300
TRG_ER_diArg_1	190	192	PF00400	0.511
TRG_ER_diArg_1	392	395	PF00400	0.536
TRG_ER_diArg_1	449	451	PF00400	0.461
TRG_ER_diArg_1	511	513	PF00400	0.546
TRG_ER_diArg_1	832	834	PF00400	0.324
TRG_ER_diArg_1	94	96	PF00400	0.586
TRG_NES_CRM1_1	747	758	PF08389	0.376
TRG_NLS_Bipartite_1	512	533	PF00514	0.587
TRG_NLS_MonoExtC_3	392	397	PF00514	0.588
TRG_NLS_MonoExtC_3	528	534	PF00514	0.607
TRG_NLS_MonoExtN_4	392	398	PF00514	0.587
TRG_NLS_MonoExtN_4	9	15	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK2	Leptomonas seymouri	64%	98%
A0A3S7WZ58	Leishmania donovani	82%	99%
A4I1K2	Leishmania infantum	83%	100%
E9AXN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9T5	Leishmania major	81%	100%
V5B2C1	Trypanosoma cruzi	33%	100%