H(+)-transporting two-sector ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase subunit beta, mitochondrial, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HEJ3_LEIBR

TriTrypDb:

LbrM.25.2500 , LBRM2903_250021100

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	1
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HEJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0005215	transporter activity	1	4
GO:0005216	monoatomic ion channel activity	4	4
GO:0005261	monoatomic cation channel activity	5	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0008324	monoatomic cation transmembrane transporter activity	4	4
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	4
GO:0015075	monoatomic ion transmembrane transporter activity	3	4
GO:0015078	proton transmembrane transporter activity	5	4
GO:0015252	proton channel activity	6	4
GO:0015267	channel activity	4	4
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	4
GO:0015399	primary active transmembrane transporter activity	4	4
GO:0016874	ligase activity	2	4
GO:0017076	purine nucleotide binding	4	4
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	4
GO:0022803	passive transmembrane transporter activity	3	4
GO:0022804	active transmembrane transporter activity	3	4
GO:0022853	active monoatomic ion transmembrane transporter activity	4	4
GO:0022857	transmembrane transporter activity	2	4
GO:0022890	inorganic cation transmembrane transporter activity	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	4
GO:0042626	ATPase-coupled transmembrane transporter activity	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	4
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	4
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:0140657	ATP-dependent activity	1	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.631
CLV_C14_Caspase3-7	89	93	PF00656	0.378
CLV_NRD_NRD_1	169	171	PF00675	0.379
CLV_NRD_NRD_1	246	248	PF00675	0.539
CLV_PCSK_KEX2_1	246	248	PF00082	0.539
CLV_PCSK_SKI1_1	170	174	PF00082	0.456
CLV_PCSK_SKI1_1	226	230	PF00082	0.484
DEG_SPOP_SBC_1	251	255	PF00917	0.605
DOC_CYCLIN_yClb1_LxF_4	11	17	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.456
DOC_USP7_MATH_2	112	118	PF00917	0.378
LIG_14-3-3_CanoR_1	174	179	PF00244	0.429
LIG_14-3-3_CanoR_1	22	30	PF00244	0.495
LIG_14-3-3_CanoR_1	57	66	PF00244	0.378
LIG_APCC_ABBA_1	13	18	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.355
LIG_BRCT_BRCA1_1	176	180	PF00533	0.435
LIG_Clathr_ClatBox_1	14	18	PF01394	0.495
LIG_FHA_1	171	177	PF00498	0.545
LIG_FHA_1	92	98	PF00498	0.378
LIG_FHA_2	44	50	PF00498	0.495
LIG_FHA_2	93	99	PF00498	0.378
LIG_GBD_Chelix_1	132	140	PF00786	0.551
LIG_LIR_Gen_1	190	200	PF02991	0.421
LIG_LIR_Gen_1	210	219	PF02991	0.558
LIG_LIR_Gen_1	86	96	PF02991	0.378
LIG_LIR_Nem_3	104	110	PF02991	0.378
LIG_LIR_Nem_3	141	146	PF02991	0.443
LIG_LIR_Nem_3	190	196	PF02991	0.428
LIG_LIR_Nem_3	201	206	PF02991	0.315
LIG_LIR_Nem_3	210	214	PF02991	0.453
LIG_LIR_Nem_3	216	222	PF02991	0.422
LIG_LIR_Nem_3	3	8	PF02991	0.495
LIG_LIR_Nem_3	86	91	PF02991	0.378
LIG_LYPXL_S_1	106	110	PF13949	0.378
LIG_LYPXL_yS_3	107	110	PF13949	0.378
LIG_PCNA_yPIPBox_3	22	34	PF02747	0.495
LIG_SH2_CRK	211	215	PF00017	0.449
LIG_SH2_NCK_1	130	134	PF00017	0.438
LIG_SH2_NCK_1	211	215	PF00017	0.449
LIG_SH2_PTP2	193	196	PF00017	0.475
LIG_SH2_SRC	73	76	PF00017	0.378
LIG_SH2_STAT5	193	196	PF00017	0.421
LIG_SH2_STAT5	4	7	PF00017	0.495
LIG_SH2_STAT5	73	76	PF00017	0.378
LIG_SH3_3	69	75	PF00018	0.378
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.439
LIG_SUMO_SIM_par_1	123	128	PF11976	0.483
LIG_WRC_WIRS_1	200	205	PF05994	0.434
MOD_CK1_1	252	258	PF00069	0.633
MOD_CK1_1	28	34	PF00069	0.495
MOD_CK1_1	65	71	PF00069	0.378
MOD_CK2_1	224	230	PF00069	0.445
MOD_CK2_1	43	49	PF00069	0.495
MOD_GlcNHglycan	103	106	PF01048	0.378
MOD_GlcNHglycan	203	206	PF01048	0.424
MOD_GlcNHglycan	29	33	PF01048	0.437
MOD_GSK3_1	170	177	PF00069	0.387
MOD_GSK3_1	21	28	PF00069	0.495
MOD_GSK3_1	250	257	PF00069	0.613
MOD_GSK3_1	58	65	PF00069	0.378
MOD_NEK2_1	21	26	PF00069	0.495
MOD_NEK2_1	91	96	PF00069	0.378
MOD_PIKK_1	174	180	PF00454	0.435
MOD_PIKK_1	21	27	PF00454	0.495
MOD_PKA_1	170	176	PF00069	0.438
MOD_PKA_2	21	27	PF00069	0.495
MOD_PKA_2	56	62	PF00069	0.495
MOD_PKB_1	168	176	PF00069	0.437
MOD_PKB_1	247	255	PF00069	0.591
MOD_Plk_1	28	34	PF00069	0.495
MOD_Plk_1	91	97	PF00069	0.378
MOD_Plk_2-3	156	162	PF00069	0.479
MOD_Plk_2-3	92	98	PF00069	0.378
MOD_Plk_4	224	230	PF00069	0.445
MOD_Plk_4	92	98	PF00069	0.378
MOD_SUMO_rev_2	156	165	PF00179	0.474
TRG_DiLeu_BaEn_1	29	34	PF01217	0.495
TRG_ENDOCYTIC_2	107	110	PF00928	0.378
TRG_ENDOCYTIC_2	143	146	PF00928	0.438
TRG_ENDOCYTIC_2	193	196	PF00928	0.475
TRG_ENDOCYTIC_2	211	214	PF00928	0.447
TRG_ER_diArg_1	246	249	PF00400	0.552
TRG_NES_CRM1_1	145	157	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J2J9	Bodo saltans	90%	100%
E8NHD0	Leishmania infantum	98%	87%
Q0QEP2	Mesocricetus auratus	71%	71%
V5BL70	Trypanosoma cruzi	29%	76%