ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEJ2_LEIBR

TriTrypDb:

LbrM.25.2490 , LBRM2903_250026800

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008716	D-alanine-D-alanine ligase activity	5	6
GO:0016740	transferase activity	2	6
GO:0016874	ligase activity	2	6
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	6
GO:0016881	acid-amino acid ligase activity	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.615
CLV_C14_Caspase3-7	350	354	PF00656	0.477
CLV_NRD_NRD_1	171	173	PF00675	0.762
CLV_NRD_NRD_1	197	199	PF00675	0.716
CLV_NRD_NRD_1	204	206	PF00675	0.673
CLV_NRD_NRD_1	252	254	PF00675	0.636
CLV_NRD_NRD_1	309	311	PF00675	0.476
CLV_NRD_NRD_1	590	592	PF00675	0.530
CLV_NRD_NRD_1	812	814	PF00675	0.720
CLV_NRD_NRD_1	92	94	PF00675	0.796
CLV_PCSK_FUR_1	198	202	PF00082	0.605
CLV_PCSK_KEX2_1	171	173	PF00082	0.853
CLV_PCSK_KEX2_1	197	199	PF00082	0.771
CLV_PCSK_KEX2_1	200	202	PF00082	0.784
CLV_PCSK_KEX2_1	206	208	PF00082	0.741
CLV_PCSK_KEX2_1	252	254	PF00082	0.641
CLV_PCSK_KEX2_1	332	334	PF00082	0.425
CLV_PCSK_KEX2_1	681	683	PF00082	0.342
CLV_PCSK_KEX2_1	734	736	PF00082	0.698
CLV_PCSK_KEX2_1	759	761	PF00082	0.622
CLV_PCSK_KEX2_1	83	85	PF00082	0.769
CLV_PCSK_KEX2_1	92	94	PF00082	0.689
CLV_PCSK_KEX2_1	98	100	PF00082	0.671
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.769
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.801
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.717
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.425
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.342
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.698
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.622
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.746
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.723
CLV_PCSK_PC7_1	755	761	PF00082	0.615
CLV_PCSK_SKI1_1	166	170	PF00082	0.758
CLV_PCSK_SKI1_1	201	205	PF00082	0.688
CLV_PCSK_SKI1_1	311	315	PF00082	0.575
CLV_PCSK_SKI1_1	392	396	PF00082	0.412
CLV_PCSK_SKI1_1	463	467	PF00082	0.412
CLV_PCSK_SKI1_1	513	517	PF00082	0.342
CLV_PCSK_SKI1_1	617	621	PF00082	0.518
CLV_PCSK_SKI1_1	674	678	PF00082	0.342
CLV_PCSK_SKI1_1	731	735	PF00082	0.581
CLV_PCSK_SKI1_1	755	759	PF00082	0.602
CLV_PCSK_SKI1_1	86	90	PF00082	0.808
CLV_PCSK_SKI1_1	92	96	PF00082	0.717
DEG_APCC_KENBOX_2	412	416	PF00400	0.451
DEG_SPOP_SBC_1	104	108	PF00917	0.718
DEG_SPOP_SBC_1	260	264	PF00917	0.566
DEG_SPOP_SBC_1	781	785	PF00917	0.582
DEG_SPOP_SBC_1	798	802	PF00917	0.526
DOC_CKS1_1	187	192	PF01111	0.722
DOC_CKS1_1	279	284	PF01111	0.589
DOC_CYCLIN_RxL_1	611	622	PF00134	0.512
DOC_CYCLIN_RxL_1	731	739	PF00134	0.595
DOC_CYCLIN_RxL_1	86	97	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.542
DOC_MAPK_gen_1	249	258	PF00069	0.599
DOC_MAPK_gen_1	329	338	PF00069	0.424
DOC_MAPK_gen_1	389	396	PF00069	0.542
DOC_MAPK_MEF2A_6	251	260	PF00069	0.549
DOC_MAPK_MEF2A_6	361	368	PF00069	0.484
DOC_MAPK_NFAT4_5	361	369	PF00069	0.581
DOC_PP1_RVXF_1	390	397	PF00149	0.542
DOC_PP1_RVXF_1	464	471	PF00149	0.542
DOC_PP1_RVXF_1	525	531	PF00149	0.542
DOC_PP1_RVXF_1	672	679	PF00149	0.612
DOC_PP1_RVXF_1	713	720	PF00149	0.505
DOC_PP4_FxxP_1	719	722	PF00568	0.542
DOC_SPAK_OSR1_1	20	24	PF12202	0.558
DOC_USP7_MATH_1	110	114	PF00917	0.827
DOC_USP7_MATH_1	120	124	PF00917	0.645
DOC_USP7_MATH_1	138	142	PF00917	0.552
DOC_USP7_MATH_1	159	163	PF00917	0.638
DOC_USP7_MATH_1	199	203	PF00917	0.828
DOC_USP7_MATH_1	271	275	PF00917	0.569
DOC_USP7_MATH_1	296	300	PF00917	0.583
DOC_USP7_MATH_1	49	53	PF00917	0.716
DOC_USP7_MATH_1	61	65	PF00917	0.707
DOC_USP7_MATH_1	666	670	PF00917	0.451
DOC_USP7_MATH_1	764	768	PF00917	0.771
DOC_USP7_MATH_1	769	773	PF00917	0.762
DOC_USP7_MATH_1	781	785	PF00917	0.499
DOC_USP7_MATH_1	790	794	PF00917	0.718
DOC_USP7_MATH_1	798	802	PF00917	0.734
DOC_USP7_UBL2_3	288	292	PF12436	0.624
DOC_USP7_UBL2_3	361	365	PF12436	0.479
DOC_USP7_UBL2_3	632	636	PF12436	0.715
DOC_USP7_UBL2_3	83	87	PF12436	0.801
DOC_WW_Pin1_4	106	111	PF00397	0.785
DOC_WW_Pin1_4	150	155	PF00397	0.820
DOC_WW_Pin1_4	179	184	PF00397	0.698
DOC_WW_Pin1_4	186	191	PF00397	0.671
DOC_WW_Pin1_4	228	233	PF00397	0.674
DOC_WW_Pin1_4	278	283	PF00397	0.499
DOC_WW_Pin1_4	4	9	PF00397	0.556
DOC_WW_Pin1_4	455	460	PF00397	0.542
DOC_WW_Pin1_4	550	555	PF00397	0.350
LIG_14-3-3_CanoR_1	172	180	PF00244	0.807
LIG_14-3-3_CanoR_1	198	204	PF00244	0.731
LIG_14-3-3_CanoR_1	234	241	PF00244	0.758
LIG_14-3-3_CanoR_1	290	296	PF00244	0.511
LIG_14-3-3_CanoR_1	310	320	PF00244	0.252
LIG_14-3-3_CanoR_1	40	48	PF00244	0.597
LIG_14-3-3_CanoR_1	608	614	PF00244	0.595
LIG_14-3-3_CanoR_1	661	668	PF00244	0.542
LIG_14-3-3_CanoR_1	763	769	PF00244	0.662
LIG_APCC_ABBA_1	409	414	PF00400	0.451
LIG_BRCT_BRCA1_1	353	357	PF00533	0.495
LIG_BRCT_BRCA1_1	475	479	PF00533	0.451
LIG_BRCT_BRCA1_1	715	719	PF00533	0.499
LIG_deltaCOP1_diTrp_1	568	576	PF00928	0.422
LIG_FHA_1	241	247	PF00498	0.714
LIG_FHA_1	270	276	PF00498	0.528
LIG_FHA_1	5	11	PF00498	0.688
LIG_FHA_1	83	89	PF00498	0.605
LIG_FHA_2	348	354	PF00498	0.472
LIG_FHA_2	694	700	PF00498	0.542
LIG_Integrin_RGD_1	650	652	PF01839	0.558
LIG_LIR_Apic_2	276	282	PF02991	0.602
LIG_LIR_Apic_2	716	722	PF02991	0.524
LIG_LIR_Gen_1	294	303	PF02991	0.491
LIG_LIR_Gen_1	315	324	PF02991	0.462
LIG_LIR_Gen_1	404	411	PF02991	0.542
LIG_LIR_Gen_1	476	483	PF02991	0.540
LIG_LIR_Gen_1	559	565	PF02991	0.434
LIG_LIR_Gen_1	691	702	PF02991	0.632
LIG_LIR_Nem_3	294	298	PF02991	0.485
LIG_LIR_Nem_3	304	309	PF02991	0.478
LIG_LIR_Nem_3	315	321	PF02991	0.479
LIG_LIR_Nem_3	404	409	PF02991	0.542
LIG_LIR_Nem_3	476	482	PF02991	0.540
LIG_LIR_Nem_3	492	498	PF02991	0.551
LIG_LIR_Nem_3	502	508	PF02991	0.500
LIG_LIR_Nem_3	559	563	PF02991	0.438
LIG_LIR_Nem_3	691	697	PF02991	0.542
LIG_LYPXL_yS_3	505	508	PF13949	0.470
LIG_Pex14_2	17	21	PF04695	0.555
LIG_Pex14_2	482	486	PF04695	0.542
LIG_SH2_CRK	306	310	PF00017	0.489
LIG_SH2_CRK	406	410	PF00017	0.542
LIG_SH2_CRK	495	499	PF00017	0.612
LIG_SH2_CRK	694	698	PF00017	0.528
LIG_SH2_NCK_1	406	410	PF00017	0.542
LIG_SH2_STAP1	318	322	PF00017	0.545
LIG_SH2_STAT5	22	25	PF00017	0.561
LIG_SH2_STAT5	481	484	PF00017	0.542
LIG_SH2_STAT5	518	521	PF00017	0.532
LIG_SH2_STAT5	540	543	PF00017	0.529
LIG_SH2_STAT5	595	598	PF00017	0.504
LIG_SH3_3	177	183	PF00018	0.769
LIG_SH3_3	184	190	PF00018	0.658
LIG_SH3_3	229	235	PF00018	0.639
LIG_SH3_3	370	376	PF00018	0.407
LIG_SH3_3	453	459	PF00018	0.568
LIG_SH3_3	461	467	PF00018	0.511
LIG_SH3_3	500	506	PF00018	0.470
LIG_SH3_3	714	720	PF00018	0.503
LIG_TRAF2_1	341	344	PF00917	0.483
LIG_TYR_ITAM	492	508	PF00017	0.612
LIG_TYR_ITIM	523	528	PF00017	0.542
LIG_TYR_ITIM	692	697	PF00017	0.615
MOD_CDC14_SPxK_1	231	234	PF00782	0.583
MOD_CDK_SPK_2	106	111	PF00069	0.610
MOD_CDK_SPK_2	550	555	PF00069	0.350
MOD_CDK_SPxK_1	228	234	PF00069	0.629
MOD_CK1_1	106	112	PF00069	0.719
MOD_CK1_1	115	121	PF00069	0.691
MOD_CK1_1	141	147	PF00069	0.647
MOD_CK1_1	152	158	PF00069	0.723
MOD_CK1_1	181	187	PF00069	0.696
MOD_CK1_1	214	220	PF00069	0.802
MOD_CK1_1	305	311	PF00069	0.534
MOD_CK1_1	51	57	PF00069	0.722
MOD_CK1_1	64	70	PF00069	0.681
MOD_CK1_1	708	714	PF00069	0.522
MOD_CK1_1	72	78	PF00069	0.633
MOD_CK1_1	762	768	PF00069	0.734
MOD_CK1_1	772	778	PF00069	0.704
MOD_CK1_1	780	786	PF00069	0.629
MOD_CK1_1	792	798	PF00069	0.779
MOD_CK1_1	799	805	PF00069	0.513
MOD_CK1_1	97	103	PF00069	0.660
MOD_GlcNHglycan	11	14	PF01048	0.627
MOD_GlcNHglycan	112	115	PF01048	0.802
MOD_GlcNHglycan	117	120	PF01048	0.734
MOD_GlcNHglycan	122	125	PF01048	0.647
MOD_GlcNHglycan	127	130	PF01048	0.749
MOD_GlcNHglycan	131	134	PF01048	0.590
MOD_GlcNHglycan	141	144	PF01048	0.589
MOD_GlcNHglycan	145	148	PF01048	0.591
MOD_GlcNHglycan	161	164	PF01048	0.819
MOD_GlcNHglycan	183	186	PF01048	0.788
MOD_GlcNHglycan	216	219	PF01048	0.771
MOD_GlcNHglycan	224	227	PF01048	0.731
MOD_GlcNHglycan	236	239	PF01048	0.670
MOD_GlcNHglycan	269	272	PF01048	0.602
MOD_GlcNHglycan	370	373	PF01048	0.599
MOD_GlcNHglycan	403	406	PF01048	0.342
MOD_GlcNHglycan	51	54	PF01048	0.751
MOD_GlcNHglycan	55	58	PF01048	0.704
MOD_GlcNHglycan	63	66	PF01048	0.633
MOD_GlcNHglycan	71	74	PF01048	0.799
MOD_GlcNHglycan	766	769	PF01048	0.686
MOD_GlcNHglycan	774	777	PF01048	0.750
MOD_GlcNHglycan	779	782	PF01048	0.565
MOD_GlcNHglycan	792	795	PF01048	0.628
MOD_GlcNHglycan	796	799	PF01048	0.575
MOD_GlcNHglycan	801	804	PF01048	0.691
MOD_GSK3_1	105	112	PF00069	0.835
MOD_GSK3_1	114	121	PF00069	0.666
MOD_GSK3_1	125	132	PF00069	0.753
MOD_GSK3_1	139	146	PF00069	0.710
MOD_GSK3_1	149	156	PF00069	0.726
MOD_GSK3_1	174	181	PF00069	0.706
MOD_GSK3_1	207	214	PF00069	0.834
MOD_GSK3_1	21	28	PF00069	0.789
MOD_GSK3_1	216	223	PF00069	0.734
MOD_GSK3_1	261	268	PF00069	0.491
MOD_GSK3_1	347	354	PF00069	0.470
MOD_GSK3_1	401	408	PF00069	0.506
MOD_GSK3_1	48	55	PF00069	0.712
MOD_GSK3_1	603	610	PF00069	0.511
MOD_GSK3_1	69	76	PF00069	0.732
MOD_GSK3_1	758	765	PF00069	0.734
MOD_GSK3_1	767	774	PF00069	0.697
MOD_GSK3_1	777	784	PF00069	0.532
MOD_GSK3_1	788	795	PF00069	0.726
MOD_GSK3_1	797	804	PF00069	0.742
MOD_N-GLC_1	124	129	PF02516	0.594
MOD_N-GLC_1	214	219	PF02516	0.615
MOD_N-GLC_1	666	671	PF02516	0.251
MOD_N-GLC_2	323	325	PF02516	0.444
MOD_N-GLC_2	415	417	PF02516	0.295
MOD_NEK2_1	21	26	PF00069	0.727
MOD_NEK2_1	312	317	PF00069	0.483
MOD_NEK2_1	367	372	PF00069	0.596
MOD_NEK2_1	41	46	PF00069	0.498
MOD_NEK2_1	69	74	PF00069	0.677
MOD_NEK2_1	705	710	PF00069	0.531
MOD_NEK2_1	9	14	PF00069	0.657
MOD_NEK2_1	94	99	PF00069	0.609
MOD_NEK2_2	216	221	PF00069	0.582
MOD_NEK2_2	296	301	PF00069	0.585
MOD_PKA_1	173	179	PF00069	0.840
MOD_PKA_1	221	227	PF00069	0.651
MOD_PKA_1	484	490	PF00069	0.542
MOD_PKA_1	758	764	PF00069	0.627
MOD_PKA_2	110	116	PF00069	0.603
MOD_PKA_2	39	45	PF00069	0.816
MOD_PKA_2	607	613	PF00069	0.492
MOD_PKA_2	660	666	PF00069	0.542
MOD_PKA_2	69	75	PF00069	0.729
MOD_PKA_2	759	765	PF00069	0.600
MOD_PKB_1	205	213	PF00069	0.600
MOD_PKB_1	444	452	PF00069	0.542
MOD_Plk_1	296	302	PF00069	0.583
MOD_Plk_1	666	672	PF00069	0.451
MOD_Plk_1	688	694	PF00069	0.542
MOD_Plk_1	698	704	PF00069	0.567
MOD_Plk_2-3	688	694	PF00069	0.542
MOD_Plk_4	446	452	PF00069	0.612
MOD_Plk_4	630	636	PF00069	0.704
MOD_Plk_4	666	672	PF00069	0.501
MOD_ProDKin_1	106	112	PF00069	0.784
MOD_ProDKin_1	150	156	PF00069	0.821
MOD_ProDKin_1	179	185	PF00069	0.701
MOD_ProDKin_1	186	192	PF00069	0.672
MOD_ProDKin_1	228	234	PF00069	0.673
MOD_ProDKin_1	278	284	PF00069	0.498
MOD_ProDKin_1	4	10	PF00069	0.554
MOD_ProDKin_1	455	461	PF00069	0.542
MOD_ProDKin_1	550	556	PF00069	0.355
MOD_SUMO_rev_2	326	334	PF00179	0.484
MOD_SUMO_rev_2	358	367	PF00179	0.488
MOD_SUMO_rev_2	477	487	PF00179	0.542
TRG_DiLeu_BaLyEn_6	732	737	PF01217	0.687
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.605
TRG_ENDOCYTIC_2	306	309	PF00928	0.469
TRG_ENDOCYTIC_2	318	321	PF00928	0.356
TRG_ENDOCYTIC_2	406	409	PF00928	0.542
TRG_ENDOCYTIC_2	495	498	PF00928	0.576
TRG_ENDOCYTIC_2	505	508	PF00928	0.500
TRG_ENDOCYTIC_2	525	528	PF00928	0.380
TRG_ENDOCYTIC_2	694	697	PF00928	0.515
TRG_ER_diArg_1	197	199	PF00400	0.666
TRG_ER_diArg_1	205	208	PF00400	0.626
TRG_ER_diArg_1	253	256	PF00400	0.587
TRG_ER_diArg_1	423	426	PF00400	0.451
TRG_ER_diArg_1	443	446	PF00400	0.520
TRG_ER_diArg_1	92	94	PF00400	0.831
TRG_NLS_Bipartite_1	740	762	PF00514	0.594
TRG_NLS_MonoCore_2	171	176	PF00514	0.848
TRG_NLS_MonoCore_2	250	255	PF00514	0.713
TRG_NLS_MonoExtC_3	250	255	PF00514	0.713
TRG_NLS_MonoExtC_3	82	87	PF00514	0.723
TRG_NLS_MonoExtN_4	171	177	PF00514	0.838
TRG_NLS_MonoExtN_4	249	256	PF00514	0.704
TRG_NLS_MonoExtN_4	755	762	PF00514	0.615
TRG_NLS_MonoExtN_4	83	90	PF00514	0.799
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZE7	Leishmania donovani	85%	94%
C9ZK70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AXR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	94%
Q4Q9R1	Leishmania major	83%	100%