Peptidase C51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEJ1_LEIBR

TriTrypDb:

LbrM.25.2480 , LBRM2903_250026900

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A4HEJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.557
CLV_NRD_NRD_1	122	124	PF00675	0.657
CLV_NRD_NRD_1	197	199	PF00675	0.524
CLV_NRD_NRD_1	204	206	PF00675	0.509
CLV_NRD_NRD_1	253	255	PF00675	0.552
CLV_PCSK_KEX2_1	122	124	PF00082	0.642
CLV_PCSK_KEX2_1	167	169	PF00082	0.678
CLV_PCSK_KEX2_1	204	206	PF00082	0.545
CLV_PCSK_KEX2_1	253	255	PF00082	0.568
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.657
CLV_PCSK_PC7_1	249	255	PF00082	0.592
CLV_PCSK_SKI1_1	243	247	PF00082	0.572
DOC_MAPK_gen_1	241	250	PF00069	0.340
DOC_PP1_RVXF_1	144	151	PF00149	0.348
DOC_PP1_RVXF_1	272	279	PF00149	0.294
DOC_PP4_FxxP_1	200	203	PF00568	0.389
DOC_USP7_UBL2_3	243	247	PF12436	0.285
LIG_14-3-3_CanoR_1	130	138	PF00244	0.363
LIG_14-3-3_CanoR_1	26	31	PF00244	0.491
LIG_14-3-3_CanoR_1	305	311	PF00244	0.249
LIG_14-3-3_CanoR_1	69	75	PF00244	0.474
LIG_Actin_WH2_2	297	315	PF00022	0.426
LIG_eIF4E_1	143	149	PF01652	0.314
LIG_FHA_1	160	166	PF00498	0.420
LIG_FHA_1	25	31	PF00498	0.561
LIG_FHA_2	185	191	PF00498	0.397
LIG_FHA_2	8	14	PF00498	0.533
LIG_HCF-1_HBM_1	269	272	PF13415	0.248
LIG_Integrin_isoDGR_2	120	122	PF01839	0.538
LIG_Integrin_RGD_1	123	125	PF01839	0.674
LIG_KLC1_Yacidic_2	289	294	PF13176	0.205
LIG_LIR_Apic_2	170	174	PF02991	0.428
LIG_LIR_Apic_2	197	203	PF02991	0.401
LIG_LIR_Apic_2	289	295	PF02991	0.284
LIG_LIR_Gen_1	187	195	PF02991	0.397
LIG_LIR_Gen_1	269	278	PF02991	0.366
LIG_LIR_Nem_3	105	111	PF02991	0.345
LIG_LIR_Nem_3	139	144	PF02991	0.256
LIG_LIR_Nem_3	187	192	PF02991	0.368
LIG_LIR_Nem_3	269	275	PF02991	0.367
LIG_LIR_Nem_3	51	57	PF02991	0.461
LIG_LIR_Nem_3	70	74	PF02991	0.387
LIG_Pex14_1	181	185	PF04695	0.421
LIG_SH2_CRK	272	276	PF00017	0.312
LIG_SH2_CRK	74	78	PF00017	0.442
LIG_SH2_GRB2like	108	111	PF00017	0.343
LIG_SH2_GRB2like	171	174	PF00017	0.425
LIG_SH2_GRB2like	97	100	PF00017	0.307
LIG_SH2_NCK_1	189	193	PF00017	0.346
LIG_SH2_PTP2	111	114	PF00017	0.406
LIG_SH2_PTP2	292	295	PF00017	0.289
LIG_SH2_PTP2	36	39	PF00017	0.391
LIG_SH2_SRC	189	192	PF00017	0.360
LIG_SH2_SRC	292	295	PF00017	0.289
LIG_SH2_STAP1	272	276	PF00017	0.298
LIG_SH2_STAT3	58	61	PF00017	0.261
LIG_SH2_STAT5	108	111	PF00017	0.371
LIG_SH2_STAT5	171	174	PF00017	0.384
LIG_SH2_STAT5	185	188	PF00017	0.201
LIG_SH2_STAT5	256	259	PF00017	0.314
LIG_SH2_STAT5	292	295	PF00017	0.350
LIG_SH2_STAT5	36	39	PF00017	0.337
LIG_SH3_1	171	177	PF00018	0.317
LIG_SH3_3	171	177	PF00018	0.426
LIG_SH3_3	312	318	PF00018	0.498
LIG_Sin3_3	206	213	PF02671	0.215
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.389
LIG_SUMO_SIM_par_1	45	51	PF11976	0.292
LIG_TRAF2_1	194	197	PF00917	0.246
LIG_TRAF2_1	318	321	PF00917	0.491
LIG_TYR_ITIM	109	114	PF00017	0.502
LIG_TYR_ITIM	34	39	PF00017	0.307
LIG_TYR_ITIM	52	57	PF00017	0.368
LIG_TYR_ITSM	185	192	PF00017	0.361
LIG_UBA3_1	300	308	PF00899	0.390
MOD_CK1_1	48	54	PF00069	0.301
MOD_CK2_1	184	190	PF00069	0.485
MOD_CK2_1	191	197	PF00069	0.365
MOD_CMANNOS	147	150	PF00535	0.464
MOD_Cter_Amidation	120	123	PF01082	0.584
MOD_GlcNHglycan	138	141	PF01048	0.330
MOD_GlcNHglycan	180	184	PF01048	0.498
MOD_GSK3_1	7	14	PF00069	0.605
MOD_GSK3_1	95	102	PF00069	0.318
MOD_N-GLC_1	270	275	PF02516	0.369
MOD_NEK2_1	104	109	PF00069	0.409
MOD_NEK2_1	53	58	PF00069	0.475
MOD_PKA_2	136	142	PF00069	0.439
MOD_Plk_1	190	196	PF00069	0.551
MOD_Plk_1	214	220	PF00069	0.452
MOD_Plk_1	270	276	PF00069	0.347
MOD_Plk_2-3	191	197	PF00069	0.329
MOD_Plk_4	104	110	PF00069	0.476
MOD_Plk_4	26	32	PF00069	0.399
MOD_Plk_4	48	54	PF00069	0.363
MOD_Plk_4	62	68	PF00069	0.437
MOD_SUMO_for_1	175	178	PF00179	0.568
MOD_SUMO_for_1	227	230	PF00179	0.437
MOD_SUMO_rev_2	191	200	PF00179	0.441
MOD_SUMO_rev_2	240	248	PF00179	0.533
TRG_DiLeu_BaEn_4	190	196	PF01217	0.273
TRG_ENDOCYTIC_2	111	114	PF00928	0.423
TRG_ENDOCYTIC_2	138	141	PF00928	0.385
TRG_ENDOCYTIC_2	189	192	PF00928	0.425
TRG_ENDOCYTIC_2	272	275	PF00928	0.390
TRG_ENDOCYTIC_2	36	39	PF00928	0.304
TRG_ENDOCYTIC_2	54	57	PF00928	0.435
TRG_ENDOCYTIC_2	74	77	PF00928	0.326
TRG_ER_diArg_1	203	205	PF00400	0.441
TRG_ER_diArg_1	252	254	PF00400	0.497
TRG_NLS_MonoExtN_4	243	250	PF00514	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	61%	100%
A0A0N1I7J8	Leptomonas seymouri	27%	84%
A0A0N1PB04	Leptomonas seymouri	28%	93%
A0A1X0NR96	Trypanosomatidae	28%	100%
A0A1X0NR98	Trypanosomatidae	25%	100%
A0A1X0NY88	Trypanosomatidae	37%	100%
A0A1X0NYK9	Trypanosomatidae	37%	100%
A0A3R7KMG1	Trypanosoma rangeli	35%	100%
A0A3S7WZA9	Leishmania donovani	84%	100%
A0A3S7X769	Leishmania donovani	27%	100%
A4HLZ4	Leishmania braziliensis	28%	99%
A4I1M7	Leishmania infantum	84%	100%
A4I9C4	Leishmania infantum	27%	90%
C9ZK72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A867	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B4C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q3Q2	Leishmania major	27%	90%
Q4Q9R0	Leishmania major	82%	100%
V5BF57	Trypanosoma cruzi	26%	100%
V5DIU8	Trypanosoma cruzi	36%	100%