Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEJ0_LEIBR

TriTrypDb:

LbrM.25.2470 , LBRM2903_250027000

Length:

1030

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	595	599	PF00656	0.782
CLV_NRD_NRD_1	345	347	PF00675	0.601
CLV_NRD_NRD_1	586	588	PF00675	0.655
CLV_NRD_NRD_1	614	616	PF00675	0.585
CLV_NRD_NRD_1	710	712	PF00675	0.516
CLV_NRD_NRD_1	809	811	PF00675	0.527
CLV_NRD_NRD_1	910	912	PF00675	0.579
CLV_PCSK_KEX2_1	345	347	PF00082	0.601
CLV_PCSK_KEX2_1	586	588	PF00082	0.655
CLV_PCSK_KEX2_1	614	616	PF00082	0.585
CLV_PCSK_KEX2_1	635	637	PF00082	0.499
CLV_PCSK_KEX2_1	710	712	PF00082	0.516
CLV_PCSK_KEX2_1	809	811	PF00082	0.518
CLV_PCSK_KEX2_1	910	912	PF00082	0.579
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.499
CLV_PCSK_PC7_1	610	616	PF00082	0.649
CLV_PCSK_SKI1_1	345	349	PF00082	0.604
CLV_PCSK_SKI1_1	561	565	PF00082	0.617
CLV_PCSK_SKI1_1	68	72	PF00082	0.489
CLV_PCSK_SKI1_1	692	696	PF00082	0.476
CLV_PCSK_SKI1_1	711	715	PF00082	0.532
CLV_PCSK_SKI1_1	847	851	PF00082	0.346
CLV_PCSK_SKI1_1	91	95	PF00082	0.461
CLV_PCSK_SKI1_1	980	984	PF00082	0.484
DEG_APCC_DBOX_1	344	352	PF00400	0.800
DEG_APCC_DBOX_1	808	816	PF00400	0.709
DEG_Nend_Nbox_1	1	3	PF02207	0.817
DEG_SPOP_SBC_1	118	122	PF00917	0.865
DEG_SPOP_SBC_1	510	514	PF00917	0.677
DEG_SPOP_SBC_1	592	596	PF00917	0.842
DEG_SPOP_SBC_1	597	601	PF00917	0.789
DOC_CKS1_1	579	584	PF01111	0.806
DOC_CKS1_1	716	721	PF01111	0.768
DOC_CYCLIN_RxL_1	692	701	PF00134	0.726
DOC_CYCLIN_RxL_1	842	855	PF00134	0.544
DOC_MAPK_gen_1	436	446	PF00069	0.659
DOC_MAPK_gen_1	561	571	PF00069	0.791
DOC_MAPK_gen_1	739	748	PF00069	0.513
DOC_MAPK_gen_1	910	918	PF00069	0.753
DOC_MAPK_gen_1	984	994	PF00069	0.759
DOC_MAPK_HePTP_8	405	417	PF00069	0.612
DOC_MAPK_MEF2A_6	408	417	PF00069	0.798
DOC_MAPK_MEF2A_6	564	573	PF00069	0.808
DOC_MAPK_MEF2A_6	782	789	PF00069	0.730
DOC_PP1_RVXF_1	344	351	PF00149	0.799
DOC_PP1_RVXF_1	837	844	PF00149	0.708
DOC_PP1_RVXF_1	89	96	PF00149	0.837
DOC_PP1_SILK_1	787	792	PF00149	0.584
DOC_PP2B_LxvP_1	420	423	PF13499	0.823
DOC_PP2B_LxvP_1	465	468	PF13499	0.639
DOC_PP2B_LxvP_1	697	700	PF13499	0.727
DOC_PP2B_LxvP_1	757	760	PF13499	0.530
DOC_PP4_FxxP_1	44	47	PF00568	0.832
DOC_PP4_FxxP_1	579	582	PF00568	0.650
DOC_USP7_MATH_1	125	129	PF00917	0.824
DOC_USP7_MATH_1	164	168	PF00917	0.753
DOC_USP7_MATH_1	201	205	PF00917	0.778
DOC_USP7_MATH_1	440	444	PF00917	0.691
DOC_USP7_MATH_1	457	461	PF00917	0.665
DOC_USP7_MATH_1	471	475	PF00917	0.773
DOC_USP7_MATH_1	481	485	PF00917	0.722
DOC_USP7_MATH_1	510	514	PF00917	0.686
DOC_USP7_MATH_1	597	601	PF00917	0.689
DOC_USP7_MATH_1	64	68	PF00917	0.702
DOC_USP7_MATH_1	753	757	PF00917	0.530
DOC_USP7_MATH_1	774	778	PF00917	0.698
DOC_USP7_MATH_1	934	938	PF00917	0.833
DOC_WW_Pin1_4	119	124	PF00397	0.719
DOC_WW_Pin1_4	282	287	PF00397	0.759
DOC_WW_Pin1_4	314	319	PF00397	0.751
DOC_WW_Pin1_4	363	368	PF00397	0.835
DOC_WW_Pin1_4	458	463	PF00397	0.650
DOC_WW_Pin1_4	482	487	PF00397	0.720
DOC_WW_Pin1_4	578	583	PF00397	0.802
DOC_WW_Pin1_4	605	610	PF00397	0.715
DOC_WW_Pin1_4	715	720	PF00397	0.663
DOC_WW_Pin1_4	883	888	PF00397	0.652
LIG_14-3-3_CanoR_1	290	296	PF00244	0.728
LIG_14-3-3_CanoR_1	349	358	PF00244	0.633
LIG_14-3-3_CanoR_1	439	445	PF00244	0.661
LIG_14-3-3_CanoR_1	791	799	PF00244	0.619
LIG_14-3-3_CanoR_1	842	846	PF00244	0.704
LIG_14-3-3_CanoR_1	873	878	PF00244	0.739
LIG_14-3-3_CanoR_1	91	96	PF00244	0.664
LIG_Actin_WH2_2	336	351	PF00022	0.810
LIG_deltaCOP1_diTrp_1	671	678	PF00928	0.548
LIG_FHA_1	179	185	PF00498	0.676
LIG_FHA_1	215	221	PF00498	0.783
LIG_FHA_1	334	340	PF00498	0.804
LIG_FHA_1	512	518	PF00498	0.844
LIG_FHA_1	719	725	PF00498	0.364
LIG_FHA_1	735	741	PF00498	0.451
LIG_FHA_1	80	86	PF00498	0.656
LIG_FHA_1	823	829	PF00498	0.711
LIG_FHA_2	326	332	PF00498	0.675
LIG_FHA_2	593	599	PF00498	0.716
LIG_FHA_2	930	936	PF00498	0.752
LIG_Integrin_RGD_1	312	314	PF01839	0.482
LIG_LIR_Apic_2	1009	1015	PF02991	0.725
LIG_LIR_Apic_2	656	660	PF02991	0.766
LIG_LIR_Gen_1	402	409	PF02991	0.779
LIG_LIR_Gen_1	671	678	PF02991	0.548
LIG_LIR_LC3C_4	336	340	PF02991	0.654
LIG_LIR_Nem_3	240	246	PF02991	0.846
LIG_LIR_Nem_3	361	365	PF02991	0.659
LIG_LIR_Nem_3	394	400	PF02991	0.786
LIG_LIR_Nem_3	402	406	PF02991	0.702
LIG_LIR_Nem_3	671	675	PF02991	0.549
LIG_LIR_Nem_3	728	734	PF02991	0.277
LIG_LYPXL_yS_3	397	400	PF13949	0.794
LIG_MAD2	652	660	PF02301	0.601
LIG_MAD2	739	747	PF02301	0.433
LIG_Pex14_2	399	403	PF04695	0.786
LIG_SH2_PTP2	657	660	PF00017	0.733
LIG_SH2_STAT3	624	627	PF00017	0.653
LIG_SH2_STAT5	22	25	PF00017	0.632
LIG_SH2_STAT5	657	660	PF00017	0.733
LIG_SH2_STAT5	725	728	PF00017	0.530
LIG_SH2_STAT5	793	796	PF00017	0.612
LIG_SH2_STAT5	877	880	PF00017	0.667
LIG_SH3_3	219	225	PF00018	0.810
LIG_SH3_3	226	232	PF00018	0.747
LIG_SH3_3	361	367	PF00018	0.686
LIG_SH3_3	514	520	PF00018	0.849
LIG_SH3_3	566	572	PF00018	0.669
LIG_SH3_3	713	719	PF00018	0.755
LIG_SH3_3	72	78	PF00018	0.853
LIG_SH3_3	726	732	PF00018	0.358
LIG_SH3_3	894	900	PF00018	0.821
LIG_SH3_3	909	915	PF00018	0.594
LIG_SH3_3	928	934	PF00018	0.585
LIG_SH3_4	802	809	PF00018	0.586
LIG_SH3_CIN85_PxpxPR_1	74	79	PF14604	0.670
LIG_Sin3_3	463	470	PF02671	0.640
LIG_Sin3_3	892	899	PF02671	0.646
LIG_SUMO_SIM_anti_2	814	820	PF11976	0.692
LIG_SUMO_SIM_par_1	210	217	PF11976	0.817
LIG_SUMO_SIM_par_1	814	820	PF11976	0.692
LIG_TRAF2_1	29	32	PF00917	0.659
LIG_UBA3_1	705	714	PF00899	0.706
LIG_WRC_WIRS_1	818	823	PF05994	0.695
MOD_CDK_SPK_2	605	610	PF00069	0.715
MOD_CK1_1	124	130	PF00069	0.853
MOD_CK1_1	148	154	PF00069	0.704
MOD_CK1_1	155	161	PF00069	0.670
MOD_CK1_1	203	209	PF00069	0.723
MOD_CK1_1	250	256	PF00069	0.857
MOD_CK1_1	270	276	PF00069	0.632
MOD_CK1_1	282	288	PF00069	0.713
MOD_CK1_1	291	297	PF00069	0.639
MOD_CK1_1	316	322	PF00069	0.696
MOD_CK1_1	333	339	PF00069	0.683
MOD_CK1_1	368	374	PF00069	0.811
MOD_CK1_1	390	396	PF00069	0.690
MOD_CK1_1	476	482	PF00069	0.642
MOD_CK1_1	513	519	PF00069	0.824
MOD_CK1_1	593	599	PF00069	0.869
MOD_CK1_1	643	649	PF00069	0.815
MOD_CK1_1	679	685	PF00069	0.735
MOD_CK1_1	777	783	PF00069	0.662
MOD_CK1_1	883	889	PF00069	0.816
MOD_CK1_1	929	935	PF00069	0.637
MOD_CK1_1	957	963	PF00069	0.709
MOD_CK2_1	325	331	PF00069	0.679
MOD_CK2_1	5	11	PF00069	0.712
MOD_CK2_1	628	634	PF00069	0.670
MOD_CK2_1	643	649	PF00069	0.707
MOD_CK2_1	817	823	PF00069	0.611
MOD_CK2_1	901	907	PF00069	0.796
MOD_Cter_Amidation	343	346	PF01082	0.591
MOD_GlcNHglycan	123	126	PF01048	0.616
MOD_GlcNHglycan	133	136	PF01048	0.600
MOD_GlcNHglycan	147	150	PF01048	0.498
MOD_GlcNHglycan	158	161	PF01048	0.478
MOD_GlcNHglycan	173	176	PF01048	0.577
MOD_GlcNHglycan	178	181	PF01048	0.603
MOD_GlcNHglycan	184	187	PF01048	0.567
MOD_GlcNHglycan	205	208	PF01048	0.589
MOD_GlcNHglycan	269	272	PF01048	0.661
MOD_GlcNHglycan	309	312	PF01048	0.566
MOD_GlcNHglycan	446	449	PF01048	0.538
MOD_GlcNHglycan	468	471	PF01048	0.588
MOD_GlcNHglycan	475	478	PF01048	0.532
MOD_GlcNHglycan	540	543	PF01048	0.637
MOD_GlcNHglycan	545	548	PF01048	0.566
MOD_GlcNHglycan	628	631	PF01048	0.523
MOD_GlcNHglycan	678	681	PF01048	0.560
MOD_GlcNHglycan	7	10	PF01048	0.506
MOD_GlcNHglycan	767	770	PF01048	0.541
MOD_GlcNHglycan	776	779	PF01048	0.503
MOD_GlcNHglycan	904	907	PF01048	0.593
MOD_GlcNHglycan	935	939	PF01048	0.637
MOD_GlcNHglycan	940	943	PF01048	0.591
MOD_GlcNHglycan	956	959	PF01048	0.398
MOD_GSK3_1	112	119	PF00069	0.852
MOD_GSK3_1	121	128	PF00069	0.783
MOD_GSK3_1	148	155	PF00069	0.859
MOD_GSK3_1	158	165	PF00069	0.744
MOD_GSK3_1	178	185	PF00069	0.633
MOD_GSK3_1	188	195	PF00069	0.696
MOD_GSK3_1	250	257	PF00069	0.857
MOD_GSK3_1	262	269	PF00069	0.728
MOD_GSK3_1	312	319	PF00069	0.764
MOD_GSK3_1	327	334	PF00069	0.730
MOD_GSK3_1	387	394	PF00069	0.667
MOD_GSK3_1	440	447	PF00069	0.842
MOD_GSK3_1	492	499	PF00069	0.718
MOD_GSK3_1	509	516	PF00069	0.706
MOD_GSK3_1	55	62	PF00069	0.797
MOD_GSK3_1	586	593	PF00069	0.808
MOD_GSK3_1	679	686	PF00069	0.738
MOD_GSK3_1	791	798	PF00069	0.624
MOD_GSK3_1	869	876	PF00069	0.829
MOD_GSK3_1	87	94	PF00069	0.651
MOD_GSK3_1	881	888	PF00069	0.694
MOD_GSK3_1	922	929	PF00069	0.636
MOD_GSK3_1	934	941	PF00069	0.806
MOD_GSK3_1	957	964	PF00069	0.670
MOD_LATS_1	260	266	PF00433	0.869
MOD_N-GLC_1	152	157	PF02516	0.628
MOD_N-GLC_1	375	380	PF02516	0.582
MOD_NEK2_1	214	219	PF00069	0.794
MOD_NEK2_1	279	284	PF00069	0.855
MOD_NEK2_1	358	363	PF00069	0.785
MOD_NEK2_1	444	449	PF00069	0.843
MOD_NEK2_1	487	492	PF00069	0.722
MOD_NEK2_1	734	739	PF00069	0.571
MOD_NEK2_1	87	92	PF00069	0.829
MOD_NEK2_1	901	906	PF00069	0.797
MOD_NEK2_1	926	931	PF00069	0.766
MOD_NEK2_2	440	445	PF00069	0.660
MOD_PIKK_1	643	649	PF00454	0.815
MOD_PIKK_1	94	100	PF00454	0.852
MOD_PKA_1	586	592	PF00069	0.681
MOD_PKA_2	261	267	PF00069	0.772
MOD_PKA_2	279	285	PF00069	0.632
MOD_PKA_2	289	295	PF00069	0.721
MOD_PKA_2	586	592	PF00069	0.681
MOD_PKA_2	841	847	PF00069	0.708
MOD_PKB_1	77	85	PF00069	0.841
MOD_Plk_1	188	194	PF00069	0.673
MOD_Plk_1	239	245	PF00069	0.847
MOD_Plk_1	330	336	PF00069	0.670
MOD_Plk_1	683	689	PF00069	0.709
MOD_Plk_1	795	801	PF00069	0.640
MOD_Plk_1	822	828	PF00069	0.616
MOD_Plk_1	830	836	PF00069	0.648
MOD_Plk_2-3	239	245	PF00069	0.667
MOD_Plk_2-3	817	823	PF00069	0.699
MOD_Plk_4	1007	1013	PF00069	0.715
MOD_Plk_4	368	374	PF00069	0.748
MOD_Plk_4	637	643	PF00069	0.724
MOD_Plk_4	653	659	PF00069	0.567
MOD_Plk_4	753	759	PF00069	0.530
MOD_Plk_4	785	791	PF00069	0.778
MOD_Plk_4	830	836	PF00069	0.740
MOD_Plk_4	873	879	PF00069	0.658
MOD_Plk_4	91	97	PF00069	0.664
MOD_Plk_4	922	928	PF00069	0.736
MOD_ProDKin_1	119	125	PF00069	0.718
MOD_ProDKin_1	282	288	PF00069	0.757
MOD_ProDKin_1	314	320	PF00069	0.752
MOD_ProDKin_1	363	369	PF00069	0.837
MOD_ProDKin_1	458	464	PF00069	0.649
MOD_ProDKin_1	482	488	PF00069	0.721
MOD_ProDKin_1	578	584	PF00069	0.803
MOD_ProDKin_1	605	611	PF00069	0.711
MOD_ProDKin_1	715	721	PF00069	0.659
MOD_ProDKin_1	883	889	PF00069	0.654
TRG_DiLeu_BaEn_1	210	215	PF01217	0.648
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.830
TRG_ENDOCYTIC_2	397	400	PF00928	0.794
TRG_ER_diArg_1	345	347	PF00400	0.801
TRG_ER_diArg_1	558	561	PF00400	0.818
TRG_ER_diArg_1	614	616	PF00400	0.836
TRG_ER_diArg_1	709	711	PF00400	0.706
TRG_ER_diArg_1	76	79	PF00400	0.670
TRG_ER_diArg_1	910	912	PF00400	0.779
TRG_ER_diArg_1	948	951	PF00400	0.830
TRG_NES_CRM1_1	728	744	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ87	Leishmania donovani	66%	100%
A4I1M8	Leishmania infantum	66%	100%
E9AXR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q9Q9	Leishmania major	65%	97%