Cytochrome_c_oxidase_assembly_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEI9_LEIBR

TriTrypDb:

LbrM.25.2460 , LBRM2903_250027100

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.488
CLV_NRD_NRD_1	246	248	PF00675	0.574
CLV_NRD_NRD_1	26	28	PF00675	0.559
CLV_NRD_NRD_1	58	60	PF00675	0.477
CLV_PCSK_KEX2_1	185	187	PF00082	0.455
CLV_PCSK_KEX2_1	240	242	PF00082	0.476
CLV_PCSK_KEX2_1	246	248	PF00082	0.392
CLV_PCSK_KEX2_1	26	28	PF00082	0.560
CLV_PCSK_KEX2_1	58	60	PF00082	0.477
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.479
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.477
CLV_PCSK_SKI1_1	182	186	PF00082	0.492
CLV_PCSK_SKI1_1	192	196	PF00082	0.511
CLV_PCSK_SKI1_1	264	268	PF00082	0.538
CLV_PCSK_SKI1_1	59	63	PF00082	0.665
DEG_APCC_DBOX_1	58	66	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.733
DOC_MAPK_DCC_7	58	67	PF00069	0.396
DOC_MAPK_gen_1	58	67	PF00069	0.396
DOC_MAPK_MEF2A_6	60	69	PF00069	0.493
DOC_MAPK_RevD_3	226	241	PF00069	0.598
DOC_PP4_FxxP_1	166	169	PF00568	0.445
DOC_PP4_FxxP_1	248	251	PF00568	0.503
DOC_PP4_FxxP_1	9	12	PF00568	0.726
DOC_USP7_MATH_1	76	80	PF00917	0.429
DOC_USP7_UBL2_3	188	192	PF12436	0.622
DOC_USP7_UBL2_3	221	225	PF12436	0.481
DOC_WW_Pin1_4	124	129	PF00397	0.561
LIG_14-3-3_CanoR_1	240	244	PF00244	0.494
LIG_14-3-3_CanoR_1	262	267	PF00244	0.599
LIG_14-3-3_CanoR_1	75	81	PF00244	0.443
LIG_BRCT_BRCA1_1	112	116	PF00533	0.413
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.522
LIG_EH1_1	37	45	PF00400	0.572
LIG_EVH1_2	168	172	PF00568	0.487
LIG_FHA_1	125	131	PF00498	0.535
LIG_FHA_1	142	148	PF00498	0.324
LIG_FHA_1	69	75	PF00498	0.445
LIG_FHA_1	91	97	PF00498	0.541
LIG_FHA_2	160	166	PF00498	0.336
LIG_LIR_Apic_2	163	169	PF02991	0.449
LIG_LIR_Apic_2	6	12	PF02991	0.694
LIG_LIR_Gen_1	113	124	PF02991	0.408
LIG_LIR_Gen_1	174	184	PF02991	0.500
LIG_LIR_Nem_3	113	119	PF02991	0.392
LIG_LIR_Nem_3	174	180	PF02991	0.450
LIG_LIR_Nem_3	242	248	PF02991	0.530
LIG_PCNA_PIPBox_1	227	236	PF02747	0.495
LIG_PCNA_yPIPBox_3	221	234	PF02747	0.468
LIG_PDZ_Class_3	277	282	PF00595	0.556
LIG_Pex14_2	244	248	PF04695	0.493
LIG_SH2_NCK_1	177	181	PF00017	0.562
LIG_SH2_STAT3	233	236	PF00017	0.503
LIG_SH2_STAT3	273	276	PF00017	0.648
LIG_SH2_STAT5	203	206	PF00017	0.431
LIG_SH2_STAT5	223	226	PF00017	0.487
LIG_SH2_STAT5	89	92	PF00017	0.417
LIG_SH3_3	145	151	PF00018	0.442
LIG_SH3_3	269	275	PF00018	0.647
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.383
LIG_SUMO_SIM_par_1	210	217	PF11976	0.456
MOD_CDK_SPxxK_3	124	131	PF00069	0.567
MOD_CK2_1	76	82	PF00069	0.406
MOD_GlcNHglycan	122	125	PF01048	0.359
MOD_GlcNHglycan	13	16	PF01048	0.655
MOD_GlcNHglycan	156	159	PF01048	0.414
MOD_GlcNHglycan	204	207	PF01048	0.430
MOD_GlcNHglycan	46	49	PF01048	0.631
MOD_GSK3_1	120	127	PF00069	0.536
MOD_GSK3_1	235	242	PF00069	0.528
MOD_GSK3_1	49	56	PF00069	0.642
MOD_N-GLC_1	104	109	PF02516	0.458
MOD_N-GLC_2	104	106	PF02516	0.505
MOD_NEK2_1	202	207	PF00069	0.419
MOD_NEK2_1	239	244	PF00069	0.599
MOD_NEK2_1	44	49	PF00069	0.669
MOD_PK_1	262	268	PF00069	0.575
MOD_PKA_2	239	245	PF00069	0.529
MOD_Plk_4	39	45	PF00069	0.579
MOD_ProDKin_1	124	130	PF00069	0.552
MOD_SUMO_for_1	187	190	PF00179	0.609
MOD_SUMO_rev_2	163	169	PF00179	0.429
MOD_SUMO_rev_2	181	187	PF00179	0.566
TRG_ENDOCYTIC_2	177	180	PF00928	0.448
TRG_ENDOCYTIC_2	245	248	PF00928	0.568
TRG_ER_diArg_1	239	241	PF00400	0.499
TRG_ER_diArg_1	245	247	PF00400	0.384
TRG_ER_diArg_1	261	264	PF00400	0.622
TRG_NLS_MonoExtC_3	184	190	PF00514	0.602
TRG_NLS_MonoExtN_4	182	189	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J2	Leptomonas seymouri	81%	100%
A0A0S4ITS5	Bodo saltans	58%	100%
A0A1X0NY80	Trypanosomatidae	68%	100%
A0A3S7WZA4	Leishmania donovani	88%	100%
A4I1M9	Leishmania infantum	88%	100%
C9ZK74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9AXR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9Q8	Leishmania major	89%	100%
V5BHW7	Trypanosoma cruzi	67%	100%