Casein kinase I, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania braziliensis

UniProt:

A4HEI6_LEIBR

TriTrypDb:

LbrM.25.2430 , LBRM2903_250024500

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HEI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEI6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.329
CLV_NRD_NRD_1	263	265	PF00675	0.337
CLV_NRD_NRD_1	341	343	PF00675	0.364
CLV_NRD_NRD_1	461	463	PF00675	0.515
CLV_NRD_NRD_1	53	55	PF00675	0.375
CLV_PCSK_KEX2_1	169	171	PF00082	0.329
CLV_PCSK_KEX2_1	263	265	PF00082	0.337
CLV_PCSK_KEX2_1	341	343	PF00082	0.491
CLV_PCSK_KEX2_1	447	449	PF00082	0.505
CLV_PCSK_KEX2_1	461	463	PF00082	0.585
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.505
CLV_PCSK_SKI1_1	174	178	PF00082	0.294
CLV_PCSK_SKI1_1	198	202	PF00082	0.460
CLV_PCSK_SKI1_1	21	25	PF00082	0.354
CLV_PCSK_SKI1_1	242	246	PF00082	0.314
CLV_PCSK_SKI1_1	295	299	PF00082	0.294
CLV_PCSK_SKI1_1	303	307	PF00082	0.310
CLV_PCSK_SKI1_1	317	321	PF00082	0.247
CLV_PCSK_SKI1_1	327	331	PF00082	0.395
CLV_PCSK_SKI1_1	341	345	PF00082	0.374
CLV_PCSK_SKI1_1	506	510	PF00082	0.533
CLV_PCSK_SKI1_1	85	89	PF00082	0.477
DEG_APCC_DBOX_1	169	177	PF00400	0.294
DEG_APCC_DBOX_1	263	271	PF00400	0.275
DEG_APCC_DBOX_1	501	509	PF00400	0.489
DOC_CKS1_1	304	309	PF01111	0.386
DOC_CYCLIN_RxL_1	18	25	PF00134	0.288
DOC_CYCLIN_RxL_1	321	332	PF00134	0.351
DOC_CYCLIN_RxL_1	501	511	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.542
DOC_MAPK_gen_1	210	218	PF00069	0.330
DOC_MAPK_gen_1	231	238	PF00069	0.264
DOC_MAPK_MEF2A_6	350	357	PF00069	0.348
DOC_MAPK_NFAT4_5	350	358	PF00069	0.356
DOC_PP1_RVXF_1	223	229	PF00149	0.260
DOC_PP1_RVXF_1	325	332	PF00149	0.367
DOC_PP2B_LxvP_1	353	356	PF13499	0.522
DOC_USP7_MATH_1	105	109	PF00917	0.543
DOC_USP7_MATH_1	113	117	PF00917	0.477
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_1	392	396	PF00917	0.519
DOC_USP7_MATH_1	471	475	PF00917	0.584
DOC_USP7_UBL2_3	313	317	PF12436	0.363
DOC_USP7_UBL2_3	51	55	PF12436	0.374
DOC_WW_Pin1_4	303	308	PF00397	0.375
LIG_14-3-3_CanoR_1	169	174	PF00244	0.321
LIG_14-3-3_CanoR_1	327	332	PF00244	0.347
LIG_14-3-3_CanoR_1	350	356	PF00244	0.434
LIG_14-3-3_CanoR_1	370	376	PF00244	0.472
LIG_14-3-3_CanoR_1	396	401	PF00244	0.576
LIG_14-3-3_CanoR_1	409	417	PF00244	0.593
LIG_AP2alpha_1	33	37	PF02296	0.397
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	268	272	PF00533	0.294
LIG_BRCT_BRCA1_1	427	431	PF00533	0.454
LIG_BRCT_BRCA1_1	494	498	PF00533	0.578
LIG_deltaCOP1_diTrp_1	439	445	PF00928	0.430
LIG_FHA_1	294	300	PF00498	0.332
LIG_FHA_2	304	310	PF00498	0.351
LIG_FHA_2	425	431	PF00498	0.523
LIG_FHA_2	9	15	PF00498	0.494
LIG_LIR_Gen_1	145	155	PF02991	0.421
LIG_LIR_Gen_1	247	255	PF02991	0.324
LIG_LIR_Gen_1	269	278	PF02991	0.294
LIG_LIR_Gen_1	336	344	PF02991	0.381
LIG_LIR_Gen_1	439	450	PF02991	0.439
LIG_LIR_Nem_3	224	230	PF02991	0.294
LIG_LIR_Nem_3	247	253	PF02991	0.324
LIG_LIR_Nem_3	269	275	PF02991	0.363
LIG_LIR_Nem_3	318	322	PF02991	0.501
LIG_LIR_Nem_3	32	36	PF02991	0.440
LIG_LIR_Nem_3	336	340	PF02991	0.255
LIG_LIR_Nem_3	439	445	PF02991	0.430
LIG_LIR_Nem_3	66	72	PF02991	0.431
LIG_LYPXL_yS_3	59	62	PF13949	0.353
LIG_NRBOX	83	89	PF00104	0.372
LIG_PDZ_Class_2	511	516	PF00595	0.489
LIG_Pex14_2	33	37	PF04695	0.417
LIG_PTB_Apo_2	27	34	PF02174	0.415
LIG_SH2_CRK	250	254	PF00017	0.324
LIG_SH2_CRK	337	341	PF00017	0.482
LIG_SH2_CRK	69	73	PF00017	0.394
LIG_SH2_GRB2like	337	340	PF00017	0.295
LIG_SH2_STAP1	438	442	PF00017	0.430
LIG_SH2_STAP1	64	68	PF00017	0.374
LIG_SH2_STAT3	40	43	PF00017	0.275
LIG_SH2_STAT5	141	144	PF00017	0.294
LIG_SH2_STAT5	166	169	PF00017	0.260
LIG_SH2_STAT5	189	192	PF00017	0.301
LIG_SH2_STAT5	217	220	PF00017	0.428
LIG_SH2_STAT5	250	253	PF00017	0.314
LIG_SH2_STAT5	276	279	PF00017	0.305
LIG_SH2_STAT5	322	325	PF00017	0.361
LIG_SH3_3	131	137	PF00018	0.398
LIG_SH3_3	355	361	PF00018	0.419
LIG_SH3_3	370	376	PF00018	0.559
LIG_SH3_3	4	10	PF00018	0.437
LIG_SH3_3	417	423	PF00018	0.507
LIG_SUMO_SIM_anti_2	306	312	PF11976	0.371
LIG_SUMO_SIM_par_1	175	181	PF11976	0.425
LIG_SUMO_SIM_par_1	377	382	PF11976	0.458
LIG_SUMO_SIM_par_1	393	402	PF11976	0.625
LIG_SUMO_SIM_par_1	422	430	PF11976	0.461
MOD_CK1_1	172	178	PF00069	0.314
MOD_CK1_1	399	405	PF00069	0.576
MOD_CK1_1	408	414	PF00069	0.473
MOD_CK1_1	453	459	PF00069	0.498
MOD_CK1_1	467	473	PF00069	0.524
MOD_CK1_1	474	480	PF00069	0.703
MOD_CK1_1	490	496	PF00069	0.520
MOD_CK1_1	63	69	PF00069	0.332
MOD_CK2_1	303	309	PF00069	0.341
MOD_CK2_1	388	394	PF00069	0.466
MOD_CK2_1	8	14	PF00069	0.549
MOD_GlcNHglycan	113	116	PF01048	0.440
MOD_GlcNHglycan	361	364	PF01048	0.564
MOD_GlcNHglycan	365	368	PF01048	0.556
MOD_GlcNHglycan	381	384	PF01048	0.511
MOD_GlcNHglycan	390	393	PF01048	0.440
MOD_GlcNHglycan	401	404	PF01048	0.463
MOD_GlcNHglycan	469	472	PF01048	0.567
MOD_GlcNHglycan	473	476	PF01048	0.682
MOD_GlcNHglycan	510	513	PF01048	0.677
MOD_GlcNHglycan	94	97	PF01048	0.443
MOD_GSK3_1	101	108	PF00069	0.518
MOD_GSK3_1	299	306	PF00069	0.367
MOD_GSK3_1	359	366	PF00069	0.494
MOD_GSK3_1	384	391	PF00069	0.565
MOD_GSK3_1	392	399	PF00069	0.512
MOD_GSK3_1	401	408	PF00069	0.466
MOD_GSK3_1	453	460	PF00069	0.563
MOD_GSK3_1	467	474	PF00069	0.542
MOD_GSK3_1	488	495	PF00069	0.581
MOD_GSK3_1	88	95	PF00069	0.452
MOD_N-GLC_1	29	34	PF02516	0.419
MOD_N-GLC_1	363	368	PF02516	0.492
MOD_N-GLC_1	92	97	PF02516	0.499
MOD_N-GLC_2	165	167	PF02516	0.260
MOD_NEK2_1	22	27	PF00069	0.377
MOD_NEK2_1	244	249	PF00069	0.314
MOD_NEK2_1	259	264	PF00069	0.167
MOD_NEK2_1	329	334	PF00069	0.422
MOD_NEK2_1	351	356	PF00069	0.459
MOD_NEK2_1	379	384	PF00069	0.496
MOD_NEK2_1	450	455	PF00069	0.545
MOD_NEK2_1	508	513	PF00069	0.523
MOD_NEK2_1	88	93	PF00069	0.399
MOD_NEK2_2	96	101	PF00069	0.480
MOD_PIKK_1	329	335	PF00454	0.352
MOD_PIKK_1	408	414	PF00454	0.563
MOD_PIKK_1	41	47	PF00454	0.310
MOD_PIKK_1	464	470	PF00454	0.566
MOD_PIKK_1	488	494	PF00454	0.561
MOD_PK_1	249	255	PF00069	0.324
MOD_PK_1	396	402	PF00069	0.577
MOD_PKA_1	169	175	PF00069	0.314
MOD_PKA_1	231	237	PF00069	0.294
MOD_PKA_2	169	175	PF00069	0.314
MOD_PKA_2	408	414	PF00069	0.611
MOD_Plk_1	80	86	PF00069	0.422
MOD_Plk_2-3	482	488	PF00069	0.496
MOD_Plk_4	172	178	PF00069	0.421
MOD_Plk_4	396	402	PF00069	0.641
MOD_ProDKin_1	303	309	PF00069	0.379
MOD_SUMO_for_1	200	203	PF00179	0.260
MOD_SUMO_for_1	50	53	PF00179	0.371
MOD_SUMO_rev_2	63	68	PF00179	0.326
TRG_DiLeu_BaEn_2	267	273	PF01217	0.260
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.570
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.470
TRG_ENDOCYTIC_2	148	151	PF00928	0.335
TRG_ENDOCYTIC_2	227	230	PF00928	0.357
TRG_ENDOCYTIC_2	250	253	PF00928	0.324
TRG_ENDOCYTIC_2	337	340	PF00928	0.395
TRG_ENDOCYTIC_2	59	62	PF00928	0.383
TRG_ENDOCYTIC_2	69	72	PF00928	0.424
TRG_ER_diArg_1	169	171	PF00400	0.330
TRG_ER_diArg_1	19	22	PF00400	0.307
TRG_ER_diArg_1	340	342	PF00400	0.358
TRG_ER_diArg_1	513	516	PF00400	0.531
TRG_NLS_MonoExtN_4	54	59	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H3	Leptomonas seymouri	31%	100%
A0A0N1IKB0	Leptomonas seymouri	31%	91%
A0A1X0NZS9	Trypanosomatidae	44%	100%
A0A3Q8IJ66	Leishmania donovani	45%	100%
A0A3S7WNZ6	Leishmania donovani	30%	94%
A0A3S7WZA2	Leishmania donovani	79%	100%
A0A422NL83	Trypanosoma rangeli	51%	100%
A4H436	Leishmania braziliensis	32%	100%
A4HFV0	Leishmania braziliensis	31%	92%
A4HIT6	Leishmania braziliensis	43%	100%
A4HMD1	Leishmania braziliensis	45%	100%
A4HSC0	Leishmania infantum	30%	94%
A4I1K4	Leishmania infantum	79%	100%
A4IAZ8	Leishmania infantum	45%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZM31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	75%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AXN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
O96999	Leishmania major	31%	94%
P42158	Arabidopsis thaliana	39%	100%
Q4Q6U1	Leishmania major	40%	100%
Q4Q9T3	Leishmania major	77%	97%
Q5R4V3	Pongo abelii	37%	100%
Q62763	Rattus norvegicus	38%	100%
Q6K9N1	Oryza sativa subsp. japonica	44%	100%
Q6NRT0	Xenopus laevis	41%	100%
Q86Y07	Homo sapiens	23%	100%
Q8WQ99	Caenorhabditis elegans	40%	100%
Q9NHE1	Leishmania major	45%	100%
Q9Y6M4	Homo sapiens	38%	100%