WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEI4_LEIBR

TriTrypDb:

LbrM.25.2410 , LBRM2903_250024700

Length:

1165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HEI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.540
CLV_C14_Caspase3-7	570	574	PF00656	0.460
CLV_C14_Caspase3-7	694	698	PF00656	0.412
CLV_NRD_NRD_1	110	112	PF00675	0.528
CLV_NRD_NRD_1	201	203	PF00675	0.411
CLV_NRD_NRD_1	241	243	PF00675	0.391
CLV_NRD_NRD_1	268	270	PF00675	0.381
CLV_NRD_NRD_1	290	292	PF00675	0.553
CLV_NRD_NRD_1	55	57	PF00675	0.517
CLV_NRD_NRD_1	605	607	PF00675	0.422
CLV_PCSK_KEX2_1	109	111	PF00082	0.504
CLV_PCSK_KEX2_1	152	154	PF00082	0.572
CLV_PCSK_KEX2_1	201	203	PF00082	0.411
CLV_PCSK_KEX2_1	241	243	PF00082	0.391
CLV_PCSK_KEX2_1	268	270	PF00082	0.381
CLV_PCSK_KEX2_1	290	292	PF00082	0.553
CLV_PCSK_KEX2_1	509	511	PF00082	0.337
CLV_PCSK_KEX2_1	688	690	PF00082	0.340
CLV_PCSK_KEX2_1	972	974	PF00082	0.383
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.492
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.337
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.340
CLV_PCSK_PC1ET2_1	972	974	PF00082	0.383
CLV_PCSK_SKI1_1	1041	1045	PF00082	0.385
CLV_PCSK_SKI1_1	269	273	PF00082	0.296
CLV_PCSK_SKI1_1	330	334	PF00082	0.495
CLV_PCSK_SKI1_1	337	341	PF00082	0.325
CLV_PCSK_SKI1_1	464	468	PF00082	0.381
CLV_PCSK_SKI1_1	510	514	PF00082	0.349
CLV_PCSK_SKI1_1	518	522	PF00082	0.356
CLV_PCSK_SKI1_1	523	527	PF00082	0.314
CLV_PCSK_SKI1_1	558	562	PF00082	0.402
CLV_PCSK_SKI1_1	56	60	PF00082	0.330
CLV_PCSK_SKI1_1	738	742	PF00082	0.628
CLV_PCSK_SKI1_1	77	81	PF00082	0.400
CLV_PCSK_SKI1_1	781	785	PF00082	0.344
CLV_PCSK_SKI1_1	809	813	PF00082	0.298
CLV_PCSK_SKI1_1	972	976	PF00082	0.419
DEG_APCC_DBOX_1	1068	1076	PF00400	0.368
DEG_APCC_DBOX_1	509	517	PF00400	0.362
DEG_APCC_DBOX_1	972	980	PF00400	0.381
DEG_COP1_1	392	401	PF00400	0.259
DEG_ODPH_VHL_1	812	825	PF01847	0.390
DEG_SCF_FBW7_1	581	588	PF00400	0.472
DOC_CKS1_1	452	457	PF01111	0.495
DOC_MAPK_gen_1	109	118	PF00069	0.477
DOC_MAPK_gen_1	201	209	PF00069	0.376
DOC_MAPK_gen_1	509	516	PF00069	0.322
DOC_MAPK_gen_1	792	800	PF00069	0.483
DOC_MAPK_gen_1	927	934	PF00069	0.421
DOC_MAPK_MEF2A_6	180	189	PF00069	0.446
DOC_MAPK_MEF2A_6	509	516	PF00069	0.322
DOC_PP1_RVXF_1	266	273	PF00149	0.296
DOC_PP1_RVXF_1	375	382	PF00149	0.303
DOC_PP4_FxxP_1	430	433	PF00568	0.330
DOC_PP4_FxxP_1	452	455	PF00568	0.471
DOC_PP4_FxxP_1	816	819	PF00568	0.333
DOC_SPAK_OSR1_1	1035	1039	PF12202	0.183
DOC_SPAK_OSR1_1	96	100	PF12202	0.315
DOC_USP7_MATH_1	1091	1095	PF00917	0.384
DOC_USP7_MATH_1	389	393	PF00917	0.283
DOC_USP7_MATH_1	585	589	PF00917	0.603
DOC_USP7_MATH_1	608	612	PF00917	0.383
DOC_USP7_MATH_1	829	833	PF00917	0.491
DOC_USP7_MATH_1	835	839	PF00917	0.569
DOC_USP7_MATH_1	869	873	PF00917	0.342
DOC_USP7_MATH_1	9	13	PF00917	0.467
DOC_USP7_UBL2_3	333	337	PF12436	0.413
DOC_WW_Pin1_4	187	192	PF00397	0.430
DOC_WW_Pin1_4	281	286	PF00397	0.325
DOC_WW_Pin1_4	451	456	PF00397	0.469
DOC_WW_Pin1_4	581	586	PF00397	0.509
DOC_WW_Pin1_4	615	620	PF00397	0.377
DOC_WW_Pin1_4	696	701	PF00397	0.494
DOC_WW_Pin1_4	7	12	PF00397	0.560
DOC_WW_Pin1_4	714	719	PF00397	0.252
DOC_WW_Pin1_4	839	844	PF00397	0.648
DOC_WW_Pin1_4	913	918	PF00397	0.401
LIG_14-3-3_CanoR_1	291	297	PF00244	0.516
LIG_14-3-3_CanoR_1	523	528	PF00244	0.341
LIG_14-3-3_CanoR_1	680	685	PF00244	0.296
LIG_14-3-3_CanoR_1	96	106	PF00244	0.546
LIG_Actin_RPEL_3	503	522	PF02755	0.445
LIG_Actin_WH2_2	361	379	PF00022	0.285
LIG_BRCT_BRCA1_1	391	395	PF00533	0.275
LIG_Clathr_ClatBox_1	1118	1122	PF01394	0.373
LIG_CSL_BTD_1	722	725	PF09270	0.484
LIG_deltaCOP1_diTrp_1	21	24	PF00928	0.297
LIG_FHA_1	1002	1008	PF00498	0.302
LIG_FHA_1	1062	1068	PF00498	0.359
LIG_FHA_1	1091	1097	PF00498	0.504
LIG_FHA_1	117	123	PF00498	0.419
LIG_FHA_1	159	165	PF00498	0.376
LIG_FHA_1	262	268	PF00498	0.304
LIG_FHA_1	298	304	PF00498	0.287
LIG_FHA_1	537	543	PF00498	0.294
LIG_FHA_1	561	567	PF00498	0.634
LIG_FHA_1	63	69	PF00498	0.312
LIG_FHA_1	670	676	PF00498	0.486
LIG_FHA_1	700	706	PF00498	0.474
LIG_FHA_1	8	14	PF00498	0.357
LIG_FHA_1	881	887	PF00498	0.425
LIG_FHA_1	919	925	PF00498	0.394
LIG_FHA_2	1045	1051	PF00498	0.418
LIG_FHA_2	1076	1082	PF00498	0.383
LIG_FHA_2	401	407	PF00498	0.526
LIG_FHA_2	429	435	PF00498	0.427
LIG_FHA_2	548	554	PF00498	0.409
LIG_FHA_2	568	574	PF00498	0.415
LIG_FHA_2	671	677	PF00498	0.376
LIG_FHA_2	885	891	PF00498	0.385
LIG_FHA_2	98	104	PF00498	0.450
LIG_GBD_Chelix_1	1088	1096	PF00786	0.436
LIG_GBD_Chelix_1	368	376	PF00786	0.341
LIG_Integrin_RGD_1	866	868	PF01839	0.458
LIG_Integrin_RGD_1	910	912	PF01839	0.263
LIG_LIR_Apic_2	815	819	PF02991	0.335
LIG_LIR_Gen_1	1029	1038	PF02991	0.274
LIG_LIR_Gen_1	1070	1077	PF02991	0.526
LIG_LIR_Gen_1	248	259	PF02991	0.490
LIG_LIR_Gen_1	392	402	PF02991	0.482
LIG_LIR_Gen_1	692	700	PF02991	0.343
LIG_LIR_Gen_1	719	725	PF02991	0.360
LIG_LIR_Gen_1	918	924	PF02991	0.576
LIG_LIR_Nem_3	1029	1033	PF02991	0.320
LIG_LIR_Nem_3	1052	1058	PF02991	0.352
LIG_LIR_Nem_3	1070	1076	PF02991	0.339
LIG_LIR_Nem_3	178	184	PF02991	0.312
LIG_LIR_Nem_3	248	254	PF02991	0.422
LIG_LIR_Nem_3	392	398	PF02991	0.440
LIG_LIR_Nem_3	515	520	PF02991	0.346
LIG_LIR_Nem_3	526	530	PF02991	0.289
LIG_LIR_Nem_3	649	653	PF02991	0.370
LIG_LIR_Nem_3	692	696	PF02991	0.351
LIG_LIR_Nem_3	719	724	PF02991	0.371
LIG_LIR_Nem_3	793	799	PF02991	0.429
LIG_LIR_Nem_3	918	923	PF02991	0.575
LIG_LIR_Nem_3	955	959	PF02991	0.335
LIG_NRBOX	1071	1077	PF00104	0.398
LIG_NRBOX	1091	1097	PF00104	0.225
LIG_NRBOX	783	789	PF00104	0.390
LIG_PALB2_WD40_1	377	385	PF16756	0.326
LIG_PCNA_PIPBox_1	365	374	PF02747	0.289
LIG_PCNA_PIPBox_1	412	421	PF02747	0.281
LIG_PCNA_PIPBox_1	950	959	PF02747	0.325
LIG_RPA_C_Fungi	1107	1119	PF08784	0.465
LIG_SH2_CRK	1040	1044	PF00017	0.320
LIG_SH2_CRK	181	185	PF00017	0.315
LIG_SH2_CRK	283	287	PF00017	0.341
LIG_SH2_CRK	69	73	PF00017	0.339
LIG_SH2_CRK	959	963	PF00017	0.311
LIG_SH2_GRB2like	1037	1040	PF00017	0.262
LIG_SH2_GRB2like	1124	1127	PF00017	0.346
LIG_SH2_GRB2like	638	641	PF00017	0.290
LIG_SH2_NCK_1	1005	1009	PF00017	0.317
LIG_SH2_NCK_1	693	697	PF00017	0.367
LIG_SH2_SRC	304	307	PF00017	0.352
LIG_SH2_SRC	636	639	PF00017	0.407
LIG_SH2_SRC	744	747	PF00017	0.458
LIG_SH2_STAP1	1124	1128	PF00017	0.491
LIG_SH2_STAT3	794	797	PF00017	0.402
LIG_SH2_STAT3	958	961	PF00017	0.310
LIG_SH2_STAT5	1037	1040	PF00017	0.262
LIG_SH2_STAT5	195	198	PF00017	0.309
LIG_SH2_STAT5	304	307	PF00017	0.352
LIG_SH2_STAT5	359	362	PF00017	0.265
LIG_SH2_STAT5	5	8	PF00017	0.592
LIG_SH2_STAT5	506	509	PF00017	0.333
LIG_SH2_STAT5	60	63	PF00017	0.320
LIG_SH2_STAT5	638	641	PF00017	0.513
LIG_SH2_STAT5	799	802	PF00017	0.387
LIG_SH2_STAT5	956	959	PF00017	0.315
LIG_SH3_3	1079	1085	PF00018	0.300
LIG_SH3_3	300	306	PF00018	0.375
LIG_SH3_3	484	490	PF00018	0.344
LIG_SH3_3	808	814	PF00018	0.298
LIG_SH3_3	929	935	PF00018	0.410
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.563
LIG_SUMO_SIM_par_1	183	188	PF11976	0.217
LIG_SUMO_SIM_par_1	389	394	PF11976	0.342
LIG_SUMO_SIM_par_1	400	406	PF11976	0.411
LIG_SUMO_SIM_par_1	442	448	PF11976	0.236
LIG_SUMO_SIM_par_1	510	515	PF11976	0.342
LIG_SUMO_SIM_par_1	785	791	PF11976	0.383
LIG_TRAF2_1	403	406	PF00917	0.434
LIG_TRAF2_1	550	553	PF00917	0.367
LIG_TRAF2_1	611	614	PF00917	0.376
LIG_TRAF2_1	996	999	PF00917	0.434
LIG_TYR_ITIM	1038	1043	PF00017	0.297
LIG_TYR_ITIM	67	72	PF00017	0.317
LIG_TYR_ITIM	691	696	PF00017	0.345
LIG_WRC_WIRS_1	251	256	PF05994	0.370
MOD_CK1_1	39	45	PF00069	0.482
MOD_CK1_1	400	406	PF00069	0.311
MOD_CK1_1	618	624	PF00069	0.413
MOD_CK1_1	699	705	PF00069	0.529
MOD_CK1_1	713	719	PF00069	0.303
MOD_CK1_1	801	807	PF00069	0.329
MOD_CK1_1	837	843	PF00069	0.610
MOD_CK1_1	85	91	PF00069	0.345
MOD_CK1_1	881	887	PF00069	0.397
MOD_CK1_1	918	924	PF00069	0.391
MOD_CK2_1	1075	1081	PF00069	0.375
MOD_CK2_1	271	277	PF00069	0.292
MOD_CK2_1	400	406	PF00069	0.453
MOD_CK2_1	547	553	PF00069	0.357
MOD_CK2_1	608	614	PF00069	0.410
MOD_CK2_1	670	676	PF00069	0.463
MOD_CK2_1	695	701	PF00069	0.467
MOD_CK2_1	9	15	PF00069	0.466
MOD_CK2_1	913	919	PF00069	0.495
MOD_CK2_1	97	103	PF00069	0.450
MOD_CK2_1	993	999	PF00069	0.309
MOD_GlcNHglycan	1147	1150	PF01048	0.586
MOD_GlcNHglycan	125	128	PF01048	0.607
MOD_GlcNHglycan	166	169	PF01048	0.537
MOD_GlcNHglycan	216	219	PF01048	0.518
MOD_GlcNHglycan	312	315	PF01048	0.278
MOD_GlcNHglycan	38	41	PF01048	0.557
MOD_GlcNHglycan	446	450	PF01048	0.358
MOD_GlcNHglycan	497	500	PF01048	0.295
MOD_GlcNHglycan	778	781	PF01048	0.643
MOD_GlcNHglycan	831	834	PF01048	0.415
MOD_GSK3_1	183	190	PF00069	0.412
MOD_GSK3_1	210	217	PF00069	0.537
MOD_GSK3_1	348	355	PF00069	0.282
MOD_GSK3_1	35	42	PF00069	0.337
MOD_GSK3_1	435	442	PF00069	0.444
MOD_GSK3_1	460	467	PF00069	0.611
MOD_GSK3_1	561	568	PF00069	0.636
MOD_GSK3_1	58	65	PF00069	0.298
MOD_GSK3_1	580	587	PF00069	0.439
MOD_GSK3_1	638	645	PF00069	0.410
MOD_GSK3_1	695	702	PF00069	0.362
MOD_GSK3_1	710	717	PF00069	0.352
MOD_GSK3_1	726	733	PF00069	0.339
MOD_GSK3_1	82	89	PF00069	0.354
MOD_GSK3_1	834	841	PF00069	0.593
MOD_GSK3_1	880	887	PF00069	0.318
MOD_GSK3_1	915	922	PF00069	0.297
MOD_N-GLC_1	297	302	PF02516	0.306
MOD_N-GLC_1	35	40	PF02516	0.379
MOD_N-GLC_1	561	566	PF02516	0.633
MOD_N-GLC_1	801	806	PF02516	0.468
MOD_NEK2_1	1028	1033	PF00069	0.299
MOD_NEK2_1	1044	1049	PF00069	0.369
MOD_NEK2_1	118	123	PF00069	0.595
MOD_NEK2_1	185	190	PF00069	0.475
MOD_NEK2_1	261	266	PF00069	0.266
MOD_NEK2_1	292	297	PF00069	0.384
MOD_NEK2_1	299	304	PF00069	0.255
MOD_NEK2_1	310	315	PF00069	0.197
MOD_NEK2_1	352	357	PF00069	0.305
MOD_NEK2_1	435	440	PF00069	0.303
MOD_NEK2_1	62	67	PF00069	0.308
MOD_NEK2_1	623	628	PF00069	0.401
MOD_NEK2_1	695	700	PF00069	0.414
MOD_NEK2_1	705	710	PF00069	0.347
MOD_NEK2_1	730	735	PF00069	0.504
MOD_NEK2_1	987	992	PF00069	0.457
MOD_NEK2_2	104	109	PF00069	0.274
MOD_PIKK_1	1028	1034	PF00454	0.285
MOD_PIKK_1	116	122	PF00454	0.552
MOD_PIKK_1	210	216	PF00454	0.433
MOD_PIKK_1	252	258	PF00454	0.450
MOD_PIKK_1	297	303	PF00454	0.304
MOD_PIKK_1	47	53	PF00454	0.460
MOD_PIKK_1	585	591	PF00454	0.604
MOD_PIKK_1	710	716	PF00454	0.341
MOD_PIKK_1	72	78	PF00454	0.313
MOD_PIKK_1	732	738	PF00454	0.467
MOD_PIKK_1	858	864	PF00454	0.363
MOD_PIKK_1	979	985	PF00454	0.279
MOD_PK_1	680	686	PF00069	0.314
MOD_PKA_2	292	298	PF00069	0.280
MOD_PKA_2	82	88	PF00069	0.378
MOD_Plk_1	1028	1034	PF00069	0.443
MOD_Plk_1	104	110	PF00069	0.389
MOD_Plk_1	247	253	PF00069	0.401
MOD_Plk_1	335	341	PF00069	0.367
MOD_Plk_1	553	559	PF00069	0.532
MOD_Plk_1	561	567	PF00069	0.704
MOD_Plk_1	918	924	PF00069	0.426
MOD_Plk_2-3	547	553	PF00069	0.375
MOD_Plk_4	1091	1097	PF00069	0.491
MOD_Plk_4	158	164	PF00069	0.270
MOD_Plk_4	247	253	PF00069	0.521
MOD_Plk_4	299	305	PF00069	0.275
MOD_Plk_4	335	341	PF00069	0.361
MOD_Plk_4	348	354	PF00069	0.256
MOD_Plk_4	397	403	PF00069	0.318
MOD_Plk_4	439	445	PF00069	0.452
MOD_Plk_4	512	518	PF00069	0.329
MOD_Plk_4	618	624	PF00069	0.433
MOD_Plk_4	726	732	PF00069	0.532
MOD_Plk_4	807	813	PF00069	0.303
MOD_Plk_4	881	887	PF00069	0.438
MOD_Plk_4	919	925	PF00069	0.511
MOD_ProDKin_1	187	193	PF00069	0.431
MOD_ProDKin_1	281	287	PF00069	0.329
MOD_ProDKin_1	451	457	PF00069	0.481
MOD_ProDKin_1	581	587	PF00069	0.508
MOD_ProDKin_1	615	621	PF00069	0.375
MOD_ProDKin_1	696	702	PF00069	0.495
MOD_ProDKin_1	7	13	PF00069	0.548
MOD_ProDKin_1	714	720	PF00069	0.246
MOD_ProDKin_1	839	845	PF00069	0.633
MOD_ProDKin_1	913	919	PF00069	0.401
MOD_SUMO_rev_2	1157	1164	PF00179	0.441
MOD_SUMO_rev_2	28	32	PF00179	0.433
TRG_DiLeu_BaEn_1	141	146	PF01217	0.326
TRG_DiLeu_BaEn_1	701	706	PF01217	0.490
TRG_DiLeu_BaEn_4	15	21	PF01217	0.475
TRG_DiLeu_BaEn_4	405	411	PF01217	0.282
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.475
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.325
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.358
TRG_ENDOCYTIC_2	1040	1043	PF00928	0.307
TRG_ENDOCYTIC_2	181	184	PF00928	0.310
TRG_ENDOCYTIC_2	636	639	PF00928	0.440
TRG_ENDOCYTIC_2	69	72	PF00928	0.328
TRG_ENDOCYTIC_2	693	696	PF00928	0.343
TRG_ENDOCYTIC_2	959	962	PF00928	0.305
TRG_ER_diArg_1	108	111	PF00400	0.456
TRG_ER_diArg_1	240	242	PF00400	0.391
TRG_ER_diArg_1	267	269	PF00400	0.404
TRG_ER_diArg_1	290	293	PF00400	0.562
TRG_ER_diArg_1	468	471	PF00400	0.437
TRG_ER_diArg_1	907	910	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	1056	1061	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H7	Leptomonas seymouri	68%	97%
A0A0S4ILG2	Bodo saltans	43%	100%
A0A1X0NYM6	Trypanosomatidae	50%	100%
A0A3R7KE52	Trypanosoma rangeli	51%	100%
A0A3S5H7E9	Leishmania donovani	83%	100%
A4I1K6	Leishmania infantum	83%	93%
C9ZK47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AXP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q24DE2	Tetrahymena thermophila (strain SB210)	25%	100%
Q4Q9T1	Leishmania major	84%	99%
V5B2C6	Trypanosoma cruzi	51%	100%