KOW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEI0_LEIBR

TriTrypDb:

LbrM.25.2370 , LBRM2903_250025200

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEI0

PDB structure(s): 7aih_O , 7am2_O , 7ane_O

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.530
CLV_NRD_NRD_1	254	256	PF00675	0.468
CLV_NRD_NRD_1	267	269	PF00675	0.432
CLV_NRD_NRD_1	30	32	PF00675	0.333
CLV_NRD_NRD_1	388	390	PF00675	0.661
CLV_PCSK_KEX2_1	13	15	PF00082	0.457
CLV_PCSK_KEX2_1	204	206	PF00082	0.400
CLV_PCSK_KEX2_1	254	256	PF00082	0.447
CLV_PCSK_KEX2_1	30	32	PF00082	0.375
CLV_PCSK_KEX2_1	388	390	PF00082	0.661
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.460
CLV_PCSK_SKI1_1	17	21	PF00082	0.526
CLV_PCSK_SKI1_1	290	294	PF00082	0.586
DEG_APCC_DBOX_1	52	60	PF00400	0.443
DEG_Kelch_Keap1_1	195	200	PF01344	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.383
DOC_MAPK_gen_1	136	143	PF00069	0.370
DOC_MAPK_gen_1	244	252	PF00069	0.585
DOC_MAPK_gen_1	51	58	PF00069	0.493
DOC_MAPK_MEF2A_6	244	252	PF00069	0.545
DOC_PP2B_LxvP_1	214	217	PF13499	0.448
DOC_USP7_MATH_1	308	312	PF00917	0.742
DOC_USP7_UBL2_3	192	196	PF12436	0.452
DOC_WW_Pin1_4	22	27	PF00397	0.491
DOC_WW_Pin1_4	341	346	PF00397	0.627
LIG_14-3-3_CanoR_1	204	209	PF00244	0.435
LIG_14-3-3_CanoR_1	268	272	PF00244	0.527
LIG_14-3-3_CanoR_1	427	433	PF00244	0.516
LIG_Actin_WH2_2	252	270	PF00022	0.433
LIG_eIF4E_1	137	143	PF01652	0.486
LIG_FHA_1	114	120	PF00498	0.486
LIG_FHA_1	180	186	PF00498	0.446
LIG_FHA_1	196	202	PF00498	0.385
LIG_FHA_1	295	301	PF00498	0.551
LIG_FHA_1	307	313	PF00498	0.693
LIG_FHA_1	320	326	PF00498	0.668
LIG_FHA_2	156	162	PF00498	0.469
LIG_HCF-1_HBM_1	73	76	PF13415	0.437
LIG_LIR_Apic_2	270	276	PF02991	0.347
LIG_LIR_Apic_2	339	345	PF02991	0.466
LIG_LIR_Apic_2	9	15	PF02991	0.438
LIG_LIR_Gen_1	361	366	PF02991	0.578
LIG_LIR_Nem_3	361	365	PF02991	0.576
LIG_PCNA_yPIPBox_3	138	152	PF02747	0.398
LIG_PDZ_Class_1	428	433	PF00595	0.641
LIG_PTAP_UEV_1	344	349	PF05743	0.475
LIG_SH2_CRK	273	277	PF00017	0.341
LIG_SH2_CRK	342	346	PF00017	0.476
LIG_SH2_GRB2like	76	79	PF00017	0.431
LIG_SH2_PTP2	362	365	PF00017	0.578
LIG_SH2_SRC	271	274	PF00017	0.545
LIG_SH2_SRC	71	74	PF00017	0.445
LIG_SH2_STAT3	242	245	PF00017	0.378
LIG_SH2_STAT3	76	79	PF00017	0.431
LIG_SH2_STAT5	262	265	PF00017	0.449
LIG_SH2_STAT5	362	365	PF00017	0.538
LIG_SH2_STAT5	43	46	PF00017	0.560
LIG_SH2_STAT5	99	102	PF00017	0.440
LIG_SH3_1	342	348	PF00018	0.473
LIG_SH3_3	148	154	PF00018	0.423
LIG_SH3_3	342	348	PF00018	0.665
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.409
LIG_SUMO_SIM_anti_2	361	370	PF11976	0.572
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.487
LIG_SUMO_SIM_par_1	115	121	PF11976	0.384
LIG_SUMO_SIM_par_1	247	253	PF11976	0.474
LIG_TRAF2_1	218	221	PF00917	0.617
LIG_UBA3_1	38	47	PF00899	0.534
MOD_CK1_1	207	213	PF00069	0.427
MOD_CK1_1	324	330	PF00069	0.566
MOD_CK1_1	361	367	PF00069	0.598
MOD_CK2_1	155	161	PF00069	0.453
MOD_CK2_1	361	367	PF00069	0.555
MOD_GlcNHglycan	120	123	PF01048	0.450
MOD_GlcNHglycan	209	212	PF01048	0.442
MOD_GSK3_1	263	270	PF00069	0.427
MOD_GSK3_1	354	361	PF00069	0.525
MOD_N-GLC_1	22	27	PF02516	0.521
MOD_NEK2_1	229	234	PF00069	0.570
MOD_NEK2_1	263	268	PF00069	0.425
MOD_NEK2_1	300	305	PF00069	0.522
MOD_NEK2_1	358	363	PF00069	0.619
MOD_NEK2_1	58	63	PF00069	0.478
MOD_PKA_1	204	210	PF00069	0.414
MOD_PKA_2	204	210	PF00069	0.414
MOD_PKA_2	267	273	PF00069	0.539
MOD_PKA_2	294	300	PF00069	0.573
MOD_PKA_2	426	432	PF00069	0.636
MOD_PKB_1	4	12	PF00069	0.441
MOD_Plk_1	219	225	PF00069	0.565
MOD_Plk_1	238	244	PF00069	0.338
MOD_Plk_1	72	78	PF00069	0.435
MOD_Plk_2-3	238	244	PF00069	0.491
MOD_Plk_4	321	327	PF00069	0.634
MOD_Plk_4	354	360	PF00069	0.545
MOD_ProDKin_1	22	28	PF00069	0.490
MOD_ProDKin_1	341	347	PF00069	0.624
MOD_SUMO_for_1	336	339	PF00179	0.678
TRG_DiLeu_BaEn_1	209	214	PF01217	0.446
TRG_DiLeu_BaEn_1	247	252	PF01217	0.459
TRG_DiLeu_BaEn_1	54	59	PF01217	0.486
TRG_DiLeu_BaEn_4	413	419	PF01217	0.690
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.580
TRG_ENDOCYTIC_2	362	365	PF00928	0.578
TRG_ENDOCYTIC_2	97	100	PF00928	0.398
TRG_ER_diArg_1	173	176	PF00400	0.575
TRG_ER_diArg_1	204	206	PF00400	0.530
TRG_ER_diArg_1	254	256	PF00400	0.488
TRG_ER_diArg_1	29	31	PF00400	0.347
TRG_ER_diArg_1	5	8	PF00400	0.425
TRG_NES_CRM1_1	184	197	PF08389	0.486
TRG_NES_CRM1_1	283	298	PF08389	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I882	Leptomonas seymouri	74%	97%
A0A0S4INZ7	Bodo saltans	58%	100%
A0A1X0NY95	Trypanosomatidae	67%	100%
A0A3Q8IDE3	Leishmania donovani	83%	93%
A0A3R7L2D8	Trypanosoma rangeli	75%	100%
A4I1L0	Leishmania infantum	83%	93%
C9ZK52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AXP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	93%
Q4Q9S7	Leishmania major	84%	100%
V5BME2	Trypanosoma cruzi	73%	100%