LeishMANIAdb
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DUF3795 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3795 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HEH9_LEIBR
TriTrypDb:
LbrM.25.2360 , LBRM2903_250025300 *
Length:
86

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH9

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_USP7_MATH_1 53 57 PF00917 0.508
DOC_USP7_UBL2_3 80 84 PF12436 0.583
DOC_WW_Pin1_4 1 6 PF00397 0.595
DOC_WW_Pin1_4 8 13 PF00397 0.451
LIG_FHA_2 67 73 PF00498 0.486
LIG_PCNA_PIPBox_1 68 77 PF02747 0.618
LIG_PCNA_yPIPBox_3 54 68 PF02747 0.503
LIG_Pex14_2 34 38 PF04695 0.481
LIG_REV1ctd_RIR_1 32 40 PF16727 0.612
LIG_SH2_STAT5 19 22 PF00017 0.518
LIG_SH2_STAT5 74 77 PF00017 0.600
MOD_CDK_SPxxK_3 8 15 PF00069 0.458
MOD_CK2_1 66 72 PF00069 0.461
MOD_CMANNOS 83 86 PF00535 0.600
MOD_GSK3_1 48 55 PF00069 0.571
MOD_NEK2_1 25 30 PF00069 0.423
MOD_PIKK_1 26 32 PF00454 0.606
MOD_ProDKin_1 1 7 PF00069 0.589
MOD_ProDKin_1 8 14 PF00069 0.447
TRG_DiLeu_BaEn_3 39 45 PF01217 0.393
TRG_ER_FFAT_2 63 72 PF00635 0.600

Homologs

Protein Taxonomy Sequence identity Coverage
A4I1L1 Leishmania infantum 74% 72%
C9ZK53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 91%
E9AXP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q9S6 Leishmania major 73% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS