EFP_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEH8_LEIBR

TriTrypDb:

LbrM.25.2350 , LBRM2903_250025400

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.460
CLV_NRD_NRD_1	86	88	PF00675	0.255
CLV_PCSK_KEX2_1	2	4	PF00082	0.552
CLV_PCSK_KEX2_1	56	58	PF00082	0.303
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.250
CLV_PCSK_SKI1_1	108	112	PF00082	0.253
CLV_PCSK_SKI1_1	39	43	PF00082	0.389
CLV_PCSK_SKI1_1	89	93	PF00082	0.242
DEG_Nend_UBRbox_1	1	4	PF02207	0.447
DOC_CYCLIN_RxL_1	103	115	PF00134	0.351
DOC_MAPK_FxFP_2	122	125	PF00069	0.338
DOC_MAPK_gen_1	103	111	PF00069	0.356
DOC_MAPK_gen_1	45	54	PF00069	0.442
DOC_MAPK_MEF2A_6	103	111	PF00069	0.356
DOC_MAPK_MEF2A_6	45	54	PF00069	0.473
DOC_MAPK_NFAT4_5	47	55	PF00069	0.455
DOC_PP1_RVXF_1	106	112	PF00149	0.348
DOC_PP4_FxxP_1	122	125	PF00568	0.338
DOC_USP7_MATH_1	138	142	PF00917	0.421
DOC_USP7_UBL2_3	191	195	PF12436	0.390
DOC_USP7_UBL2_3	219	223	PF12436	0.374
DOC_WW_Pin1_4	125	130	PF00397	0.549
DOC_WW_Pin1_4	29	34	PF00397	0.490
LIG_FHA_1	10	16	PF00498	0.696
LIG_FHA_1	185	191	PF00498	0.335
LIG_FHA_1	203	209	PF00498	0.491
LIG_FHA_2	165	171	PF00498	0.376
LIG_LIR_Gen_1	116	126	PF02991	0.379
LIG_LIR_Gen_1	170	178	PF02991	0.396
LIG_LIR_Gen_1	98	107	PF02991	0.388
LIG_LIR_Nem_3	116	122	PF02991	0.498
LIG_LIR_Nem_3	170	175	PF02991	0.402
LIG_LIR_Nem_3	98	102	PF02991	0.407
LIG_SH2_CRK	59	63	PF00017	0.455
LIG_SH2_STAT5	181	184	PF00017	0.340
LIG_SH3_3	120	126	PF00018	0.379
LIG_SH3_3	132	138	PF00018	0.463
LIG_SH3_3	20	26	PF00018	0.701
LIG_SH3_3	218	224	PF00018	0.443
LIG_SUMO_SIM_par_1	203	210	PF11976	0.411
MOD_CK2_1	138	144	PF00069	0.424
MOD_CK2_1	164	170	PF00069	0.415
MOD_GlcNHglycan	111	114	PF01048	0.364
MOD_GlcNHglycan	17	20	PF01048	0.765
MOD_GSK3_1	164	171	PF00069	0.368
MOD_GSK3_1	173	180	PF00069	0.449
MOD_GSK3_1	29	36	PF00069	0.651
MOD_GSK3_1	5	12	PF00069	0.706
MOD_GSK3_1	78	85	PF00069	0.473
MOD_NEK2_1	109	114	PF00069	0.328
MOD_PIKK_1	33	39	PF00454	0.644
MOD_PIKK_1	64	70	PF00454	0.442
MOD_Plk_1	173	179	PF00069	0.479
MOD_Plk_2-3	164	170	PF00069	0.371
MOD_Plk_4	177	183	PF00069	0.489
MOD_ProDKin_1	125	131	PF00069	0.551
MOD_ProDKin_1	29	35	PF00069	0.490
TRG_DiLeu_BaEn_1	105	110	PF01217	0.355
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.494
TRG_DiLeu_LyEn_5	105	110	PF01217	0.355
TRG_ENDOCYTIC_2	59	62	PF00928	0.471
TRG_ER_diArg_1	1	3	PF00400	0.465
TRG_ER_diArg_1	106	109	PF00400	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC1	Leptomonas seymouri	88%	99%
A0A0S4IL43	Bodo saltans	73%	96%
A0A1X0NYW1	Trypanosomatidae	76%	100%
A0A3R7KDV7	Trypanosoma rangeli	76%	100%
A0A3S7WZ68	Leishmania donovani	89%	100%
A4I1L2	Leishmania infantum	89%	100%
C9ZK54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AXP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q9S5	Leishmania major	89%	99%