LeishMANIAdb
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Rho-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Rho-GAP domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HEH7_LEIBR
TriTrypDb:
LbrM.25.2340 , LBRM2903_250025500
Length:
966

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEH7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 432 436 PF00656 0.583
CLV_C14_Caspase3-7 927 931 PF00656 0.395
CLV_NRD_NRD_1 244 246 PF00675 0.533
CLV_NRD_NRD_1 309 311 PF00675 0.495
CLV_NRD_NRD_1 564 566 PF00675 0.659
CLV_NRD_NRD_1 782 784 PF00675 0.399
CLV_NRD_NRD_1 787 789 PF00675 0.423
CLV_NRD_NRD_1 894 896 PF00675 0.378
CLV_PCSK_KEX2_1 17 19 PF00082 0.504
CLV_PCSK_KEX2_1 181 183 PF00082 0.550
CLV_PCSK_KEX2_1 244 246 PF00082 0.497
CLV_PCSK_KEX2_1 259 261 PF00082 0.418
CLV_PCSK_KEX2_1 308 310 PF00082 0.500
CLV_PCSK_KEX2_1 335 337 PF00082 0.449
CLV_PCSK_KEX2_1 497 499 PF00082 0.559
CLV_PCSK_KEX2_1 564 566 PF00082 0.656
CLV_PCSK_KEX2_1 782 784 PF00082 0.394
CLV_PCSK_KEX2_1 786 788 PF00082 0.406
CLV_PCSK_KEX2_1 894 896 PF00082 0.378
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.504
CLV_PCSK_PC1ET2_1 181 183 PF00082 0.550
CLV_PCSK_PC1ET2_1 259 261 PF00082 0.516
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.449
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.559
CLV_PCSK_PC7_1 782 788 PF00082 0.399
CLV_PCSK_SKI1_1 17 21 PF00082 0.575
CLV_PCSK_SKI1_1 170 174 PF00082 0.541
CLV_PCSK_SKI1_1 191 195 PF00082 0.426
CLV_PCSK_SKI1_1 244 248 PF00082 0.479
CLV_PCSK_SKI1_1 343 347 PF00082 0.523
CLV_PCSK_SKI1_1 410 414 PF00082 0.450
CLV_PCSK_SKI1_1 758 762 PF00082 0.528
CLV_PCSK_SKI1_1 849 853 PF00082 0.436
CLV_PCSK_SKI1_1 864 868 PF00082 0.399
DEG_APCC_DBOX_1 243 251 PF00400 0.476
DEG_APCC_DBOX_1 621 629 PF00400 0.451
DEG_APCC_DBOX_1 701 709 PF00400 0.500
DEG_MDM2_SWIB_1 459 467 PF02201 0.486
DOC_CKS1_1 171 176 PF01111 0.562
DOC_CKS1_1 35 40 PF01111 0.502
DOC_CYCLIN_RxL_1 211 222 PF00134 0.431
DOC_CYCLIN_RxL_1 406 418 PF00134 0.483
DOC_CYCLIN_RxL_1 755 764 PF00134 0.527
DOC_CYCLIN_RxL_1 847 856 PF00134 0.287
DOC_CYCLIN_yCln2_LP_2 313 319 PF00134 0.507
DOC_MAPK_gen_1 244 252 PF00069 0.437
DOC_MAPK_gen_1 343 353 PF00069 0.487
DOC_MAPK_gen_1 849 855 PF00069 0.391
DOC_MAPK_gen_1 894 902 PF00069 0.412
DOC_MAPK_MEF2A_6 90 99 PF00069 0.386
DOC_PP1_RVXF_1 246 253 PF00149 0.515
DOC_PP1_RVXF_1 530 536 PF00149 0.673
DOC_PP1_RVXF_1 838 845 PF00149 0.558
DOC_PP2B_LxvP_1 313 316 PF13499 0.506
DOC_PP2B_LxvP_1 412 415 PF13499 0.439
DOC_PP2B_LxvP_1 583 586 PF13499 0.576
DOC_PP2B_LxvP_1 789 792 PF13499 0.461
DOC_PP2B_PxIxI_1 228 234 PF00149 0.507
DOC_PP4_FxxP_1 118 121 PF00568 0.403
DOC_PP4_FxxP_1 210 213 PF00568 0.363
DOC_PP4_FxxP_1 535 538 PF00568 0.687
DOC_PP4_FxxP_1 613 616 PF00568 0.453
DOC_USP7_MATH_1 387 391 PF00917 0.403
DOC_USP7_MATH_1 415 419 PF00917 0.419
DOC_USP7_MATH_1 477 481 PF00917 0.564
DOC_USP7_MATH_1 621 625 PF00917 0.508
DOC_USP7_UBL2_3 957 961 PF12436 0.635
DOC_USP7_UBL2_3 962 966 PF12436 0.656
DOC_WW_Pin1_4 170 175 PF00397 0.550
DOC_WW_Pin1_4 217 222 PF00397 0.406
DOC_WW_Pin1_4 225 230 PF00397 0.466
DOC_WW_Pin1_4 34 39 PF00397 0.502
DOC_WW_Pin1_4 527 532 PF00397 0.654
DOC_WW_Pin1_4 55 60 PF00397 0.643
DOC_WW_Pin1_4 695 700 PF00397 0.530
DOC_WW_Pin1_4 82 87 PF00397 0.347
LIG_14-3-3_CanoR_1 100 104 PF00244 0.386
LIG_14-3-3_CanoR_1 388 392 PF00244 0.396
LIG_14-3-3_CanoR_1 410 415 PF00244 0.445
LIG_14-3-3_CanoR_1 428 434 PF00244 0.383
LIG_14-3-3_CanoR_1 622 626 PF00244 0.523
LIG_14-3-3_CanoR_1 749 755 PF00244 0.484
LIG_AP2alpha_2 741 743 PF02296 0.461
LIG_APCC_ABBA_1 351 356 PF00400 0.381
LIG_BIR_III_4 328 332 PF00653 0.532
LIG_BRCT_BRCA1_1 143 147 PF00533 0.501
LIG_BRCT_BRCA1_1 156 160 PF00533 0.468
LIG_Clathr_ClatBox_1 396 400 PF01394 0.405
LIG_Clathr_ClatBox_1 852 856 PF01394 0.268
LIG_deltaCOP1_diTrp_1 611 617 PF00928 0.466
LIG_FHA_1 14 20 PF00498 0.508
LIG_FHA_1 207 213 PF00498 0.392
LIG_FHA_1 35 41 PF00498 0.539
LIG_FHA_1 466 472 PF00498 0.400
LIG_FHA_1 575 581 PF00498 0.657
LIG_FHA_1 586 592 PF00498 0.479
LIG_FHA_1 630 636 PF00498 0.657
LIG_FHA_1 751 757 PF00498 0.481
LIG_FHA_1 76 82 PF00498 0.463
LIG_FHA_1 83 89 PF00498 0.409
LIG_FHA_1 909 915 PF00498 0.533
LIG_FHA_1 921 927 PF00498 0.475
LIG_FHA_2 104 110 PF00498 0.303
LIG_FHA_2 259 265 PF00498 0.487
LIG_FHA_2 411 417 PF00498 0.631
LIG_FHA_2 430 436 PF00498 0.390
LIG_FHA_2 655 661 PF00498 0.673
LIG_FHA_2 865 871 PF00498 0.489
LIG_FHA_2 905 911 PF00498 0.458
LIG_FXI_DFP_1 345 349 PF00024 0.505
LIG_IRF3_LxIS_1 929 936 PF10401 0.420
LIG_LIR_Apic_2 209 213 PF02991 0.289
LIG_LIR_Apic_2 611 616 PF02991 0.465
LIG_LIR_Gen_1 109 118 PF02991 0.402
LIG_LIR_Gen_1 21 29 PF02991 0.545
LIG_LIR_Gen_1 461 471 PF02991 0.345
LIG_LIR_Gen_1 774 781 PF02991 0.352
LIG_LIR_Gen_1 909 919 PF02991 0.589
LIG_LIR_Nem_3 109 115 PF02991 0.396
LIG_LIR_Nem_3 157 163 PF02991 0.404
LIG_LIR_Nem_3 21 26 PF02991 0.542
LIG_LIR_Nem_3 347 351 PF02991 0.471
LIG_LIR_Nem_3 376 382 PF02991 0.397
LIG_LIR_Nem_3 461 466 PF02991 0.339
LIG_LIR_Nem_3 588 593 PF02991 0.464
LIG_LIR_Nem_3 611 615 PF02991 0.466
LIG_LIR_Nem_3 774 778 PF02991 0.350
LIG_LIR_Nem_3 909 915 PF02991 0.598
LIG_LRP6_Inhibitor_1 337 343 PF00058 0.513
LIG_LYPXL_S_1 382 386 PF13949 0.443
LIG_LYPXL_yS_3 383 386 PF13949 0.444
LIG_MYND_2 791 795 PF01753 0.460
LIG_PCNA_APIM_2 756 762 PF02747 0.532
LIG_PCNA_yPIPBox_3 719 728 PF02747 0.376
LIG_Pex14_1 379 383 PF04695 0.417
LIG_Pex14_2 160 164 PF04695 0.387
LIG_Pex14_2 459 463 PF04695 0.496
LIG_Pex14_2 613 617 PF04695 0.375
LIG_Pex14_2 908 912 PF04695 0.450
LIG_SH2_CRK 29 33 PF00017 0.634
LIG_SH2_NCK_1 29 33 PF00017 0.634
LIG_SH2_NCK_1 327 331 PF00017 0.468
LIG_SH2_PTP2 112 115 PF00017 0.374
LIG_SH2_STAP1 269 273 PF00017 0.373
LIG_SH2_STAP1 881 885 PF00017 0.386
LIG_SH2_STAP1 922 926 PF00017 0.473
LIG_SH2_STAT3 922 925 PF00017 0.470
LIG_SH2_STAT5 112 115 PF00017 0.385
LIG_SH2_STAT5 29 32 PF00017 0.701
LIG_SH2_STAT5 590 593 PF00017 0.422
LIG_SH2_STAT5 759 762 PF00017 0.510
LIG_SH2_STAT5 769 772 PF00017 0.352
LIG_SH2_STAT5 799 802 PF00017 0.436
LIG_SH2_STAT5 881 884 PF00017 0.388
LIG_SH2_STAT5 901 904 PF00017 0.280
LIG_SH2_STAT5 922 925 PF00017 0.470
LIG_SH3_3 168 174 PF00018 0.538
LIG_SH3_3 381 387 PF00018 0.433
LIG_SH3_3 669 675 PF00018 0.578
LIG_SH3_3 736 742 PF00018 0.583
LIG_SH3_3 83 89 PF00018 0.415
LIG_SH3_3 835 841 PF00018 0.503
LIG_SUMO_SIM_anti_2 649 655 PF11976 0.540
LIG_SUMO_SIM_anti_2 774 780 PF11976 0.402
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.440
LIG_SUMO_SIM_par_1 367 373 PF11976 0.334
LIG_SUMO_SIM_par_1 410 416 PF11976 0.497
LIG_SUMO_SIM_par_1 670 676 PF11976 0.571
LIG_SUMO_SIM_par_1 78 85 PF11976 0.360
LIG_SUMO_SIM_par_1 851 856 PF11976 0.346
LIG_TRAF2_1 294 297 PF00917 0.384
LIG_TRAF2_1 439 442 PF00917 0.562
LIG_TRAF2_1 656 659 PF00917 0.537
LIG_TRAF2_1 68 71 PF00917 0.520
LIG_TRAF2_2 538 543 PF00917 0.537
LIG_TYR_ITIM 110 115 PF00017 0.372
LIG_TYR_ITIM 591 596 PF00017 0.455
LIG_UBA3_1 110 117 PF00899 0.446
LIG_UBA3_1 195 200 PF00899 0.385
LIG_WW_2 86 89 PF00397 0.394
MOD_CDC14_SPxK_1 220 223 PF00782 0.501
MOD_CDK_SPK_2 225 230 PF00069 0.531
MOD_CDK_SPK_2 527 532 PF00069 0.654
MOD_CDK_SPxK_1 217 223 PF00069 0.418
MOD_CDK_SPxxK_3 225 232 PF00069 0.521
MOD_CDK_SPxxK_3 695 702 PF00069 0.532
MOD_CK1_1 165 171 PF00069 0.467
MOD_CK1_1 481 487 PF00069 0.617
MOD_CK1_1 504 510 PF00069 0.686
MOD_CK1_1 567 573 PF00069 0.640
MOD_CK1_1 747 753 PF00069 0.553
MOD_CK1_1 771 777 PF00069 0.342
MOD_CK1_1 80 86 PF00069 0.460
MOD_CK1_1 936 942 PF00069 0.612
MOD_CK2_1 258 264 PF00069 0.503
MOD_CK2_1 291 297 PF00069 0.395
MOD_CK2_1 315 321 PF00069 0.452
MOD_CK2_1 410 416 PF00069 0.456
MOD_CK2_1 600 606 PF00069 0.455
MOD_CK2_1 864 870 PF00069 0.490
MOD_CK2_1 904 910 PF00069 0.439
MOD_Cter_Amidation 242 245 PF01082 0.516
MOD_Cter_Amidation 959 962 PF01082 0.676
MOD_GlcNHglycan 132 135 PF01048 0.610
MOD_GlcNHglycan 143 146 PF01048 0.553
MOD_GlcNHglycan 164 167 PF01048 0.539
MOD_GlcNHglycan 240 244 PF01048 0.559
MOD_GlcNHglycan 254 257 PF01048 0.416
MOD_GlcNHglycan 424 427 PF01048 0.434
MOD_GlcNHglycan 482 486 PF01048 0.630
MOD_GlcNHglycan 498 501 PF01048 0.518
MOD_GlcNHglycan 572 575 PF01048 0.651
MOD_GlcNHglycan 645 648 PF01048 0.585
MOD_GlcNHglycan 770 773 PF01048 0.412
MOD_GlcNHglycan 943 946 PF01048 0.669
MOD_GSK3_1 30 37 PF00069 0.503
MOD_GSK3_1 429 436 PF00069 0.558
MOD_GSK3_1 477 484 PF00069 0.565
MOD_GSK3_1 501 508 PF00069 0.682
MOD_GSK3_1 560 567 PF00069 0.620
MOD_GSK3_1 569 576 PF00069 0.605
MOD_GSK3_1 660 667 PF00069 0.604
MOD_GSK3_1 76 83 PF00069 0.489
MOD_GSK3_1 860 867 PF00069 0.488
MOD_GSK3_1 900 907 PF00069 0.455
MOD_GSK3_1 920 927 PF00069 0.380
MOD_GSK3_1 934 941 PF00069 0.491
MOD_GSK3_1 99 106 PF00069 0.296
MOD_LATS_1 862 868 PF00433 0.481
MOD_N-GLC_1 154 159 PF02516 0.338
MOD_N-GLC_1 570 575 PF02516 0.701
MOD_N-GLC_1 952 957 PF02516 0.552
MOD_NEK2_1 208 213 PF00069 0.325
MOD_NEK2_1 252 257 PF00069 0.395
MOD_NEK2_1 374 379 PF00069 0.523
MOD_NEK2_1 429 434 PF00069 0.551
MOD_NEK2_1 628 633 PF00069 0.549
MOD_NEK2_1 635 640 PF00069 0.592
MOD_NEK2_1 708 713 PF00069 0.455
MOD_NEK2_1 77 82 PF00069 0.648
MOD_NEK2_1 860 865 PF00069 0.399
MOD_NEK2_1 908 913 PF00069 0.507
MOD_NEK2_1 933 938 PF00069 0.562
MOD_NEK2_1 99 104 PF00069 0.373
MOD_PIKK_1 374 380 PF00454 0.442
MOD_PKA_1 258 264 PF00069 0.503
MOD_PKA_1 564 570 PF00069 0.654
MOD_PKA_2 387 393 PF00069 0.398
MOD_PKA_2 429 435 PF00069 0.494
MOD_PKA_2 505 511 PF00069 0.545
MOD_PKA_2 560 566 PF00069 0.620
MOD_PKA_2 621 627 PF00069 0.517
MOD_PKA_2 99 105 PF00069 0.378
MOD_Plk_1 415 421 PF00069 0.491
MOD_Plk_1 649 655 PF00069 0.540
MOD_Plk_1 693 699 PF00069 0.524
MOD_Plk_1 747 753 PF00069 0.553
MOD_Plk_1 91 97 PF00069 0.444
MOD_Plk_2-3 291 297 PF00069 0.395
MOD_Plk_2-3 448 454 PF00069 0.595
MOD_Plk_2-3 818 824 PF00069 0.471
MOD_Plk_2-3 879 885 PF00069 0.403
MOD_Plk_4 387 393 PF00069 0.398
MOD_Plk_4 429 435 PF00069 0.559
MOD_Plk_4 471 477 PF00069 0.499
MOD_Plk_4 585 591 PF00069 0.503
MOD_Plk_4 649 655 PF00069 0.540
MOD_Plk_4 731 737 PF00069 0.476
MOD_Plk_4 750 756 PF00069 0.581
MOD_Plk_4 765 771 PF00069 0.384
MOD_Plk_4 77 83 PF00069 0.408
MOD_Plk_4 790 796 PF00069 0.432
MOD_Plk_4 91 97 PF00069 0.410
MOD_ProDKin_1 170 176 PF00069 0.558
MOD_ProDKin_1 217 223 PF00069 0.418
MOD_ProDKin_1 225 231 PF00069 0.458
MOD_ProDKin_1 34 40 PF00069 0.502
MOD_ProDKin_1 527 533 PF00069 0.655
MOD_ProDKin_1 55 61 PF00069 0.647
MOD_ProDKin_1 695 701 PF00069 0.531
MOD_ProDKin_1 82 88 PF00069 0.342
MOD_SUMO_for_1 231 234 PF00179 0.423
MOD_SUMO_for_1 761 764 PF00179 0.504
MOD_SUMO_rev_2 927 933 PF00179 0.546
TRG_DiLeu_BaEn_1 92 97 PF01217 0.440
TRG_DiLeu_BaEn_4 296 302 PF01217 0.368
TRG_DiLeu_BaLyEn_6 233 238 PF01217 0.511
TRG_DiLeu_BaLyEn_6 407 412 PF01217 0.482
TRG_ENDOCYTIC_2 112 115 PF00928 0.385
TRG_ENDOCYTIC_2 29 32 PF00928 0.633
TRG_ENDOCYTIC_2 383 386 PF00928 0.444
TRG_ENDOCYTIC_2 593 596 PF00928 0.454
TRG_ER_diArg_1 244 246 PF00400 0.483
TRG_ER_diArg_1 307 310 PF00400 0.483
TRG_ER_diArg_1 427 430 PF00400 0.469
TRG_ER_diArg_1 786 788 PF00400 0.423
TRG_ER_diArg_1 893 895 PF00400 0.370
TRG_NES_CRM1_1 682 694 PF08389 0.467
TRG_NLS_Bipartite_1 244 262 PF00514 0.472
TRG_NLS_MonoExtC_3 13 18 PF00514 0.656
TRG_NLS_MonoExtC_3 180 186 PF00514 0.461
TRG_Pf-PMV_PEXEL_1 245 249 PF00026 0.467
TRG_Pf-PMV_PEXEL_1 287 291 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 417 421 PF00026 0.423
TRG_Pf-PMV_PEXEL_1 602 606 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I315 Leptomonas seymouri 55% 100%
A0A3Q8IBU0 Leishmania donovani 79% 100%
A4I1L3 Leishmania infantum 79% 100%
E9AXP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q9S4 Leishmania major 78% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS