J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEH4_LEIBR

TriTrypDb:

LbrM.25.2310 , LBRM2903_250025800

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HEH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH4

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044571	[2Fe-2S] cluster assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0043933	protein-containing complex organization	4	4
GO:0051259	protein complex oligomerization	6	4
GO:0065003	protein-containing complex assembly	5	4

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051087	protein-folding chaperone binding	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.563
CLV_NRD_NRD_1	148	150	PF00675	0.490
CLV_NRD_NRD_1	188	190	PF00675	0.590
CLV_NRD_NRD_1	6	8	PF00675	0.745
CLV_PCSK_FUR_1	4	8	PF00082	0.470
CLV_PCSK_KEX2_1	148	150	PF00082	0.490
CLV_PCSK_KEX2_1	188	190	PF00082	0.638
CLV_PCSK_KEX2_1	6	8	PF00082	0.745
CLV_PCSK_SKI1_1	122	126	PF00082	0.545
CLV_PCSK_SKI1_1	149	153	PF00082	0.753
DOC_CKS1_1	110	115	PF01111	0.329
DOC_CKS1_1	158	163	PF01111	0.550
DOC_MAPK_gen_1	188	196	PF00069	0.578
DOC_PP4_FxxP_1	32	35	PF00568	0.352
DOC_USP7_MATH_1	179	183	PF00917	0.671
DOC_USP7_MATH_1	209	213	PF00917	0.557
DOC_USP7_MATH_1	92	96	PF00917	0.570
DOC_USP7_UBL2_3	207	211	PF12436	0.553
DOC_WW_Pin1_4	109	114	PF00397	0.418
DOC_WW_Pin1_4	157	162	PF00397	0.598
DOC_WW_Pin1_4	79	84	PF00397	0.638
LIG_14-3-3_CanoR_1	148	152	PF00244	0.593
LIG_14-3-3_CanoR_1	188	194	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_BRCT_BRCA1_1	162	166	PF00533	0.588
LIG_EH1_1	49	57	PF00400	0.381
LIG_FHA_1	110	116	PF00498	0.335
LIG_LIR_Gen_1	227	235	PF02991	0.495
LIG_LIR_Nem_3	227	231	PF02991	0.517
LIG_PTB_Apo_2	101	108	PF02174	0.410
LIG_PTB_Phospho_1	101	107	PF10480	0.410
LIG_SH2_CRK	49	53	PF00017	0.508
LIG_SH2_GRB2like	102	105	PF00017	0.416
LIG_SH2_GRB2like	49	52	PF00017	0.555
LIG_SH2_NCK_1	102	106	PF00017	0.428
LIG_SH2_SRC	102	105	PF00017	0.435
LIG_SH2_STAP1	102	106	PF00017	0.453
LIG_SH2_STAT5	114	117	PF00017	0.430
LIG_SH2_STAT5	119	122	PF00017	0.407
LIG_SH2_STAT5	205	208	PF00017	0.570
LIG_SH2_STAT5	230	233	PF00017	0.469
LIG_SH2_STAT5	28	31	PF00017	0.446
LIG_SH3_3	155	161	PF00018	0.687
LIG_SH3_3	32	38	PF00018	0.389
LIG_SUMO_SIM_par_1	169	175	PF11976	0.455
LIG_TRAF2_1	136	139	PF00917	0.543
MOD_CDK_SPxxK_3	109	116	PF00069	0.413
MOD_CK1_1	10	16	PF00069	0.770
MOD_CK1_1	20	26	PF00069	0.730
MOD_CK2_1	132	138	PF00069	0.561
MOD_CK2_1	169	175	PF00069	0.516
MOD_CK2_1	179	185	PF00069	0.523
MOD_DYRK1A_RPxSP_1	157	161	PF00069	0.494
MOD_GlcNHglycan	10	13	PF01048	0.708
MOD_GlcNHglycan	134	137	PF01048	0.624
MOD_GlcNHglycan	89	92	PF01048	0.652
MOD_GSK3_1	10	17	PF00069	0.662
MOD_GSK3_1	226	233	PF00069	0.619
MOD_GSK3_1	75	82	PF00069	0.687
MOD_GSK3_1	93	100	PF00069	0.596
MOD_NEK2_2	106	111	PF00069	0.466
MOD_PK_1	189	195	PF00069	0.479
MOD_PKA_2	13	19	PF00069	0.722
MOD_PKA_2	147	153	PF00069	0.544
MOD_PKB_1	116	124	PF00069	0.545
MOD_Plk_1	226	232	PF00069	0.492
MOD_Plk_1	97	103	PF00069	0.477
MOD_Plk_2-3	169	175	PF00069	0.554
MOD_ProDKin_1	109	115	PF00069	0.418
MOD_ProDKin_1	157	163	PF00069	0.591
MOD_ProDKin_1	79	85	PF00069	0.637
MOD_SUMO_for_1	124	127	PF00179	0.562
TRG_DiLeu_BaEn_1	138	143	PF01217	0.568
TRG_ENDOCYTIC_2	107	110	PF00928	0.387
TRG_ENDOCYTIC_2	28	31	PF00928	0.451
TRG_ENDOCYTIC_2	49	52	PF00928	0.528
TRG_ER_diArg_1	115	118	PF00400	0.448
TRG_ER_diArg_1	187	189	PF00400	0.582
TRG_ER_diArg_1	4	7	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K0	Leptomonas seymouri	64%	88%
A0A1X0NZR6	Trypanosomatidae	41%	89%
A0A3S7WZD6	Leishmania donovani	82%	88%
A0A422NGH8	Trypanosoma rangeli	39%	92%
A4I1L6	Leishmania infantum	82%	88%
C9ZK58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	96%
E9AXQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	86%
Q4Q9S1	Leishmania major	82%	100%
V5BHV1	Trypanosoma cruzi	43%	77%