Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LSM domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEH2_LEIBR

TriTrypDb:

LbrM.25.2290 , LBRM2903_250026000

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005681	spliceosomal complex	3	2
GO:0005688	U6 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	2
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

A4HEH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.423
CLV_MEL_PAP_1	6	12	PF00089	0.211
CLV_NRD_NRD_1	6	8	PF00675	0.230
CLV_PCSK_KEX2_1	8	10	PF00082	0.213
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.268
CLV_PCSK_SKI1_1	75	79	PF00082	0.171
DEG_APCC_DBOX_1	74	82	PF00400	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.267
DOC_CYCLIN_yClb5_NLxxxL_5	15	24	PF00134	0.505
DOC_MAPK_gen_1	7	15	PF00069	0.468
DOC_USP7_MATH_1	67	71	PF00917	0.458
LIG_14-3-3_CanoR_1	7	13	PF00244	0.428
LIG_APCC_ABBA_1	102	107	PF00400	0.481
LIG_FHA_1	34	40	PF00498	0.443
LIG_NRP_CendR_1	128	130	PF00754	0.432
LIG_SH2_NCK_1	105	109	PF00017	0.500
LIG_SH2_SRC	105	108	PF00017	0.495
LIG_SH2_STAT5	5	8	PF00017	0.440
LIG_SUMO_SIM_par_1	11	16	PF11976	0.468
LIG_TRAF2_1	80	83	PF00917	0.505
MOD_CK1_1	11	17	PF00069	0.411
MOD_CK1_1	70	76	PF00069	0.422
MOD_CK2_1	34	40	PF00069	0.411
MOD_GlcNHglycan	69	72	PF01048	0.308
MOD_GSK3_1	62	69	PF00069	0.476
MOD_GSK3_1	91	98	PF00069	0.418
MOD_PK_1	8	14	PF00069	0.411
MOD_PKA_1	8	14	PF00069	0.411
MOD_PKA_2	8	14	PF00069	0.425
MOD_PKA_2	91	97	PF00069	0.356
MOD_Plk_4	8	14	PF00069	0.411
TRG_ER_diArg_1	115	118	PF00400	0.416
TRG_ER_diArg_1	127	130	PF00400	0.522
TRG_ER_diArg_1	6	9	PF00400	0.425
TRG_NES_CRM1_1	4	16	PF08389	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X1	Leptomonas seymouri	69%	100%
A0A0S4J0G1	Bodo saltans	36%	100%
A0A1X0NYL8	Trypanosomatidae	47%	100%
A0A3Q8IFD7	Leishmania donovani	85%	99%
A0A3R7KAX5	Trypanosoma rangeli	55%	100%
A4I1L8	Leishmania infantum	85%	99%
C9ZK60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AXQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q1ZXD5	Dictyostelium discoideum	30%	100%
Q4Q9R9	Leishmania major	84%	100%