Pyruvate dehydrogenase E1 component subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate dehydrogenase E1 beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HEH1_LEIBR

TriTrypDb:

LbrM.25.2280 , LBRM2903_250026100

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045254	pyruvate dehydrogenase complex	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A4HEH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEH1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006085	acetyl-CoA biosynthetic process	6	12
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033866	nucleoside bisphosphate biosynthetic process	6	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0035383	thioester metabolic process	3	12
GO:0035384	thioester biosynthetic process	4	12
GO:0043436	oxoacid metabolic process	4	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044272	sulfur compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071616	acyl-CoA biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004738	pyruvate dehydrogenase activity	4	12
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.544
CLV_C14_Caspase3-7	293	297	PF00656	0.504
CLV_PCSK_KEX2_1	331	333	PF00082	0.441
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.545
CLV_PCSK_SKI1_1	212	216	PF00082	0.356
CLV_PCSK_SKI1_1	258	262	PF00082	0.316
CLV_PCSK_SKI1_1	265	269	PF00082	0.314
CLV_PCSK_SKI1_1	331	335	PF00082	0.461
CLV_PCSK_SKI1_1	4	8	PF00082	0.509
DOC_CDC14_PxL_1	143	151	PF14671	0.504
DOC_MAPK_gen_1	206	216	PF00069	0.521
DOC_MAPK_gen_1	261	269	PF00069	0.528
DOC_MAPK_gen_1	56	64	PF00069	0.609
DOC_PP2B_LxvP_1	295	298	PF13499	0.504
DOC_PP4_FxxP_1	121	124	PF00568	0.497
DOC_PP4_FxxP_1	198	201	PF00568	0.419
DOC_USP7_MATH_1	104	108	PF00917	0.614
DOC_USP7_MATH_1	133	137	PF00917	0.501
DOC_USP7_MATH_1	15	19	PF00917	0.607
DOC_USP7_MATH_1	6	10	PF00917	0.577
DOC_USP7_MATH_2	298	304	PF00917	0.504
DOC_USP7_UBL2_3	228	232	PF12436	0.590
DOC_USP7_UBL2_3	258	262	PF12436	0.482
DOC_WW_Pin1_4	306	311	PF00397	0.500
LIG_14-3-3_CanoR_1	265	270	PF00244	0.515
LIG_14-3-3_CanoR_1	301	308	PF00244	0.504
LIG_14-3-3_CanoR_1	4	12	PF00244	0.476
LIG_14-3-3_CterR_2	332	335	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BIR_III_4	159	163	PF00653	0.504
LIG_BRCT_BRCA1_1	135	139	PF00533	0.544
LIG_BRCT_BRCA1_1	288	292	PF00533	0.504
LIG_FHA_1	45	51	PF00498	0.504
LIG_FHA_2	266	272	PF00498	0.511
LIG_FHA_2	9	15	PF00498	0.517
LIG_LIR_Apic_2	195	201	PF02991	0.436
LIG_LIR_Gen_1	289	299	PF02991	0.504
LIG_LIR_Gen_1	86	94	PF02991	0.504
LIG_LIR_Nem_3	254	260	PF02991	0.547
LIG_LIR_Nem_3	289	295	PF02991	0.504
LIG_LIR_Nem_3	86	90	PF02991	0.544
LIG_PCNA_yPIPBox_3	313	327	PF02747	0.515
LIG_Pex14_2	198	202	PF04695	0.415
LIG_SH2_CRK	143	147	PF00017	0.515
LIG_SH2_NCK_1	143	147	PF00017	0.515
LIG_SH2_SRC	294	297	PF00017	0.504
LIG_SH2_STAP1	311	315	PF00017	0.504
LIG_SH2_STAT5	294	297	PF00017	0.494
LIG_SH3_3	148	154	PF00018	0.504
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.590
LIG_SUMO_SIM_par_1	173	178	PF11976	0.507
LIG_UBA3_1	256	262	PF00899	0.544
LIG_WRC_WIRS_1	87	92	PF05994	0.544
MOD_CDK_SPxxK_3	306	313	PF00069	0.504
MOD_CK2_1	265	271	PF00069	0.511
MOD_GlcNHglycan	102	105	PF01048	0.304
MOD_GlcNHglycan	110	113	PF01048	0.300
MOD_GlcNHglycan	127	130	PF01048	0.260
MOD_GlcNHglycan	17	20	PF01048	0.385
MOD_GSK3_1	100	107	PF00069	0.581
MOD_GSK3_1	183	190	PF00069	0.548
MOD_GSK3_1	252	259	PF00069	0.501
MOD_GSK3_1	265	272	PF00069	0.491
MOD_GSK3_1	4	11	PF00069	0.609
MOD_GSK3_1	44	51	PF00069	0.428
MOD_NEK2_1	108	113	PF00069	0.525
MOD_NEK2_2	104	109	PF00069	0.581
MOD_PIKK_1	133	139	PF00454	0.504
MOD_PIKK_1	316	322	PF00454	0.504
MOD_PKA_2	252	258	PF00069	0.520
MOD_PKA_2	300	306	PF00069	0.504
MOD_Plk_1	212	218	PF00069	0.528
MOD_Plk_1	269	275	PF00069	0.504
MOD_Plk_2-3	288	294	PF00069	0.590
MOD_Plk_4	104	110	PF00069	0.581
MOD_Plk_4	252	258	PF00069	0.511
MOD_ProDKin_1	306	312	PF00069	0.500
MOD_SUMO_for_1	205	208	PF00179	0.504
MOD_SUMO_rev_2	208	214	PF00179	0.564
MOD_SUMO_rev_2	21	31	PF00179	0.522
TRG_ENDOCYTIC_2	143	146	PF00928	0.515
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M5	Leptomonas seymouri	33%	91%
A0A0N0P8J5	Leptomonas seymouri	88%	96%
A0A0S4J2J6	Bodo saltans	76%	96%
A0A1X0NJN2	Trypanosomatidae	34%	91%
A0A1X0NY97	Trypanosomatidae	78%	97%
A0A3Q8IJ06	Leishmania donovani	33%	92%
A0A3S7WZ91	Leishmania donovani	94%	96%
A0A422N7P1	Trypanosoma rangeli	33%	92%
A0A422NGI4	Trypanosoma rangeli	78%	96%
A2CI50	Chlorokybus atmophyticus	40%	100%
A4HM44	Leishmania braziliensis	33%	92%
A4I1L9	Leishmania infantum	94%	96%
A4IAQ6	Leishmania infantum	33%	92%
A6KXB3	Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154)	26%	100%
A6VKQ3	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	24%	100%
C9ZK62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	96%
D0A2G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
E9AEI2	Leishmania major	32%	100%
E9AXQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	96%
E9B5P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	92%
G0RYE0	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	62%	88%
O34591	Bacillus subtilis (strain 168)	37%	98%
O44451	Caenorhabditis elegans	61%	95%
O64688	Arabidopsis thaliana	42%	83%
O66113	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	59%	73%
P09061	Pseudomonas putida	40%	99%
P0A0A1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P0A0A2	Staphylococcus aureus (strain MW2)	36%	100%
P0A0A3	Staphylococcus aureus	36%	100%
P11177	Homo sapiens	60%	93%
P11966	Bos taurus	59%	93%
P21839	Bos taurus	36%	85%
P21874	Geobacillus stearothermophilus	39%	100%
P21882	Bacillus subtilis (strain 168)	37%	100%
P21953	Homo sapiens	35%	85%
P26269	Ascaris suum	57%	93%
P27746	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	40%	99%
P32473	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	62%	92%
P35488	Acholeplasma laidlawii	34%	100%
P35738	Rattus norvegicus	36%	86%
P37941	Bacillus subtilis (strain 168)	40%	100%
P47515	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	33%	100%
P49432	Rattus norvegicus	59%	93%
P51266	Porphyra purpurea	44%	100%
P52904	Pisum sativum	63%	93%
P55573	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	25%	97%
P75391	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	33%	100%
P99063	Staphylococcus aureus (strain N315)	36%	100%
P9WF02	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	39%	71%
P9WIS0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	96%
P9WIS1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	96%
Q09171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	63%	92%
Q0J0H4	Oryza sativa subsp. japonica	64%	89%
Q10G39	Oryza sativa subsp. japonica	43%	84%
Q1ACL0	Chara vulgaris	41%	100%
Q1RJX3	Rickettsia bellii (strain RML369-C)	55%	100%
Q1XDM1	Neopyropia yezoensis	43%	100%
Q2QM55	Oryza sativa subsp. japonica	42%	86%
Q32RM2	Zygnema circumcarinatum	42%	100%
Q32RS0	Staurastrum punctulatum	42%	100%
Q38799	Arabidopsis thaliana	66%	92%
Q4Q9R8	Leishmania major	94%	100%
Q4UKQ7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	56%	100%
Q55FN7	Dictyostelium discoideum	39%	91%
Q58092	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	22%	100%
Q5HGZ0	Staphylococcus aureus (strain COL)	36%	100%
Q5HQ75	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	36%	100%
Q5RE79	Pongo abelii	60%	93%
Q5SLR3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	41%	100%
Q68XA8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	55%	100%
Q6ABX8	Leifsonia xyli subsp. xyli (strain CTCB07)	34%	99%
Q6B8T1	Gracilaria tenuistipitata var. liui	42%	100%
Q6GAC0	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GHZ1	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6P3A8	Mus musculus	35%	86%
Q6Z1G7	Oryza sativa subsp. japonica	64%	90%
Q72GU2	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	40%	100%
Q7K5K3	Drosophila melanogaster	61%	92%
Q85FX1	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	45%	100%
Q86HX0	Dictyostelium discoideum	63%	94%
Q8CPN2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	36%	100%
Q8MA03	Chaetosphaeridium globosum	43%	100%
Q92IS2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	57%	100%
Q9C6Z3	Arabidopsis thaliana	41%	83%
Q9D051	Mus musculus	59%	93%
Q9I1M1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	39%	96%
Q9LDY2	Arabidopsis thaliana	36%	94%
Q9MUR4	Mesostigma viride	41%	100%
Q9R9N4	Rhizobium meliloti (strain 1021)	56%	73%
Q9SAV3	Arabidopsis thaliana	34%	95%
Q9TLS3	Cyanidium caldarium	40%	100%
Q9ZDR3	Rickettsia prowazekii (strain Madrid E)	55%	100%
V5BIR9	Trypanosoma cruzi	35%	91%
V5DIT8	Trypanosoma cruzi	77%	97%