PORR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEG9_LEIBR

TriTrypDb:

LbrM.25.2260 , LBRM2903_250026300

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.451
CLV_C14_Caspase3-7	55	59	PF00656	0.582
CLV_MEL_PAP_1	133	139	PF00089	0.320
CLV_NRD_NRD_1	279	281	PF00675	0.433
CLV_NRD_NRD_1	291	293	PF00675	0.525
CLV_NRD_NRD_1	34	36	PF00675	0.625
CLV_PCSK_KEX2_1	279	281	PF00082	0.433
CLV_PCSK_KEX2_1	34	36	PF00082	0.625
CLV_PCSK_SKI1_1	2	6	PF00082	0.727
CLV_PCSK_SKI1_1	239	243	PF00082	0.517
CLV_PCSK_SKI1_1	279	283	PF00082	0.521
CLV_Separin_Metazoa	236	240	PF03568	0.367
DEG_APCC_DBOX_1	117	125	PF00400	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_SCF_FBW7_1	146	151	PF00400	0.322
DEG_SCF_FBW7_1	187	193	PF00400	0.448
DEG_SPOP_SBC_1	52	56	PF00917	0.553
DOC_CKS1_1	145	150	PF01111	0.346
DOC_CKS1_1	187	192	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.461
DOC_MAPK_RevD_3	20	35	PF00069	0.647
DOC_PP2B_LxvP_1	126	129	PF13499	0.410
DOC_PP2B_LxvP_1	235	238	PF13499	0.353
DOC_USP7_MATH_1	12	16	PF00917	0.680
DOC_USP7_MATH_1	190	194	PF00917	0.743
DOC_USP7_MATH_1	64	68	PF00917	0.605
DOC_WW_Pin1_4	104	109	PF00397	0.434
DOC_WW_Pin1_4	144	149	PF00397	0.400
DOC_WW_Pin1_4	186	191	PF00397	0.641
DOC_WW_Pin1_4	21	26	PF00397	0.612
DOC_WW_Pin1_4	39	44	PF00397	0.591
DOC_WW_Pin1_4	46	51	PF00397	0.672
DOC_WW_Pin1_4	58	63	PF00397	0.695
LIG_14-3-3_CanoR_1	136	146	PF00244	0.498
LIG_14-3-3_CanoR_1	192	200	PF00244	0.627
LIG_14-3-3_CanoR_1	2	7	PF00244	0.613
LIG_14-3-3_CanoR_1	271	277	PF00244	0.523
LIG_14-3-3_CanoR_1	279	285	PF00244	0.433
LIG_14-3-3_CanoR_1	34	38	PF00244	0.764
LIG_14-3-3_CanoR_1	90	99	PF00244	0.486
LIG_deltaCOP1_diTrp_1	228	232	PF00928	0.468
LIG_FHA_1	145	151	PF00498	0.597
LIG_FHA_1	167	173	PF00498	0.530
LIG_FHA_1	209	215	PF00498	0.647
LIG_FHA_1	92	98	PF00498	0.439
LIG_FHA_2	201	207	PF00498	0.657
LIG_FHA_2	211	217	PF00498	0.588
LIG_GSK3_LRP6_1	46	51	PF00069	0.509
LIG_LIR_Apic_2	144	148	PF02991	0.493
LIG_LIR_Apic_2	176	181	PF02991	0.516
LIG_LIR_Gen_1	228	237	PF02991	0.463
LIG_LIR_Gen_1	8	18	PF02991	0.641
LIG_LIR_Nem_3	228	232	PF02991	0.468
LIG_LIR_Nem_3	8	13	PF02991	0.635
LIG_LYPXL_yS_3	248	251	PF13949	0.555
LIG_MAD2	112	120	PF02301	0.531
LIG_MYND_1	25	29	PF01753	0.445
LIG_MYND_1	80	84	PF01753	0.491
LIG_MYND_3	172	176	PF01753	0.486
LIG_REV1ctd_RIR_1	261	271	PF16727	0.557
LIG_SH2_PTP2	145	148	PF00017	0.375
LIG_SH2_PTP2	250	253	PF00017	0.383
LIG_SH2_STAT5	145	148	PF00017	0.573
LIG_SH2_STAT5	224	227	PF00017	0.450
LIG_SH2_STAT5	250	253	PF00017	0.404
LIG_SH3_3	184	190	PF00018	0.621
LIG_SH3_3	40	46	PF00018	0.600
LIG_SH3_3	47	53	PF00018	0.544
LIG_SUMO_SIM_par_1	83	88	PF11976	0.463
LIG_TRAF2_1	120	123	PF00917	0.517
LIG_TRAF2_2	152	157	PF00917	0.355
LIG_UBA3_1	162	170	PF00899	0.390
LIG_WRC_WIRS_1	7	12	PF05994	0.506
MOD_CDK_SPxK_1	186	192	PF00069	0.564
MOD_CK1_1	107	113	PF00069	0.411
MOD_CK1_1	141	147	PF00069	0.410
MOD_CK1_1	272	278	PF00069	0.479
MOD_CK1_1	51	57	PF00069	0.696
MOD_CK1_1	67	73	PF00069	0.553
MOD_CK2_1	210	216	PF00069	0.618
MOD_DYRK1A_RPxSP_1	104	108	PF00069	0.431
MOD_GlcNHglycan	15	18	PF01048	0.715
MOD_GlcNHglycan	253	256	PF01048	0.330
MOD_GlcNHglycan	270	274	PF01048	0.355
MOD_GlcNHglycan	67	70	PF01048	0.608
MOD_GlcNHglycan	72	75	PF01048	0.642
MOD_GSK3_1	137	144	PF00069	0.544
MOD_GSK3_1	186	193	PF00069	0.595
MOD_GSK3_1	2	9	PF00069	0.635
MOD_GSK3_1	21	28	PF00069	0.567
MOD_GSK3_1	33	40	PF00069	0.684
MOD_GSK3_1	48	55	PF00069	0.593
MOD_NEK2_1	13	18	PF00069	0.741
MOD_NEK2_1	288	293	PF00069	0.513
MOD_NEK2_2	210	215	PF00069	0.410
MOD_PIKK_1	107	113	PF00454	0.306
MOD_PKA_2	13	19	PF00069	0.537
MOD_PKA_2	191	197	PF00069	0.569
MOD_PKA_2	251	257	PF00069	0.340
MOD_PKA_2	33	39	PF00069	0.768
MOD_Plk_4	141	147	PF00069	0.410
MOD_Plk_4	220	226	PF00069	0.480
MOD_Plk_4	272	278	PF00069	0.509
MOD_ProDKin_1	104	110	PF00069	0.428
MOD_ProDKin_1	144	150	PF00069	0.387
MOD_ProDKin_1	186	192	PF00069	0.655
MOD_ProDKin_1	21	27	PF00069	0.614
MOD_ProDKin_1	39	45	PF00069	0.593
MOD_ProDKin_1	46	52	PF00069	0.666
MOD_ProDKin_1	58	64	PF00069	0.693
MOD_SUMO_rev_2	151	160	PF00179	0.363
MOD_SUMO_rev_2	236	243	PF00179	0.574
TRG_DiLeu_BaEn_1	88	93	PF01217	0.498
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.579
TRG_ENDOCYTIC_2	248	251	PF00928	0.595
TRG_ENDOCYTIC_2	260	263	PF00928	0.365
TRG_ER_diArg_1	278	280	PF00400	0.455
TRG_ER_FFAT_2	140	151	PF00635	0.373
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC8	Leptomonas seymouri	53%	91%
A0A1X0NY85	Trypanosomatidae	35%	95%
A0A3S7WZA0	Leishmania donovani	67%	92%
A0A422NGK2	Trypanosoma rangeli	35%	100%
A4I1M1	Leishmania infantum	67%	92%
C9ZK64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9AXQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	94%
Q4Q9R6	Leishmania major	67%	100%
V5BHV8	Trypanosoma cruzi	34%	100%