Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HEG8_LEIBR

TriTrypDb:

LbrM.25.2250 , LBRM2903_250026400

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.584
CLV_C14_Caspase3-7	89	93	PF00656	0.606
CLV_NRD_NRD_1	148	150	PF00675	0.455
CLV_NRD_NRD_1	153	155	PF00675	0.454
CLV_NRD_NRD_1	187	189	PF00675	0.548
CLV_NRD_NRD_1	192	194	PF00675	0.624
CLV_NRD_NRD_1	207	209	PF00675	0.508
CLV_NRD_NRD_1	213	215	PF00675	0.610
CLV_NRD_NRD_1	233	235	PF00675	0.639
CLV_NRD_NRD_1	268	270	PF00675	0.648
CLV_NRD_NRD_1	278	280	PF00675	0.631
CLV_NRD_NRD_1	296	298	PF00675	0.636
CLV_PCSK_KEX2_1	148	150	PF00082	0.367
CLV_PCSK_KEX2_1	192	194	PF00082	0.645
CLV_PCSK_KEX2_1	207	209	PF00082	0.550
CLV_PCSK_KEX2_1	213	215	PF00082	0.610
CLV_PCSK_KEX2_1	233	235	PF00082	0.639
CLV_PCSK_KEX2_1	268	270	PF00082	0.644
CLV_PCSK_KEX2_1	278	280	PF00082	0.639
CLV_PCSK_KEX2_1	296	298	PF00082	0.636
CLV_PCSK_PC7_1	188	194	PF00082	0.560
CLV_PCSK_PC7_1	203	209	PF00082	0.542
CLV_PCSK_SKI1_1	100	104	PF00082	0.513
CLV_PCSK_SKI1_1	126	130	PF00082	0.451
CLV_PCSK_SKI1_1	148	152	PF00082	0.468
CLV_PCSK_SKI1_1	155	159	PF00082	0.414
DOC_MAPK_gen_1	154	162	PF00069	0.353
DOC_MAPK_gen_1	188	197	PF00069	0.558
DOC_USP7_MATH_1	209	213	PF00917	0.555
DOC_USP7_MATH_1	239	243	PF00917	0.663
DOC_USP7_MATH_1	300	304	PF00917	0.622
DOC_USP7_MATH_1	81	85	PF00917	0.528
DOC_WW_Pin1_4	235	240	PF00397	0.665
DOC_WW_Pin1_4	71	76	PF00397	0.620
LIG_14-3-3_CanoR_1	188	192	PF00244	0.549
LIG_14-3-3_CanoR_1	2	7	PF00244	0.512
LIG_14-3-3_CanoR_1	288	295	PF00244	0.581
LIG_14-3-3_CanoR_1	304	309	PF00244	0.596
LIG_14-3-3_CanoR_1	42	49	PF00244	0.626
LIG_FHA_1	109	115	PF00498	0.478
LIG_FHA_1	120	126	PF00498	0.414
LIG_FHA_1	17	23	PF00498	0.528
LIG_FHA_2	271	277	PF00498	0.538
LIG_LIR_Gen_1	127	136	PF02991	0.438
LIG_LIR_Nem_3	46	52	PF02991	0.494
LIG_PCNA_PIPBox_1	110	119	PF02747	0.347
LIG_SH2_SRC	170	173	PF00017	0.465
LIG_SH2_STAT5	170	173	PF00017	0.403
LIG_SH3_1	246	252	PF00018	0.504
LIG_SH3_3	241	247	PF00018	0.670
LIG_SH3_3	72	78	PF00018	0.608
LIG_SUMO_SIM_par_1	121	127	PF11976	0.356
LIG_WW_1	251	254	PF00397	0.582
MOD_CK1_1	124	130	PF00069	0.442
MOD_CK1_1	15	21	PF00069	0.530
MOD_CK1_1	238	244	PF00069	0.681
MOD_CK1_1	35	41	PF00069	0.506
MOD_CK1_1	5	11	PF00069	0.703
MOD_CK1_1	50	56	PF00069	0.709
MOD_CK1_1	62	68	PF00069	0.594
MOD_CK1_1	96	102	PF00069	0.464
MOD_Cter_Amidation	266	269	PF01082	0.702
MOD_GlcNHglycan	129	132	PF01048	0.440
MOD_GlcNHglycan	14	17	PF01048	0.587
MOD_GlcNHglycan	241	244	PF01048	0.698
MOD_GlcNHglycan	257	260	PF01048	0.618
MOD_GlcNHglycan	30	33	PF01048	0.457
MOD_GlcNHglycan	52	55	PF01048	0.742
MOD_GlcNHglycan	9	12	PF01048	0.568
MOD_GSK3_1	104	111	PF00069	0.424
MOD_GSK3_1	12	19	PF00069	0.680
MOD_GSK3_1	209	216	PF00069	0.530
MOD_GSK3_1	235	242	PF00069	0.636
MOD_GSK3_1	28	35	PF00069	0.535
MOD_GSK3_1	284	291	PF00069	0.812
MOD_GSK3_1	300	307	PF00069	0.603
MOD_GSK3_1	43	50	PF00069	0.552
MOD_GSK3_1	62	69	PF00069	0.565
MOD_GSK3_1	82	89	PF00069	0.557
MOD_N-GLC_1	255	260	PF02516	0.550
MOD_N-GLC_1	284	289	PF02516	0.668
MOD_N-GLC_1	60	65	PF02516	0.525
MOD_N-GLC_1	87	92	PF02516	0.579
MOD_NEK2_1	7	12	PF00069	0.501
MOD_NEK2_2	121	126	PF00069	0.439
MOD_PIKK_1	270	276	PF00454	0.540
MOD_PK_1	104	110	PF00069	0.421
MOD_PKA_1	213	219	PF00069	0.539
MOD_PKA_2	12	18	PF00069	0.457
MOD_PKA_2	187	193	PF00069	0.554
MOD_PKA_2	213	219	PF00069	0.539
MOD_PKA_2	50	56	PF00069	0.653
MOD_Plk_1	104	110	PF00069	0.480
MOD_Plk_1	60	66	PF00069	0.539
MOD_Plk_1	93	99	PF00069	0.451
MOD_Plk_4	104	110	PF00069	0.447
MOD_Plk_4	124	130	PF00069	0.409
MOD_ProDKin_1	235	241	PF00069	0.666
MOD_ProDKin_1	71	77	PF00069	0.621
TRG_ENDOCYTIC_2	49	52	PF00928	0.504
TRG_ER_diArg_1	147	149	PF00400	0.367
TRG_ER_diArg_1	191	193	PF00400	0.664
TRG_ER_diArg_1	207	209	PF00400	0.593
TRG_ER_diArg_1	233	235	PF00400	0.606
TRG_ER_diArg_1	295	297	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H0	Leptomonas seymouri	43%	97%
A0A3S7WZ80	Leishmania donovani	70%	100%
A4I1M2	Leishmania infantum	70%	100%
E9AXQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q9R5	Leishmania major	71%	97%