DUF1935 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania braziliensis

UniProt:

A4HEG7_LEIBR

TriTrypDb:

LbrM.25.2240 , LBRM2903_250026500

Length:

139

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 5
Forrest at al. (procyclic)	no	yes: 7
Silverman et al.	no	yes: 1
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 52
NetGPI	no	yes: 0, no: 52

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0097542	ciliary tip	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2

Expansion

Sequence features

A4HEG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG7

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0044782	cilium organization	5	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	137	139	PF00082	0.665
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.420
CLV_PCSK_SKI1_1	27	31	PF00082	0.336
CLV_PCSK_SKI1_1	50	54	PF00082	0.408
DOC_USP7_UBL2_3	133	137	PF12436	0.631
DOC_USP7_UBL2_3	30	34	PF12436	0.387
LIG_14-3-3_CanoR_1	65	74	PF00244	0.170
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.378
LIG_FHA_1	111	117	PF00498	0.394
LIG_FHA_2	79	85	PF00498	0.423
LIG_LIR_Nem_3	49	54	PF02991	0.360
LIG_NRBOX	39	45	PF00104	0.423
LIG_NRP_CendR_1	137	139	PF00754	0.420
LIG_PCNA_yPIPBox_3	30	44	PF02747	0.324
LIG_SH2_CRK	18	22	PF00017	0.512
LIG_SH2_SRC	45	48	PF00017	0.424
LIG_SH2_STAP1	112	116	PF00017	0.423
LIG_SH2_STAP1	60	64	PF00017	0.386
LIG_SH2_STAT3	8	11	PF00017	0.592
LIG_SH2_STAT5	112	115	PF00017	0.423
LIG_SH2_STAT5	67	70	PF00017	0.397
LIG_SH3_2	22	27	PF14604	0.423
LIG_SH3_3	19	25	PF00018	0.423
LIG_TRAF2_1	21	24	PF00917	0.433
MOD_CK1_1	111	117	PF00069	0.399
MOD_CK1_1	6	12	PF00069	0.543
MOD_CK1_1	69	75	PF00069	0.423
MOD_CK2_1	111	117	PF00069	0.423
MOD_CK2_1	69	75	PF00069	0.374
MOD_CK2_1	78	84	PF00069	0.423
MOD_GlcNHglycan	8	11	PF01048	0.517
MOD_GSK3_1	108	115	PF00069	0.402
MOD_N-GLC_1	54	59	PF02516	0.337
MOD_N-GLC_1	78	83	PF02516	0.423
MOD_NMyristoyl	1	7	PF02799	0.562
MOD_PIKK_1	98	104	PF00454	0.383
MOD_Plk_1	54	60	PF00069	0.388
MOD_Plk_1	78	84	PF00069	0.423
TRG_DiLeu_BaEn_2	99	105	PF01217	0.423
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.405
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y3	Leptomonas seymouri	38%	100%
A0A0N1HYV4	Leptomonas seymouri	36%	100%
A0A0N1I5S6	Leptomonas seymouri	38%	90%
A0A0N1I8U4	Leptomonas seymouri	32%	100%
A0A0N1P9P7	Leptomonas seymouri	36%	71%
A0A0N1PCZ0	Leptomonas seymouri	35%	100%
A0A0N1PE11	Leptomonas seymouri	96%	98%
A0A1X0NNW3	Trypanosomatidae	33%	100%
A0A1X0NW79	Trypanosomatidae	33%	70%
A0A1X0NW95	Trypanosomatidae	38%	100%
A0A1X0NWV3	Trypanosomatidae	38%	93%
A0A1X0NYV3	Trypanosomatidae	53%	100%
A0A3Q8I9V9	Leishmania donovani	36%	100%
A0A3Q8IBM6	Leishmania donovani	34%	100%
A0A3Q8IDP8	Leishmania donovani	36%	92%
A0A3Q8IKN9	Leishmania donovani	38%	100%
A0A3R7MB04	Trypanosoma rangeli	36%	100%
A0A3R7MWC6	Trypanosoma rangeli	38%	100%
A0A3S7WW23	Leishmania donovani	30%	100%
A0A3S7WZ86	Leishmania donovani	95%	98%
A0A422MSY8	Trypanosoma rangeli	36%	83%
A0A422MSZ3	Trypanosoma rangeli	41%	100%
A0A422MUY0	Trypanosoma rangeli	31%	93%
A0A422N058	Trypanosoma rangeli	40%	91%
A4H7N9	Leishmania braziliensis	37%	100%
A4H7P0	Leishmania braziliensis	37%	100%
A4HW29	Leishmania infantum	36%	100%
A4HYW6	Leishmania infantum	34%	100%
A4HYX1	Leishmania infantum	36%	92%
A4HYX3	Leishmania infantum	30%	100%
A4HYX4	Leishmania infantum	39%	100%
A4I1M3	Leishmania infantum	95%	98%
C9ZIF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZIF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZIF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AIH8	Leishmania braziliensis	34%	100%
E9AII3	Leishmania braziliensis	38%	100%
E9AII5	Leishmania braziliensis	34%	100%
E9AII6	Leishmania braziliensis	38%	100%
E9APT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AUR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AUR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	92%
E9AUS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AUS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AXQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
P84150	Leishmania major	34%	100%
Q4Q9R4	Leishmania major	94%	100%
Q4QFP8	Leishmania major	36%	100%
Q5SDH3	Leishmania major	34%	100%
Q5SDH4	Leishmania major	30%	100%
Q5SDH5	Leishmania major	36%	99%