RMI1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEG6_LEIBR

TriTrypDb:

LbrM.25.2230 , LBRM2903_250026600

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0031422	RecQ family helicase-topoisomerase III complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HEG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG6

Function

Biological processes
Term	Name	Level	Count
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.534
CLV_C14_Caspase3-7	285	289	PF00656	0.775
CLV_NRD_NRD_1	415	417	PF00675	0.518
CLV_NRD_NRD_1	487	489	PF00675	0.495
CLV_PCSK_KEX2_1	415	417	PF00082	0.518
CLV_PCSK_KEX2_1	487	489	PF00082	0.497
CLV_PCSK_SKI1_1	108	112	PF00082	0.310
CLV_PCSK_SKI1_1	323	327	PF00082	0.462
CLV_PCSK_SKI1_1	384	388	PF00082	0.629
DEG_APCC_DBOX_1	107	115	PF00400	0.405
DEG_ODPH_VHL_1	37	49	PF01847	0.651
DOC_CKS1_1	159	164	PF01111	0.405
DOC_CYCLIN_RxL_1	103	115	PF00134	0.510
DOC_CYCLIN_RxL_1	168	179	PF00134	0.487
DOC_CYCLIN_RxL_1	447	455	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.546
DOC_MAPK_gen_1	103	111	PF00069	0.567
DOC_MAPK_gen_1	487	496	PF00069	0.318
DOC_USP7_MATH_1	489	493	PF00917	0.466
DOC_USP7_MATH_1	79	83	PF00917	0.645
DOC_WW_Pin1_4	142	147	PF00397	0.405
DOC_WW_Pin1_4	158	163	PF00397	0.361
DOC_WW_Pin1_4	304	309	PF00397	0.738
DOC_WW_Pin1_4	363	368	PF00397	0.616
DOC_WW_Pin1_4	394	399	PF00397	0.454
DOC_WW_Pin1_4	402	407	PF00397	0.560
DOC_WW_Pin1_4	409	414	PF00397	0.616
DOC_WW_Pin1_4	75	80	PF00397	0.738
LIG_14-3-3_CanoR_1	450	455	PF00244	0.480
LIG_14-3-3_CanoR_1	66	71	PF00244	0.547
LIG_APCC_ABBA_1	254	259	PF00400	0.534
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BIR_III_2	143	147	PF00653	0.405
LIG_BRCT_BRCA1_1	177	181	PF00533	0.562
LIG_CtBP_PxDLS_1	206	212	PF00389	0.516
LIG_EH1_1	84	92	PF00400	0.227
LIG_FHA_1	132	138	PF00498	0.405
LIG_FHA_1	159	165	PF00498	0.405
LIG_FHA_1	216	222	PF00498	0.541
LIG_FHA_1	352	358	PF00498	0.487
LIG_FHA_1	386	392	PF00498	0.516
LIG_FHA_1	463	469	PF00498	0.556
LIG_FHA_1	84	90	PF00498	0.484
LIG_LIR_Gen_1	178	187	PF02991	0.483
LIG_LIR_Gen_1	388	395	PF02991	0.453
LIG_LIR_Nem_3	178	184	PF02991	0.476
LIG_LIR_Nem_3	388	392	PF02991	0.460
LIG_LIR_Nem_3	447	452	PF02991	0.415
LIG_MYND_1	35	39	PF01753	0.645
LIG_SH2_CRK	198	202	PF00017	0.542
LIG_SH2_CRK	281	285	PF00017	0.541
LIG_SH2_CRK	389	393	PF00017	0.505
LIG_SH2_STAP1	389	393	PF00017	0.510
LIG_SH2_STAT5	12	15	PF00017	0.623
LIG_SH3_1	281	287	PF00018	0.532
LIG_SH3_2	327	332	PF14604	0.575
LIG_SH3_3	159	165	PF00018	0.562
LIG_SH3_3	25	31	PF00018	0.679
LIG_SH3_3	281	287	PF00018	0.599
LIG_SH3_3	309	315	PF00018	0.602
LIG_SH3_3	324	330	PF00018	0.606
LIG_SH3_3	340	346	PF00018	0.535
LIG_SH3_3	439	445	PF00018	0.524
LIG_SH3_3	497	503	PF00018	0.624
LIG_SH3_3	69	75	PF00018	0.586
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.324
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.586
LIG_SUMO_SIM_par_1	183	189	PF11976	0.535
LIG_SUMO_SIM_par_1	450	455	PF11976	0.331
LIG_UBA3_1	90	97	PF00899	0.405
MOD_CDK_SPK_2	402	407	PF00069	0.444
MOD_CDK_SPxK_1	409	415	PF00069	0.516
MOD_CDK_SPxxK_3	409	416	PF00069	0.555
MOD_CK1_1	113	119	PF00069	0.591
MOD_CK1_1	121	127	PF00069	0.562
MOD_CK1_1	191	197	PF00069	0.579
MOD_CK1_1	307	313	PF00069	0.764
MOD_CK1_1	366	372	PF00069	0.548
MOD_CK1_1	396	402	PF00069	0.555
MOD_CK1_1	78	84	PF00069	0.690
MOD_CK2_1	396	402	PF00069	0.328
MOD_CK2_1	489	495	PF00069	0.589
MOD_GlcNHglycan	120	123	PF01048	0.386
MOD_GlcNHglycan	165	168	PF01048	0.350
MOD_GlcNHglycan	188	193	PF01048	0.362
MOD_GlcNHglycan	398	401	PF01048	0.334
MOD_GlcNHglycan	42	45	PF01048	0.481
MOD_GlcNHglycan	81	84	PF01048	0.706
MOD_GSK3_1	110	117	PF00069	0.522
MOD_GSK3_1	118	125	PF00069	0.485
MOD_GSK3_1	2	9	PF00069	0.687
MOD_GSK3_1	217	224	PF00069	0.563
MOD_GSK3_1	267	274	PF00069	0.637
MOD_GSK3_1	288	295	PF00069	0.683
MOD_GSK3_1	304	311	PF00069	0.733
MOD_GSK3_1	351	358	PF00069	0.511
MOD_GSK3_1	363	370	PF00069	0.615
MOD_GSK3_1	55	62	PF00069	0.778
MOD_GSK3_1	75	82	PF00069	0.721
MOD_N-GLC_1	409	414	PF02516	0.514
MOD_NEK2_1	110	115	PF00069	0.586
MOD_NEK2_1	217	222	PF00069	0.542
MOD_NEK2_1	266	271	PF00069	0.624
MOD_NEK2_1	387	392	PF00069	0.544
MOD_NEK2_1	40	45	PF00069	0.641
MOD_NEK2_1	452	457	PF00069	0.466
MOD_PIKK_1	313	319	PF00454	0.718
MOD_PK_1	66	72	PF00069	0.539
MOD_PKA_2	271	277	PF00069	0.697
MOD_PKA_2	33	39	PF00069	0.628
MOD_PKA_2	489	495	PF00069	0.470
MOD_PKA_2	65	71	PF00069	0.548
MOD_PKB_1	64	72	PF00069	0.543
MOD_Plk_1	6	12	PF00069	0.659
MOD_Plk_1	97	103	PF00069	0.496
MOD_Plk_2-3	6	12	PF00069	0.620
MOD_Plk_4	387	393	PF00069	0.553
MOD_Plk_4	489	495	PF00069	0.448
MOD_Plk_4	85	91	PF00069	0.496
MOD_ProDKin_1	142	148	PF00069	0.405
MOD_ProDKin_1	158	164	PF00069	0.361
MOD_ProDKin_1	304	310	PF00069	0.740
MOD_ProDKin_1	363	369	PF00069	0.624
MOD_ProDKin_1	394	400	PF00069	0.455
MOD_ProDKin_1	402	408	PF00069	0.569
MOD_ProDKin_1	409	415	PF00069	0.617
MOD_ProDKin_1	75	81	PF00069	0.735
TRG_DiLeu_BaEn_1	425	430	PF01217	0.403
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.461
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.750
TRG_ENDOCYTIC_2	198	201	PF00928	0.542
TRG_ENDOCYTIC_2	389	392	PF00928	0.514
TRG_ER_diArg_1	106	109	PF00400	0.586
TRG_ER_diArg_1	195	198	PF00400	0.550
TRG_ER_diArg_1	486	488	PF00400	0.425
TRG_ER_diArg_1	63	66	PF00400	0.552
TRG_NES_CRM1_1	176	189	PF08389	0.562
TRG_NES_CRM1_1	245	259	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I876	Leptomonas seymouri	53%	100%
A0A0S4ILE1	Bodo saltans	25%	100%
A0A3S7WZC3	Leishmania donovani	77%	100%
A0A422NGJ8	Trypanosoma rangeli	29%	100%
A4I1M4	Leishmania infantum	77%	100%
C9ZK66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q9R3	Leishmania major	78%	98%
V5DIU3	Trypanosoma cruzi	32%	100%