FFD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein SCD6.10

Species:

Leishmania braziliensis

UniProt:

A4HEG4_LEIBR

TriTrypDb:

LbrM.25.2210 , LBRM2903_250012300

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1990124	messenger ribonucleoprotein complex	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HEG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033962	P-body assembly	7	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.604
CLV_NRD_NRD_1	181	183	PF00675	0.588
CLV_NRD_NRD_1	262	264	PF00675	0.650
CLV_NRD_NRD_1	282	284	PF00675	0.614
CLV_NRD_NRD_1	45	47	PF00675	0.359
CLV_PCSK_KEX2_1	143	145	PF00082	0.604
CLV_PCSK_KEX2_1	181	183	PF00082	0.588
CLV_PCSK_KEX2_1	282	284	PF00082	0.614
CLV_PCSK_SKI1_1	72	76	PF00082	0.321
DOC_USP7_MATH_1	111	115	PF00917	0.788
DOC_USP7_MATH_1	116	120	PF00917	0.554
DOC_USP7_MATH_1	122	126	PF00917	0.520
DOC_USP7_UBL2_3	228	232	PF12436	0.524
DOC_USP7_UBL2_3	236	240	PF12436	0.489
DOC_WW_Pin1_4	79	84	PF00397	0.679
LIG_14-3-3_CanoR_1	123	129	PF00244	0.714
LIG_APCC_ABBA_1	74	79	PF00400	0.496
LIG_BRCT_BRCA1_1	124	128	PF00533	0.643
LIG_BRCT_BRCA1_1	240	244	PF00533	0.515
LIG_FHA_1	30	36	PF00498	0.491
LIG_FHA_1	55	61	PF00498	0.575
LIG_FHA_2	187	193	PF00498	0.559
LIG_LIR_Gen_1	241	250	PF02991	0.509
LIG_LIR_Gen_1	58	66	PF02991	0.465
LIG_LIR_Nem_3	241	247	PF02991	0.502
LIG_LIR_Nem_3	58	64	PF02991	0.465
LIG_MLH1_MIPbox_1	240	244	PF16413	0.515
LIG_Pex14_2	204	208	PF04695	0.511
LIG_SH2_SRC	129	132	PF00017	0.722
LIG_SH3_3	90	96	PF00018	0.704
LIG_SUMO_SIM_par_1	28	36	PF11976	0.472
MOD_CDK_SPxxK_3	79	86	PF00069	0.681
MOD_CK1_1	114	120	PF00069	0.777
MOD_CK1_1	133	139	PF00069	0.625
MOD_CK1_1	25	31	PF00069	0.559
MOD_CK2_1	10	16	PF00069	0.559
MOD_CK2_1	219	225	PF00069	0.543
MOD_Cter_Amidation	44	47	PF01082	0.359
MOD_GlcNHglycan	113	116	PF01048	0.646
MOD_GlcNHglycan	118	121	PF01048	0.605
MOD_GlcNHglycan	161	164	PF01048	0.642
MOD_GlcNHglycan	176	179	PF01048	0.688
MOD_GSK3_1	111	118	PF00069	0.682
MOD_GSK3_1	239	246	PF00069	0.625
MOD_GSK3_1	25	32	PF00069	0.543
MOD_GSK3_1	269	276	PF00069	0.596
MOD_N-GLC_1	159	164	PF02516	0.755
MOD_NEK2_1	243	248	PF00069	0.591
MOD_NEK2_1	274	279	PF00069	0.620
MOD_NEK2_2	124	129	PF00069	0.668
MOD_PKA_1	219	225	PF00069	0.515
MOD_PKA_2	122	128	PF00069	0.810
MOD_PKA_2	150	156	PF00069	0.748
MOD_PKA_2	66	72	PF00069	0.484
MOD_Plk_1	130	136	PF00069	0.508
MOD_Plk_1	238	244	PF00069	0.554
MOD_Plk_1	29	35	PF00069	0.496
MOD_Plk_1	72	78	PF00069	0.478
MOD_Plk_2-3	239	245	PF00069	0.531
MOD_Plk_4	239	245	PF00069	0.531
MOD_Plk_4	72	78	PF00069	0.478
MOD_ProDKin_1	79	85	PF00069	0.679
MOD_SUMO_rev_2	186	196	PF00179	0.628
MOD_SUMO_rev_2	215	222	PF00179	0.491
MOD_SUMO_rev_2	225	233	PF00179	0.495
MOD_SUMO_rev_2	69	74	PF00179	0.521
TRG_ER_diArg_1	180	182	PF00400	0.612
TRG_ER_diArg_1	281	283	PF00400	0.592
TRG_ER_diArg_1	288	291	PF00400	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC4	Leptomonas seymouri	72%	100%
A0A1X0P4R0	Trypanosomatidae	48%	100%
A0A3Q8IGG5	Leishmania donovani	81%	99%
A0A3R7KUL5	Trypanosoma rangeli	45%	100%
A4I195	Leishmania infantum	81%	99%
D0A5I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P45978	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	84%
Q4QA41	Leishmania major	86%	100%
Q9BX40	Homo sapiens	31%	76%
V5BN65	Trypanosoma cruzi	47%	91%