Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEG3_LEIBR

TriTrypDb:

LbrM.25.2200 , LBRM2903_250012400

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.300
CLV_C14_Caspase3-7	421	425	PF00656	0.529
CLV_C14_Caspase3-7	524	528	PF00656	0.643
CLV_NRD_NRD_1	185	187	PF00675	0.400
CLV_NRD_NRD_1	436	438	PF00675	0.435
CLV_NRD_NRD_1	458	460	PF00675	0.458
CLV_PCSK_FUR_1	434	438	PF00082	0.561
CLV_PCSK_KEX2_1	185	187	PF00082	0.400
CLV_PCSK_KEX2_1	436	438	PF00082	0.435
CLV_PCSK_KEX2_1	458	460	PF00082	0.457
CLV_PCSK_SKI1_1	134	138	PF00082	0.435
CLV_PCSK_SKI1_1	186	190	PF00082	0.471
CLV_PCSK_SKI1_1	452	456	PF00082	0.474
DEG_APCC_DBOX_1	133	141	PF00400	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.339
DEG_SPOP_SBC_1	161	165	PF00917	0.601
DEG_SPOP_SBC_1	172	176	PF00917	0.409
DOC_CKS1_1	267	272	PF01111	0.487
DOC_CYCLIN_RxL_1	214	224	PF00134	0.280
DOC_CYCLIN_RxL_1	288	301	PF00134	0.521
DOC_CYCLIN_RxL_1	392	402	PF00134	0.498
DOC_CYCLIN_RxL_1	456	464	PF00134	0.546
DOC_CYCLIN_RxL_1	474	482	PF00134	0.244
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.432
DOC_MAPK_gen_1	131	139	PF00069	0.518
DOC_MAPK_gen_1	185	193	PF00069	0.392
DOC_MAPK_gen_1	458	465	PF00069	0.447
DOC_MAPK_gen_1	570	579	PF00069	0.616
DOC_MAPK_HePTP_8	183	195	PF00069	0.266
DOC_MAPK_MEF2A_6	185	192	PF00069	0.370
DOC_MAPK_MEF2A_6	443	450	PF00069	0.424
DOC_MAPK_MEF2A_6	458	467	PF00069	0.447
DOC_MAPK_NFAT4_5	185	193	PF00069	0.387
DOC_MAPK_NFAT4_5	458	466	PF00069	0.475
DOC_PP1_RVXF_1	393	400	PF00149	0.493
DOC_USP7_MATH_1	104	108	PF00917	0.540
DOC_USP7_MATH_1	11	15	PF00917	0.584
DOC_USP7_MATH_1	156	160	PF00917	0.510
DOC_USP7_MATH_1	172	176	PF00917	0.607
DOC_USP7_MATH_1	347	351	PF00917	0.748
DOC_USP7_MATH_1	393	397	PF00917	0.445
DOC_USP7_MATH_1	453	457	PF00917	0.501
DOC_USP7_MATH_1	87	91	PF00917	0.721
DOC_WW_Pin1_4	260	265	PF00397	0.617
DOC_WW_Pin1_4	266	271	PF00397	0.691
LIG_14-3-3_CanoR_1	185	191	PF00244	0.464
LIG_14-3-3_CanoR_1	280	287	PF00244	0.503
LIG_14-3-3_CanoR_1	31	36	PF00244	0.405
LIG_14-3-3_CanoR_1	436	446	PF00244	0.344
LIG_14-3-3_CanoR_1	452	462	PF00244	0.523
LIG_Actin_WH2_2	116	133	PF00022	0.546
LIG_Actin_WH2_2	25	41	PF00022	0.533
LIG_BRCT_BRCA1_1	395	399	PF00533	0.284
LIG_BRCT_BRCA1_1	581	585	PF00533	0.481
LIG_CaM_IQ_9	494	510	PF13499	0.395
LIG_Clathr_ClatBox_1	180	184	PF01394	0.287
LIG_CtBP_PxDLS_1	264	268	PF00389	0.460
LIG_eIF4E_1	352	358	PF01652	0.377
LIG_FHA_1	125	131	PF00498	0.448
LIG_FHA_1	147	153	PF00498	0.464
LIG_FHA_1	187	193	PF00498	0.475
LIG_FHA_1	216	222	PF00498	0.521
LIG_FHA_1	230	236	PF00498	0.407
LIG_FHA_1	249	255	PF00498	0.195
LIG_FHA_1	398	404	PF00498	0.375
LIG_FHA_1	43	49	PF00498	0.438
LIG_FHA_1	442	448	PF00498	0.493
LIG_FHA_1	485	491	PF00498	0.437
LIG_FHA_1	538	544	PF00498	0.499
LIG_FHA_2	487	493	PF00498	0.495
LIG_Integrin_RGD_1	419	421	PF01839	0.460
LIG_IRF3_LxIS_1	446	451	PF10401	0.283
LIG_LIR_Gen_1	470	479	PF02991	0.291
LIG_LIR_Gen_1	549	560	PF02991	0.410
LIG_LIR_Nem_3	323	327	PF02991	0.533
LIG_LIR_Nem_3	33	38	PF02991	0.414
LIG_LIR_Nem_3	470	475	PF02991	0.293
LIG_LIR_Nem_3	549	555	PF02991	0.395
LIG_PCNA_yPIPBox_3	244	257	PF02747	0.473
LIG_PDZ_Class_3	580	585	PF00595	0.729
LIG_Pex14_1	36	40	PF04695	0.538
LIG_Pex14_2	135	139	PF04695	0.529
LIG_SH2_NCK_1	337	341	PF00017	0.513
LIG_SH2_PTP2	324	327	PF00017	0.562
LIG_SH2_SRC	324	327	PF00017	0.562
LIG_SH2_STAP1	305	309	PF00017	0.482
LIG_SH2_STAP1	352	356	PF00017	0.411
LIG_SH2_STAT5	309	312	PF00017	0.557
LIG_SH2_STAT5	324	327	PF00017	0.562
LIG_SH2_STAT5	366	369	PF00017	0.520
LIG_SH2_STAT5	416	419	PF00017	0.669
LIG_SH2_STAT5	472	475	PF00017	0.308
LIG_SH3_3	224	230	PF00018	0.504
LIG_SH3_3	258	264	PF00018	0.356
LIG_SH3_3	95	101	PF00018	0.735
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.397
LIG_SUMO_SIM_anti_2	232	239	PF11976	0.423
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.511
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.446
LIG_SUMO_SIM_anti_2	444	451	PF11976	0.375
LIG_SUMO_SIM_par_1	25	30	PF11976	0.562
LIG_SUMO_SIM_par_1	444	451	PF11976	0.434
LIG_SxIP_EBH_1	76	89	PF03271	0.515
LIG_TRAF2_1	16	19	PF00917	0.565
LIG_TRAF2_1	427	430	PF00917	0.416
LIG_UBA3_1	28	37	PF00899	0.518
LIG_UBA3_1	389	395	PF00899	0.365
LIG_WRC_WIRS_1	472	477	PF05994	0.274
MOD_CDK_SPxxK_3	266	273	PF00069	0.487
MOD_CK1_1	107	113	PF00069	0.697
MOD_CK1_1	159	165	PF00069	0.594
MOD_CK1_1	348	354	PF00069	0.726
MOD_CK1_1	49	55	PF00069	0.587
MOD_CK1_1	528	534	PF00069	0.596
MOD_CK1_1	74	80	PF00069	0.750
MOD_CK2_1	359	365	PF00069	0.511
MOD_GlcNHglycan	109	112	PF01048	0.712
MOD_GlcNHglycan	168	171	PF01048	0.690
MOD_GlcNHglycan	347	350	PF01048	0.710
MOD_GlcNHglycan	469	472	PF01048	0.419
MOD_GlcNHglycan	52	55	PF01048	0.648
MOD_GlcNHglycan	523	526	PF01048	0.659
MOD_GlcNHglycan	531	534	PF01048	0.557
MOD_GlcNHglycan	73	76	PF01048	0.759
MOD_GlcNHglycan	80	83	PF01048	0.734
MOD_GlcNHglycan	85	88	PF01048	0.623
MOD_GlcNHglycan	89	92	PF01048	0.667
MOD_GSK3_1	109	116	PF00069	0.713
MOD_GSK3_1	152	159	PF00069	0.476
MOD_GSK3_1	162	169	PF00069	0.689
MOD_GSK3_1	27	34	PF00069	0.307
MOD_GSK3_1	393	400	PF00069	0.387
MOD_GSK3_1	42	49	PF00069	0.542
MOD_GSK3_1	437	444	PF00069	0.430
MOD_GSK3_1	448	455	PF00069	0.411
MOD_GSK3_1	467	474	PF00069	0.235
MOD_GSK3_1	521	528	PF00069	0.629
MOD_GSK3_1	70	77	PF00069	0.765
MOD_GSK3_1	83	90	PF00069	0.766
MOD_NEK2_1	1	6	PF00069	0.378
MOD_NEK2_1	109	114	PF00069	0.743
MOD_NEK2_1	130	135	PF00069	0.523
MOD_NEK2_1	152	157	PF00069	0.465
MOD_NEK2_1	27	32	PF00069	0.522
MOD_NEK2_1	448	453	PF00069	0.444
MOD_NEK2_1	461	466	PF00069	0.422
MOD_NEK2_1	467	472	PF00069	0.281
MOD_NEK2_1	479	484	PF00069	0.432
MOD_NEK2_1	547	552	PF00069	0.540
MOD_NEK2_2	366	371	PF00069	0.528
MOD_NEK2_2	393	398	PF00069	0.421
MOD_PIKK_1	397	403	PF00454	0.533
MOD_PIKK_1	453	459	PF00454	0.520
MOD_PKA_2	104	110	PF00069	0.524
MOD_PKA_2	130	136	PF00069	0.514
MOD_PKA_2	279	285	PF00069	0.555
MOD_PKA_2	30	36	PF00069	0.409
MOD_PKA_2	479	485	PF00069	0.475
MOD_PKA_2	537	543	PF00069	0.571
MOD_Plk_2-3	486	492	PF00069	0.545
MOD_Plk_4	3	9	PF00069	0.580
MOD_Plk_4	31	37	PF00069	0.445
MOD_Plk_4	366	372	PF00069	0.462
MOD_Plk_4	461	467	PF00069	0.509
MOD_Plk_4	471	477	PF00069	0.451
MOD_Plk_4	486	492	PF00069	0.322
MOD_Plk_4	547	553	PF00069	0.422
MOD_ProDKin_1	260	266	PF00069	0.627
TRG_DiLeu_BaEn_1	222	227	PF01217	0.523
TRG_DiLeu_BaEn_1	385	390	PF01217	0.376
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.553
TRG_ENDOCYTIC_2	202	205	PF00928	0.401
TRG_ENDOCYTIC_2	305	308	PF00928	0.573
TRG_ENDOCYTIC_2	324	327	PF00928	0.562
TRG_ENDOCYTIC_2	472	475	PF00928	0.308
TRG_ER_diArg_1	434	437	PF00400	0.454
TRG_NES_CRM1_1	210	224	PF08389	0.413
TRG_NES_CRM1_1	365	377	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P679	Leptomonas seymouri	49%	81%
A0A1X0P4F4	Trypanosomatidae	29%	100%
A0A3R7MYK8	Trypanosoma rangeli	29%	100%
A0A3S7WYU6	Leishmania donovani	75%	87%
A4I196	Leishmania infantum	75%	87%
D0A5I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	87%
Q4QA40	Leishmania major	74%	100%
V5BXH6	Trypanosoma cruzi	29%	100%