J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEG2_LEIBR

TriTrypDb:

LbrM.25.2190 , LBRM2903_250012500

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HEG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.635
CLV_NRD_NRD_1	159	161	PF00675	0.457
CLV_NRD_NRD_1	58	60	PF00675	0.521
CLV_NRD_NRD_1	9	11	PF00675	0.521
CLV_PCSK_KEX2_1	158	160	PF00082	0.448
CLV_PCSK_KEX2_1	58	60	PF00082	0.492
CLV_PCSK_KEX2_1	68	70	PF00082	0.448
CLV_PCSK_KEX2_1	9	11	PF00082	0.521
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.448
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.475
CLV_PCSK_SKI1_1	18	22	PF00082	0.552
CLV_PCSK_SKI1_1	182	186	PF00082	0.368
CLV_PCSK_SKI1_1	193	197	PF00082	0.656
CLV_PCSK_SKI1_1	27	31	PF00082	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.702
DOC_MAPK_gen_1	156	166	PF00069	0.622
DOC_MAPK_MEF2A_6	158	166	PF00069	0.548
DOC_PP1_RVXF_1	146	152	PF00149	0.661
DOC_PP2B_LxvP_1	84	87	PF13499	0.696
DOC_USP7_MATH_1	139	143	PF00917	0.670
DOC_USP7_MATH_1	87	91	PF00917	0.666
DOC_WW_Pin1_4	130	135	PF00397	0.657
LIG_14-3-3_CanoR_1	58	66	PF00244	0.743
LIG_14-3-3_CterR_2	193	197	PF00244	0.474
LIG_Actin_WH2_2	171	188	PF00022	0.379
LIG_Clathr_ClatBox_1	75	79	PF01394	0.547
LIG_EH1_1	173	181	PF00400	0.454
LIG_FHA_1	39	45	PF00498	0.659
LIG_FHA_2	89	95	PF00498	0.623
LIG_GBD_Chelix_1	175	183	PF00786	0.349
LIG_LIR_Gen_1	60	70	PF02991	0.738
LIG_Pex14_2	74	78	PF04695	0.645
LIG_SH2_STAT5	136	139	PF00017	0.670
LIG_SH3_3	128	134	PF00018	0.641
LIG_SH3_3	181	187	PF00018	0.447
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.639
LIG_SUMO_SIM_par_1	79	85	PF11976	0.695
LIG_TRFH_1	151	155	PF08558	0.686
LIG_UBA3_1	178	182	PF00899	0.349
MOD_CK1_1	141	147	PF00069	0.689
MOD_CK1_1	88	94	PF00069	0.664
MOD_CK2_1	50	56	PF00069	0.580
MOD_CK2_1	87	93	PF00069	0.683
MOD_Cter_Amidation	66	69	PF01082	0.468
MOD_GSK3_1	21	28	PF00069	0.702
MOD_GSK3_1	45	52	PF00069	0.595
MOD_N-GLC_1	188	193	PF02516	0.732
MOD_NEK2_1	21	26	PF00069	0.755
MOD_NEK2_1	37	42	PF00069	0.634
MOD_NEK2_2	13	18	PF00069	0.584
MOD_PIKK_1	139	145	PF00454	0.740
MOD_PIKK_1	57	63	PF00454	0.693
MOD_PKA_2	21	27	PF00069	0.620
MOD_PKA_2	57	63	PF00069	0.741
MOD_Plk_1	188	194	PF00069	0.524
MOD_Plk_1	88	94	PF00069	0.680
MOD_Plk_4	45	51	PF00069	0.629
MOD_ProDKin_1	130	136	PF00069	0.659
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.672
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.766
TRG_ENDOCYTIC_2	62	65	PF00928	0.792
TRG_ER_diArg_1	146	149	PF00400	0.656
TRG_ER_diArg_1	159	161	PF00400	0.626
TRG_ER_diArg_1	8	10	PF00400	0.716
TRG_NLS_MonoExtC_3	157	163	PF00514	0.658
TRG_NLS_MonoExtN_4	155	162	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP6	Leptomonas seymouri	70%	100%
A0A0S4IQD4	Bodo saltans	46%	100%
A0A1X0P4F3	Trypanosomatidae	60%	100%
A0A3S7WYX1	Leishmania donovani	80%	100%
A0A422NX26	Trypanosoma rangeli	64%	100%
A4I197	Leishmania infantum	80%	100%
D0A5I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AXD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QA39	Leishmania major	81%	100%