Tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tyrosine phosphatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HEG1_LEIBR

TriTrypDb:

LbrM.25.2180 , LBRM2903_250012600

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.469
CLV_C14_Caspase3-7	327	331	PF00656	0.394
CLV_NRD_NRD_1	285	287	PF00675	0.269
CLV_NRD_NRD_1	301	303	PF00675	0.269
CLV_NRD_NRD_1	332	334	PF00675	0.409
CLV_PCSK_KEX2_1	301	303	PF00082	0.269
CLV_PCSK_KEX2_1	332	334	PF00082	0.417
DEG_COP1_1	227	237	PF00400	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.419
DEG_SPOP_SBC_1	96	100	PF00917	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.414
DOC_PP2B_LxvP_1	83	86	PF13499	0.512
DOC_PP4_FxxP_1	135	138	PF00568	0.534
DOC_USP7_MATH_1	174	178	PF00917	0.759
DOC_USP7_MATH_1	180	184	PF00917	0.584
DOC_USP7_MATH_1	233	237	PF00917	0.657
DOC_USP7_MATH_1	62	66	PF00917	0.430
DOC_USP7_MATH_1	95	99	PF00917	0.584
DOC_WW_Pin1_4	134	139	PF00397	0.607
DOC_WW_Pin1_4	198	203	PF00397	0.606
DOC_WW_Pin1_4	78	83	PF00397	0.520
LIG_14-3-3_CanoR_1	163	172	PF00244	0.593
LIG_APCC_ABBA_1	316	321	PF00400	0.469
LIG_Clathr_ClatBox_1	323	327	PF01394	0.469
LIG_FHA_1	34	40	PF00498	0.333
LIG_FHA_2	131	137	PF00498	0.546
LIG_FHA_2	244	250	PF00498	0.469
LIG_GBD_Chelix_1	251	259	PF00786	0.269
LIG_LIR_Apic_2	133	138	PF02991	0.535
LIG_LIR_Gen_1	129	138	PF02991	0.541
LIG_LIR_Gen_1	171	180	PF02991	0.518
LIG_LIR_Gen_1	313	323	PF02991	0.469
LIG_LIR_Nem_3	129	135	PF02991	0.544
LIG_LIR_Nem_3	261	267	PF02991	0.469
LIG_LIR_Nem_3	298	303	PF02991	0.487
LIG_LIR_Nem_3	313	318	PF02991	0.469
LIG_LIR_Nem_3	58	63	PF02991	0.429
LIG_LIR_Nem_3	72	76	PF02991	0.506
LIG_LIR_Nem_3	79	83	PF02991	0.504
LIG_LYPXL_yS_3	265	268	PF13949	0.469
LIG_MYND_1	202	206	PF01753	0.501
LIG_NRBOX	255	261	PF00104	0.469
LIG_Pex14_2	315	319	PF04695	0.469
LIG_SH2_CRK	26	30	PF00017	0.361
LIG_SH2_CRK	80	84	PF00017	0.660
LIG_SH2_STAT5	10	13	PF00017	0.388
LIG_SH2_STAT5	132	135	PF00017	0.561
LIG_SH2_STAT5	214	217	PF00017	0.538
LIG_SH2_STAT5	80	83	PF00017	0.661
LIG_SH3_3	204	210	PF00018	0.565
LIG_SUMO_SIM_par_1	265	270	PF11976	0.469
LIG_SUMO_SIM_par_1	292	299	PF11976	0.469
LIG_SUMO_SIM_par_1	320	327	PF11976	0.516
LIG_TYR_ITIM	263	268	PF00017	0.516
MOD_CDK_SPK_2	198	203	PF00069	0.493
MOD_CK1_1	176	182	PF00069	0.727
MOD_CK1_1	55	61	PF00069	0.434
MOD_CK2_1	225	231	PF00069	0.686
MOD_CK2_1	243	249	PF00069	0.457
MOD_CK2_1	292	298	PF00069	0.490
MOD_Cter_Amidation	330	333	PF01082	0.429
MOD_GlcNHglycan	109	112	PF01048	0.690
MOD_GlcNHglycan	176	179	PF01048	0.665
MOD_GlcNHglycan	227	230	PF01048	0.669
MOD_GlcNHglycan	277	280	PF01048	0.269
MOD_GlcNHglycan	54	57	PF01048	0.389
MOD_GSK3_1	118	125	PF00069	0.720
MOD_GSK3_1	130	137	PF00069	0.570
MOD_GSK3_1	164	171	PF00069	0.705
MOD_GSK3_1	174	181	PF00069	0.547
MOD_GSK3_1	198	205	PF00069	0.547
MOD_GSK3_1	322	329	PF00069	0.587
MOD_GSK3_1	62	69	PF00069	0.460
MOD_N-GLC_1	130	135	PF02516	0.594
MOD_N-GLC_1	305	310	PF02516	0.269
MOD_NEK2_1	267	272	PF00069	0.469
MOD_NEK2_1	28	33	PF00069	0.365
MOD_NEK2_1	52	57	PF00069	0.380
MOD_PKA_1	332	338	PF00069	0.402
MOD_PKA_2	122	128	PF00069	0.542
MOD_PKA_2	332	338	PF00069	0.402
MOD_Plk_1	130	136	PF00069	0.585
MOD_Plk_2-3	322	328	PF00069	0.516
MOD_Plk_4	251	257	PF00069	0.469
MOD_Plk_4	292	298	PF00069	0.469
MOD_Plk_4	332	338	PF00069	0.402
MOD_Plk_4	55	61	PF00069	0.438
MOD_ProDKin_1	134	140	PF00069	0.609
MOD_ProDKin_1	198	204	PF00069	0.608
MOD_ProDKin_1	78	84	PF00069	0.519
MOD_SUMO_rev_2	236	241	PF00179	0.601
TRG_DiLeu_BaEn_4	321	327	PF01217	0.469
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.469
TRG_ENDOCYTIC_2	132	135	PF00928	0.541
TRG_ENDOCYTIC_2	214	217	PF00928	0.533
TRG_ENDOCYTIC_2	26	29	PF00928	0.353
TRG_ENDOCYTIC_2	264	267	PF00928	0.504
TRG_ENDOCYTIC_2	300	303	PF00928	0.469
TRG_ENDOCYTIC_2	80	83	PF00928	0.661
TRG_ER_diArg_1	300	302	PF00400	0.469
TRG_ER_diArg_1	332	334	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW7	Leptomonas seymouri	55%	90%
A0A3S7WYV2	Leishmania donovani	82%	100%
A4I198	Leishmania infantum	81%	100%
E9AXD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QA38	Leishmania major	79%	100%