Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEG0_LEIBR

TriTrypDb:

LbrM.25.2170 , LBRM2903_250012700

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.489
CLV_NRD_NRD_1	178	180	PF00675	0.640
CLV_NRD_NRD_1	18	20	PF00675	0.396
CLV_NRD_NRD_1	2	4	PF00675	0.559
CLV_NRD_NRD_1	43	45	PF00675	0.529
CLV_PCSK_FUR_1	153	157	PF00082	0.418
CLV_PCSK_KEX2_1	155	157	PF00082	0.442
CLV_PCSK_KEX2_1	18	20	PF00082	0.396
CLV_PCSK_KEX2_1	2	4	PF00082	0.559
CLV_PCSK_KEX2_1	43	45	PF00082	0.529
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.441
CLV_PCSK_PC7_1	151	157	PF00082	0.403
CLV_PCSK_SKI1_1	112	116	PF00082	0.539
DEG_Nend_UBRbox_1	1	4	PF02207	0.562
DEG_SCF_FBW7_1	54	60	PF00400	0.518
DOC_CKS1_1	54	59	PF01111	0.527
DOC_MAPK_gen_1	131	140	PF00069	0.373
DOC_MAPK_gen_1	2	11	PF00069	0.641
DOC_MAPK_MEF2A_6	133	142	PF00069	0.360
DOC_MAPK_RevD_3	140	156	PF00069	0.364
DOC_SPAK_OSR1_1	10	14	PF12202	0.433
DOC_USP7_MATH_1	171	175	PF00917	0.515
DOC_USP7_UBL2_3	127	131	PF12436	0.420
DOC_USP7_UBL2_3	133	137	PF12436	0.416
DOC_USP7_UBL2_3	176	180	PF12436	0.617
DOC_WW_Pin1_4	53	58	PF00397	0.420
LIG_14-3-3_CanoR_1	3	13	PF00244	0.482
LIG_FHA_1	113	119	PF00498	0.296
LIG_FHA_1	93	99	PF00498	0.498
LIG_FHA_2	91	97	PF00498	0.493
LIG_LIR_Gen_1	170	177	PF02991	0.512
LIG_LIR_Nem_3	148	152	PF02991	0.381
LIG_LIR_Nem_3	8	14	PF02991	0.431
LIG_LIR_Nem_3	94	100	PF02991	0.495
LIG_SH2_GRB2like	97	100	PF00017	0.493
LIG_SH2_STAT3	100	103	PF00017	0.522
LIG_SH2_STAT5	97	100	PF00017	0.438
LIG_TYR_ITIM	70	75	PF00017	0.382
MOD_CDK_SPxK_1	53	59	PF00069	0.535
MOD_CK2_1	90	96	PF00069	0.405
MOD_GlcNHglycan	33	36	PF01048	0.573
MOD_GSK3_1	171	178	PF00069	0.577
MOD_GSK3_1	53	60	PF00069	0.392
MOD_NEK2_1	14	19	PF00069	0.588
MOD_NEK2_1	158	163	PF00069	0.403
MOD_NEK2_1	175	180	PF00069	0.522
MOD_NEK2_1	4	9	PF00069	0.516
MOD_NEK2_1	48	53	PF00069	0.527
MOD_NEK2_2	171	176	PF00069	0.585
MOD_PIKK_1	158	164	PF00454	0.461
MOD_PIKK_1	182	188	PF00454	0.645
MOD_PKA_2	5	11	PF00069	0.513
MOD_Plk_2-3	90	96	PF00069	0.436
MOD_ProDKin_1	53	59	PF00069	0.420
MOD_SUMO_rev_2	130	139	PF00179	0.396
TRG_ENDOCYTIC_2	149	152	PF00928	0.397
TRG_ENDOCYTIC_2	172	175	PF00928	0.469
TRG_ENDOCYTIC_2	71	74	PF00928	0.368
TRG_ER_diArg_1	1	3	PF00400	0.565
TRG_ER_diArg_1	42	44	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM8	Leptomonas seymouri	80%	100%
A0A0S4IKU3	Bodo saltans	52%	100%
A0A1X0P4E1	Trypanosomatidae	58%	93%
A0A3Q8IC88	Leishmania donovani	87%	100%
A0A422NWZ6	Trypanosoma rangeli	63%	100%
A4I199	Leishmania infantum	87%	100%
D0A5J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	95%
E9AXD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA37	Leishmania major	88%	100%