Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEF5_LEIBR

TriTrypDb:

LbrM.25.2120 , LBRM2903_250013400

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HEF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.282
CLV_NRD_NRD_1	233	235	PF00675	0.305
CLV_NRD_NRD_1	8	10	PF00675	0.436
CLV_PCSK_FUR_1	215	219	PF00082	0.248
CLV_PCSK_FUR_1	231	235	PF00082	0.326
CLV_PCSK_KEX2_1	214	216	PF00082	0.296
CLV_PCSK_KEX2_1	217	219	PF00082	0.280
CLV_PCSK_KEX2_1	233	235	PF00082	0.295
CLV_PCSK_KEX2_1	8	10	PF00082	0.437
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.306
DEG_Nend_UBRbox_1	1	4	PF02207	0.589
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.656
DOC_MAPK_DCC_7	56	66	PF00069	0.553
DOC_MAPK_gen_1	253	262	PF00069	0.503
DOC_MAPK_gen_1	5	14	PF00069	0.634
DOC_MAPK_gen_1	56	66	PF00069	0.580
DOC_MAPK_MEF2A_6	253	262	PF00069	0.520
DOC_MAPK_MEF2A_6	274	282	PF00069	0.525
DOC_MAPK_MEF2A_6	59	66	PF00069	0.688
DOC_MAPK_MEF2A_6	83	92	PF00069	0.617
DOC_PP4_FxxP_1	45	48	PF00568	0.692
LIG_14-3-3_CanoR_1	157	163	PF00244	0.510
LIG_14-3-3_CanoR_1	215	221	PF00244	0.486
LIG_Actin_WH2_2	39	55	PF00022	0.694
LIG_ActinCP_TwfCPI_2	45	53	PF01115	0.700
LIG_eIF4E_1	23	29	PF01652	0.648
LIG_EVH1_2	62	66	PF00568	0.684
LIG_FHA_1	211	217	PF00498	0.439
LIG_LIR_Gen_1	166	177	PF02991	0.514
LIG_LIR_Nem_3	15	20	PF02991	0.648
LIG_LIR_Nem_3	166	172	PF02991	0.497
LIG_LIR_Nem_3	219	223	PF02991	0.470
LIG_LIR_Nem_3	292	298	PF02991	0.305
LIG_PCNA_yPIPBox_3	233	246	PF02747	0.536
LIG_PTB_Apo_2	241	248	PF02174	0.455
LIG_PTB_Phospho_1	241	247	PF10480	0.450
LIG_SH2_CRK	223	227	PF00017	0.460
LIG_SH2_GRB2like	295	298	PF00017	0.505
LIG_SH2_PTP2	259	262	PF00017	0.449
LIG_SH2_STAP1	169	173	PF00017	0.492
LIG_SH2_STAP1	201	205	PF00017	0.503
LIG_SH2_STAP1	295	299	PF00017	0.308
LIG_SH2_STAT5	195	198	PF00017	0.477
LIG_SH2_STAT5	259	262	PF00017	0.439
LIG_SH2_STAT5	295	298	PF00017	0.364
LIG_SH3_2	48	53	PF14604	0.619
LIG_SH3_3	174	180	PF00018	0.568
LIG_SH3_3	21	27	PF00018	0.613
LIG_SH3_3	45	51	PF00018	0.613
LIG_SH3_3	57	63	PF00018	0.610
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.660
LIG_SUMO_SIM_par_1	70	76	PF11976	0.660
LIG_TYR_ITIM	221	226	PF00017	0.310
LIG_UBA3_1	242	248	PF00899	0.346
MOD_CK1_1	118	124	PF00069	0.419
MOD_CK1_1	149	155	PF00069	0.444
MOD_GlcNHglycan	136	139	PF01048	0.565
MOD_GSK3_1	282	289	PF00069	0.276
MOD_GSK3_1	86	93	PF00069	0.570
MOD_N-GLC_2	281	283	PF02516	0.341
MOD_NEK2_1	173	178	PF00069	0.421
MOD_NEK2_1	18	23	PF00069	0.600
MOD_NEK2_1	293	298	PF00069	0.334
MOD_NEK2_2	158	163	PF00069	0.392
MOD_PIKK_1	90	96	PF00454	0.450
MOD_PKA_2	115	121	PF00069	0.425
MOD_PKA_2	216	222	PF00069	0.322
MOD_Plk_1	173	179	PF00069	0.441
MOD_Plk_4	118	124	PF00069	0.432
MOD_Plk_4	158	164	PF00069	0.428
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.622
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.563
TRG_ENDOCYTIC_2	169	172	PF00928	0.358
TRG_ENDOCYTIC_2	223	226	PF00928	0.300
TRG_ENDOCYTIC_2	259	262	PF00928	0.311
TRG_ENDOCYTIC_2	275	278	PF00928	0.348
TRG_ENDOCYTIC_2	40	43	PF00928	0.503
TRG_ER_diArg_1	215	218	PF00400	0.342
TRG_ER_diArg_1	230	233	PF00400	0.342
TRG_ER_diArg_1	7	9	PF00400	0.529
TRG_NES_CRM1_1	70	85	PF08389	0.587
TRG_NLS_MonoExtC_3	213	218	PF00514	0.345
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB7	Leptomonas seymouri	81%	100%
A0A1X0P4P9	Trypanosomatidae	68%	100%
A0A3S7WYX0	Leishmania donovani	94%	100%
A4I1A4	Leishmania infantum	94%	100%
D0A5J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AXE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QA32	Leishmania major	94%	100%
V5BN61	Trypanosoma cruzi	67%	100%