Mediator of RNA polymerase II transcription subunit 21

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEF4_LEIBR

TriTrypDb:

LbrM.25.2110 , LBRM2903_250013500

Length:

162


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Could not find GO cellular_component term for this entry.

A4HEF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF4


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.466
CLV_NRD_NRD_1	76	78	PF00675	0.594
CLV_PCSK_KEX2_1	134	136	PF00082	0.521
CLV_PCSK_KEX2_1	75	77	PF00082	0.601
CLV_PCSK_SKI1_1	90	94	PF00082	0.552
DOC_USP7_MATH_1	126	130	PF00917	0.469
LIG_APCC_ABBA_1	137	142	PF00400	0.507
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_BIR_III_2	29	33	PF00653	0.467
LIG_BIR_III_4	105	109	PF00653	0.543
LIG_FHA_2	37	43	PF00498	0.471
LIG_FHA_2	69	75	PF00498	0.536
LIG_LIR_Gen_1	11	19	PF02991	0.355
LIG_LIR_Nem_3	11	16	PF02991	0.360
LIG_Rb_pABgroove_1	134	142	PF01858	0.512
LIG_SH2_CRK	13	17	PF00017	0.486
LIG_SH2_NCK_1	140	144	PF00017	0.372
LIG_SH2_SRC	13	16	PF00017	0.361
LIG_SH2_SRC	140	143	PF00017	0.374
LIG_SH2_STAP1	13	17	PF00017	0.358
LIG_SH2_STAP1	140	144	PF00017	0.504
LIG_SH2_STAT5	15	18	PF00017	0.473
LIG_SUMO_SIM_par_1	112	119	PF11976	0.559
LIG_SUMO_SIM_par_1	135	142	PF11976	0.510
LIG_TRAF2_1	39	42	PF00917	0.459
MOD_CK2_1	36	42	PF00069	0.503
MOD_CK2_1	68	74	PF00069	0.479
MOD_Cter_Amidation	132	135	PF01082	0.521
MOD_GlcNHglycan	105	109	PF01048	0.558
MOD_GlcNHglycan	128	131	PF01048	0.538
MOD_NEK2_1	155	160	PF00069	0.587
MOD_NEK2_1	46	51	PF00069	0.671
MOD_NEK2_1	93	98	PF00069	0.374
MOD_PKA_2	68	74	PF00069	0.557
MOD_Plk_4	31	37	PF00069	0.621
MOD_Plk_4	59	65	PF00069	0.591
MOD_Plk_4	93	99	PF00069	0.295
TRG_DiLeu_BaEn_4	41	47	PF01217	0.477
TRG_ENDOCYTIC_2	13	16	PF00928	0.489
TRG_ER_diArg_1	134	136	PF00400	0.466
TRG_ER_diArg_1	75	77	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.371


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P682	Leptomonas seymouri	59%	100%
A0A1X0P4E5	Trypanosomatidae	35%	100%
A0A3Q8IN81	Leishmania donovani	83%	100%
A0A3R7L9Z8	Trypanosoma rangeli	33%	93%
A4I1A5	Leishmania infantum	83%	100%
D0A5J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AXE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QA31	Leishmania major	83%	100%
V5B7Q6	Trypanosoma cruzi	33%	100%