C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania braziliensis

UniProt:

A4HEF3_LEIBR

TriTrypDb:

LbrM.25.2100 , LBRM2903_250013600

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.541
CLV_C14_Caspase3-7	86	90	PF00656	0.521
CLV_NRD_NRD_1	145	147	PF00675	0.591
CLV_NRD_NRD_1	191	193	PF00675	0.499
CLV_NRD_NRD_1	306	308	PF00675	0.632
CLV_NRD_NRD_1	322	324	PF00675	0.494
CLV_NRD_NRD_1	354	356	PF00675	0.406
CLV_PCSK_FUR_1	189	193	PF00082	0.506
CLV_PCSK_KEX2_1	145	147	PF00082	0.583
CLV_PCSK_KEX2_1	191	193	PF00082	0.499
CLV_PCSK_KEX2_1	306	308	PF00082	0.565
CLV_PCSK_KEX2_1	354	356	PF00082	0.406
CLV_PCSK_SKI1_1	150	154	PF00082	0.523
CLV_PCSK_SKI1_1	355	359	PF00082	0.489
CLV_PCSK_SKI1_1	364	368	PF00082	0.501
CLV_PCSK_SKI1_1	564	568	PF00082	0.506
CLV_PCSK_SKI1_1	639	643	PF00082	0.508
CLV_PCSK_SKI1_1	646	650	PF00082	0.468
DEG_APCC_DBOX_1	631	639	PF00400	0.368
DEG_SCF_FBW7_1	292	298	PF00400	0.493
DEG_SCF_FBW7_1	456	461	PF00400	0.622
DEG_SCF_FBW7_2	446	453	PF00400	0.527
DEG_SPOP_SBC_1	337	341	PF00917	0.440
DEG_SPOP_SBC_1	365	369	PF00917	0.599
DOC_CDC14_PxL_1	481	489	PF14671	0.443
DOC_CKS1_1	292	297	PF01111	0.490
DOC_CKS1_1	605	610	PF01111	0.394
DOC_CYCLIN_yCln2_LP_2	605	611	PF00134	0.429
DOC_MAPK_gen_1	189	198	PF00069	0.484
DOC_MAPK_gen_1	306	313	PF00069	0.497
DOC_MAPK_MEF2A_6	191	200	PF00069	0.464
DOC_MAPK_MEF2A_6	306	313	PF00069	0.485
DOC_MAPK_MEF2A_6	471	478	PF00069	0.458
DOC_MAPK_MEF2A_6	506	515	PF00069	0.430
DOC_MAPK_RevD_3	309	324	PF00069	0.418
DOC_PP1_RVXF_1	148	155	PF00149	0.638
DOC_PP1_RVXF_1	242	249	PF00149	0.514
DOC_PP2B_LxvP_1	74	77	PF13499	0.499
DOC_USP7_MATH_1	170	174	PF00917	0.434
DOC_USP7_MATH_1	265	269	PF00917	0.504
DOC_USP7_MATH_1	300	304	PF00917	0.638
DOC_USP7_MATH_1	326	330	PF00917	0.476
DOC_USP7_MATH_1	365	369	PF00917	0.707
DOC_USP7_MATH_1	373	377	PF00917	0.557
DOC_USP7_MATH_1	408	412	PF00917	0.592
DOC_USP7_MATH_1	466	470	PF00917	0.599
DOC_USP7_MATH_1	66	70	PF00917	0.588
DOC_USP7_MATH_1	92	96	PF00917	0.543
DOC_USP7_UBL2_3	646	650	PF12436	0.464
DOC_WW_Pin1_4	210	215	PF00397	0.497
DOC_WW_Pin1_4	218	223	PF00397	0.458
DOC_WW_Pin1_4	291	296	PF00397	0.493
DOC_WW_Pin1_4	446	451	PF00397	0.570
DOC_WW_Pin1_4	454	459	PF00397	0.614
DOC_WW_Pin1_4	604	609	PF00397	0.608
DOC_WW_Pin1_4	621	626	PF00397	0.325
DOC_WW_Pin1_4	88	93	PF00397	0.562
LIG_14-3-3_CanoR_1	157	167	PF00244	0.578
LIG_14-3-3_CanoR_1	354	362	PF00244	0.513
LIG_14-3-3_CanoR_1	434	440	PF00244	0.608
LIG_Actin_WH2_2	14	29	PF00022	0.390
LIG_Actin_WH2_2	234	252	PF00022	0.531
LIG_Actin_WH2_2	309	325	PF00022	0.502
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_2	89	93	PF00653	0.539
LIG_BIR_III_4	451	455	PF00653	0.658
LIG_BIR_III_4	465	469	PF00653	0.508
LIG_CSL_BTD_1	252	255	PF09270	0.453
LIG_eIF4E_1	395	401	PF01652	0.437
LIG_FHA_1	160	166	PF00498	0.478
LIG_FHA_1	222	228	PF00498	0.580
LIG_FHA_1	296	302	PF00498	0.563
LIG_FHA_1	329	335	PF00498	0.459
LIG_FHA_1	356	362	PF00498	0.416
LIG_FHA_1	468	474	PF00498	0.532
LIG_FHA_1	521	527	PF00498	0.316
LIG_FHA_1	567	573	PF00498	0.471
LIG_FHA_2	161	167	PF00498	0.604
LIG_FHA_2	338	344	PF00498	0.576
LIG_FHA_2	402	408	PF00498	0.510
LIG_FHA_2	442	448	PF00498	0.525
LIG_FHA_2	460	466	PF00498	0.641
LIG_FHA_2	82	88	PF00498	0.653
LIG_LIR_Apic_2	597	602	PF02991	0.392
LIG_LIR_Gen_1	17	26	PF02991	0.469
LIG_LIR_Nem_3	17	23	PF02991	0.468
LIG_LIR_Nem_3	251	256	PF02991	0.482
LIG_LIR_Nem_3	303	308	PF02991	0.472
LIG_PCNA_yPIPBox_3	538	549	PF02747	0.337
LIG_PTB_Apo_2	486	493	PF02174	0.369
LIG_REV1ctd_RIR_1	151	161	PF16727	0.515
LIG_REV1ctd_RIR_1	490	498	PF16727	0.468
LIG_SH2_CRK	23	27	PF00017	0.432
LIG_SH2_CRK	599	603	PF00017	0.424
LIG_SH2_NCK_1	599	603	PF00017	0.424
LIG_SH2_STAP1	194	198	PF00017	0.424
LIG_SH2_STAT3	395	398	PF00017	0.427
LIG_SH2_STAT5	125	128	PF00017	0.529
LIG_SH2_STAT5	223	226	PF00017	0.549
LIG_SH2_STAT5	395	398	PF00017	0.505
LIG_SH3_3	179	185	PF00018	0.490
LIG_SH3_3	287	293	PF00018	0.474
LIG_SH3_3	311	317	PF00018	0.469
LIG_SH3_CIN85_PxpxPR_1	507	512	PF14604	0.383
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.468
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.370
LIG_SUMO_SIM_par_1	444	449	PF11976	0.526
LIG_SUMO_SIM_par_1	606	613	PF11976	0.375
LIG_TYR_ITIM	21	26	PF00017	0.392
LIG_WRC_WIRS_1	567	572	PF05994	0.409
MOD_CAAXbox	657	660	PF01239	0.501
MOD_CK1_1	161	167	PF00069	0.474
MOD_CK1_1	173	179	PF00069	0.454
MOD_CK1_1	218	224	PF00069	0.514
MOD_CK1_1	268	274	PF00069	0.687
MOD_CK1_1	280	286	PF00069	0.508
MOD_CK1_1	459	465	PF00069	0.668
MOD_CK1_1	579	585	PF00069	0.549
MOD_CK1_1	83	89	PF00069	0.564
MOD_CK1_1	95	101	PF00069	0.581
MOD_CK2_1	337	343	PF00069	0.525
MOD_CK2_1	441	447	PF00069	0.606
MOD_CK2_1	81	87	PF00069	0.648
MOD_CMANNOS	274	277	PF00535	0.627
MOD_GlcNHglycan	176	179	PF01048	0.502
MOD_GlcNHglycan	279	282	PF01048	0.593
MOD_GlcNHglycan	302	305	PF01048	0.590
MOD_GlcNHglycan	328	331	PF01048	0.449
MOD_GlcNHglycan	375	378	PF01048	0.549
MOD_GlcNHglycan	379	382	PF01048	0.503
MOD_GlcNHglycan	414	417	PF01048	0.575
MOD_GlcNHglycan	426	429	PF01048	0.560
MOD_GlcNHglycan	54	57	PF01048	0.537
MOD_GlcNHglycan	578	581	PF01048	0.726
MOD_GlcNHglycan	582	585	PF01048	0.582
MOD_GlcNHglycan	596	599	PF01048	0.311
MOD_GlcNHglycan	612	615	PF01048	0.343
MOD_GlcNHglycan	94	97	PF01048	0.649
MOD_GSK3_1	170	177	PF00069	0.480
MOD_GSK3_1	268	275	PF00069	0.645
MOD_GSK3_1	276	283	PF00069	0.549
MOD_GSK3_1	291	298	PF00069	0.516
MOD_GSK3_1	338	345	PF00069	0.504
MOD_GSK3_1	373	380	PF00069	0.538
MOD_GSK3_1	408	415	PF00069	0.690
MOD_GSK3_1	454	461	PF00069	0.610
MOD_GSK3_1	576	583	PF00069	0.550
MOD_GSK3_1	603	610	PF00069	0.486
MOD_GSK3_1	79	86	PF00069	0.579
MOD_GSK3_1	88	95	PF00069	0.604
MOD_N-GLC_1	158	163	PF02516	0.496
MOD_N-GLC_1	576	581	PF02516	0.446
MOD_NEK2_1	171	176	PF00069	0.428
MOD_NEK2_1	208	213	PF00069	0.588
MOD_NEK2_1	336	341	PF00069	0.444
MOD_NEK2_1	356	361	PF00069	0.523
MOD_NEK2_1	492	497	PF00069	0.472
MOD_NEK2_1	603	608	PF00069	0.432
MOD_PKA_2	402	408	PF00069	0.559
MOD_PKB_1	637	645	PF00069	0.517
MOD_Plk_1	234	240	PF00069	0.467
MOD_Plk_1	520	526	PF00069	0.304
MOD_Plk_4	107	113	PF00069	0.548
MOD_Plk_4	226	232	PF00069	0.446
MOD_Plk_4	281	287	PF00069	0.531
MOD_Plk_4	309	315	PF00069	0.462
MOD_Plk_4	328	334	PF00069	0.476
MOD_Plk_4	356	362	PF00069	0.461
MOD_Plk_4	441	447	PF00069	0.522
MOD_ProDKin_1	210	216	PF00069	0.495
MOD_ProDKin_1	218	224	PF00069	0.454
MOD_ProDKin_1	291	297	PF00069	0.491
MOD_ProDKin_1	446	452	PF00069	0.571
MOD_ProDKin_1	454	460	PF00069	0.615
MOD_ProDKin_1	604	610	PF00069	0.605
MOD_ProDKin_1	621	627	PF00069	0.319
MOD_ProDKin_1	88	94	PF00069	0.562
TRG_DiLeu_BaEn_4	633	639	PF01217	0.374
TRG_ENDOCYTIC_2	23	26	PF00928	0.394
TRG_ER_diArg_1	188	191	PF00400	0.511
TRG_ER_diArg_1	305	307	PF00400	0.680
TRG_ER_diArg_1	353	355	PF00400	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP2	Leptomonas seymouri	43%	100%
A0A3S7WYX9	Leishmania donovani	68%	99%
A4I1A6	Leishmania infantum	68%	99%
E9AXE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QA30	Leishmania major	68%	100%