LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HEF2_LEIBR
TriTrypDb:
LbrM.25.2090 , LBRM2903_250013700
Length:
95

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HEF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.478
CLV_PCSK_KEX2_1 3 5 PF00082 0.478
DEG_Nend_Nbox_1 1 3 PF02207 0.693
DOC_PP2B_LxvP_1 16 19 PF13499 0.659
DOC_PP4_FxxP_1 17 20 PF00568 0.658
DOC_PP4_FxxP_1 26 29 PF00568 0.649
DOC_WW_Pin1_4 44 49 PF00397 0.430
LIG_14-3-3_CanoR_1 9 19 PF00244 0.677
LIG_BRCT_BRCA1_1 13 17 PF00533 0.662
LIG_deltaCOP1_diTrp_1 90 94 PF00928 0.447
LIG_FHA_1 11 17 PF00498 0.672
LIG_FHA_2 31 37 PF00498 0.609
LIG_LIR_Apic_2 14 20 PF02991 0.659
LIG_LIR_Apic_2 22 28 PF02991 0.658
LIG_LIR_Nem_3 90 95 PF02991 0.428
LIG_Pex14_2 38 42 PF04695 0.376
LIG_SH2_SRC 54 57 PF00017 0.484
LIG_SH2_STAP1 78 82 PF00017 0.432
LIG_SH2_STAT3 60 63 PF00017 0.465
LIG_SH2_STAT3 73 76 PF00017 0.407
LIG_SH2_STAT5 54 57 PF00017 0.484
LIG_SH2_STAT5 73 76 PF00017 0.461
LIG_SH2_STAT5 78 81 PF00017 0.436
MOD_GlcNHglycan 21 24 PF01048 0.495
MOD_GSK3_1 30 37 PF00069 0.611
MOD_NEK2_1 2 7 PF00069 0.653
MOD_NEK2_1 34 39 PF00069 0.602
MOD_PKA_2 2 8 PF00069 0.674
MOD_Plk_4 34 40 PF00069 0.517
MOD_ProDKin_1 44 50 PF00069 0.430
TRG_ENDOCYTIC_2 86 89 PF00928 0.432
TRG_ER_diArg_1 2 4 PF00400 0.690

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4J9 Leptomonas seymouri 91% 100%
A0A3S5H7E3 Leishmania donovani 98% 100%
A4I1A7 Leishmania infantum 98% 100%
E9AXE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QA29 Leishmania major 97% 100%
V5BSX9 Trypanosoma cruzi 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS