Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania braziliensis

UniProt:

A4HEF1_LEIBR

TriTrypDb:

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HEF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.634
CLV_NRD_NRD_1	139	141	PF00675	0.632
CLV_NRD_NRD_1	150	152	PF00675	0.615
CLV_NRD_NRD_1	182	184	PF00675	0.621
CLV_NRD_NRD_1	188	190	PF00675	0.622
CLV_NRD_NRD_1	223	225	PF00675	0.590
CLV_NRD_NRD_1	229	231	PF00675	0.614
CLV_NRD_NRD_1	54	56	PF00675	0.642
CLV_NRD_NRD_1	58	60	PF00675	0.640
CLV_NRD_NRD_1	62	64	PF00675	0.640
CLV_NRD_NRD_1	66	68	PF00675	0.632
CLV_PCSK_FUR_1	137	141	PF00082	0.635
CLV_PCSK_FUR_1	186	190	PF00082	0.625
CLV_PCSK_KEX2_1	133	135	PF00082	0.634
CLV_PCSK_KEX2_1	139	141	PF00082	0.632
CLV_PCSK_KEX2_1	150	152	PF00082	0.615
CLV_PCSK_KEX2_1	182	184	PF00082	0.621
CLV_PCSK_KEX2_1	188	190	PF00082	0.622
CLV_PCSK_KEX2_1	228	230	PF00082	0.612
CLV_PCSK_KEX2_1	54	56	PF00082	0.642
CLV_PCSK_KEX2_1	58	60	PF00082	0.640
CLV_PCSK_KEX2_1	62	64	PF00082	0.640
CLV_PCSK_KEX2_1	66	68	PF00082	0.632
CLV_PCSK_PC7_1	129	135	PF00082	0.625
CLV_PCSK_PC7_1	178	184	PF00082	0.615
CLV_PCSK_PC7_1	224	230	PF00082	0.602
CLV_PCSK_PC7_1	50	56	PF00082	0.640
CLV_PCSK_PC7_1	58	64	PF00082	0.639
CLV_PCSK_SKI1_1	17	21	PF00082	0.589
CLV_PCSK_SKI1_1	230	234	PF00082	0.604
DEG_APCC_DBOX_1	23	31	PF00400	0.411
DEG_SCF_FBW7_1	231	237	PF00400	0.393
DOC_CKS1_1	231	236	PF01111	0.395
DOC_MAPK_FxFP_2	267	270	PF00069	0.366
DOC_MAPK_MEF2A_6	268	275	PF00069	0.356
DOC_MAPK_MEF2A_6	36	43	PF00069	0.430
DOC_PP1_RVXF_1	236	242	PF00149	0.387
DOC_PP1_RVXF_1	262	268	PF00149	0.372
DOC_PP4_FxxP_1	267	270	PF00568	0.366
DOC_WW_Pin1_4	104	109	PF00397	0.382
DOC_WW_Pin1_4	153	158	PF00397	0.386
DOC_WW_Pin1_4	2	7	PF00397	0.381
DOC_WW_Pin1_4	230	235	PF00397	0.400
DOC_WW_Pin1_4	247	252	PF00397	0.387
DOC_WW_Pin1_4	31	36	PF00397	0.424
DOC_WW_Pin1_4	66	71	PF00397	0.424
LIG_14-3-3_CanoR_1	101	111	PF00244	0.387
LIG_14-3-3_CanoR_1	150	160	PF00244	0.392
LIG_14-3-3_CanoR_1	213	217	PF00244	0.373
LIG_14-3-3_CanoR_1	238	242	PF00244	0.388
LIG_14-3-3_CanoR_1	24	28	PF00244	0.407
LIG_14-3-3_CanoR_1	246	251	PF00244	0.386
LIG_14-3-3_CanoR_1	268	274	PF00244	0.358
LIG_14-3-3_CanoR_1	62	70	PF00244	0.430
LIG_14-3-3_CanoR_1	90	99	PF00244	0.423
LIG_FHA_1	205	211	PF00498	0.373
LIG_FHA_1	234	240	PF00498	0.386
LIG_FHA_2	276	282	PF00498	0.340
LIG_LIR_Nem_3	74	79	PF02991	0.407
LIG_SH2_PTP2	289	292	PF00017	0.199
LIG_SH2_SRC	289	292	PF00017	0.199
LIG_SH2_SRC	9	12	PF00017	0.382
LIG_SH2_STAT3	209	212	PF00017	0.375
LIG_SH2_STAT5	209	212	PF00017	0.375
LIG_SH2_STAT5	289	292	PF00017	0.199
LIG_SH2_STAT5	9	12	PF00017	0.382
LIG_SH3_3	32	38	PF00018	0.423
MOD_CDK_SPK_2	31	36	PF00069	0.424
MOD_CK1_1	100	106	PF00069	0.404
MOD_CK1_1	132	138	PF00069	0.433
MOD_CK1_1	149	155	PF00069	0.407
MOD_CK1_1	181	187	PF00069	0.423
MOD_CK1_1	199	205	PF00069	0.381
MOD_CK1_1	215	221	PF00069	0.367
MOD_CK1_1	22	28	PF00069	0.403
MOD_CK1_1	249	255	PF00069	0.393
MOD_CK1_1	260	266	PF00069	0.374
MOD_CK1_1	46	52	PF00069	0.435
MOD_CK1_1	53	59	PF00069	0.441
MOD_CK1_1	61	67	PF00069	0.437
MOD_CK1_1	89	95	PF00069	0.424
MOD_GSK3_1	100	107	PF00069	0.399
MOD_GSK3_1	125	132	PF00069	0.415
MOD_GSK3_1	149	156	PF00069	0.402
MOD_GSK3_1	174	181	PF00069	0.409
MOD_GSK3_1	19	26	PF00069	0.398
MOD_GSK3_1	195	202	PF00069	0.386
MOD_GSK3_1	211	218	PF00069	0.373
MOD_GSK3_1	230	237	PF00069	0.396
MOD_GSK3_1	245	252	PF00069	0.386
MOD_GSK3_1	269	276	PF00069	0.354
MOD_GSK3_1	277	284	PF00069	0.329
MOD_GSK3_1	45	52	PF00069	0.434
MOD_GSK3_1	53	60	PF00069	0.440
MOD_GSK3_1	61	68	PF00069	0.435
MOD_LATS_1	123	129	PF00433	0.411
MOD_LATS_1	172	178	PF00433	0.406
MOD_LATS_1	84	90	PF00433	0.424
MOD_N-GLC_1	146	151	PF02516	0.620
MOD_N-GLC_1	195	200	PF02516	0.588
MOD_N-GLC_1	20	25	PF02516	0.598
MOD_N-GLC_1	252	257	PF02516	0.600
MOD_N-GLC_1	260	265	PF02516	0.576
MOD_N-GLC_1	86	91	PF02516	0.626
MOD_N-GLC_1	97	102	PF02516	0.618
MOD_NEK2_1	19	24	PF00069	0.396
MOD_NEK2_1	197	202	PF00069	0.385
MOD_NEK2_1	273	278	PF00069	0.349
MOD_NEK2_1	88	93	PF00069	0.423
MOD_PIKK_1	138	144	PF00454	0.431
MOD_PIKK_1	187	193	PF00454	0.415
MOD_PKA_1	54	60	PF00069	0.440
MOD_PKA_1	62	68	PF00069	0.435
MOD_PKA_2	100	106	PF00069	0.404
MOD_PKA_2	132	138	PF00069	0.433
MOD_PKA_2	149	155	PF00069	0.407
MOD_PKA_2	181	187	PF00069	0.423
MOD_PKA_2	212	218	PF00069	0.372
MOD_PKA_2	23	29	PF00069	0.408
MOD_PKA_2	237	243	PF00069	0.385
MOD_PKA_2	245	251	PF00069	0.384
MOD_PKA_2	257	263	PF00069	0.384
MOD_PKA_2	46	52	PF00069	0.435
MOD_PKA_2	53	59	PF00069	0.441
MOD_PKA_2	61	67	PF00069	0.437
MOD_PKA_2	89	95	PF00069	0.424
MOD_Plk_1	260	266	PF00069	0.374
MOD_Plk_1	97	103	PF00069	0.415
MOD_Plk_4	199	205	PF00069	0.381
MOD_Plk_4	237	243	PF00069	0.385
MOD_ProDKin_1	104	110	PF00069	0.380
MOD_ProDKin_1	153	159	PF00069	0.385
MOD_ProDKin_1	2	8	PF00069	0.382
MOD_ProDKin_1	230	236	PF00069	0.398
MOD_ProDKin_1	247	253	PF00069	0.390
MOD_ProDKin_1	31	37	PF00069	0.425
MOD_ProDKin_1	66	72	PF00069	0.423
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.408
TRG_ENDOCYTIC_2	289	292	PF00928	0.199
TRG_ER_diArg_1	137	140	PF00400	0.438
TRG_ER_diArg_1	15	18	PF00400	0.383
TRG_ER_diArg_1	186	189	PF00400	0.429
TRG_ER_diArg_1	227	230	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.576